The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Emotion Modulation in PTSD: Clinical and Neurobiological Evidence for a Dissociative Subtype
Open accessAbstract
In this article, the authors present evidence regarding a dissociative subtype of PTSD, with clinical and neurobiological features that can be distinguished from nondissociative PTSD. The dissociative subtype is characterized by overmodulation of affect, while the more common undermodulated type involves the predominance of reexperiencing and hyperarousal symptoms. This article focuses on the neural manifestations of the dissociative subtype in PTSD and compares it to those underlying the reexperiencing/hyperaroused subtype. A model that includes these two types of emotion dysregulation in PTSD is described. In this model, reexperiencing/hyperarousal reactivity is viewed as a form of emotion dysregulation that involves emotional undermodulation, mediated by failure of prefrontal inhibition of limbic regions. In contrast, the dissociative subtype of PTSD is described as a form of emotion dysregulation that involves emotional overmodulation mediated by midline prefrontal inhibition of the same limbic regions. Both types of modulation are involved in a dynamic interplay and lead to alternating symptom profiles in PTSD. These findings have important implications for treatment of PTSD, including the need to assess patients with PTSD for dissociative symptoms and to incorporate the treatment of dissociative symptoms into stage-oriented trauma treatment.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Specifically, when the prefrontal cortex is shutdown among individuals with classic PTSD, it can propagate an emotion under-modulation symptom profile, which includes hypervigilance and hyperarousal symptoms.”
From How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD (2021) · cites this paper as Lanius et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In response to trauma scripts, patients with the reexperiencing/hyperarousal response—as in PTSD—show decreased activation in anterior brain regions implicated in regulating arousal and emotion (ventromedial prefrontal cortex and rostral anterior cingulate cortex), decreased activation in the thalamus and occipital cortices, and increased activity in the amygdala and insula.53–58”
From Fear and the Defense Cascade (2015) · cites this paper as [56]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Building on this seminal work, Lanius et al. (2010) proposed a neurobiological model of PTSD-DS, characterized primarily by symptoms of derealization, depersonalization, and tonic hypoarousal that contrasted with the more typical symptoms of re-experiencing and hyperarousal that feature predominately in the majority of cases of PTSD.”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Lanius et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Ultimately, this undermines the proposed neurobiological basis (e.g. Lanius et al., 2010; Terpou et al., 2019) of the defense cascade model and the dissociative subtype as a whole.”
From Trauma-related dissociation and the autonomic nervous system: a systematic literature review of psychophysiological correlates of dissociative experiencing in PTSD patients (2022) · cites this paper as Lanius et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In addition to these core cognitive and affective symptoms, individuals with PTSD have shown unique neural signatures that overlap with key brain regions involved in the sensory transmission of incoming interoceptive and exteroceptive sensations, including the brainstem, the insula, and the prefrontal cortex (Lanius et al., 2010; Nicholson et al., 2015, 2017; Daniels et al., 2016; Sierk et al., 2”
From How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD (2021) · cites this paper as Lanius et al., 2010
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Moreover, in patients with the PTSD dissociative subtype, the prefrontal cortex is thought to play an inhibitory role on subcortical structures identified in the innate alarm system, including the amygdala and the periaqueductal gray, which contributes to an emotion over-modulation symptom profile, including depersonalization/derealization and emotional detachment behaviors (Lanius et al., 2010; N”
From How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD (2021) · cites this paper as Lanius et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Here, we propose that sensory-based treatments may be an alternative mechanism that can bring online the prefrontal cortex, a key brain region for multisensory integration, emotion regulation and social cognition, which may be offline under certain conditions (Lanius et al., 2010; Aupperle et al., 2013).”
From How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD (2021) · cites this paper as Lanius et al., 2010
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Lanius and colleagues have proposed a model of heightened prefrontal recruitment with associated dampening of amygdala-based threat responding [64].”
From Trauma, PTSD, and the Developing Brain (2017) · cites this paper as [64]
The cited source says what the claim attributes to it.
In the citing paper
“Similarly, greater activity in prefrontal cortex was associated with subjective feelings of dissociation (e.g., depersonalization/derealization) across various emotionally provocative tasks [147–149].”
From Treatment of dissociative identity disorder: leveraging neurobiology to optimize success (2024) · cites this paper as [147]
The cited source says what the claim attributes to it.
In the citing paper
“prior work indicates that individuals with the dissociative subtype of PTSD have greater activity in regions associated with “top-down” regulation (e.g., prefrontal cortex) and diminished activity in limbic regions (e.g., amygdala) when presented with emotionally provocative autobiographical trauma-related scripts [147,148].”
From Treatment of dissociative identity disorder: leveraging neurobiology to optimize success (2024) · cites this paper as [147]
The cited source says what the claim attributes to it.
In the citing paper
“Thereby, dissociation can become maladaptive [10] and possibly interfere with treatment [46–50].”
From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“Dissociation can also develop in the aftermath of trauma and generalize across situations”
From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“Based on more recent neuroimaging findings in PTSD [10], Lanius and colleagues (2010) proposed a neurobiological model that distinguishes between two types of responses to traumatic reminders or other stressors: patients with a dissociative response type (D-PTSD) are thought to “over-modulate” their emotions, as opposed to patients who primarily suffer from re-experiencing symptoms”
From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“Patients who reported a stronger increase of state dissociation (DSS) showed significantly lower amygdala reactivity to negative distractors [139], in line with aforementioned findings by Hazlett and colleagues [135] and theoretical models [10].”
From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“Dissociation may be a protective strategy to cope with overwhelming emotions in traumatic/stressful situations [1, 3, 10].”
From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“Pathological dissociation is a complex and heterogeneous phenomenon [2–4, 153], which has been closely linked to traumatic stress [1, 10].”
