Cognitive Abilities and 50- and 100-msec Paired-Click Processes in Schizophrenia
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OBJECTIVE: Abnormal 50- and 100-msec event-related brain activity derived from paired-click procedures are well established in schizophrenia. There is little agreement on whether group differences in the ratio score, i.e., the ratio of EEG amplitude after the second stimulus (S2) to the amplitude after the first stimulus (S1), reflect an encoding or gating abnormality. In addition, the functional implications remain unclear. In the present study, EEG and magnetoencephalography (MEG) were used to examine paired-click measures and cognitive correlates of paired-click activity. METHOD: EEG and whole-cortex MEG data were acquired during the standard paired-click paradigm in 73 comparison subjects and 79 schizophrenia patients. Paired-click ratio scores were obtained at 50 msec (P50 evoked potential at Cz, M50 at left and right superior temporal gyrus [STG]) and 100 msec (N100 at Cz, M100 at left and right STG). A cognitive battery assessing attention, working memory, and long-delay memory was administered. IQ was also estimated. RESULTS: Groups differed on ratio score and amplitude of S1 response. Ratio scores at 50 msec and 100 msec and S1 amplitude predicted variance in attention (primarily S1 amplitude), working memory, and long-delay memory. The attention findings remained after removal of variance associated with IQ. CONCLUSIONS: Associations between paired-click measures and cognitive performance in patients support 50-msec and 100-msec ratio and amplitude scores as clinically significant biomarkers of schizophrenia. In general, cognitive performance was better predicted by the ability to encode auditory information than the ability to filter redundant information.
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P50 inhibitory gating deficits in schizophrenia have been associated with the frequency and intensity of auditory hallucinations and with neurocognitive measures of decreased vigilance and attention.
“P50 inhibitory gating deficits in schizophrenia have been associated with the frequency and intensity of auditory hallucinations and with neurocognitive measures of decreased vigilance and attention, consistent with the role of inhibitory sensory gating in protecting the brain from being responsive to extraneous stimuli while it is trying to focus attention on a task (16, 17).”
From Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia (2015) · cites this paper as [17]
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“Actually, some researchers have reported a similar pattern of cognitive deficits between patients with schizophrenia and the first-degree relatives, including working memory, set shifting, and prepotent response (Johnstone et al., 2002; Brewer et al., 2005; Snitz et al., 2006).”
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“Studies evaluating the association between P50 ratio and cognitive functions in SCZ have reported inconsistent results, since some studies found a significant correlation between this EEG index and impairments in different cognitive domains such as attention [144,149,150], working memory [145,149], speed of processing…”
BackgroundMethodResultInfluentialOverlapping auditory M100 and M200 abnormalities in schizophrenia and bipolar disorder: A MEG study
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“…click sounds, previous studies found M50 gating deficits in the left hemisphere in schizophrenia patients (Hanlon et al., 2005; Hirano et al., 2010; Smith et al., 2010; Thoma et al., 2003), thus suggesting that the asymmetry of gating deficits may be importantly related to schizophrenia…”
BackgroundMethodEdgar, J. C., Hunter, M. A., Huang, M., Smith, A. K., Chen, Y., Sadek, J. R., Lu, B. Y., Miller, G. A., & Cañive, J. M. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.009 · Cited by 37 · see citing works
“The sample in Smith et al. (2010) included 73 controls and 79 patients with SCZ.”
BackgroundMethodResultInfluentialSelf-citationP50 sensory gating is a trait marker of the bipolar spectrum
Cabranes, J. A., Ancín, I., Santos, J. L., Sánchez‐Morla, E. M., García-Jiménez, M. Á., Rodríguez-Moya, L., Fernández, C., & Barabash, A. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.06.008 · Cited by 32 · see citing works
“result from an abnormally low response to S1 stimuli, or a decreased attenuation of the S2 response, this fact could explain why the ratio is more deficitary in the BDI sample, so that an increment in the encoding system might be an attempt of BDII patients to make up for the deficits in the filtering system (Smith et…”
BackgroundNguyen, A. T., Hetrick, W. P., O’Donnell, B. F., & Brenner, C. A. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.01.014 · Cited by 31 · see citing works
Chronic effects of cannabis on sensory gating
Broyd, S. J., Greenwood, L., Croft, R. J., Dalecki, A., Todd, J., Michie, P. T., Johnstone, S. J., & Solowij, N. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.04.015 · Cited by 31 · see citing works
“Long-term users were also observed to have significantly smaller P50 amplitude to the first click, a finding consistent with the patient literature (e.g. Clementz and Blumenfeld, 2001; Smith et al., 2010) and suggests long-term exposure to cannabis may adversely affect encoding as well as well as gating (Smith et al.”
