Sequential Treatment With Fluoxetine and Relapse-Prevention CBT to Improve Outcomes in Pediatric Depression
Open accessAbstract
OBJECTIVE: The authors evaluated a sequential treatment strategy of fluoxetine and relapse-prevention cognitive-behavioral therapy (CBT) to determine effects on remission and relapse in youths with major depressive disorder. METHOD: Youths 8-17 years of age with major depression were treated openly with fluoxetine for 6 weeks. Those with an adequate response (defined as a reduction of 50% or more on the Children's Depression Rating Scale-Revised [CDRS-R]) were randomly assigned to receive continued medication management alone or continued medication management plus CBT for an additional 6 months. The CBT was modified to address residual symptoms and was supplemented by well-being therapy. Primary outcome measures were time to remission (with remission defined as a CDRS-R score of 28 or less) and rate of relapse (with relapse defined as either a CDRS-R score of 40 or more with a history of 2 weeks of symptom worsening, or clinical deterioration). RESULTS: Of the 200 participants enrolled in acute-phase treatment, 144 were assigned to continuation treatment with medication management alone (N=69) or medication management plus CBT (N=75). During the 30-week continuation treatment period, time to remission did not differ significantly between treatment groups (hazard ratio=1.26, 95% CI=0.87, 1.82). However, the medication management plus CBT group had a significantly lower risk of relapse than the medication management only group (hazard ratio=0.31, 95% CI=0.13, 0.75). The estimated probability of relapse by week 30 was lower with medication management plus CBT than with medication management only (9% compared with 26.5%). CONCLUSIONS: Continuation-phase relapse-prevention CBT was effective in reducing the risk of relapse but not in accelerating time to remission in children and adolescents with major depressive disorder.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Three independent randomized controlled trials using the sequential combination of cognitive therapy and WBT were performed in Italy, Germany, and the US.
“Three independent randomized controlled trials using the sequential combination of cognitive therapy and WBT were performed in Italy 73,74 , Germany 75 and the US 76 .”
From The pursuit of euthymia (2020) · cites this paper as [76]
The Methods describe a single-site randomized trial approved at the University of Texas Southwestern Medical Center, supporting its identification as a US trial. But the Discussion describes the sequence as fluoxetine followed by relapse-prevention CBT, not cognitive therapy combined with well-being therapy (WBT). This source also does not establish the stated total of three trials. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,588 · see citing works
Statistical Power Analysis for the Behavioral Sciences (2nd ed.).
Lachenbruch, P. A., & Cohen, J. (1989) · Journal of the American Statistical Association · doi:10.2307/2290095 · Cited by 37,385 · see citing works
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148 · see citing works
Keller, M. B. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800180050009 · Cited by 1,643 · see citing works
Bridge, J. A., Iyengar, S., Salary, C. B., Barbe, R. P., Birmaher, B., Pincus, H. A., Ren, L., & Brent, D. A. (2007) · JAMA · doi:10.1001/jama.297.15.1683 · Cited by 1,086 · see citing works
Major depressive disorder in older adolescents
Lewinsohn, P. M., Rohde, P., & Seeley, J. R. (1998) · Clinical Psychology Review · doi:10.1016/s0272-7358(98)00010-5 · Cited by 1,078 · see citing works
Birmaher, B., & Brent, D. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318145ae1c · Cited by 1,056 · see citing works
Effects of psychotherapy for depression in children and adolescents: A meta-analysis
Weisz, J. R., McCarty, C. A., & Valeri, S. M. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.1.132 · Cited by 942 · see citing works
Brent, D. A., Emslie, G. J., Clarke, G. N., Wagner, K. D., Asarnow, J. R., Keller, M., Vitiello, B., Ritz, L., Iyengar, S., Abebe, K. Z., et al. (2008) · JAMA · doi:10.1001/jama.299.8.901 · Cited by 705 · see citing works