From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“Neurobiological studies of PTSD-DS continue to underscore the observation that depersonalization and derealization represent distinct responses from re-experiencing/hyperarousal reactivity in persons with PTSD (Lanius et al., 2010(Lanius et al., , 2012(Lanius et al., , 2006;;Nicholson et al., 2015).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Lanius et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“Specifically, whereas reliving responses are thought to be mediated by a failure of prefrontal inhibition or top-down control of limbic regions, depersonalization and derealization responses are thought to be mediated by increased prefrontal inhibition of limbic regions.”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Lanius et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“this pattern of brain activity is similar to that seen in patients with the PTSD-DS during presentation of trauma-related scripts (Lanius et al., 2010(Lanius et al., , 2012(Lanius et al., , 2006)).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Lanius et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“Evidence of distinct patterns of neural activity (Frewen and Lanius, 2006;Lanius et al., 2010Lanius et al., , 2012) )”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Lanius et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“Lanius et al. (2010) postulated that among individuals with the PTSD dissociative subtype, overactivation in the prefrontal cortex exerts top-down inhibitory effects on the amygdala, which is a key structure for emotion processing.”
From How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD (2021) · cites this paper as Lanius et al. (2010)
The cited source says what the claim attributes to it.
In the citing paper
“Interestingly, these patterns differ from previous studies conducted by our research group that suggest among individuals with the PTSD dissociative subtype, the prefrontal cortex exerts top-down inhibitory effects on emotional reactivity structures (Lanius et al., 2010; Nicholson et al., 2017).”
From How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD (2021) · cites this paper as Lanius et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Emotional processing of fear: Exposure to corrective information.
Foa, E. B., & Kozak, M. J. (1986) · Psychological Bulletin · doi:10.1037/0033-2909.99.1.20 · Cited by 5,396 · cited 2×
“Foa and colleagues (49) have suggested that such symptoms can prevent emotional engagement with traumarelated information and thereby reduce treatment effectiveness (50).”
BackgroundEtkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391 · cited 2×
“Patients with reexperiencing/hyperaroused PTSD exhibit abnormally low activation in medial anterior brain regions that are implicated in arousal modulation and emotion regulation more generally, including the ventromedial prefrontal cortex (19) and the rostral anterior cingulate cortex (24).”
BackgroundSYMPTOMATOLOGY AND MANAGEMENT OF ACUTE GRIEF
Lindemann, E. (1944) · American Journal of Psychiatry · doi:10.1176/ajp.101.2.141 · Cited by 3,308
Childhood traumas: an outline and overview
Terr, L. C. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.1.10 · Cited by 2,281 · cited 1×
“Terr (39) proposed two types of traumatic experiences.”
BackgroundPerry, B. D., Pollard, R. A., Blakley, T. L., Baker, W. L., & Vigilante, D. (1995) · Infant Mental Health Journal · doi:10.1002/1097-0355(199524)16:4 · Cited by 1,327
Neural Systems Underlying the Suppression of Unwanted Memories
Anderson, M. C., Ochsner, K. N., Kuhl, B. A., Cooper, J. C., Robertson, E. R., Whitfield‐Gabrieli, S., Glover, G. H., & Gabrieli, J. D. E. (2004) · Science · doi:10.1126/science.1089504 · Cited by 1,121 · cited 2×
“The authors conclude that their study provides a possible neurobiological model for suppression of unwanted memories, consistent with the occurrence of dissociative amnesia (33).”
BackgroundResultCloître, M., Koenen, K. C., Cohen, L. R., & Han, H. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.70.5.1067 · Cited by 1,099 · cited 2×
“(54) provide data to support the idea that patients must develop mood regulation and grounding skills, identify and modify disordered attachment schemas learned in childhood, and work on competence in social interactions.”
BackgroundCloitre, M., Koenen, K. C., Cohen, L. R., & Han, H. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.5.1067 · Cited by 1,097
Dissociation, somatization, and affect dysregulation: the complexity of adaptation of trauma
van der Kolk, B. A., Pelcovitz, D., Roth, S., Mandel, F. S., McFARLANE, A. C., & Herman, J. L. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.7.83 · Cited by 886
Shin, L. M., Orr, S. P., Carson, M. A., Rauch, S. L., Macklin, M. L., Lasko, N. B., Peters, P. M., Metzger, L. J., Dougherty, D. D., Cannistraro, P. A., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.2.168 · Cited by 790 · cited 2×
“These include PET studies showing a negative correlation between blood flow in the left ventromedial prefrontal cortex and the amygdala during emotional tasks (26), and negative correlations between medial prefrontal cortex and the amygdala during fear conditioning (25).”
Background
Research works printed but not linked: 8
- 10.1176/ajp.158.8.1239b · DOI
- Keane TM, 2008, J Rehabil Res Dev, 45, vii
- Ludaescher P, J Psych Neurosci
- 10.1176/ajp.153.1.83 · DOI
- Krystal JH , Bennett A , Bremner JD , Southwick SM , Charney DS : Toward a cognitive neuroscience of dissociation and altered memory functions in post-traumatic stress disorder, in Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to PTSD. Edited by , Friedman MJ , Charney DS , Deutch AY . Philadelphia, Lippincott-Raven, 1995, pp 239–269
- Herman JL : Sequelae of prolonged and repeated trauma: evidence for a complex posttraumatic syndrome (DESNOS), in Posttraumatic Stress Disorder: DSM-IV and Beyond. Edited by , Davidson JRT , Foa EB . Washington, DC, American Psychiatric Press, 1993, pp 213–228
- Kleindienst N, J Pers Disord
- Ebner-Priemer UW, 2009, J Psychiatry Neurosci, 34, 214
Cited by
Sorted by citations
Items 401–500 of 1,000
Shu, I.-W., Onton, J., Prabhakar, N., O'Connell, R. M., Simmons, A. N., & Matthews, S. C. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.057 · Cited by 28
Dysfunctional affect regulation in borderline personality disorder and in somatoform disorder
van Dijke, A. (2012) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v3i0.19566 · Cited by 27
“…& Target, 2002), inhibitory regulation seem to have been overlooked and may be of particular importance in the assessment and treatment of chronic childhood trauma-related pathology such as comorbid BPD SoD or CPTSD (Ford, 2005; Lanius et al., 2010; Lanius, Frewen, Vermetten, & Yehuda, 2011).”
