The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Association of FKBP5 Polymorphisms With Suicidal Events in the Treatment of Resistant Depression in Adolescents (TORDIA) Study
Open accessAbstract
OBJECTIVE: The authors sought to assess the relationship between candidate genes and two clinical outcomes, namely, symptomatic improvement and the occurrence of suicidal events, in a sample of treatment-resistant depressed adolescents. METHOD: A subsample of depressed adolescents participating in the Treatment of SSRI-Resistant Depression in Adolescents (TORDIA) trial, 155 of whom were of European origin, were genotyped with respect to 21 polymorphisms on 12 genes that have a reported association with depression, treatment response, or suicidal events. Participants had not responded to a previous adequate trial with an antidepressant and were randomized to receive either another selective serotonin reuptake inhibitor or venlafaxine, with or without cognitive-behavioral therapy (CBT). Single-nucleotide polymorphism (SNP) analyses were conducted using PLINK with permutation procedures. RESULTS: No relationship was observed between any polymorphism and response to treatment. The FKBP5 (which codes for a protein causing subsensitivity of the glucocorticoid receptor) rs1360780TT and rs3800373GG genotypes were associated with suicidal events (N=18), even after controlling for treatment effects and relevant covariates. These two SNPs were in significant linkage disequilibrium (r=0.91). CONCLUSIONS: The FKBP5 genotypes associated with suicidal events in this study have been reported by others to cause the greatest degree of glucocorticoid receptor subsensitivity. These results are consistent with those of other studies linking alterations in the hypothalamic-pituitary-adrenal axis with suicidal behavior. The small number of events and lack of a placebo condition make these results preliminary. Replication with a larger sample and a placebo condition is needed to assess whether these events are related to treatment.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Glucocorticoid receptors are subject to genetic effects via chaperone proteins like SKA1 and FKBP5 (58, 148, 149), as well as epigenetic changes (i.e., methylation) observed in response to maternal deprivation in rats (150) and in suicide decedents with a history of childhood adversity (60).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [149]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation
Beck, A. T., Steer, R. A., & Carbin, M. G. (1988) · Clinical Psychology Review · doi:10.1016/0272-7358(88)90050-5 · Cited by 11,696
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148
Self-citationECDEU Assessment Manual: (591322011-001)
Guy, W. (1976) · PsycEXTRA Dataset · doi:10.1037/e591322011-001 · Cited by 1,896
Non-suicidal self-injury among adolescents: Diagnostic correlates and relation to suicide attempts
NOCK, M., JOINERJR, T., GORDON, K., LLOYDRICHARDSON, E., & PRINSTEIN, M. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2006.05.010 · Cited by 1,617
A Note on Exact Tests of Hardy-Weinberg Equilibrium
Wigginton, J. E., Cutler, D. J., & Abecasis, G. R. (2005) · The American Journal of Human Genetics · doi:10.1086/429864 · Cited by 1,492
Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362
Bridge, J. A., Iyengar, S., Salary, C. B., Barbe, R. P., Birmaher, B., Pincus, H. A., Ren, L., & Brent, D. A. (2007) · JAMA · doi:10.1001/jama.297.15.1683 · Cited by 1,086
Self-citationBirmaher, B., & Brent, D. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318145ae1c · Cited by 1,056
Self-citationPosner, K., Oquendo, M. A., Gould, M., Stanley, B., & Davies, M. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.7.1035 · Cited by 1,025
Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1479 · Cited by 977
Research works printed but not linked: 4
- Kato M, Mol Psychiatry
- 1994, American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed (DSM-IV)
- Poznanski EO, 1985, Psychopharmacol Bull, 21, 979
- 10.1210/endo.141.11.7785 · DOI · Paper page
Cited by
Sorted by citations
Items 101–138 of 138
Feng, X.-L., Wang, F., Zou, Y., Li, W.-F., Tian, Y., Pan, F., & Huang, F. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2010.00514.x · Cited by 6
Treatment of Resistant Depression in Adolescents (TORDIA): Week 24 Outcomes
Mack, A. H. (2011) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/j.ypsy.2010.09.013 · Cited by 5
Precision Psychiatry: Personalized Clinical Approach to Depression
Perna, G., Balletta, R., & Nemeroff, C. B. (2017) · Springer eBooks · doi:10.1007/978-981-10-6580-4_21 · Cited by 5
Troy, T. F., Poweleit, E. A., Strawn, J. R., Martin, L. J., & Ramsey, L. B. (2020) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2019.0180 · Cited by 5
Jiang, Z., Wang, J., Yu, X., Li, C., Shao, Y., & Wang, Z. (2020) · Medicine · doi:10.1097/md.0000000000022274 · Cited by 5
Healy, D., Bechthold, K., & Tolias, P. P. (2014) · Personalized Medicine · doi:10.2217/pme.13.93 · Cited by 5
[The prevalence of obesity among the adult population of Kazakhstan].