BackgroundResultSmucny, J., Stevens, K. E., Olincy, A., & Tregellas, J. R. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.77 · Cited by 28 · see citing works
Region-specific reduction of auditory sensory gating in older adults
Cheng, C., Baillet, S., & Lin, Y. (2015) · Brain and Cognition · doi:10.1016/j.bandc.2015.10.004 · Cited by 30 · see citing works
“…as schizophrenia (Brenner et al., 2009; Clementz, Geyer, & Braff, 1998; Light, Geyer, Clementz, Cadenhead, & Braff, 2000; Patterson et al., 2008; Smith et al., 2010), traumatic brain injury (Arciniegas et al., 2000), migraine (Ambrosini, De Pasqua, Afra, Sandor, & Schoenen, 2001; Siniatchkin,…”
Pre-attentive information processing and impulsivity in bipolar disorder
Swann, A. C., Lijffijt, M., Lane, S. D., Steinberg, J. L., Acas, M. D., Cox, B., & Moeller, F. G. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.08.018 · Cited by 29 · see citing works
“P50 amplitudes were also related to rapid-response impulsivity (Tables 4 and 5), and more strongly correlated with attention and working memory after correction for IQ (Smith et al., 2010) than P50 gating ratio.”
BackgroundTargeted training modifies oscillatory brain activity in schizophrenia patients
Popov, T. G., Carolus, A. M., Schubring, D., Popova, P., Miller, G. A., & Rockstroh, B. S. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.03.010 · Cited by 27 · see citing works
“…brain potentials or fields P50/M50 ratio reliably distinguishes SZ and HC (e.g., Adler et al., 1982; Bramon et al., 2004; Hanlon et al., 2005; Smith et al., 2010; Yee et al., 2010; Popov et al., 2011a; Carolus et al., 2014), effects of trainingwere evaluated in the paired-click design in the…”
BackgroundSelf-citationKnott, V., Smith, D., de la Salle, S., Impey, D., Choueiry, J., Beaudry, E., Smith, M. K., Saghir, S., Ilivitsky, V., & Labelle, A. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114553254 · Cited by 27 · see citing works
“Email: Verner.Knott@theroyal.ca domain (Cullum et al., 1993; Erwin et al., 1998; Potter et al., 2006; Smith et al., 2010; Smucny et al., 2013; Thoma et al., 2003).”
BackgroundCOMT Val108/158Met genotype modulates human sensory gating
Majić, T., Rentzsch, J., Gudlowski, Y., Ehrlich, S., Juckel, G., Sander, T., Lang, U. E., Winterer, G., & Gallinat, J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.12.031 · Cited by 26 · see citing works
“Some authors published associations between stronger (better) P50 sensory gating and better performance on cognitive tasks in healthy subjects (Smith et al., 2010; Hsieh et al., 2004), while others observed no correlations with verbal learning, memory or neurophysiological markers of attention…”
BackgroundResultSensory Gating Deficits in First-Episode Psychosis
Morales‐Muñoz, I., Barba, R. J., Fernández‐Guinea, S., Rodríguez–Jiménez, R., Jiménez‐Arriero, M. Á., Criado, J. R., & Rubio, G. (2016) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000572 · Cited by 24 · see citing works
“Most of the bibliography has been focused in P50 deficits in schizophrenia, showing several impairments in these patients (Erwin et al., 1998; Smith et al., 2010; Smucny et al., 2013), whereas less research has been performed regarding N1 and P2 functioning.”
BackgroundFrontal and superior temporal auditory processing abnormalities in schizophrenia
Chen, Y., Edgar, J. C., Huang, M., Hunter, M. A., Epstein, E. M., Howell, B. C., Lu, B. Y., Bustillo, J., Miller, G. A., & Cañive, J. M. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.05.002 · Cited by 22 · see citing works
“Given that our and others previous paired-click findings indicated group differences for the S1 but not the second click (S2)1 (Smith et al., 2010; Turetsky et al., 2008), the present study focused on examining early S1 activity at 50 ms and 100 ms.”