Self-citationCOMPTON, S. N., MARCH, J. S., BRENT, D., ALBANO, A. M., WEERSING, V. R., & CURRY, J. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000127589.57468.bf · Cited by 616 · see citing works
Prevention of Recurrent Depression With Cognitive Behavioral Therapy: Preliminary Findings
Fava, G. A., Rafanelli, C., Grandi, S., Conti, S., & Belluardo, P. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.9.816 · Cited by 491 · see citing works
Clarke, G., Rohde, P., Lewinsohn, P., Hops, H., & Seeley, J. (1999) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/00004583-199903000-00014 · Cited by 485 · see citing works
Children’s Depression Rating Scale – Revised (CDRS-R)
Keller, F., Grieb, J., Ernst, M., Spröber, N., Fegert, J. M., & Kölch, M. G. (2011) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000090 · Cited by 453 · see citing works
Increasing Psychological Well‐Being and Resilience by Psychotherapeutic Methods
Fava, G. A., & Tomba, E. (2009) · Journal of Personality · doi:10.1111/j.1467-6494.2009.00604.x · Cited by 362 · see citing works
Kennard, B. D., Silva, S. G., Vitiello, B., Curry, J. F., Kratochvil, C. J., Simons, A. D., Hughes, J. L., Feeny, N. C., Weller, E. B., SWEENEY, M., et al. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000242228.75516.21 · Cited by 280 · see citing works
Self-citationCognitive behavioral treatment of residual symptoms in primary major depressive disorder
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.9.1295 · Cited by 266 · see citing works
Fluoxetine versus placebo in preventing relapse of major depression in children and adolescents
Emslie, G. J., Kennard, B. D., Mayes, T. L., Nightingale-Teresi, J., Carmody, T., Hughes, C. W., Rush, A. J., Tao, R., & Rintelmann, J. W. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07091453 · Cited by 188 · see citing works
Self-citationKennard, B. D., Silva, S. G., Tonev, S. T., Rohde, P., Hughes, J. L., Vitiello, B., Kratochvil, C. J., Curry, J. F., Emslie, G. J., Reinecke, M. A., et al. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31819176f9 · Cited by 187 · see citing works
Self-citationReview of the efficacy and safety of antidepressants in youth depression
Cheung, A. H., Emslie, G. J., & Mayes, T. L. (2005) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01467.x · Cited by 183 · see citing works
Self-citationEmslie, G. J., Heiligenstein, J. H., HOOG, S. L., Wagner, K. D., Findling, R. L., McCracken, J. T., Nilsson, M., & Jacobson, J. G. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000140453.89323.57 · Cited by 146 · see citing works
Self-citationGuidi, J., Fava, G. A., Fava, M., & Papakostas, G. I. (2011) · Psychological Medicine · doi:10.1017/s0033291710000826 · Cited by 118 · see citing works
KROLL, L., HARRINGTON, R., JAYSON, D., FRASER, J., & GOWERS, S. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199609000-00013 · Cited by 106 · see citing works
Kennard, B. D., Emslie, G. J., Mayes, T. L., Nightingale-Teresi, J., Nakonezny, P. A., Hughes, J. L., Jones, J. M., Tao, R., Stewart, S. M., & Jarrett, R. B. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31818914a1 · Cited by 98 · see citing works
Self-citationPreventing Depressive Relapse and Recurrence in Higher-Risk Cognitive Therapy Responders
Jarrett, R. B., Minhajuddin, A., Gershenfeld, H. K., Friedman, E. S., & Thase, M. E. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1969 · Cited by 87 · see citing works
New modalities of assessment and treatment planning in depression
Fava, G., & Tomba, E. (2010) · CNS Drugs · doi:10.2165/11531580-000000000-00000 · Cited by 68 · see citing works
Relapse and Recurrence in Pediatric Depression
Kennard, B. D., Emslie, G. J., Mayes, T. L., & Hughes, J. L. (2006) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2006.05.003 · Cited by 50 · see citing works
Self-citationStockman, J. A. (2009) · Yearbook of Pediatrics · doi:10.1016/s0084-3954(08)79063-8 · Cited by 48 · see citing works
Stockman, J. A. (2009) · Yearbook of Pediatrics · doi:10.1016/s0084-3954(08)79103-6 · Cited by 44 · see citing works
The National Institute of Mental Health.
