Cited by 1,269Tryptophan and brain disordersSchizophrenia research and treatmentMaternal Mental Health During Pregnancy and Postpartum

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Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

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Brown, Alan S., Derkits, Elena J.·2010·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2009.09030361PMC PMC3652286

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Abstract

An emerging literature from epidemiologic, clinical, and preclinical investigations has provided evidence that gestational exposure to infection contributes to the etiology of schizophrenia. In recent years, these studies have moved from ecologic designs, which ascertain infection based on epidemics in populations, to investigations that have capitalized on reliable biomarkers in individual pregnancies. These studies have documented specific candidate infections that appear to be associated with an elevated risk of schizophrenia. Animal models of maternal immune activation inspired by this work have revealed intriguing findings indicating behavioral, neurochemical, and neurophysiologic abnormalities consistent with observations in schizophrenia. In parallel studies in humans and animals, investigators are working to uncover the cellular and molecular mechanisms by which in utero exposure to infection contributes to schizophrenia risk. In this review, the authors discuss and critically evaluate the epidemiologic literature on in utero exposure to infection and schizophrenia, summarize emerging animal models of maternal immune activation, and discuss putative unique and common mechanisms by which in utero exposure to infection alters neurodevelopment, potentially increasing susceptibility to schizophrenia. The promise of this work for facilitating the identification of susceptibility loci in genetic studies of schizophrenia is illustrated by examples of interaction between in utero exposure to infection and genetic variants. The authors then elaborate on possible implications of this work, including the use of preventive measures for reducing the incidence of schizophrenia. Finally, they discuss new approaches aimed at addressing current challenges in this area of research.

