Down-Regulation of SIRT1 Gene Expression in Major Depressive Disorder

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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Gene expression in major depressive disorder

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Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

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Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

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Epigenetic mechanisms of major depression: Targeting neuronal plasticity

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Mitochondrial dysfunction: A fatal blow in depression

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Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

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Role and possible mechanisms of Sirt1 in depression

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Sirtuins in Neuroendocrine Regulation and Neurological Diseases

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Emerging roles of SIRT1 activator, SRT2104, in disease treatment

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Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling

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Depressive symptoms in schizophrenia patients: A possible relationship between SIRT1 and BDNF

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Salvianolic Acid B Improves Chronic Mild Stress-Induced Depressive Behaviors in Rats: Involvement of AMPK/SIRT1 Signaling Pathway

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Resveratrol Attenuates Chronic Unpredictable Mild Stress-Induced Alterations in the SIRT1/PGC1α/SIRT3 Pathway and Associated Mitochondrial Dysfunction in Mice

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The SIRT-1/Nrf2/HO-1 axis: Guardians of neuronal health in neurological disorders

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Evidence supporting a mechanistic role of sirtuins in mood and metabolic disorders

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Altered expression of long noncoding RNAs in patients with major depressive disorder

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SIRT1 Decreases Emotional Pain Vulnerability with Associated CaMKIIα Deacetylation in Central Amygdala

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The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population

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Resveratrol alleviates postpartum depression-like behavior by activating autophagy via SIRT1 and inhibiting AKT/mTOR pathway

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The role of polyunsaturated fatty acids in the neurobiology of major depressive disorder and suicide risk

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miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in Hippocampus

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CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress

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Peroxisome proliferator-activated receptor gamma co-activator-1 alpha in depression and the response to electroconvulsive therapy

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Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

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A mitochondrial nexus in major depressive disorder: Integration with the psycho-immune-neuroendocrine network

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Effect of antipsychotics and mood stabilisers on metabolism in bipolar disorder: a network meta-analysis of randomised-controlled trials

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Peripheral blood SIRT1 mRNA levels in depression and treatment with electroconvulsive therapy

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Acetyl-11-keto-beta boswellic acid(AKBA) modulates CSTC-pathway by activating SIRT-1/Nrf2-HO-1 signalling in experimental rat model of obsessive-compulsive disorder: Evidenced by CSF, blood plasma and histopathological alterations

Sethi, P., Mehan, S., Khan, Z., & Chhabra, S. (2023) · NeuroToxicology · doi:10.1016/j.neuro.2023.08.001 · Cited by 27 · see citing works

A Comprehensive Analysis of the Effect of SIRT1 Variation on the Risk of Schizophrenia and Depressive Symptoms

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The molecular basis of depression: implications of sex-related differences in epigenetic regulation

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Dissecting major depression: The role of blood biomarkers and adverse childhood experiences in distinguishing clinical subgroups

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Activation of SIRT-1 Signalling in the Prevention of Bipolar Disorder and Related Neurocomplications: Target Activators and Influences on Neurological Dysfunctions

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Association of a SIRT1 polymorphism with changes of gray matter volume in patients with first-episode medication-naïve major depression

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Major depressive disorder-associated SIRT1 locus affects the risk for suicide in women after middle age

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Relationship between SIRT1 gene and adolescent depressive disorder with nonsuicidal self-injury behavior

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Intranasal AdipoRon Mitigated Anxiety and Depression-Like Behaviors in 6-OHDA-Induced Parkinson ’s Disease Rat Model: Going Beyond Motor Symptoms

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SIRT1 rs3758391 and Major Depressive Disorder: New Data and Meta-Analysis

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Downregulated SIRT1 in the CeA is involved in chronic pain-depression comorbidity

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Mitochondrial dysfunction in depression: Mechanisms and targeted therapy strategies

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Exploring the role of esketamine in alleviating depressive symptoms in mice via the PGC-1α/irisin/ERK1/2 signaling pathway

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Sirtuin Type 1 Mediates the Antidepressant Effect of S-Ketamine in a Chronic Unpredictable Stress Model