Kadyrova, R. K., & Salkhanov, B. A. (1990) · PubMed · Cited by 5
Antidepressiva und Selbstgefährdung: ein Widerspruch?
Hatzinger, M. (2019) · Praxis · doi:10.1024/1661-8157/a003235 · Cited by 4
Garcia-Quiñones, J. A., Sanchez-Dominguez, C. N., Serna-Rodríguez, M. F., Marino-Martínez, I. A., Rivas, A., & Pérez‐Maya, A. A. (2023) · Archives of Suicide Research · doi:10.1080/13811118.2023.2176269 · Cited by 4
Importance of genomic studies for drug withdrawal with mental toxicities
Lu, D.-Y., & Lu, T.-R. (2011) · Drugs and Therapy Studies · doi:10.4081/dts.2011.e11 · Cited by 4
Pak, T. K., Ayvaci, E. R., Carmody, T. J., Jamma, L., Feng, Z., Nekovei, A., Emslie, G. J., & Trivedi, M. H. (2025) · iScience · doi:10.1016/j.isci.2025.112290 · Cited by 4
Self-citationTrebatická, J., Vatrál, M., Katrenčíková, B., Muchová, J., & Ďuračková, Z. (2025) · Antioxidants · doi:10.3390/antiox14060699 · Cited by 6
Cîmpianu, M. E., Onișan, E., Sărac, V. M., Sărac, I., Ganea, M., Gligor, O., Bâlici, Ș., Nicula, G. Z., Domșa, E. M., Cîmpianu, T., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168053 · Cited by 4
Antidepressants and Suicide Risk: Harmful or Useful?
Courtet, P., Nobile, B., & López‐Castromán, J. (2017) · Springer eBooks · doi:10.1007/978-981-10-4816-6_18 · Cited by 4
Assessing Psychiatric Adverse Effects during Clinical Drug Development
Rudorfer, M. V., & Hillefors, M. (2012) · Pharmaceutical Medicine · doi:10.1007/bf03262382 · Cited by 3
A patient-centered model of the action of psychotropic drugs
Rajkumar, R. P. (2015) · Personalized Medicine Universe · doi:10.1016/j.pmu.2015.03.001 · Cited by 3
Fang, T., Liu, M., Tian, X.-Y., Lu, G.-Y., Li, F. Y., Zhang, X., Liu, F., Hao, W., Wu, N., Li, H., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1147060 · Cited by 3
Zhao, X., Wang, D., Chang, M., He, Z. J., Zeng, Z., Ren, M., Hu, Y., & Li, Z. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.03.138 · Cited by 2
Treatment-Resistant Depression in Adolescents: A Comprehensive Review
Carandang, C. G. (2013) · Journal of Depression & Anxiety · doi:10.4172/2167-1044.1000128 · Cited by 2
Kalkman, H. O. (2021) · Psychiatry International · doi:10.3390/psychiatryint2010008 · Cited by 2
Genetics of Treatment‐resistant Depression
Fabbri, C., Porcelli, S., & Serretti, A. (2013) · doi:10.1002/9781118556719.ch3 · Cited by 2
Association of FKBP5 gene haplotypes with completed suicide in the Japanese population
Hishimoto, A., Sasada, T., Fukutake, M., Shiroiwa, K., Supriyanto, I., & Shirakawa, O. (2011) · European Psychiatry · doi:10.1016/s0924-9338(11)73320-x · Cited by 2
Baharikhoob, P., Maslej, M. M., Wong, A. H. C., Mulsant, B. H., Blumberger, D. M., Courtney, D., Husain, M. I., Kurdyak, P. A., Kleinman, R. A., Torfason, A., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-087561 · Cited by 1
Genetic Characteristics of Pediatric Major Depressive Disorder
Aydın, R., Baytunca, M. B., & Erermiş, S. (2014) · The Journal of Pediatric Research · doi:10.4274/jpr.92486 · Cited by 1
Genetic Factors Underlying Treatment Resistance in Psychiatry
Maron, E., Lan, C., & Nutt, D. (2018) · Springer eBooks · doi:10.1007/978-981-10-4358-1_3 · Cited by 2
A Narrative Review: Serotonin Reuptake Inhibitors and the Risk of Suicidal Ideation in Adolescents
Gage, D. S., Priefer, V. E., & Priefer, R. (2025) · Adolescents · doi:10.3390/adolescents5010005 · Cited by 1
The Role of Genetic and Environmental Risk Factors in Aetiology of Suicidal Behaviour
Zainullina, A., Valiullina, A., & Хуснутдинова, Э. К. (2016) · Palgrave Macmillan UK eBooks · doi:10.1057/9781137437327_11 · Cited by 1
Relationships of Genes and Early‐Life Experience to the Neurobiology of Suicidal Behavior