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Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821
Infectious Diseases of the Fetus and Newborn Infant
Remington, J. S., & Klein, J. O. (1984) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-198401000-00024 · Cited by 2,460
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
Common variants conferring risk of schizophrenia
†Genetic Risk and Outcome in Psychosis (GROUP), Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietiläinen, O. P. H., Mors, O., et al. (2009) · Nature · doi:10.1038/nature08186 · Cited by 1,677
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605
Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction
Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.026 · Cited by 1,409
Herpes simplex virus infections
Whitley, R. J., & Roizman, B. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04638-9 · Cited by 1,391
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
Mednick, S. A. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800260109013 · Cited by 1,203
Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review
Cannon, M. D., Jones, P. B., & Murray, R. M. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1080 · Cited by 1,190
Common variants on chromosome 6p22.1 are associated with schizophrenia
Shi, J., Levinson, D. F., Duan, J., Sanders, A. R., Zheng, Y., Pe’er, I., Dudbridge, F., Holmans, P., Whittemore, A. S., Mowry, B. J., et al. (2009) · Nature · doi:10.1038/nature08192 · Cited by 1,154
Identification of loci associated with schizophrenia by genome-wide association and follow-up
Molecular Genetics of Schizophrenia Collaboration, O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., et al. (2008) · Nature Genetics · doi:10.1038/ng.201 · Cited by 1,070
Serologic Evidence of Prenatal Influenza in the Etiology of Schizophrenia
Brown, A. S., Begg, M. D., Gravenstein, S., Schaefer, C. A., Wyatt, R. J., Bresnahan, M. A., Babulas, V. P., & Susser, E. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.774 · Cited by 1,048
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Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00297.2003 · Cited by 1,025
Axonal Neuregulin-1 Regulates Myelin Sheath Thickness
Michailov, G. V., Sereda, M. W., Brinkmann, B. G., Fischer, T. M., Haug, B., Birchmeier, C., Role, L. W., Lai, C., Schwab, M. H., & Nave, K. (2004) · Science · doi:10.1126/science.1095862 · Cited by 940
Maternal Intrauterine Infection, Cytokines, and Brain Damage in the Preterm Newborn
Dammann, O., & Leviton, A. (1997) · Pediatric Research · doi:10.1203/00006450-199707000-00001 · Cited by 886
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Stephan, K. E., Baldeweg, T., & Friston, K. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.005 · Cited by 841
White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction
Davis, K. L., Stewart, D. G., Friedman, J. I., Buchsbaum, M., Harvey, P. D., Hof, P. R., Buxbaum, J., & Haroutunian, V. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.5.443 · Cited by 793
Immune involvement in schizophrenia and autism: Etiology, pathology and animal models
Patterson, P. H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.016 · Cited by 766
Advancing Paternal Age and the Risk of Schizophrenia
Malaspina, D., Harlap, S., Fennig, S., Heiman, D., Nahon, D., Feldman, D., & Susser, E. S. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.361 · Cited by 562
A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development
Kamiya, A., Kubo, K., Tomoda, T., Takaki, M., Youn, R., Ozeki, Y., Sawamura, N., Park, U., Kudo, C., Okawa, M., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1328 · Cited by 531
Behavioral phenotypes of Disc1 missense mutations in mice
Clapcote, S. J., Lipina, T. V., Millar, J. K., Mackie, S., Christie, S., Ogawa, F., Lerch, J. P., Trimble, K., Uchiyama, M., Sakuraba, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.015 · Cited by 526
Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
Callicott, J. H., Straub, R. E., Pezawas, L., Egan, M. F., Mattay, V. S., Hariri, A. R., Verchinski, B. A., Meyer‐Lindenberg, A., Balkissoon, R., Kolachana, B. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500515102 · Cited by 519
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Buka, S. L. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.11.1032 · Cited by 512
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Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia
Pletnikov, M., Ayhan, Y., Nikolskaia, O., Xu, Y., Ovanesov, M., Huang, H., Mori, S., Moran, T., & Ross, C. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002079 · Cited by 375
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Buka, S. L., Tsuang, M. T., Torrey, E. F., Klebanoff, M. A., Wagner, R., & Yolken, R. H. (2001) · Brain Behavior and Immunity · doi:10.1006/brbi.2001.0644 · Cited by 316
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Sørensen, H. J., Mortensen, E. L., Reinisch, J. M., & Mednick, S. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn121 · Cited by 261
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Shen, S., Lang, B., Nakamoto, C., Zhang, F., Pu, J., Kuan, S. L., Chatzi, C. A., He, S., Mackie, I., Brandon, N. J., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3299-08.2008 · Cited by 257
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Sham, P. C., O’Callaghan, E., Takei, N., Murray, G. K., Hare, E. H., & Murray, R. M. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.160.4.461 · Cited by 250
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Buka, S. L., Cannon, T. D., Torrey, E. F., & Yolken, R. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.022 · Cited by 233