InfluentialSelf-citationStone, D. B., Coffman, B. A., Bustillo, J., Aine, C. J., & Stephen, J. M. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00788 · Cited by 20 · see citing works
EEG and MEG Probes of Schizophrenia Pathophysiology
Neustadter, E. S., Mathiak, K., & Turetsky, B. I. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801829-3.00021-5 · Cited by 22 · see citing works
Smoking, MATRICS consensus cognitive battery and P50 sensory gating in a Han Chinese population
Tan, S., Cui, J.-F., Fan, F., Zhao, Y., Chen, N., Fan, H., Zhang, J.-G., Wang, Y., Yoon, J. H., Soares, J. C., et al. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.06.045 · Cited by 21 · see citing works
“The amplitude of evoked brain ctivity 50 ms (hence called the P50) after each click is typially measured with electroencephalography (EEG) at electrode Cz Smith et al., 2010).”
MethodDysregulation of auditory neuroplasticity in schizophrenia
Voss, P., Thomas, M. E., Guercio, G. D., & de Villers‐Sidani, E. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.04.025 · Cited by 21 · see citing works
Smucny, J., & Tregellas, J. R. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117705071 · Cited by 21 · see citing works
“…been replicated in many laboratories, is predictive of cognitive function in several domains, including attention (Cullum et al., 1993; Potter et al., 2006; Smith et al., 2010; Smucny et al., 2013) and is one of the most frequently investigated electrophysiological endophenotypes in schizophrenia.”
BackgroundAssociation of cognitive and P50 suppression deficits in chronic patients with schizophrenia.
Xia, L., Wang, D.-M., Wang, J.-S., Xu, H., Huo, L., Tian, Y., Dai, Q., Wei, S.-C., Wang, W., Zhang, G.-Y., et al. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.12.405 · Cited by 17 · see citing works
Electrophysiological and behavioral responses to ketamine in mice with reduced Akt1 expression
Featherstone, R. E., Tatard-Leitman, V. M., Suh, J., Lin, R., Lucki, I., & Siegel, S. J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-2997-9 · Cited by 19 · see citing works
“2009), and both measures show a relationship to positive symptoms as well as deficits in working memory and attention (Erwin et al. 1998; Lijffijt et al. 2009; Potter et al. 2006; Smith et al. 2010).”
BackgroundGooding, D. C., Gjini, K., Burroughs, S. A., & Boutros, N. N. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.08.049 · Cited by 19 · see citing works
“deficit of schizophrenia patients extents to these later phases of information processing (Smith et al., 2010; Turetsky et al., 2009).”
BackgroundFunctional cognitive and cortical abnormalities in chronic and first-admission schizophrenia
Carolus, A. M., Schubring, D., Popov, T. G., Popova, P., Miller, G. A., & Rockstroh, B. S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.05.012 · Cited by 18 · see citing works
“Several studies have related the larger P50/ M50 gating ratio in SZ to inadequate S1 encoding, reflected in smaller S1-evoked P50/M50 or N100/M100 amplitude (e.g., Clementz and Blumenfeld, 2001; Smith et al., 2010; Chen et al., 2013; Hamm et al., 2014).”
Self-citationXia, L., Yuan, L., Du, X., Wang, D., Wang, J., Xu, H., Huo, L., Tian, Y., Dai, Q., Wei, S., et al. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.11.012 · Cited by 18 · see citing works
Cheng, C., Hsiao, F., Hsieh, Y., & Wang, P. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00039 · Cited by 16 · see citing works
Choueiry, J., Blais, C. M., Shah, D. K., Smith, D., Fisher, D. J., Ilivitsky, V., & Knott, V. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119836217 · Cited by 16 · see citing works
Giordano, G. M., Brando, F., Perrottelli, A., Lorenzo, G. D., Siracusano, A., Giuliani, L., Pezzella, P., Altamura, M., Bellomo, A., Cascino, G., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.790745 · Cited by 15 · see citing works
Schubring, D., Popov, T. G., Miller, G. A., & Rockstroh, B. S. (2017) · Psychophysiology · doi:10.1111/psyp.13006 · Cited by 15 · see citing works
Self-citationMagnetoencephalography for Schizophrenia
Edgar, J. C., Guha, A., & Miller, G. A. (2020) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2020.01.002 · Cited by 14 · see citing works
“, 2003), while other studies find no gating/habituation abnormality in Sz(Bachmann et al., 2010; Smith et al., 2010).”