Mann, J. J., & Currier, D. (2016) · Wiley eBooks · doi:10.1002/9781118903223.ch9 · Cited by 1
Advances in Research on Adolescent Suicide and a High Priority Agenda for Future ResearchPreprint
Clayton, M. G., Pollak, O. H., Owens, S., Miller, A. B., & Prinstein, M. J. (2021) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/jqs5u · Cited by 1
Age-associated increases in FKBP51 facilitate tau neurotoxicity
Blair, L. J. (2014) · Digital Commons - University of South Florida (University of South Florida)
Plener, P. L. (2014) · Springer eBooks · doi:10.1007/978-3-662-44338-5_3
Pharmacogenetic Studies of Suicide: Potential Relevance of Main Polymorphic CYPs and ABCB1
Peñas‐Lledó, E., Delgado, A., & LLerena, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26282-6_33
Molecular basis of tryptophan metabolism disorders associated with depression
Wigner, P., Gałecki, P., & Śliwiński, T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817935-2.00019-2 · Cited by 1
Valentino, R. J., & Bangasser, D. A. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717964010.793465779
Dual proximity-based interactome mapping of FKBP51 and FKBP52 uncovers shared metabolic networks
Hill, S. E., Parikh, P., Gebru, N. T., Banjade, S., Guergues, J., Wohlfahrt, J., Stevens, S. M., & Blair, L. J. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153968
Ivashchenko, D. V., Grass, S. V., Sobur, V. V., Викторович, Ш. П., Shubin, A. V., Deitch, R. V., Kondratieva, R. V., Shagovenko, E. N., Chernetsova, Y. V., Николаевна, Т. С., et al. (2025) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202512510212
Ivashchenko, D. V., Grass, S. V., Sobur, V. V., Викторович, Ш. П., Shubin, A. V., Deitch, R. V., Kondratieva, R. V., Shagovenko, E. N., Chernetsova, Y. V., Николаевна, Т. С., et al. (2026) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-026-01990-5
Individualized pharmacogenomics for depressive episodes: A narrative review
HADDAD, M., Dieckmann, L. H. J., Hoss, G. R. W., Mari, J. D. J., Young, A. H., & Juruena, M. F. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.122261
Metadata
- Authors
- Brent, D., Melhem, N., Ferrell, R., Emslie, G., Wagner, K. D., Ryan, N., Vitiello, B., Birmaher, B., Mayes, T., Zelazny, J., Onorato, M., Devlin, B., Clarke, G., DeBar, L., & Keller, M.
- Affiliations
- Suburban Hospital (US)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2010-02-01
- Volume
- 167
- Issue
- 2
- Pages
- 190-197
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC2887294
- OpenAlex
- W2144565283
- Cited by
- 138
- References
- 38
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 12 · 2015: 10 · 2014: 14 · 2013: 9 · 2012: 16
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- National Institute of Mental Health (MH61958, K01MH077930, U01MH061856, MH-66371, U01MH061835, U01MH061869, MH-61869, U01MH062014, MH61856, K01MH77930, MH-61835, MH61864, U01MH061958, P30MH066371, U01MH061864, MH62014)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- FKBP5, suicidal behavior, treatment-resistant depression, adolescents, single nucleotide polymorphisms, rs1360780, hypothalamic-pituitary-adrenal axis, candidate genes, antidepressant response, venlafaxine, cognitive behavioral therapy
- MeSH terms
- Venlafaxine Hydrochloride, Tacrolimus Binding Protein 5, Adolescent, Cyclohexanols, Depressive Disorder, Female, Genotype, Humans, Male, Polymorphism, Genetic, Suicide, Suicide, Attempted, Cognitive Behavioral Therapy, Logistic Models, Treatment Failure, Selective Serotonin Reuptake Inhibitors, Polymorphism, Single Nucleotide, Tacrolimus Binding Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
