The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Maternal Smoking During Pregnancy and Bipolar Disorder in Offspring
Open accessAbstract
OBJECTIVE: Maternal smoking during pregnancy is associated with a number of adverse externalizing outcomes for offspring from childhood to adulthood. The relationship between maternal smoking and bipolar disorder in offspring, which includes externalizing symptoms among its many manifestations, has not been investigated in depth. The authors examined whether offspring exposed to maternal smoking in utero would be at increased lifetime risk for bipolar disorder after accounting for other factors related to maternal smoking. METHOD: Individuals with bipolar disorder (N=79) were ascertained from the birth cohort of the Child Health and Development Study. Case subjects were identified by a combination of clinical, database, and direct mailing sources; all case subjects were directly interviewed and diagnosed using DSM-IV criteria. Comparison subjects (N=654) were matched to case subjects on date of birth (±30 days), sex, membership in the cohort at the time of illness onset, and availability of maternal archived sera. RESULTS: After adjusting for potential confounders, offspring exposed to in utero maternal smoking exhibited a twofold greater risk for bipolar disorder (odds ratio=2.014, 95% confidence interval=1.48-2.53, p=0.01). The associations were noted primarily among bipolar offspring without psychotic features. CONCLUSIONS: Prenatal tobacco exposure may be one suspected cause of bipolar disorder. However, it will be necessary to account for other unmeasured familial factors before causal teratogenic effects can be suggested.
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“Of note, even maternal smoking while pregnant appears to raise the risk of BD two-fold in the off-springs (24).”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [24]
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Metadata
- Authors
- Talati, A., Bao, Y., Kaufman, J., Shen, L., Schaefer, C. A., & Brown, A. S.
- Affiliations
- Kaiser Permanente (US)
- Venue
- American Journal of Psychiatry
- Published
- 2013-10
- Volume
- 170
- Issue
- 10
- Pages
- 1178-1185
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC4086419
- OpenAlex
- W2159091361
- Cited by
- 104
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 44 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 8 · 2013: 2
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institute of Mental Health (5R01-MH073080-05, R01MH073080, K02MH065422, R01MH069819, 5K02-MH65422)
- National Institute on Drug Abuse (K01DA029598)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- smoking during pregnancy, prenatal tobacco exposure, bipolar disorder, offspring risk, externalizing problems, Child Health and Development Studies, teratogenicity
- MeSH terms
- Adult, Bipolar Disorder, Birth Weight, Female, Humans, Infant, Newborn, Internal-External Control, Male, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Smoking, Tobacco Smoke Pollution, Cohort Studies, Matched-Pair Analysis
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