BackgroundSelf-citationEdgar, J. C., Fisk, C. L., Chen, Y., Stone‐Howell, B., Liu, S., Hunter, M. A., Huang, M., Bustillo, J., Cañive, J. M., & Miller, G. A. (2018) · Psychophysiology · doi:10.1111/psyp.13074 · Cited by 14 · see citing works
“Other studies have shown that decreased 100 ms auditory activity is associated with impairment on tests of attention as well as reduced gray matter (J. C. Edgar et al., 2012; Smith et al., 2010).”
BackgroundSelf-citationEdgar, J. C., Blaskey, L. G., Green, H. L., Konka, K. G., Shen, G., DiPiero, M. A., Berman, J., Bloy, L., Liu, S., McBride, E., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.584557 · Cited by 14 · see citing works
“Children were selected according to the following criteria: (1) no history of traumatic brain injury, significant medical or neurological abnormality, known genetic syndrome, or diagnosed neurodevelopmental or learning disorders, (2) no active psychosis, (3) no MRI contraindications, (4) no sensory impairments (somato…”
MethodSelf-citationAbnormal frontal generator during auditory sensory gating in panic disorder: An MEG study
Cheng, C., Chan, P.-Y. S., Hsu, S., & Liu, C.-Y. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.04.006 · Cited by 13 · see citing works
Effect of alpha-NETA on auditory event related potentials in sensory gating study paradigm in mice
Aa, A., Es, D., Volnova, A. B., et al. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134470 · Cited by 13 · see citing works
Stevens, K. E., Zheng, L., Floyd, K. L., & Stitzel, J. A. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.044 · Cited by 12 · see citing works
“This deficit can manifest as poor attentional control (Cullum et al., 1993; Harris et al., 2004; Yee et al., 1998) although other studies do not find this relationship (Sánchez-Morla et al., 2013; Smith et al., 2010).”
Age Effect on Automatic Inhibitory Function of the Somatosensory and Motor Cortex: An MEG Study
Cheng, C., Lin, M., & Yang, S.-H. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00053 · Cited by 11 · see citing works
“Accumulating evidence has shown that pre-attentive SG is associated with many aspects of cognitive function, such as working memory, attention and processing speed, in these clinical patients (Smith et al., 2010; Thomas et al., 2010).”
BackgroundCheng, C., Hsu, S., & Liu, C.-Y. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.11.013 · Cited by 10 · see citing works
Associations and Heritability of Auditory Encoding, Gray Matter, and Attention in Schizophrenia
Chen, Y., Howell, B. C., Edgar, J. C., Huang, M., Kochunov, P. V., Hunter, M. A., Wootton, C., Lu, B. Y., Bustillo, J., Sadek, J. R., et al. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby111 · Cited by 10 · see citing works
“ANOVAs showed a group main effect (F(2,157) = 10.”
BackgroundMethodInfluentialSelf-citationXia, L., Wang, D., Wei, G., Wang, J., Zhou, H., Xu, H., Tian, Y., Dai, Q., Xiu, M., Chen, D., et al. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110246 · Cited by 9 · see citing works
Micoulaud‐Franchi, J., Faugère, M., Boyer, L., Cermolacce, M., Richieri, R. M., Faget, C., Philip, P., Vion‐Dury, J., & Lançon, C. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.04.005 · Cited by 10 · see citing works
“Sensory gating deficit has been related to cognitive impairments in patients with schizophrenia (Cullum et al., 1993; Erwin et al., 1998; Smith et al., 2010).”