BackgroundResultBryant, R. A., Erlinger, M., Felmingham, K. L., Klimova, A., Williams, L. M., Malhi, G. S., Forbes, D., & Korgaonkar, M. S. (2020) · Psychological Medicine · doi:10.1017/s0033291720001129 · Cited by 32
“This finding accords with the evidence of reduced activation of affective networks in PTSD patients with the dissociative subtype of PTSD (Lanius et al., 2010), who do not respond optimally to TF-CBT (Wolf, Lunny, & Schnurr, 2016).”
ResultVelotti, P., Civilla, C., Rogier, G., & Zobel, S. B. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.590021 · Cited by 30
“Among other things, more and more research (9, 61) supports the existence of a dissociative subtype of PTSD that has been included in the fifth edition of the”
BackgroundJepsen, E. K. K., Langeland, W., & Heir, T. (2013) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v4i0.22825 · Cited by 34
“Overall, our findings confirm the clinical utility of identifying traumatized patients with PTSD and severe levels of dissociation, and tailoring treatment to this patient group (Cloitre et al., 2012; Lanius et al., 2010; Resick et al., 2012).”
BackgroundHien, D. A., López‐Castro, T., Papini, S., Gorman, B. S., & Ruglass, L. M. (2017) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2017.10.003 · Cited by 28
“ED varies across patients and can cause significant clinical management issues such as emotional lability and even suicidal gestures (e.g., Cloitre, Miranda, Stovall, & Han, 2005; Lanius et al., 2010).”
BackgroundChapter 24. Dissociative Identity Disorder
Brand, B. L., Loewenstein, R. J., & Lanius, R. A. (2014) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585625048.gg24 · Cited by 29
Self-citationOut-of-body memory encoding causes third-person perspective at recall
Bergouignan, L., Nyberg, L. H., & Ehrsson, H. H. (2021) · Journal of Cognitive Psychology · doi:10.1080/20445911.2021.1958823 · Cited by 34
“The possible contribution of dissociative experiences during encoding (Lanius et al., 2010) to later changes in visual perspective during recall is di ffi cult to study, both in patients and experimentally therefore, has not been given much attention in the literature (for a discussion on clinical…”
BackgroundKamen, C. S., Bergström, J., Koopman, C., Lee, S. S., & Gore-Felton, C. E. (2012) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2011.608629 · Cited by 27
“…imaging literature to date has cited hyperarousal and dissociation as separate responses to traumatic stress, responses that can in fact distinguish a dissociative subtype of PTSD from one marked primarily by physiological arousal and cognitive intrusions (Lanius et al., 2010; Pain et al., 2009).”
BackgroundTerhune, D. B., & Cardeña, E. (2015) · Current Directions in Psychological Science · doi:10.1177/0963721415604611 · Cited by 27
“treatment course than those with fewer dissociative symptoms (Lanius et al., 2010).”
BackgroundRegulating posttraumatic stress disorder symptoms with neurofeedback: Regaining control of the mind
Nicholson, A. A., Ros, T., Jetly, R., & Lanius, R. A. (2020) · Journal of Military Veteran and Family Health · doi:10.3138/jmvfh.2019-0032 · Cited by 28
Self-citationPosttraumatic Stress Disorder: Beyond DSM-IV
Chu, J. A. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10030310 · Cited by 27
“In this issue of the Journal, Lanius and colleagues review the clinical and neurobiological evidence of a dissociative subtype of PTSD in order to increase its recognition, accurate assessment, and effective treatment (2).”
BackgroundAttachment Representations and Autonomic Regulation in Maltreating and Nonmaltreating Mothers
Reijman, S., Alink, L. R. A., Compier-De Block, L. H. C. G., Werner, C. D., Maras, A., Rijnberk, C., Van Ijzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2017) · Development and Psychopathology · doi:10.1017/s0954579416001036 · Cited by 26
“More recently, evidence was presented for a dissociative subtype of PTSD, following a similar model of excessive prefrontal inhibition of limbic regions (Lanius et al., 2010).”
BackgroundMoser, D. A., Aue, T., Wang, Z., Rusconi Serpa, S., Favez, N., Peterson, B. S., & Schechter, D. S. (2013) · Stress · doi:10.3109/10253890.2013.816280 · Cited by 26
“Based on this hypothesis from the relevant literature (Lanius et al., 2010), we expected that, in IPV-PTSD mothers, dissociation would be associated with diminished activation in the limbic system (e.”
BackgroundMethodResultInfluentialComplex trauma, dissociation and Borderline Personality Disorder: Working with integration failures
Mosquera, D., & Steele, K. (2017) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2017.01.010 · Cited by 29
“…(spaciness, thinking of nothing/dorsal vagal shutdown) (Allen, Console, & Lewis, 1999; Schore, 2009); symptoms of depersonalization/derealisation (Lanius et al., 2010); and division of the personality (Van der Hart, Nijenhuis, & Steele, 2006; Steele, Dorahy, Van der Hart, & Nijenhuis, 2009).”
Cognitive and neural facets of dissociation in a traumatized population.