Felix, R. H. (1963) · Franklin Watts eBooks · doi:10.1037/11547-030 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [25]Emslie GJ Kennard BD Mayes TL Nightingale-Teresi J Carmody T Hughes CW Rush AJ Tao R Rintelmann JW Fluoxetine versus placebo in preventing relapse of major depression in children and adolescents Am J Psychiatry 2008 165 4 459 67 18281410 PMC2824429
Cited by
Sorted by citations
Cheung, A. H., Zuckerbrot, R. A., Jensen, P. S., Laraque, D., Stein, R. E. K., GLAD-PC STEERING GROUP, Levitt, A., Birmaher, B., Campo, J., Clarke, G., et al. (2018) · Pediatrics · doi:10.1542/peds.2017-4082 · Cited by 299 · see citing works
Self-citationWalter, H. J., Abright, A. R., Bukstein, O. G., Diamond, J., Keable, H., Ripperger-Suhler, J. A., & Rockhill, C. (2022) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2022.10.001 · Cited by 200 · see citing works
Fava, G. A., & Bech, P. (2016) · Psychotherapy and Psychosomatics · doi:10.1159/000441244 · Cited by 176 · see citing works
Fava, G. A., & Guidi, J. (2020) · World Psychiatry · doi:10.1002/wps.20698 · Cited by 143 · see citing works
Hopelessness as a Predictor of Suicide Ideation in Depressed Male and Female Adolescent Youth
Wolfe, K. L., Nakonezny, P. A., Owen, V. J., Rial, K. V., Moorehead, A., Kennard, B. D., & Emslie, G. J. (2017) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.12428 · Cited by 126 · see citing works
Self-citationRice, S., Gleeson, J., Davey, C., Hetrick, S., Parker, A., Lederman, R., Wadley, G., Murray, G., Herrman, H., Chambers, R., et al. (2018) · Early Intervention in Psychiatry · doi:10.1111/eip.12354 · Cited by 118 · see citing works
Frisch, M. B. (2016) · doi:10.1002/9781118468197.ch27 · Cited by 116 · see citing works
Jacobs, R. H., Watkins, E. R., Peters, A. T., Feldhaus, C. G., Barba, A., Carbray, J. A., & Langenecker, S. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163952 · Cited by 110 · see citing works
Fava, G. A. (2016) · doi:10.1002/9781118468197.ch26 · Cited by 105 · see citing works
Davey, C. G., Chanen, A. M., Hetrick, S. E., Cotton, S., Ratheesh, A., Amminger, G. P., Koutsogiannis, J., Phelan, M., Mullen, E., Harrison, B. J., et al. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30215-9 · Cited by 104 · see citing works
Well-Being Therapy: Current Indications and Emerging Perspectives
Fava, G. A. (2016) · Psychotherapy and Psychosomatics · doi:10.1159/000444114 · Cited by 96 · see citing works
Fava, G. A., Cosci, F., Guidi, J., & Tomba, E. (2017) · Depression and Anxiety · doi:10.1002/da.22629 · Cited by 95 · see citing works
Depressive disorders in childhood and adolescence
Brent, D. A., & Maalouf, F. (2015) · Wiley eBooks · doi:10.1002/9781118381953.ch63 · Cited by 94 · see citing works
The clinical role of well-being therapy
Guidi, J., Rafanelli, C., & Fava, G. A. (2018) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2018.1492013 · Cited by 85 · see citing works
Transcranial Magnetic Stimulation for Adolescent Depression