BackgroundAltered auditory repetition suppression and MMNm in relation to cognitive tests in older adults
Yang, S.-H., Wang, P., & Cheng, C. (2019) · Biological Psychology · doi:10.1016/j.biopsycho.2019.107725 · Cited by 8 · see citing works
Xia, L., Liu, R., Zhou, H., Tian, Y., Dai, Q., Xiu, M., Chen, D., Wang, D., & Zhang, X. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110380 · Cited by 8 · see citing works
Review of Schizophrenia Research Using MEG
Rojas, D. C. (2014) · Springer eBooks · doi:10.1007/978-3-642-33045-2_41 · Cited by 8 · see citing works
ERPs Studies of Short- and Long-Term Habituation in Humans: A Systematic Review
Pinto, J. A. P., Vogel, E. H., Aylwin, M. D. L. L., & Kreither, J. (2022) · Psykhe (Santiago) · doi:10.7764/psykhe.2021.36885 · Cited by 8 · see citing works
Popov, T. G., Rockstroh, B. S., & Miller, G. A. (2021) · Psychophysiology · doi:10.1111/psyp.13770 · Cited by 7 · see citing works
Self-citationLi, S., Chan, S. Y., Higgins, A., & Hall, M. (2021) · Psychological Medicine · doi:10.1017/s0033291721004463 · Cited by 7 · see citing works
“Studies in chronic SZ reported relationships between P50 sensory dysfunction and neurocognitive impairments, involving attention, working memory and processing speed (Dalecki et al., 2016; Smith et al., 2010; Thoma et al., 2003).”
Li, S., Yu, B., Wang, D., Xia, L., Wang, L., Chen, D., Xiu, M., & Zhang, X. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.12.143 · Cited by 7 · see citing works
de la Salle, S., Choueiry, J., McIntosh, J. F., Bowers, H., Ilivitsky, V., & Knott, V. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06090-z · Cited by 5 · see citing works
“1987), a lower S1-P50 amplitude found in some studies of schizophrenia patients has been interpreted as an impairment in “gating in” and is suggested to indicate the brain’s failure to register and/or attend to novel and changing S1 auditory stimuli which, as in the case of our non-significant reduction in S1-P50 by k…”
BackgroundYang, Q., Zhang, Y., Yang, K., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1036421 · Cited by 5 · see citing works
“Individuals with schizophrenia show sensory gating deficits, which may be associated with impaired sustained attention (6), slowed processing speed (7), and poor working memory performance (7, 8).”
BackgroundMajor, S. T., Carpenter, K. L. H., Beyer, L. N., Kwak, H., Dawson, G., & Murias, M. (2019) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000245 · Cited by 5 · see citing works
Niemantsverdriet, M. B. A., Slotema, C. W., van der Veen, F. M., van der Gaag, M., Sommer, I. E., Deen, M. L., & Franken, I. H. A. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112545 · Cited by 5 · see citing works
Sensory gating deficits and childhood trauma in the onset of first-episode schizophrenia
Wang, L., Zeng, W., Yin, Y., Zhou, Y., Huang, J., Zhang, P., Chen, S., Fan, H., Luο, X., Tan, S., et al. (2022) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2022.103385 · Cited by 4 · see citing works
Panahi, R., Akbari, M., Jarollahi, F., Haghani, H., Leili, E. K., & Zia, M. (2023) · Dyslexia · doi:10.1002/dys.1754 · Cited by 4 · see citing works
Guha, A., Popov, T. G., Bartholomew, M. E., Reed, A. C., Diehl, C., Subotnik, K. L., Ventura, J., Nuechterlein, K. H., Miller, G. A., & Yee, C. M. (2024) · Psychophysiology · doi:10.1111/psyp.14627 · Cited by 4 · see citing works
Self-citationPsychophysiological Study of the Mechanisms of Sustained Attention Deficit in Schizophrenia
Kirenskaya, A. V., Myamlin, V. V., & Ткаченко, А. А. (2021) · Human Physiology · doi:10.1134/s0362119721010060 · Cited by 4 · see citing works
Electrophysiological Evidence in Schizophrenia in Relation to Treatment Response
Sueyoshi, K., & Sumiyoshi, T. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00259 · Cited by 4 · see citing works
“Specifically, deficits of P50 suppression have been linked to poor performance on tests of cognitive domains, such as attention (34–36), working memory (11, 36), processing speed (11, 34), and executive function (35).”