Fani, N., King, T. Z., Powers, A. D., Hardy, R. A., Siegle, G. J., Blair, J., Surapaneni, S., van Rooij, S. J. H., Ressler, K. J., Jovanović, T., et al. (2018) · Emotion · doi:10.1037/emo0000466 · Cited by 28
“However, another model has been proposed to accommodate the differing patterns of neural response that characterize dissociative PTSD (Lanius et al., 2010); here, highly dissociative traumatized people as “overmodulators” of affect, who tend to demonstrate increased neural response in medial…”
BackgroundMethodInfluentialImaging of Posttraumatic Stress Disorder
Kamiya, K., & Abe, O. (2019) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2019.09.010 · Cited by 29
Siegel, C., LASKA, E. M., Lin, Z., Xu, M., Amara, D. A., Jeffers, M. K., Qian, M., Milton, N., Flory, J. D., Hammamieh, R., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01324-8 · Cited by 26
Sommer, J. L., Blaney, C., Mota, N. P., Bilevicius, E., Beatie, B. E., Kilborn, K., Chang, U., Sareen, J., & El-Gabalawy, R. M. (2021) · Journal of Traumatic Stress · doi:10.1002/jts.22726 · Cited by 28
Seng, J. S., Li, Y., Yang, J. J., King, A. P. J., Low, L. K., Sperlich, M. I., Rowe, H. J., Lee, H., Muzik, M., Ford, J. D., et al. (2017) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1016/j.jogn.2017.10.008 · Cited by 27
“Researchers of the specific physiology of the dissociative subtype of PTSD showed a phenotype that appears to have different patterns of emotion dysregulation (Lanius et al., 2010).”
BackgroundSymptom variability in depersonalization–derealization disorder: A latent profile analysis
Millman, L. S. M., Hunter, E. C. M., Orgs, G., David, A. S., & Terhune, D. B. (2021) · Journal of Clinical Psychology · doi:10.1002/jclp.23241 · Cited by 28
Muscatello, M. R. A., Rizzo, A., Celebre, L., Mento, C., Pandolfo, G., Cedro, C., Battaglia, F., Zoccali, R. A., & Bruno, A. (2019) · International Journal of Social Psychiatry · doi:10.1177/0020764019872227 · Cited by 25
“Hyperarousal, a fundamental basic dimension associated with stress responses, is defined as a state of hypervigilance, startle response, increased responsiveness to stimuli and increased levels of alertness and anxiety (Lanius et al., 2010).”
BackgroundScalabrini, A., Cavicchioli, M., Benedetti, F., Mucci, C., & Northoff, G. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02520-w · Cited by 25
“This approach aims at integrating psychological and neuronal dynamics that could serve for a more precise differential diagnosis and treatment indication of different forms of trauma.”
InfluentialDutra, S. J., & Wolf, E. J. (2016) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2016.10.003 · Cited by 27
Stanley, E. A. (2014) · Wiley eBooks · doi:10.1002/9781118294895.ch50 · Cited by 25
What We Know and What We Need to Learn About the Treatment of Dissociative Disorders
Brand, B. L. (2012) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2012.672550 · Cited by 24
“Exciting strides have begun to reveal the neurobiology of dissociation, resulting in a review article about the dissociative subtype of PTSD being the recent cover story of the American Journal of Psychiatry (Lanius et al., 2010).”
BackgroundSelf-citationNeurobiological and genetic correlates of the dissociative subtype of posttraumatic stress disorder.
Wolf, E. J., Hawn, S. E., Sullivan, D. R., Miller, M. W., Sanborn, V., Brown, E., Neale, Z., Fein-Schaffer, D., Zhao, X., Logue, M. W., et al. (2023) · Journal of Psychopathology and Clinical Science · doi:10.1037/abn0000795 · Cited by 23
Talmon, A., & Ginzburg, K. (2018) · Journal of Interpersonal Violence · doi:10.1177/0886260518799450 · Cited by 25
“One of the common forms of emotional dysregulation, often observed among CSA survivors, is dissociation (Lanius et al., 2010).”
BackgroundCramer, A. O. J., Leertouwer, I., Lanius, R. A., & Frewen, P. (2020) · Journal of Traumatic Stress · doi:10.1002/jts.22488 · Cited by 26
“…in any medium, provided the original work is properly cited. from those with PTSD who do not experience DP or DR during both a resting state and in response to trauma-related stimuli (e.g., Harricharan et al., 2016, Lanius et al., 2010; Nicholson et al., 2016, 2017; Olivé et al., 2018).”
BackgroundSelf-citationProtopopescu, A., Boyd, J. E., O’Connor, C., Rhind, S. G., Jetly, R., Lanius, R. A., & McKinnon, M. C. (2021) · Journal of Military Veteran and Family Health · doi:10.3138/jmvfh-2020-0036 · Cited by 25
Self-citationRosso, I. M., Silveri, M. M., Olson, E. A., Jensen, J. E., & Ren, B. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01197-x · Cited by 23
Neuroimaging and Dissociative Disorders
Staniloiu, A., Vitcu, I., & Hans, J. (2012) · InTech eBooks · doi:10.5772/30746 · Cited by 24
“subtype (Lanius et al., 2010).”
Neural correlates and structural markers of emotion dysregulation in traumatized civilians
Powers, A. D., Stevens, J. S., van Rooij, S. J. H., Ely, T. D., Fani, N., Jovanović, T., Ressler, K. J., & Bradley, B. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx005 · Cited by 24
“Our finding further supports previous research showing hyperactivation of dmPFC and dACC in individuals with PTSD (Lanius et al., 2010; Rougemont-Bücking et al., 2011).”
Result(2017) · PubMed · Cited by 23
Detecting clinical and simulated dissociative identity disorder with the Test of Memory Malingering.
Brand, B. L., Webermann, A. R., Snyder, B. L., & Kaliush, P. R. (2018) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000405 · Cited by 23
Self-citationPACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats
Meloni, E. G., Kaye, K. T., Venkataraman, A., & Carlezon, W. A. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.011 · Cited by 21
Myers, N. S., & Llera, S. J. (2020) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2020.1719265 · Cited by 28
The neurobiology of posttraumatic stress disorder: Dysfunction in the prefrontal-amygdala circuit?
