Cited by 484Personality Disorders and PsychopathologyBipolar Disorder and TreatmentMental Health Research Topics

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index; none of the 25 sources its claims cite is checked for support yet.

Attainment and Stability of Sustained Symptomatic Remission and Recovery Among Patients With Borderline Personality Disorder and Axis II Comparison Subjects: A 16-Year Prospective Follow-Up Study

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Abstract

OBJECTIVE: The purposes of this study were to determine time to attainment of symptom remission and to recovery lasting 2, 4, 6, or 8 years among patients with borderline personality disorder and comparison subjects with other personality disorders and to determine the stability of these outcomes. METHOD: A total of 290 inpatients with borderline personality disorder and 72 comparison subjects with other axis II disorders were assessed during their index admission using a series of semistructured interviews, which were administered again at eight successive 2-year follow-up sessions. For inclusion in the study, patients with borderline personality disorder had to meet criteria for both the Revised Diagnostic Interview for Borderlines and DSM-III-R. RESULTS: Borderline patients were significantly slower to achieve remission or recovery (which involved good social and vocational functioning as well as symptomatic remission) than axis II comparison subjects. However, by the time of the 16-year follow-up assessment, both groups had achieved similarly high rates of remission (range for borderline patients: 78%-99%; range for axis II comparison subjects: 97%-99%) but not recovery (40%-60% compared with 75%-85%). In contrast, symptomatic recurrence and loss of recovery occurred more rapidly and at substantially higher rates among borderline patients than axis II comparison subjects (recurrence: 10%-36% compared with 4%-7%; loss of recovery: 20%-44% compared with 9%-28%). CONCLUSIONS: Our results suggest that sustained symptomatic remission is substantially more common than sustained recovery from borderline personality disorder and that sustained remissions and recoveries are substantially more difficult for individuals with borderline personality disorder to attain and maintain than for individuals with other forms of personality disorder.

Overview

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Crossref · 10.1176/appi.ajp.2011.11101550

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27 of 27 references verified0 citation errors · 0 not checkable

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  • It may state two separate claims as one. 6
  • Probably not a substantial claim. 6
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  • The paper relies on this without support.

    The borderline and axis II comparison groups are comparable on baseline characteristics that could affect the outcomes, apart from their diagnoses.

    “Borderline patients were significantly slower to achieve remission or recovery (which involved good social and vocational functioning as well as symptomatic remission) than axis II comparison subjects.”
    “The corresponding rates for those with another personality disorder ranged from 99% to 97%.”
  • The paper relies on this without support.

    Patients lost to follow-up do not differ systematically from those retained in ways that affect the study's outcome estimates.

    “In terms of continuing participation, 87.5% (N=231/264) of surviving borderline patients (13 died by suicide and 13 died of other causes) were reinterviewed at all eight follow-up waves.”
    “A similar rate of participation was found for axis II comparison subjects, with 82.9% (N=58/70) of surviving patients in this study group (one died by suicide and one died of other causes) being reassessed at all eight follow-up waves.”
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  1. Stone MH, 1990, The Fate of Borderline Patients

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Metadata

Authors
Zanarini, M. C., Frankenburg, F. R., Reich, D. B., & Fitzmaurice, G.
Affiliations
McLean Hospital (US)
Venue
American Journal of Psychiatry
Published
2012-05
Volume
169
Issue
5
Pages
476-483
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W2002571950
Cited by
484
References
27
Citations by year
2026: 20 · 2025: 29 · 2024: 31 · 2023: 23 · 2022: 30 · 2021: 32 · 2020: 60 · 2019: 44 · 2018: 41 · 2017: 32 · 2016: 30 · 2015: 36 · 2014: 43 · 2013: 25 · 2012: 7
FWCI
40.25
Type
journal article
Language
en
Open access
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH062169)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
borderline personality disorder, personality disorders, symptom remission, recovery, relapse, long-term outcomes, social functioning, vocational functioning, Axis II personality disorders, hospitalized patients
MeSH terms
Adolescent, Adult, Antisocial Personality Disorder, Borderline Personality Disorder, Dependent Personality Disorder, Follow-Up Studies, Humans, Interview, Psychological, Paranoid Personality Disorder, Passive-Aggressive Personality Disorder, Personality Disorders, Prospective Studies, Recurrence, Remission Induction, Social Adjustment, Time Factors, Proportional Hazards Models, Case-Control Studies, Treatment Outcome, Kaplan-Meier Estimate, Young Adult

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