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Cited by 212Schizophrenia research and treatmentNeural and Behavioral Psychology StudiesMental Health and Psychiatry

Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia

Cullum, C.Munro, Harris, Josette G., Waldo, Merilyne C., Smernoff, Eric, Madison, Alice, Nagamoto, Herbert T., Griffith, Jay, Adler, Lawrence E. +1 more·1993·Schizophrenia Research
DOI 10.1016/0920-9964(93)90048-n
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Abstract

The behavior of the P50 wave of the auditory evoked potential in a paired stimulus or conditioning-testing paradigm has been used as a measure of sensory gating disturbance in schizophrenia. Schizophrenics fail to decrement the P50 response to the second stimulus of the pair, so that the ratio of the test to the conditioning amplitude is elevated over normal values. The aim of this study was to compare this neurophysiological measure to neuropsychological measures of attention and memory. As expected, schizophrenics performed worse than controls on most measures. The time to complete a digit cancellation test, a measure of sustained attention, was found to be particularly longer in schizophrenics than in control subjects. Furthermore, the increased time to complete this task correlated with the increased ratio of the amplitude of the test P50 response to the conditioning response in the schizophrenics. Thus, a neurophysiological defect in sensory gating may relate to a disorder in sustained attention in schizophrenia. Although the P50 wave may come from the hippocampus, neuropsychological measures of verbal learning and memory were not correlated with alterations in the P50 ratio.

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  • P50 inhibitory gating deficits in schizophrenia have been associated with the frequency and intensity of auditory hallucinations and with neurocognitive measures of decreased vigilance and attention.

    “P50 inhibitory gating deficits in schizophrenia have been associated with the frequency and intensity of auditory hallucinations and with neurocognitive measures of decreased vigilance and attention, consistent with the role of inhibitory sensory gating in protecting the brain from being responsive to extraneous stimuli while it is trying to focus attention on a task (16, 17).”

    From Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia (2015) · cites this paper as [16]

  • Persistent abnormalities in P50 gating are associated with impaired ability to focus attention on specific tasks, a cognitive deficit associated with poor psychosocial rehabilitation.

    “Persistent abnormalities in P50 gating are associated with impaired ability to focus attention on specific tasks, a cognitive deficits associated with poor psychosocial rehabilitation (16).”

    From Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia (2015) · cites this paper as [16]

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Authors
Cullum, C. M., Harris, J. G., Waldo, M. C., Smernoff, E., Madison, A., Nagamoto, H. T., Griffith, J., Adler, L. E., & Freedman, R.
Affiliations
Denver VA Medical Center (US)
Corresponding author
Freedman, Robert
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
1993-08
Volume
10
Issue
2
Pages
131-141
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/0920-9964(93)90048-n
OpenAlex
W2013002369
Cited by
212
References
63
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 15 · 2014: 9 · 2013: 12 · 2012: 6
FWCI
1.95
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service
  • National Institute of Mental Health (MH 15442, MH-44212, MH 38321, P50MH044212, T32MH015442)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
schizophrenia, attentional dysfunction
MeSH terms
Adult, Arousal, Attention, Cerebral Cortex, Evoked Potentials, Auditory, Female, Hippocampus, Humans, Male, Neuropsychological Tests, Reaction Time, Mental Recall, Reference Values, Schizophrenia, Schizophrenic Psychology

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