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Babulas, V. P., Factor-Litvak, P. R., Goetz, R. R., Schaefer, C. A., & Brown, A. S. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.5.927 · Cited by 233
Self-citation
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Krystal, J. H., D’Souza, C., Petrakis, I. L., Belger, A., Berman, R., Charney, D. S., Abi‐Saab, W., & Madonick, S. H. (1999) · Harvard Review of Psychiatry · doi:10.3109/hrp.7.3.125 · Cited by 232
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Yau, H.-J. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.3.252 · Cited by 225
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Watson, C. G. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790120089011 · Cited by 224
Regulation of NMDA Receptors by Neuregulin Signaling in Prefrontal Cortex
Gu, Z., Jiang, Q., Fu, A. K. Y., Ip, N. Y., & Yan, Z. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1086-05.2005 · Cited by 220
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Self-citation
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Faulkner, R. L., Jang, M., Liu, X.-B., Duan, X., Sailor, K. A., Kim, J. Y., Ge, S., Jones, E. G., Ming, G., Song, H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806658105 · Cited by 218
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GILMORE, J., & FREDRIKJARSKOG, L. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00123-5 · Cited by 209
Association Between Prenatal Exposure to Poliovirus Infection and Adult Schizophrenia
Suvisaari, J., Haukka, J. K., Tanskanen, A. J., Hovi, T., & Lönnqvist, J. K. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.7.1100 · Cited by 192
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Riley, B., & Kendler, K. S. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201571 · Cited by 190
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Chen, Y.-J. J., Johnson, M. A., Lieberman, M. D., Goodchild, R. E., Schobel, S., Lewandowski, N., Rosoklija, G., Liu, R.-C., Gingrich, J. A., Small, S., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1815-08.2008 · Cited by 188
Association between −G308A tumor necrosis factor alpha gene polymorphism and schizophrenia
Boin, F., Zanardini, R., Pioli, R., Altamura, C. A., Maes, M. H. J., & Gennarelli, M. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000815 · Cited by 179
Maternal Influenza in the Etiology of Schizophrenia
Kendell, R. E. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810100020004 · Cited by 174
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Mednick, S. A., HUTTUNEN, M. O., & Machón, R. A. (1994) · Schizophrenia Bulletin · doi:10.1093/schbul/20.2.263 · Cited by 168
Cytokine production in chorioamnionitis
Saji, F., Samejima, Y., Kamiura, S., Sawai, K., Shimoya, K., & Kimura, T. (2000) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(00)00064-4 · Cited by 162
Decline in the Incidence of Schizophrenia in Finnish Cohorts Born From 1954 to 1965
Suvisaari, J., Haukka, J. K., Tanskanen, A. J., & Lönnqvist, J. K. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.8.733 · Cited by 148
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Baud, O., Émilie, D., Pelletier, E., Lacaze‐Masmonteil, T., Zupan, V., Fernandez, H., Dehan, M., Frydman, R., & Ville, Y. G. (1999) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1999.tb08088.x · Cited by 146
Season of Birth in Schizophrenia
O’Callaghan, E., Gibson, T., Colohan, H. A., Walshe, D. G., Buckley, P., Larkin, C., & Waddington, J. L. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.158.6.764 · Cited by 138
Prenatal exposure to influenza as a risk factor for adult schizophrenia
Limosin, F., Rouillon, F., Payan, C., Cohen, J., & Strub, N. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2003.00052.x · Cited by 137
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Marx, C. E., Jarskog, L. F., Lauder, J. M., Lieberman, J. A., & Gilmore, J. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01209-4 · Cited by 134
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Westergaard, T., Mortensen, P. B., Pedersen, C. B., Wohlfahrt, J., & Melbye, M. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.993 · Cited by 133
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Rimer, M., Barrett, D. W., Maldonado, M. A., Vock, V. M., & Gonzalez-Lima, F. (2005) · Neuroreport · doi:10.1097/00001756-200502280-00014 · Cited by 120
Schizophrenia following in utero exposure to the 1957 influenza epidemics in Japan
Kunugi, H., Nanko, S., Takei, N., Saito, K., Hayashi, N., & Kazamatsuri, H. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.450 · Cited by 119
Prenatal Exposure to the 1957 Influenza Epidemic and Adult Schizophrenia: A Follow-Up Study
Cannon, M. D., Cotter, D., Coffey, V. P., Sham, P. C., Takei, N., Larkin, C., Murray, R. M., & O’Callaghan, E. (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.168.3.368 · Cited by 116
The Relationship of Schizophrenic Births to 16 Infectious Diseases
O’Callaghan, E., Sham, P. C., Takei, N., Murray, G. K., Glover, G. R., Hare, E. H., & Murray, R. M. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.165.3.353 · Cited by 110
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Takei, N., Mortensen, P. B., Kl˦ning, U., Murray, R. M., Sham, P. C., O’Callaghan, E., & Munk‐Jørgensen, P. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00592-7 · Cited by 105
Influenza
Kilbourne, E. D. (1987) · Springer eBooks · doi:10.1007/978-1-4684-5239-6 · Cited by 105
The Design of the Prenatal Determinants of Schizophrenia Study
Susser, E., Schaefer, C. A., Brown, A. S., Begg, M. D., & Wyatt, R. J. (2000) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033451 · Cited by 104
Self-citation
Psychiatric Epidemiology
Susser, E., Schwartz, S., Morabia, A., & Bromet, E. J. (2006) · doi:10.1093/acprof:oso/9780195101812.001.0001 · Cited by 99