Croarkin, P. E., & MacMaster, F. P. (2019) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2018.07.003 · Cited by 65 · see citing works
Findling, R. L., McNamara, N., Pavuluri, M. N., Frazier, J. A., Rynn, M. A., Scheffer, R. E., Kafantaris, V., Robb, A. S., DelBello, M. P., Kowatch, R. A., et al. (2018) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.07.901 · Cited by 57 · see citing works
Skarphéðinsson, G., Nadai, A. S. D., Storch, E. A., Lewin, A. B., & Ivarsson, T. (2016) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-016-0863-0 · Cited by 47 · see citing works
The emerging role of euthymia in psychotherapy research and practice
Guidi, J., & Fava, G. A. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101941 · Cited by 40 · see citing works
Emslie, G. J., Kennard, B. D., Mayes, T. L., Nakonezny, P. A., Moore, J., Jones, J. M., Foxwell, A. A., & King, J. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.09.014 · Cited by 40 · see citing works
Self-citationTomba, E., Tecuta, L., Schumann, R., & Ballardini, D. (2017) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2017.01.001 · Cited by 37 · see citing works
Rohden, A. I., Benchaya, M. C., Camargo, R. S., Moreira, T. D. C., Barros, H. M. T., & Ferigolo, M. (2017) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.03.017 · Cited by 35 · see citing works
Robberegt, S. J., Brouwer, M. E., Kooiman, B., Stikkelbroek, Y. A. J., Nauta, M. H., & Bockting, C. (2022) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2022.04.014 · Cited by 28 · see citing works
Neurocognitive and functional heterogeneity in depressed youth
Baller, E. B., Kaczkurkin, A. N., Sotiras, A., Adebimpe, A., Bassett, D. S., Calkins, M. E., Chand, G. B., Cui, Z., Gur, R. E., Gur, R. C., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00871-w · Cited by 29 · see citing works
Stimpfl, J. N., Walkup, J. T., Robb, A. S., Alford, A. E., Stahl, S. M., McCracken, J. T., Stancil, S. L., Ramsey, L. B., Emslie, G. J., & Strawn, J. R. (2024) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2024.0099 · Cited by 26 · see citing works
Self-citationRecent developments in the treatment of major depressive disorder in children and adolescents
Hussain, H., Dubicka, B., & Wilkinson, P. O. (2018) · Evidence-Based Mental Health · doi:10.1136/eb-2018-102937 · Cited by 24 · see citing works
Feldhaus, C. G., Jacobs, R. H., Watkins, E. R., Peters, A. T., Bessette, K. L., & Langenecker, S. A. (2020) · Journal of Child and Family Studies · doi:10.1007/s10826-020-01711-7 · Cited by 23 · see citing works
Conceptual and Clinical Innovations of Well-being Therapy
Guidi, J., & Fava, G. A. (2021) · International Journal of Cognitive Therapy · doi:10.1007/s41811-021-00101-1 · Cited by 21 · see citing works
Ding, S., Li, L., & Zhou, F.-M. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00831.2014 · Cited by 20 · see citing works
Radstaak, M., Hüning, L., & Bohlmeijer, E. T. (2020) · Journal of Traumatic Stress · doi:10.1002/jts.22500 · Cited by 22 · see citing works
S3-Leitlinie Depressive Störungen im Kindes- und Jugendalter: Wo geht es hin?