Lobo, I., Oliveira, L., David, I. A., Pereira, M. G., Volchan, E., Rocha-Rego, V., Figueira, I. L. D. V., & Mocaiber, I. (2011) · Psychology & Neuroscience · doi:10.3922/j.psns.2011.2.004 · Cited by 25
Moral reasoning in women with posttraumatic stress disorder related to childhood abuse
Nazarov, A., Walaszczyk, V., Frewen, P., Oremus, C., Lanius, R. A., & McKinnon, M. C. (2016) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v7.31028 · Cited by 24
Self-citationParlar, M. E., Densmore, M., Hall, G. B., Lanius, R. A., & McKinnon, M. C. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.07.004 · Cited by 23
“has recently been identified in patients with MDD and may relate to more severe depression (De Bellis et al., 2013; Lanius et al., 2010; Molina-Serrano et al., 2008; Žikić et al., 2009) and a history of trauma (Molina-Serrano et al.”
Self-citationAschbacher, K., Mellon, S. H., Wolkowitz, O. M., Henn‐Haase, C., Yehuda, R., Flory, J. D., Bierer, L. M., Amara, D. A., Marmar, C. R., & Mueller, S. G. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9759-y · Cited by 20
“, hypervigilance), whereas a “dissociative subtype” of PTSD has been associated with over-regulated affect (Lanius et al. 2010).”
Evidence for subjective emotional numbing following induced acute dissociation
Shin, G. I., Goldstein, L. H., & Pick, S. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.05.004 · Cited by 21
“Emotional processing hampered by dissociation can be described as overmodulating (Lanius et al., 2010) or emotional numbing (Medford et al.”
BackgroundKrause-Utz, A., Dierick, T., Josef, T., Chatzaki, E., Willem, A., Hoogenboom, J., & Elzinga, B. M. (2021) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-021-00150-0 · Cited by 28
Vancappel, A., Suzan, L., Bailly, S., Fraigneau, M., Réveillère, C., & El‐Hage, W. (2021) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2021.100235 · Cited by 23
Mertens, Y. L., Manthey, A., Sierk, A., Walter, H., & Daniels, J. K. (2022) · BJPsych Open · doi:10.1192/bjo.2022.65 · Cited by 23
Shafie, M., Shahmohamadi, E., Cattarinussi, G., Moghaddam, H. S., Akhondzadeh, S., Sambataro, F., Moltrasio, C., & Delvecchio, G. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.09.001 · Cited by 22
Vásquez, D., de Arellano, M. A., Reid-Quiñones, K., Bridges, A. J., Rheingold, A. A., Stocker, R., & Danielson, C. K. (2012) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2012.678471 · Cited by 22
“Peritraumatic dissociative symptoms have been recognized as a predictor PTSD in adults (Lanius et al., 2010), and several studies have demonstrated that peritraumatic dissociation predicts PTSD symptoms in such diverse samples as male Vietnam veterans (Marmar et al.”
InfluentialInpatient Treatment for Adult Survivors of Childhood Sexual Abuse: A Preliminary Outcome Study
Jepsen, E. K. K., Svagaard, T., Thelle, M. I., McCullough, L., & Martinsen, E. W. (2009) · Journal of Trauma & Dissociation · doi:10.1080/15299730902956812 · Cited by 22
Complex PTSD is on the trauma spectrum: Comment on Resick et al. (2012)
Goodman, M. S. (2012) · Journal of Traumatic Stress · doi:10.1002/jts.21695 · Cited by 22
Ospina, J. P., Jalilianhasanpour, R., & Perez, D. L. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64196-0.00014-5 · Cited by 23
“corticolimbic alteration across mood and trauma-related disorders(Lanius et al., 2010; Etkin, 2010).”
Dissociation as a trauma-related phenomenon.
Brand, B. L., & Frewen, P. (2017) · American Psychological Association eBooks · doi:10.1037/0000019-013 · Cited by 23
Self-citationA theoretical framework for the neurobiology of chronic traumatization
Williamson, P. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01770.x · Cited by 22
“A distinction is also made between patients who show significant symptoms of depersonalization, derealization, and analgesia and patients who predominantly exhibit re-experiencing and flashback-type symptoms; the latter demonstrated a failure of prefrontal inhibition of limbic regions, and the former showed increased…”
BackgroundSzabó, Á., Galla, Z., Spekker, E., Szűcs, M., Martos, D., Takeda, K., Ozaki, K., Inoue, H., Yamamoto, S., Toldi, J., et al. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl25706 · Cited by 27
Brzozowska, A., & Grabowski, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115216 · Cited by 39
“Due to a different clinical and biological picture, a dissociative subtype of PTSD is sometimes distinguished [153–156].”
The Concept of Peritraumatic Dissociation
Mattos, P. F., Pedrini, J. A., Fiks, J. P., & Mello, M. F. (2015) · Qualitative Health Research · doi:10.1177/1049732315610521 · Cited by 21
Ross, J. A., & Bockstaele, E. J. V. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14714 · Cited by 20
The network structure of posttraumatic stress symptoms in war‐affected children and adolescents
Scharpf, F., Saupe, L. B., Crombach, A., Haer, R., Ibrahim, H., Neuner, F., Peltonen, K., Qouta, S., Saile, R., & Hecker, T. (2022) · JCPP Advances · doi:10.1002/jcv2.12124 · Cited by 21
“dissociative PTSD (Lanius et al., 2010), this may account for the relatively high centrality of dissociative reactions among children.”
