Cited by 163Cardiac Health and Mental HealthTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Treatment-Resistant Depression and Mortality After Acute Coronary Syndrome

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Carney, Robert M., Freedland, Kenneth E.·2009·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2008.08081239PMC PMC3465939

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Abstract

Depression is a risk factor for morbidity and mortality in patients with coronary heart disease, especially following acute coronary syndrome. Evidence from recent clinical trials suggests that treatment-resistant depression may be associated with a particularly high risk of mortality or cardiac morbidity in patients following acute coronary syndrome. This article reviews this evidence and considers possible explanations for this relationship. Directions for future research are also considered, with particular emphasis on efforts to elucidate the underlying mechanisms and to develop more efficacious treatments for depression in patients with coronary heart disease.

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Authors: Carney, R. M., & Freedland, K. E.
Affiliations: Washington University in St. Louis (US)
ORCID: Carney, Robert M.
Freedland, Kenneth E.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2009-04
Volume: 166
Issue: 4
Pages: 410-417
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2008.08081239
PMC: PMC3465939
OpenAlex: W2129412441
Cited by: 163
References: 62
Citations by year: 2025: 3 · 2024: 11 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 5 · 2013: 17 · 2012: 14
FWCI: 3.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL076808, HL-76808)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: treatment-resistant depression, acute coronary syndrome, mortality, coronary artery disease, cardiac morbidity, depression as risk factor
MeSH terms: Antidepressive Agents, Combined Modality Therapy, Depressive Disorder, Major, Major Depressive Disorder, Drug Resistance, Drug Therapy, Combination, Follow-Up Studies, Humans, Myocardial Infarction, Personality Inventory, Psychometrics, Citalopram, Comorbidity, Cognitive Behavioral Therapy, Survival Rate, Randomized Controlled Trials as Topic, Bupropion, Acute Coronary Syndrome, Secondary Prevention

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Treatment-Resistant Depression and Mortality After Acute Coronary Syndrome

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