The Collaborative Longitudinal Personality Disorders Study: baseline axis I/II and II/II diagnostic co-occurrence
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Objective: To describe baseline diagnostic co‐occurrence in the Collaborative Longitudinal Personality Disorders Study. Method: Six hundred and sixty‐eight patients were reliably assessed with diagnostic interviews for DSM‐IV Axis I and II disorders to create five groups: Schizotypal (STPD), Borderline (BPD), Avoidant (AVPD), Obsessive‐Compulsive (OCPD) and Major Depressive Disorder (MDD) without personality disorder (PD). Results: Mean number of Axis I lifetime diagnoses was 3.4; STPD and BPD groups had more diagnoses than AVPD, OCPD, and MDD groups. Significant Axis I co‐occurrences emerged for Social Phobia/AVPD, PTSD/BPD and Substance Use/BPD. Mean number of co‐occurring PDs was 1.4; STPD had more than BPD group which had more than AVPD and OCPD groups. Significant PD co‐occurrence emerged for: STPD/ Paranoid and Schizoid PDs, BPD with Antisocial and Dependent PDs, and lower frequency for OCPD/Antisocial PD. Conclusion: Diagnostic co‐occurrences generally followed base rates, while significant departures resemble those of controlled literature.
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There are increased rates of comorbidity of mood and anxiety disorders in patients with borderline personality disorder.
“The inclusion of a variety of anxiety and mood disorders would accurately reflect the increased rates of comorbidity of these disorders in patients with BPD [12,13]”
From Psychosocial impairment and treatment utilization by patients with borderline personality disorder, other personality disorders, mood and anxiety disorders, and a healthy comparison group (2007) · cites this paper as [12]
The Lifetime Axis I disorders section (page not supplied) reports significantly elevated PTSD co-occurrence in the BPD group, supporting the anxiety-disorder part for PTSD. The Axis I/II co-occurrence section says major depression was common across personality-disorder groups and not specific to BPD. The paper therefore does not establish broadly increased comorbidity of both mood and anxiety disorders in patients with BPD. (LLM, conf=0.86)
Experimental — accuracy not yet measuredRates of diagnostic cooccurrence among the PD groups were reflective of clinical samples.
“although rates of diagnostic cooccurrence among the PD groups was reflective of clinical samples [12,22,23].”
BPD is highly co-morbid with other psychological disorders, such as major depression and anxiety disorders.
“BPD is also highly co-morbid with other psychological disorders, such as major depression and anxiety disorders [4], and is associated with frequent utilization of healthcare services and high costs to the society [5].”
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Self-citationPersonality and Anxiety Disorders: A Review
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Self-citationPredictors of 2-Year Outcome for Patients With Borderline Personality Disorder
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Self-citationThe relationship between borderline personality disorder and bipolar disorder
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Personality Disorders Predict Relapse After Remission From an Episode of Major Depressive Disorder
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Self-citationDefense Mechanisms in Schizotypal, Borderline, Antisocial, and Narcissistic Personality Disorders
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Self-citationNatural Course of Bulimia Nervosa and of Eating Disorder Not Otherwise Specified
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Self-citationPersonality disorder risk factors for suicide attempts over 10 years of follow-up.
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The Validity of the Five-Factor Model Prototypes for Personality Disorders in Two Clinical Samples.
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Ten‐Year Rank‐Order Stability of <scp>P</scp>ersonality Traits and Disorders in a Clinical Sample
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Comorbidity of Personality Disorder among Substance Use Disorder Patients: A Narrative Review
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Plausibility and Possible Determinants of Sudden “Remissions” in Borderline Patients
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Self-citationThe association of personality disorders with the prospective 7-year course of anxiety disorders
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- Authors
- McGlashan, T. H., Grilo, C. M., Skodol, A. E., Gunderson, J. G., Shea, M. T., Morey, L. C., Zanarini, M. C., & Stout, R. L.
- Affiliations
- Yale University (US)
- New York State Psychiatric Institute (US)
- Harvard University (US)
- Brown University (US)
- Vanderbilt University (US)
- Corresponding author
- McGlashan, Thomas H.
- ORCID
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2000-10
- Volume
- 102
- Issue
- 4
- Pages
- 256-264
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2061987281
- Cited by
- 542
- References
- 0
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 14 · 2023: 13 · 2022: 21 · 2021: 23 · 2020: 16 · 2019: 25 · 2018: 19 · 2017: 23 · 2016: 18 · 2015: 27 · 2014: 35 · 2013: 26 · 2012: 28
- FWCI
- 16.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (50850, R10 MH50837, MH-50837, R10 MH 50838, 50838, R10MH050837, 50840, R10MH050838, R10MH050839, R10 MH50839, 50839, 50837)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- personality disorders, Axis I disorders, Axis II personality disorders, schizotypal personality disorder, borderline personality disorder, avoidant personality disorder, obsessive-compulsive personality disorder, major depressive disorder, social anxiety disorder, post-traumatic stress disorder, substance use disorders, paranoid personality disorder, antisocial personality disorder, dependent personality disorder
- MeSH terms
- Mental Disorders, Follow-Up Studies, Humans, Personality Disorders, Psychiatric Status Rating Scales, Severity of Illness Index, Reproducibility of Results
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