Murphy, R. J. (2023) · PubMed Central · Cited by 21
Interpersonal Psychotherapy (IPT) for PTSD: A Case Study
Rafaeli, A. K., & Markowitz, J. C. (2011) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.2011.65.3.205 · Cited by 21
“patients who dissociate may fare better receiving affect-focused therapy than exposurebased therapy (Lanius et al., 2010).”
BackgroundLi, M., Han, F., & Shi, Y. (2011) · Neurological Sciences · doi:10.1007/s10072-011-0597-1 · Cited by 21
“Post-traumatic stress disorder (PTSD) is a psychiatric disorder that occurs after life-threatening traumatic events, such as military combat, natural disaster, terrorist attack, serious accident, or violent personal assault [1].”
BackgroundWeniger, G., Siemerkus, J., Barke, A., Lange, C., Ruhleder, M., Sachsse, U., Schmidt‐Samoa, C., Dechent, P., & Irle, E. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.11.004 · Cited by 22
“…and intrusions have been related to impaired cognition, reduced size of the hippocampus, and an undermodulation of limbic brain regions, whereas the dissociative pattern of trauma response is characterized by an overmodulation of affect and thereby hypoactive limbic regions (Lanius et al., 2010a).”
BackgroundMental state identification, borderline pathology, and the neglected role of childhood trauma.
Weinstein, S. R., Meehan, K. B., Cain, N. M., Ripoll, L. H., Boussi, A., Papouchis, N., Siever, L. J., & New, A. S. (2015) · Personality Disorders Theory Research and Treatment · doi:10.1037/per0000139 · Cited by 21
Chou, C.-Y., La Marca, R., Steptoe, A., & Brewin, C. R. (2018) · European Journal of Psychotraumatology · doi:10.1080/20008198.2018.1472988 · Cited by 21
“They were also identified as predictors of poorer responses to exposure therapies due to their inhibiting effects on conscious engagement during traumatic memory processing (Lanius, Brand, Vermetten, Frewen, & Spiegel, 2012; Lanius et al., 2010).”
BackgroundMostoufi, S. M., Godfrey, K. M., Ahumada, S. M., Hossain, N., Song, T., Wright, L. J., Lohr, J. B., & Afari, N. (2014) · Annals of General Psychiatry · doi:10.1186/s12991-014-0031-1 · Cited by 22
“One potential explanation is that those with PTSD may experience dissociation, involving disruption in body awareness and a detachment from the emotional content of a traumatic experience [43] that may also numb these individuals to physical pain [44].”
BackgroundBrain functional integration: an epidemiologic study on stress-producing dissociative phenomena
Sperandeo, R., Monda, V., Messina, G., Carotenuto, M., Maldonato, M. N., Moretto, E., Leone, E., Luca, V. D., Monda, M., & Messina, A. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s146250 · Cited by 20
Lieberman, J. M., Rabellino, D., Densmore, M., Frewen, P., Steyrl, D., Scharnowski, F., Théberge, J., Hosseini‐Kamkar, N., Neufeld, R. W. J., Jetly, R., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1229729 · Cited by 20
Self-citationTrauma-related psychiatric comorbidity of somatization disorder among women in eastern Turkey
Taycan, O., Şar, V., Çelik, C., & Taycan, S. E. (2014) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2014.08.052 · Cited by 20
“This subtype is associated with childhood adversities alongside the traumatic event(s) in adulthood leading to the main diagnosis [60–62].”
BackgroundFrewen, P., Hegadoren, K., Coupland, N. J., Rowe, B. H., Neufeld, R. W. J., & Lanius, R. A. (2015) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2015.1022925 · Cited by 21
“…in persons with posttraumatic stress disorder (PTSD) has been described in recent psychological trauma research (e.g., Carlson, Dalenberg, & McDade-Montez, 2012; Dalenberg & Carlson, 2012; Lanius, Brand, Vermetten, Frewen, & Spiegel, 2012; Lanius et al., 2010, 2014; Spiegel et al., 2011, 2013).”
BackgroundSelf-citationBækkelund, H., Frewen, P., Lanius, R. A., Berg, A. O., & Arnevik, E. A. (2018) · European Journal of Psychotraumatology · doi:10.1080/20008198.2018.1544025 · Cited by 22
“pervasive symptoms of derealization and depersonalization and often related to childhood abuse (Lanius, Brand, Vermetten, Frewen, & Spiegel, 2012; Lanius et al., 2010).”
BackgroundSelf-citationSierk, A., Manthey, A., Brakemeier, E., Walter, H., & Daniels, J. K. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00274-x · Cited by 24
“In regard to limbic structures, we selected regions from the FreeSurfer parcellation (Desikan Killany atlas), which are proposed to belong to the limbic system (cf. Isaacson 2013) and which have been reported to be undermodulated in PTSD-D (Lanius et al. 2010).”
BackgroundMethodInfluentialNeuroimaging-based variability in subtyping biomarkers for psychiatric heterogeneity
Wen, Z., Hammoud, M. Z., Siegel, C., LASKA, E. M., Amara, D. A., Etkin, A., Milad, M. R., & Marmar, C. R. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02807-y · Cited by 23
“One is to search for clinical subtypes and relate these to underlying neurobiological mechanisms [13, 14].”
