Suppression of the P50 Evoked Response and Neuregulin 1-Induced AKT Phosphorylation in First-Episode Schizophrenia
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OBJECTIVE: Diminished suppression of the P50 auditory evoked potential is a widely used sensory gating phenotype in the molecular genetic studies of schizophrenia. The aim of this study was to explore the relationship between this phenotype and neuregulin 1-related intracellular signaling processes. METHOD: The P50 evoked potential was recorded in 30 first-episode, never-medicated patients with schizophrenia and in 30 healthy comparison volunteers. Neuregulin 1-induced activation of the phosphoinositide 3'-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3beta system was characterized by the measurement of the phosphorylated AKT to total AKT ratio in peripheral B lymphoblasts. RESULTS: Relative to comparison subjects, patients with first-episode schizophrenia displayed diminished P50 suppression and decreased neuregulin 1-induced AKT phosphorylation. There was a significant relationship between P50 suppression and AKT phosphorylation. CONCLUSION: Decreased neuregulin 1-induced activation of the PI3K/AKT system is associated with impaired sensory gating in first-episode schizophrenia.
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NRG1 forms neuregulin.
“Another related gene is NRG1 which forms neuregulin (28, 29).”
From Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia (2015) · cites this paper as [29]
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- Authors
- Kéri, S., Beniczky, S., & Kelemen, O.
- Affiliations
- Semmelweis University (HU)
- Venue
- American Journal of Psychiatry
- Published
- 2010-04-01
- Volume
- 167
- Issue
- 4
- Pages
- 444-450
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1986394310
- Cited by
- 35
- References
- 40
- Citations by year
- 2022: 1 · 2020: 3 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- first-episode schizophrenia, sensory gating, neuregulin-1, Akt phosphorylation, PI3K/Akt signaling, glycogen synthase kinase-3β, B lymphoblasts, genetic susceptibility
- MeSH terms
- Adult, Cognition Disorders, Evoked Potentials, Auditory, Female, Hippocampus, Humans, Male, Nucleus Accumbens, Phosphorylation, Phosphotransferases, Schizophrenia, Severity of Illness Index, Wechsler Scales, Signal Transduction, Neuregulin-1, Proto-Oncogene Proteins c-akt, Sensory Gating
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