Schulte‐Körne, G., Klingele, C., Zsigo, C., & Kloek, M. (2023) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-023-03721-4 · Cited by 16 · see citing works
Safer, D. J., & ZITO, J. M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00705 · Cited by 14 · see citing works
Public Health Perspectives on Depressive Disorders
Cohen, N. L. (2017) · Johns Hopkins University Press eBooks · doi:10.1353/book.52762 · Cited by 14 · see citing works
O’Sullivan, S., McEnery, C., Cagliarini, D., Hinton, J. D. X., Valentine, L., Nicholas, J., Chen, N. A., Castagnini, E., Lester, J., Kanellopoulos, E., et al. (2024) · JMIR Mental Health · doi:10.2196/49217 · Cited by 13 · see citing works
Krivosova, M., Adamčáková, J., Kaadt, E., Mumm, B. H., Dvorská, D., Braný, D., Daňková, Z., Dohál, M., Samec, M., Ferencová, N., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.094 · Cited by 13 · see citing works
Wilcox, H. C., Kharrazi, H. H. K., Wilson, R. F., Musci, R. J., Susukida, R., Gharghabi, F., Zhang, A. W., Wissow, L. S., & Robinson, K. A. (2016) · Annals of Internal Medicine · doi:10.7326/m16-1281 · Cited by 13 · see citing works
Robberegt, S. J., Kooiman, B., Albers, C. J., Nauta, M. H., Bockting, C., & Stikkelbroek, Y. A. J. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-058560 · Cited by 12 · see citing works
Adolescent Depression: Identification and Treatment
Boyd, R. C., Lewis, J., Borreggine, K. L., & Benton, T. D. (2018) · Current Treatment Options in Pediatrics · doi:10.1007/s40746-018-0135-y · Cited by 11 · see citing works
Kooiman, B., Robberegt, S. J., Albers, C., Bockting, C., Stikkelbroek, Y. A. J., & Nauta, M. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1229713 · Cited by 9 · see citing works
Agarwal, A., Batra, S. D., Prasad, R., Verma, A., Jilani, A. Q., & Kant, S. (2018) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2018.902 · Cited by 11 · see citing works
The Handbook of Wellness Medicine
Snellings, J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182 · Cited by 11 · see citing works
Liu, W., Li, G., Wang, C., Yu, M., Zhu, M., & Yang, L. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s367931 · Cited by 10 · see citing works
Adaptation of Group-Based Suicide Intervention for Latinx Youth in a Community Mental Health Center
Kennard, B. D., Moorehead, A., Stewart, S. M., El‐Behadli, A. F., Mbroh, H., Goga, K. M., Wildman, R., Michaels, M. M., & Higashi, R. T. (2020) · Journal of Child and Family Studies · doi:10.1007/s10826-020-01718-0 · Cited by 10 · see citing works
Self-citationZainal, N. H. (2023) · Psychological Medicine · doi:10.1017/s0033291723003306 · Cited by 9 · see citing works
Las Ideas Equivocadas sobre la Depresión Infantil y Adolescente y su Tratamiento
Sanz, J., & García‐Vera, M. P. (2020) · Clínica y Salud · doi:10.5093/clysa2020a4 · Cited by 9 · see citing works
Atkinson, S. D., Thurman, L., Ramaker, S., Buckley, G., Jones, S. R., England, R. D., & Wajsbrot, D. (2018) · CNS Spectrums · doi:10.1017/s1092852918001128 · Cited by 7 · see citing works
Ruiz, E., Beatty, A., & Weyandt, L. L. (2023) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2022.0090 · Cited by 6 · see citing works
Well-being Therapy in Depressive Disorders
Mansueto, G., & Cosci, F. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6044-0_19 · Cited by 6 · see citing works
Improving Remission and Preventing Relapse in Youths With Major Depression
Birmaher, B. B. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14060705 · Cited by 6 · see citing works
Termination in cognitive–behavioral therapy with children, adolescents, and parents.
Vidair, H. B., Feyijinmi, G. O., & Feindler, E. L. (2016) · Psychotherapy · doi:10.1037/pst0000086 · Cited by 6 · see citing works
Youth depression: are two treatments better than one?