A protocol for managing dissociative symptoms in refugee populations
Chessell, Z. J., Brady, F., Akbar, S., Stevens, A., & Young, K. (2019) · The Cognitive Behaviour Therapist · doi:10.1017/s1754470x19000114 · Cited by 19
“…of progress impact outcomes of evidence-based treatments that attempt to integrate the trauma memory into the individual’s autobiographical memory (Lanius et al., 2010, 2012; Spitzer et al., 2006), others demonstrate positive outcomes despite dissociation (Hagenaars et al., 2010; Halvorsen et…”
BackgroundWhich Methodological Practice(s) for Psychotherapy Science? A Systematic Review and a Proposal
Gelo, O. C. G., Lagetto, G., Dinoi, C., Belfiore, E., Lombi, E., Blasi, S., Aria, M., & Ciavolino, E. (2019) · Integrative Psychological and Behavioral Science · doi:10.1007/s12124-019-09494-3 · Cited by 25
Lee, M., Anumagalla, P., & Pavuluri, M. N. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00303-9 · Cited by 20
Caulfield, N. M., Karnick, A. T., & Capron, D. W. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.10.097 · Cited by 23
Deen, A., Biedermann, S. V., Lotzin, A., Krüger-Gottschalk, A., Dyer, A., Knaevelsrud, C., Rau, H., Schellong, J., Ehring, T. W., & Schäfer, I. (2022) · European Journal of Psychotraumatology · doi:10.1080/20008198.2022.2031591 · Cited by 25
“The inclusion of this subtype is based on neurobiological, clinical and psychometric findings (e.g. Lanius, Brand, Vermetten, Frewen, & Spiegel, 2012; Lanius et al., 2010; Stein et al., 2012; Wolf et al., 2012a).”
BackgroundInfluentialQuetiapine Treatment for Post-traumatic Stress Disorder: A Systematic Review of the Literature
Crapanzano, C., Damiani, S., Casolaro, I., & Amendola, C. (2023) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2023.21.1.49 · Cited by 19
In Search of an Adult Attachment Stress Provocation to Measure Effect on the Oxytocin System
Munro‐Kramer, M. L., Brown, S. L., Pournajafi‐Nazarloo, H., Carter, C. S., Lopez, W. D., & Seng, J. S. (2013) · Journal of the American Psychiatric Nurses Association · doi:10.1177/1078390313492173 · Cited by 21
“Current literature (Lanius et al., 2010; Seng, D’Andrea, & Ford, in press; Seng et al., 2013; Stein et al., 2012; Wolf et al., 2012) suggests that there may well be a dissociative subtype of PTSD.”
BackgroundNakeyar, C., & Frewen, P. (2016) · Canadian Psychology/Psychologie canadienne · doi:10.1037/cap0000067 · Cited by 19
“…to acquire of PTSD relevance is HR, however, elevated resting HR can be indicative of many disorders, and normal or even low HR is not a contraindication to PTSD diagnosis, but rather may even be a sign of a hypo-aroused, emotionally numb or dissociative phenotype (e.g., Lanius et al., 2010).”
BackgroundA Network Analysis to Identify Associations between PTSD and Dissociation among Teenagers
Cardeña, E., Gušić, S., & Cervin, M. (2021) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2021.1989122 · Cited by 19
“The relation between dissociative symptoms and posttraumatic and other psychiatric symptoms is of great theoretical and practical importance (Cardeña et al., 2012; Lanius et al., 2010).”
BackgroundStimulus Deprivation and Overstimulation as Dissociogenic Agents in Postmodern Oppressive Societies
Şar, V., & Öztürk, E. (2012) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2013.724346 · Cited by 21
Vigilance/Avoidance to Expected and Presented Stimuli in Trauma Survivors: An Eye-Tracking Study
Kimble, M., & Hyatt, A. S. (2019) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2019.1572041 · Cited by 19
“Furthermore, the inclusion of a dissociative subtype within the PTSD diagnosis in the DSM-5 further recognizes that there are distinct patterns of symptoms even within the PTSD diagnosis (Lanius et al., 2010).”
BackgroundWebb, E. K., Huggins, A. A., Belleau, E. L., Taubitz, L. E., Hanson, J. L., deRoon‐Cassini, T. A., & Larson, C. L. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.03.004 · Cited by 19
“892 Biological Psychiatry: Cognitive Neuroscience and Neuroimaging S derealization and conceptualized as an overmodulation of affect (30,33).”
BackgroundTransforming social perspectives with cognitive maps
Arzy, S., & Kaplan, R. (2022) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsac017 · Cited by 17
“The dissociative subtype is characterized by overmodulation of affect, while the (more common) non-dissociative subtype involves the predominance of re-experiencing the traumatic event itself and hyperarousal symptoms (Lanius et al., 2010).”
BackgroundHyperexcitability: From Normal Fear to Pathological Anxiety and Trauma
Rosen, J. B., & Schulkin, J. A. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.727054 · Cited by 22
Dissociation in patients with epilepsy and functional seizures: A narrative review of the literature
Cassady, M. K., & Baslet, G. C. (2023) · Seizure · doi:10.1016/j.seizure.2023.06.020 · Cited by 20
Hansen, M., Armour, C., Wang, L., Elklit, A., & Bryant, R. A. (2015) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2015.02.005 · Cited by 21
“The first formal recognition of dissociative presentations in longer-term traumatic responding occurred in DSM-5 because of initial evidence that PTSD patients with dissociative tendencies had distinctive neural and behavioral characteristics (Felmingham et al., 2008; Lanius et al., 2010).”
BackgroundPosttraumatic Overmodulation, Callous–Unemotional Traits, and Offending Among Justice-Involved Youth
Mozley, M. M., Lin, B., & Kerig, P. K. (2018) · Journal of Aggression Maltreatment & Trauma · doi:10.1080/10926771.2017.1420724 · Cited by 18
“In contrast, undermodulation represents the experience of heightened emotional reactivity after trauma exposure, as evidenced by hyperarousal or intrusion symptoms (Frewen & Lanius, 2006; Lanius et al., 2010).”
BackgroundInfluentialThe traumatogenic potential of law enforcement home raids: An exploratory report.
Lopez, W. D., Novak, N. L., Harner, M., Martínez, R., & Seng, J. S. (2018) · Traumatology An International Journal · doi:10.1037/trm0000148 · Cited by 19
“, 2013), and mounting evidence from biological phenotyping (Lanius et al., 2010).”