Influenza epidemics and incidence of schizophrenia, affective disorders and mental retardation in Western Australia: no evidence of a major effect
Morgan, V. A., Castle, D. J., Page, A. C., Fazio, S., Gurrin, L. C., Burton, P. R., Montgomery, P., & Jablensky, A. V. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00033-9 · Cited by 98
Prenatal exposure to influenza and the development of schizophrenia: is the effect confined to females?
Takei, N., Sham, P. C., O’Callaghan, E., Murray, G. K., Glover, G. R., & Murray, R. M. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.1.117 · Cited by 94
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Wood, J. D., Bonath, F., Kumar, S., Ross, C. A., & Cunliffe, V. T. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn361 · Cited by 91
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Babovic, D., O’Tuathaigh, C. M. P., O'Connor, A. M., O'Sullivan, G. J., Tighe, O., Croke, D. T., Karayiorgou, M., Gogos, J. A., Cotter, D., & Waddington, J. L. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.006 · Cited by 90
Schizophrenia and influenza
Crow, T. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)90109-3 · Cited by 90
No relation between risk of schizophrenia and prenatal exposure to influenza in Holland
Susser, E., Lin, S. P., Brown, A. S., Lumey, L. H., & Erlenmeyer‐Kimling, L. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.6.922 · Cited by 90
Self-citation
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O’Tuathaigh, C. M. P., O'Connor, A.-M., O'Sullivan, G. J., Lai, D., Harvey, R. P., Croke, D. T., & Waddington, J. L. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.018 · Cited by 88
ERP abnormalities during semantic processing in schizophrenia☆
Adams, J., Faux, S. F., Nestor, P. G., Shenton, M. E., Marcy, B., Smith, S. T., & McCarley, R. W. (1993) · Schizophrenia Research · doi:10.1016/0920-9964(93)90059-r · Cited by 81
No Evidence of Relation Between Maternal Exposure to Herpes Simplex Virus Type 2 and Risk of Schizophrenia?
Brown, A. S., Schaefer, C. A., Quesenberry, C. P., Shen, L., & Susser, E. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.12.2178 · Cited by 76
Self-citation
Heterozygous neuregulin 1 mice display greater baseline and Δ9-tetrahydrocannabinol-induced c-Fos expression
Boucher, A. A., Hunt, G. E., Karl, T., Micheau, J., McGregor, I. S., & Arnold, J. C. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.08.020 · Cited by 73
Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
O’Donovan, M. C., Norton, N., Williams, H. J., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M. L., Carroll, L. S., Georgieva, L., Dwyer, S., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.108 · Cited by 72
Schizophrenia and the influenza epidemics of 1957 in Japan
Izumoto, Y., Inoue, S., & Yasuda, N. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00359-x · Cited by 70
Evidence Against Maternal Influenza as a Risk Factor for Schizophrenia
Selten, J., & Slaets, J. P. J. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.164.5.674 · Cited by 65
Stalking the Schizovirus
Torrey, Ε. F. (1988) · Schizophrenia Bulletin · doi:10.1093/schbul/14.2.223 · Cited by 62
Does Influenza Cause Schizophrenia? A Five Year Review
McGrath, J. J., & Castle, D. J. (1995) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048679509075888 · Cited by 55
Serologic evidence for prenatal influenza in the etiology of schizophrenia
Brown, A. S., Begg, M. D., Gravenstein, S., Schaefer, C. A., Wyatt, R. J., Bresnahan, M. A., Babulas, V. P., & Susser, E. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)80098-1 · Cited by 53
Self-citation
Schizophrenia and prenatal exposure to the 1957 A2 influenza epidemic in Croatia
Erlenmeyer‐Kimling, L., Folnegović, Z., Hrabak-Žerjavić, V., Borcić, B., Folnegović-Šmalc, V., & Susser, E. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.10.1496 · Cited by 52
Enlargement of the lateral ventricles in mutant DISC1 transgenic mice
Pletnikov, M. V., Ayhan, Y., Xu, Y., Nikolskaia, O. V., Ovanesov, M. V., Huang, H., Mori, S., Moran, T. H., & Ross, C. A. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002144 · Cited by 51
Does prenatal influenza divert susceptible females from later affective psychosis to schizophrenia?
Takei, N., O’Callaghan, E., Sham, P. C., Glover, G. R., & Murray, R. M. (1993) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1993.tb03468.x · Cited by 49
No relationship between schizophrenic birth and influenza epidemics in Japan
Mino, Y., Oshima, I., Tsuda, T., & Okagami, K. (2000) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00003-0 · Cited by 43
Prenatal exposure to influenza and schizophrenia in surinamese and Dutch Antillean immigrants to The Netherlands
Selten, J., Slaets, J. P. J., & Kahn, R. S. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00105-9 · Cited by 40
Maternal exposure to influenza and paranoid schizophrenia
Grech, A., Takei, N., & Murray, R. M. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00056-x · Cited by 24
No significant association between prenatal exposure topoliovirus epidemics and psychosis
Cahill, M., Chant, D. C., Welham, J., & McGrath, J. J. (2002) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2001.01006.x · Cited by 15
Schizophrenia risk for women from in utero exposure to influenza
Takei, N., Murray, R. M., Sham, P. C., & O’Callaghan, E. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.1.150b · Cited by 12
The Direct Embryotoxicity of Immunoglobulin G Fractions From Patients With Systemic Lupus Erythematosus
Nadler, D., Klein, N. W., Aramli, L. A., Chambers, B. J., MAVES, M., & Wener, M. H. (1995) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1995.tb00963.x · Cited by 11
Cytokines
Weizman, R., & Bessler, H. (1998) · CRC Press eBooks · doi:10.1201/9781420048193.ch1 · Cited by 10