Vitiello, B. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30281-0 · Cited by 5 · see citing works
Garzon, J. F., Elmaadawi, A. Z., Aaronson, S. T., Schrodt, G. R., Holbert, R. C., Zuckerman, S., Demitrack, M. A., Strawn, J. R., & Croarkin, P. E. (2024) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2024.0067 · Cited by 4 · see citing works
Literature study on the Efficacy of antidepressants with CBT in the treatment of depression
Menon, S., & Bhagat, V. (2022) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2022.00465 · Cited by 2 · see citing works
Kennard, B. D., Gupta, M., Hensley, J. K., Heerschap, J. K., Durham, A. P. M., Wildman, R., & Nakonezny, P. (2024) · Journal of Child and Family Studies · doi:10.1007/s10826-023-02761-3 · Cited by 3 · see citing works
Self-citationA Systematic Review : Well-being Therapy
Telaumbanua, V. R., & Yudiharso, A. (2020) · Insight Jurnal Pemikiran dan Penelitian Psikologi · doi:10.32528/ins.v16i1.3212 · Cited by 3 · see citing works
The Handbook of Wellness Medicine
Snellings, J. E. (2021) · Family Medicine · doi:10.22454/fammed.2021.204951 · Cited by 3 · see citing works
Perera, D. M., & Moe, J. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.005 · Cited by 2 · see citing works
Wellness Interventions in the Workplace
Chernoff, R. A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.020 · Cited by 2 · see citing works
Sharma‐Brymer, V., Dashper, K. L., & Brymer, E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.034 · Cited by 2 · see citing works
Well-Being and Work–Life Balance
Bolton, M. A., Lobben, I., Pruzinsky, T., & Stern, T. A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.046 · Cited by 1 · see citing works
Forgiveness, Gratitude, and Spirituality
Idicula, S. A., Thrower, N., & Lomax, J. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.029 · Cited by 1 · see citing works
Bokarius, V., & Bokarius, A. V. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.037 · Cited by 2 · see citing works
Wellness Interventions in Patients Living with Chronic Medical Conditions
Steiner, A. J., Aguilar-Hernandez, L., Pizano, D. R., Dascal, J., & IsHak, W. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.014 · Cited by 1 · see citing works
Cao, P., Li, Y., Yang, L., Guo, L., Hua, J., Zhang, S., Li, C., Dang, B., Sun, Y., Liu, M., et al. (2025) · Systematic Reviews · doi:10.1186/s13643-025-02909-w · Cited by 1 · see citing works
Ooi, S. L., & Pak, S. C. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.033 · Cited by 1 · see citing works
Dieppe, P. A., Goldingay, S., & Warber, S. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.042 · Cited by 1 · see citing works
Emotional Intelligence and Its Role in Sustaining Fulfillment in Life
Sax, H. C., & Gewertz, B. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.038 · Cited by 1 · see citing works
Family Relations, Friendships, and Love
Alsup, S., Weisbaum, E., Vogel, T., & Siegel, D. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.047 · Cited by 1 · see citing works
Singh, T., Ghosh, D., Pasipanodya, T. E., Raj, S., & Mittal, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85757-4.00009-2 · Cited by 1 · see citing works
Croarkin, P. E., Nakonezny, P. A., Morris, D. W., Rush, A. J., Kennard, B. D., & Emslie, G. J. (2024) · JAACAP Open · doi:10.1016/j.jaacop.2024.05.002 · Cited by 1 · see citing works
Self-citationIs atomoxetine effective in some comorbid mental disorders in ADHD?
Cesnekova, D., Šnircová, E., Nosalova, G., & Ondrejka, I. (2016) · European Pharmaceutical Journal · doi:10.1515/afpuc-2016-0003 · Cited by 1 · see citing works
New Applications of Well-Being Therapy
Benasi, G., Guidi, J., Rafanelli, C., & Fava, G. A. (2019) · RIVISTA SPERIMENTALE DI FRENIATRIA · doi:10.3280/rsf2019-001006 · Cited by 1 · see citing works
Fava, G. A., & Guidi, J. (2020) · Ärztliche Psychotherapie · doi:10.21706/aep-15-3-149 · Cited by 1 · see citing works
The Role of Aesthetics in Wellness
Mikhail, A. A., & Ngor, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.032 · Cited by 1 · see citing works
Ogunyemi, D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.011 · Cited by 1 · see citing works
Volle, D. C., & DeBonis, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.023 · Cited by 1 · see citing works
Allergic, Infectious, and Immunological Processes
Riaz, O., Orimaye, S. O., Al-Khateeb, T., Sodeke, P. O., Awujoola, A. O., & Goodkin, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.012 · Cited by 1 · see citing works
Melchert, T. P. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.004 · Cited by 1 · see citing works