BackgroundMethodGuetta, R. E., Wilcox, E., Stoop, T. B., Maniates, H., Ryabchenko, K. A., Miller, M. W., & Wolf, E. J. (2019) · Behavior Therapy · doi:10.1016/j.beth.2019.02.003 · Cited by 18
“A growing body of imaging studies have raised the possibility that the dissociative subtype is associated with a neurobiological signature defined by increased topdown processing from frontal cortical regions and reduced limbic responsiveness (the opposite pattern from that observed for those with PTSD symptoms withou…”
BackgroundModrowski, C. A., Chaplo, S. D., Kerig, P. K., & Mozley, M. M. (2019) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000469 · Cited by 18
Childhood Trauma and Dissociative Disorders
Şar, V. (2020) · Springer eBooks · doi:10.1007/978-3-030-49414-8_16 · Cited by 22
Impaired executive function exacerbates neural markers of posttraumatic stress disorder
Jagger-Rickels, A. C., Stumps, A. D., Rothlein, D., Park, H., Fortenbaugh, F. C., Zuberer, A., Fonda, J. R., Fortier, C. B., Degutis, J. M., Milberg, W., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291721000842 · Cited by 18
“Another neurobiological theory that may explain the results of this study describes emotional over-modulation and under-modulation (Lanius et al., 2010, 2012).”
BackgroundResultInfluentialÖzdemir, B. H., Çeli̇k, C., & Öznur, T. (2015) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v6.26657 · Cited by 19
Revisiting the Role of the Amygdala in Posttraumatic Stress Disorder
Forster, G. L., Simons, R. M., & Baugh, L. A. (2017) · InTech eBooks · doi:10.5772/67585 · Cited by 22
“Related, participants from women-only studies are victims of childhood sexual abuse, which is associated with dissociative PTSD [14].”
BackgroundMethodInfluentialTreatment of dissociative identity disorder: leveraging neurobiology to optimize success
Purcell, J. B., Brand, B., Browne, H. A., Chefetz, R. A., Shanahan, M., Bair, Z. A., Baranowski, K. A., Davis, V., Mangones, P., Modell, R. L., et al. (2024) · Expert review of neurotherapeutics · doi:10.1080/14737175.2024.2316153 · Cited by 18
“…individuals with the dissociative subtype of PTSD have greater activity in regions associated with ‘top-down’ regulation (e.g. prefrontal cortex) and diminished activity in limbic regions (e.g. amygdala) when presented with emotionally provocative autobiographical trauma-related scripts [146,147].”
BackgroundSelf-citationCavicchioli, M., Ogliari, A. C., Maffei, C., Mucci, C., Northoff, G., & Scalabrini, A. (2023) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13547 · Cited by 18
“of PTSD dissociative subtype.(28,29) This evidence was not fully surprising in light of robust associations between depersonalization/ derealization reactions and PTSD hyperarousal cluster of symptoms.”
BackgroundMethodInfluentialGene Expression Profiles in Relation to Tension and Dissociation in Borderline Personality Disorder
Schmahl, C. G., Arvastson, L., Tamm, J. A., Bohus, M., Abdourahman, A., & Antonijevic, I. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070787 · Cited by 16
“Neuroimaging studies point to decreased activity in the amygdala in conjunction with increased medial prefrontal/ anterior cingulate activity [49,50].”
BackgroundSelf-citationSwitch Function and Pathological Dissociation in Acute Psychiatric Inpatients
Chiu, C., Tseng, M. M., Chien, Y., Liao, S., Liu, C., Yeh, Y., & Hwu, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154667 · Cited by 17
“Superior cognitive control may underlie the characteristic over-modulation of emotional representations under catastrophic stress in traumatised patients comorbid with dissociative pathology [54,55].”
BackgroundFine, N. B., Achituv, M., Etkin, A., Merin, O., & Shalev, A. Y. (2018) · European Journal of Psychotraumatology · doi:10.1080/20008198.2018.1442602 · Cited by 17
“Dissociative types of PTSD might have a different underlying neural mechanism and specific deficits in emotional learning (Ebner-Priemer et al., 2009; Lanius et al., 2010).”
Background
Metadata
- Authors
- Lanius, R. A., Vermetten, E., Loewenstein, R. J., Brand, B., Schmahl, C., Bremner, J. D., & Spiegel, D.
- Affiliations
- Western University (CA)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2010-06-01
- Volume
- 167
- Issue
- 6
- Pages
- 640-647
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC3226703
- OpenAlex
- W2124556602
- Cited by
- 1,123
- References
- 53
- Citations by year
- 2026: 61 · 2025: 74 · 2024: 64 · 2023: 67 · 2022: 69 · 2021: 74 · 2020: 71 · 2019: 61 · 2018: 84 · 2017: 84 · 2016: 71 · 2015: 66 · 2014: 86 · 2013: 57 · 2012: 74
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- AstraZeneca
- H. Lundbeck A/S
- National Institutes of Health (UL1TR000454)
- National Institute on Aging (P01AG018784)
- National Heart, Lung, and Blood Institute (R01HL088726)
- National Institute of Mental Health (R21MH080208, R01MH056120, R01MH047226, K24MH076955, T32MH067547, R01MH060556)
- National Cancer Institute (R01CA118567, R01CA061309, U01CA197282)
- National Center for Research Resources (S10RR016917)
- National Center for Advancing Translational Sciences
- National Center for Complementary and Integrative Health (RC1AT005733, P30AT005886)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- post-traumatic stress disorder, emotional dysregulation, re-experiencing, hyperarousal, limbic regions, dissociation, trauma treatment, symptom profiles
- MeSH terms
- Affect, Amygdala, Cerebral Cortex, Chronic Disease, Dissociative Disorders, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Memory Disorders, Neural Inhibition, Stress Disorders, Post-Traumatic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