Flagged first, then by citations

Research works printed but not linked: 3

Martin , Dombrowski SC : Prenatal infections, in Prenatal Exposures: Psychological and Educational Consequences for Children. New York, Springer, 2008, pp 57–86
Dukes CS , Luft BJ , Durack DT , Scheld WM , Whitley RJ : Toxoplasmosis, in Infections of the Central Nervous System. Edited by , Scheld WM , Whitley RJ , Durack DT . Philadelphia, Lippincott-Raven, 1997, pp 785–806
Rothman KJ, 2008, Modern Epidemiology, 3rd ed

Sorted by citations

Rethinking schizophrenia
Insel, T. R. (2010) · Nature · doi:10.1038/nature09552 · Cited by 1,783
Microglia development follows a stepwise program to regulate brain homeostasis
Matcovitch-Natan, O., Winter, D. R., Giladi, A., Vargas Aguilar, S., Spinrad, A., Sarrazin, S., Ben-Yehuda, H., David, E., Zelada González, F., Perrin, P., et al. (2016) · Science · doi:10.1126/science.aad8670 · Cited by 1,180
Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms
Troyer, E. A., Kohn, J. N., & Hong, S. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.04.027 · Cited by 964
Maternal immune activation and abnormal brain development across CNS disorders
Knuesel, I., Chicha, L., Britschgi, M., Schobel, S. A., Bodmer, M., Hellings, J. A., Toovey, S., & Prinssen, E. P. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.187 · Cited by 880
Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment
Khandaker, G. M., Cousins, L., Deakin, J., Lennox, B. R., Yolken, R., & Jones, P. B. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00122-9 · Cited by 926

See all 1,269

Authors: Brown, A. S., & Derkits, E. J.
Affiliations: New York State Psychiatric Institute (US)
ORCID: Brown, Alan S.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2010-03-01
Volume: 167
Issue: 3
Pages: 261-280
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2009.09030361
PMC: PMC3652286
OpenAlex: W2040789766
Cited by: 1,269
References: 99
Citations by year: 2026: 33 · 2025: 47 · 2024: 73 · 2023: 68 · 2022: 74 · 2021: 78 · 2020: 90 · 2019: 79 · 2018: 84 · 2017: 68 · 2016: 90 · 2015: 89 · 2014: 87 · 2013: 89 · 2012: 98
FWCI: 34.35
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (K02MH065422, R01MH082052, R01MH060249, 1R01MH-082052-01A1)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (N01-HD13334, N010HD-6-3258)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords: prenatal infection, schizophrenia, maternal immune activation, intrauterine infection, brain development, animal models, genetic susceptibility loci, gene-environment interaction, infection biomarkers, schizophrenia prevention, etiology of schizophrenia
MeSH terms: Animals, Cross-Sectional Studies, Female, Herpes Genitalis, Humans, Infant, Newborn, Influenza, Human, Pregnancy, Pregnancy Complications, Infectious, Prenatal Exposure Delayed Effects, Pyelonephritis, Risk Factors, Schizophrenia, Social Environment, Toxoplasmosis, Congenital, Cohort Studies, Causality, Cytokines, Genetic Predisposition to Disease, Epigenesis, Genetic, Mice, Rats, Genome-Wide Association Study

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Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

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