BackgroundReview of Schizophrenia Research Using MEG
Rojas, D. C. (2019) · Springer eBooks · doi:10.1007/978-3-319-62657-4_41-1 · Cited by 3 · see citing works
Lang, X., Wang, D., Zhou, H., Wang, L., Kosten, T. R., & Zhang, X. (2022) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2022.103421 · Cited by 2 · see citing works
Review of Schizophrenia Research Using MEG
Rojas, D. C. (2019) · Springer eBooks · doi:10.1007/978-3-030-00087-5_41 · Cited by 2 · see citing works
Лебедева, И. С., Карелин, С. А., Ahadov, T. A., Tomyshev, A. S., Ublinskiy, M. V., Semenova, N. A., Бархатова, А. Н., & Каледа, В. Г. (2016) · Human Physiology · doi:10.1134/s0362119716040125 · Cited by 2 · see citing works
“The absence of statistically significant deviations of the “sensory filter” index in schizophrenic patients has also been reported [21], although most studies have found such abnormalities [22, 23].”
ResultŞahin, D., Hever, F., Bossert, M., Herwig, K., Aschenbrenner, S., Weisbrod, M., & Sharma, A. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114162 · Cited by 2 · see citing works
Baran, B., Denis, D., Mylonas, D., Arpaci, H., Spitzer, C., Raymund, N., Talbot, C., Kohnke, E., Larson, O., Stickgold, R., et al. (2026) · Schizophrenia · doi:10.1038/s41537-026-00735-0 · Cited by 1 · see citing works
Barbalat, G., & Nicolas Franck, B. (2020) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2020.04.089 · Cited by 1 · see citing works
Jian, J.-R., Lin, Y.-Y., Connor, L. T., et al. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136336 · Cited by 1 · see citing works
The effect of noise trauma and high-frequency stimulation on thalamic sensory gating in rodentsPreprint
Zare, A., van Zwieten, G., Kotz, S. A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.03.023143 · Cited by 1 · see citing works
“In fact, P50 abnormalities have been found in the EEG of patients suffering from schizophrenia [37, 38].”
BackgroundContents of the American Journal of Psychiatry
(2010) · The British Journal of Psychiatry · doi:10.1192/s000712500028882x · Cited by 1 · see citing works
Abnormal P50 sensory gating in schizophrenia: A permutation fuzzy entropy analysis
Zhang, W., Liu, S., Xiang, J., et al. (2018) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2018.04.0406
“[23] found that the P50 potentials in Cz were more marked than those at other”
Smith, E. S., Crawford, T. J., & Reid, V. M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.10.144014
Oliver, W., Parker, D., Hetrick, W. P., & Clementz, B. A. (2021) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2021.100033
“Third, recovery from stimulation (the period after sensory registration and before the next stimulus when there is no obvious evoked response) differs between psychosis and healthy subjects (Brenner et al., 2009; Clementz and Blumenfeld, 2001; Hamm et al., 2014; Johannesen et al., 2005, 2013; Smith et al., 2010).”
Background(2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283514a53
Onitsuka, T., & Hirano, S. (2016) · Springer eBooks · doi:10.1007/978-4-431-55729-6_14
The Use of Event-Related Potentials in the Study of Schizophrenia: An Overview
Crown, L. M., Featherstone, R. E., Sobell, J. L., Parekh, K., & Siegel, S. J. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-69491-2_11
- Authors
- Smith, A. K., Edgar, J. C., Huang, M., Lu, B. Y., Thoma, R. J., Hanlon, F. M., McHaffie, G., Jones, A. P., Paz, R. D., Miller, G. A., & Cañive, J. M.
- Affiliations
- Mind Research Network (US)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2010-10
- Volume
- 167
- Issue
- 10
- Pages
- 1264-1275
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC3272497
- OpenAlex
- W2119369829
- Cited by
- 88
- References
- 61
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 7 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 8 · 2012: 4
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Stanley Medical Research Institute
- National Institute of Mental Health (R01 MH-61358, R01MH065304, R01 MH 061358, T32 MH-19554, T32 MH019554, R01 MH-65304)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- schizophrenia, paired-click paradigm, P50, N1 component, M50, M100, auditory event-related potentials, auditory gating, auditory coding, attention, working memory, IQ, biomarkers, superior temporal gyrus, cognitive performance
- MeSH terms
- Acoustic Stimulation, Adult, Attention, Cognition, Cognition Disorders, Electroencephalography, Evoked Potentials, Humans, Functional Laterality, Magnetic Resonance Imaging, Memory, Neuropsychological Tests, Schizophrenia, Temporal Lobe, Magnetoencephalography, Sensory Gating
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