IsHak, W. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.052 · Cited by 2 · see citing works
Penalty for Delay of Game? Sobering Results in Treating Adolescent Depression
Brent, D. A. (2016) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2015.12.004
Practical pharmacotherapy in child psychiatry: an update
Brown, R., & James, A. C. (2015) · BJPsych Advances · doi:10.1192/apt.bp.114.013193
Psychopharmacological Treatment for Depression in Children and Adolescents
Chapman, M. R., Hughes, J. L., Kennard, B. D., Mayes, T. L., & Emslie, G. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804394-3.00011-5
Self-citationFrank, R. (2022) · Therapieziel Wohlbefinden · doi:10.1007/978-3-662-53471-7_5 · Cited by 1 · see citing works
Pediatric Psychopharmacology: Commonly Used Medications in Children
Scahill, L. D., & Rojas, J. (2018) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190634841.013.49
Le processus de validation de la Well-Being Therapy
Fava, G. A. (2018) · Elsevier eBooks · doi:10.1016/b978-2-294-76050-1.00003-9
Les enfants et les adolescents
Fava, G. A. (2018) · Elsevier eBooks · doi:10.1016/b978-2-294-76050-1.00019-2
Veazie, S., Gilbert, J., Winchell, K. A., Paynter, R. A., & Guise, J. (2019)
Mindfulness, Meditation, and Yoga
Budd, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.028
Work, Love, Play, and Joie de Vivre
Groningen, N. V., IsHak, W. W., Ganjian, S., Ong, M. K., & Slusser, W. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.045
Acupuncture, Herbs, and Ayurvedic Medicine
Postolov, L., & Gilberg-Lenz, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.031
Circadian Rhythm in the Digital Age
Ezzat-Velinov, M., & Guarneri, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.035
Chaudhry, M., Gordon, A., Tadros, E., Sun, C., Tobia, G., & IsHak, W. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.019
The Personalized Wellness Life Plan
IsHak, W. W., Bart, R., Gohar, Y., Lorea, N., Eskander, L., Chang, T., Cohen, S., Furman, K., Nayyar, P. P., & DeBonis, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.050
Exercise, Dance, Tai Chi, Pilates, and Alexander Technique
Altug, Z. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.025
Louy, C., Sweet, C., Pollock, G. A., de Zagon, C., Louy, Z., Weiss, J. M., & Maher, D. P. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.017
Pharmaceuticals and Alternatives for Wellness
Parisi, T., Heath, B., Wen, R. Y., & IsHak, W. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.024
Bucciarelli, A., Ellison, G. K., Sommer, E. K., & Spooner, H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.036
Screening and Assessment Methods for Wellness
Greenberg, J. M., Castillo, E. G., IsHak, W. W., & Wells, K. B. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.002
The Role of Leisure, Recreation, and Play in Health and Well-Being
Payne, L. L., & An, J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.048
Positive Neuropsychology, Cognitive Rehabilitation, and Neuroenhancement
Pimental, P. A., O'Hara, J. B., Christopher, J., & Ciampanelli, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.030
Wellness in Children and Adolescents
Zanko, C., & Stuber, M. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182.016
- Authors
- Kennard, B. D., Emslie, G. J., Mayes, T. L., Nakonezny, P. A., Jones, J. M., Foxwell, A. A., & King, J.
- Affiliations
- Children's Medical Center (US)
- Venue
- American Journal of Psychiatry
- Published
- 2014-10
- Volume
- 171
- Issue
- 10
- Pages
- 1083-1090
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC4182111
- OpenAlex
- W2050645823
- Cited by
- 134
- References
- 30
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 8 · 2021: 3 · 2020: 62 · 2019: 5 · 2018: 11 · 2017: 7 · 2016: 11 · 2015: 5 · 2014: 1
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of State
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- University of Miami
- Valeant Pharmaceuticals International
- Mylan
- Texas Department of State Health Services
- H. Lundbeck A/S
- Forest Laboratories
- Allergan
- National Institute of Mental Health (R01MH039188)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- childhood depression, major depressive disorder, fluoxetine, continuation treatment, relapse prevention, remission, children and adolescents, well-being therapy, residual depressive symptoms
- MeSH terms
- Adolescent, Child, Combined Modality Therapy, Major Depressive Disorder, Female, Fluoxetine, Humans, Male, Recurrence, Remission Induction, Time Factors, Cognitive Behavioral Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
