Cited by 35Schizophrenia research and treatmentMental Health and PsychiatryNeurotransmitter Receptor Influence on Behavior

Suppression of the P50 Evoked Response and Neuregulin 1-Induced AKT Phosphorylation in First-Episode Schizophrenia

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Kéri, Szabolcs, Beniczky, Sándor, Kelemen, Oguz·2010·American Journal of Psychiatry

Abstract

OBJECTIVE: Diminished suppression of the P50 auditory evoked potential is a widely used sensory gating phenotype in the molecular genetic studies of schizophrenia. The aim of this study was to explore the relationship between this phenotype and neuregulin 1-related intracellular signaling processes. METHOD: The P50 evoked potential was recorded in 30 first-episode, never-medicated patients with schizophrenia and in 30 healthy comparison volunteers. Neuregulin 1-induced activation of the phosphoinositide 3'-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3beta system was characterized by the measurement of the phosphorylated AKT to total AKT ratio in peripheral B lymphoblasts. RESULTS: Relative to comparison subjects, patients with first-episode schizophrenia displayed diminished P50 suppression and decreased neuregulin 1-induced AKT phosphorylation. There was a significant relationship between P50 suppression and AKT phosphorylation. CONCLUSION: Decreased neuregulin 1-induced activation of the PI3K/AKT system is associated with impaired sensory gating in first-episode schizophrenia.

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Crossref · 10.1176/appi.ajp.2009.09050723

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Authors
Kéri, S., Beniczky, S., & Kelemen, O.
Affiliations
Semmelweis University (HU)
Venue
American Journal of Psychiatry
Published
2010-04-01
Volume
167
Issue
4
Pages
444-450
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W1986394310
Cited by
35
References
40
Citations by year
2022: 1 · 2020: 3 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
4.12
Type
journal article
Language
en
Licence
other-oa
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
first-episode schizophrenia, sensory gating, neuregulin-1, Akt phosphorylation, PI3K/Akt signaling, glycogen synthase kinase-3β, B lymphoblasts, genetic susceptibility
MeSH terms
Adult, Cognition Disorders, Evoked Potentials, Auditory, Female, Hippocampus, Humans, Male, Nucleus Accumbens, Phosphorylation, Phosphotransferases, Schizophrenia, Severity of Illness Index, Wechsler Scales, Signal Transduction, Neuregulin-1, Proto-Oncogene Proteins c-akt, Sensory Gating

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