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SIRT1 Allele Frequencies in Depressed Patients of European Descent in Russia

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LncRNA-84277 is involved in chronic pain-related depressive behaviors through miR-128-3p/SIRT1 axis in central amygdala

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Correlations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section

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Running exercise alleviates depressive-like behaviors through the activation of PINK1-Parkin mediated mitophagy in mice exposed to chronic social defeat stress

Sun, L., Wu, L., Xu, Z., Zeng, W., & Wang, Y. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116714 · Cited by 8 · see citing works

Environmental and genetic risk factors of depression converge on neuronal dysfunction driven by changes in cholesterol homeostasis

Oberst, P., Xu, N., Munguba, H., Zhang, C., Zhong, A., Zhou, T., Liston, C. M., Levitz, J., & Studer, L. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.08.011 · Cited by 8 · see citing works

Silent information regulator 1 mediates H2S-inhibited chronic restraint stress-induced depressive-like behaviors by regulating hippocampal autophagy

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Neuroimaging Genomics a Predictor of Major Depressive Disorder (MDD)

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Effect of the SIRT1 gene on regional cortical grey matter density in the Han Chinese population

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Sirtuin 1 underlies depression-related behaviors by modulating the serotonin system in the dorsal raphe nucleus in female mice

Xu, L., Cao, Y., Zhang, S., Du, L., Wang, W., Liu, J., Wang, D., Zhao, D., Cui, M., Jiang, S., et al. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111400 · Cited by 5 · see citing works

Depression: epigenetics and epitranscriptomic modifications

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Hippocampal microRNA-181a overexpression participates in anxiety and ethanol related behaviors via regulating the expression of SIRT-1

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Role of Dietary Polyphenols in NAD+-Dependent Deacetylase SIRT 1 in Stress-Induced Depression

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Asymmetry, cytoarchitectonic morphology and genetics associated with Broca’s area in schizophrenia

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Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide

Gammoh, O., Ibrahim, A., Yehya, A., Alqudah, A. M., Qnais, E. Y., Altaber, S., Alrob, O. A., Aljabali, A. A. A., & Tambuwala, M. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25041960 · Cited by 4 · see citing works

The role and therapeutic potential of mitophagy in major depressive disorder

Shi, X.-N., Liu, C., Lin, L., Yao, M.-L., Zhong, Z., & Jiang, Y.-M. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1564276 · Cited by 3 · see citing works

Cell Type‐Specific Loss of SIRT1 in Central Amygdala Leads to Depression‐Like Behaviors by Altering Neuronal Excitability in Mice

Huang, H., Ding, X., Lin, Y., Hu, W., Zhou, C.-R., Chen, T., Zhou, Y., Dong, W., Zhou, C., & Wu, Y. (2026) · Acta Physiologica · doi:10.1111/apha.70176 · Cited by 2 · see citing works

SRT1720 ameliorates LPS-induced depressive-like behaviors in mice and activates Parkin-mediated mitophagy

Sun, L., Li, C., Shi, J., Zeng, W., Wu, L., Wan, S., & Wang, Y. (2025) · BMC Neuroscience · doi:10.1186/s12868-025-00968-2 · Cited by 2 · see citing works

Neuroprotective and Behavioral Benefits of Exogenous Ketone Supplementation-Evoked Ketosis

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Modulations of SIRTUINs and Management of Brain Disorders

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SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling

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Are Sirtuins 1 and 2 Relevant Players in Relapsing–Remitting Multiple Sclerosis?

Chojdak-Łukasiewicz, J., Bizoń, A., Kołtuniuk, A., Waliszewska‐Prosół, M., Budrewicz, S. P., Piwowar, A., & Pokryszko‐Dragan, A. (2024) · Biomedicines · doi:10.3390/biomedicines12092027 · Cited by 1 · see citing works

Neurobiologic correlates of depression: illustration of challenges in bench-to-bedside translation

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Peripheral blood SIRT1 mRNA levels in depression and treatment with electroconvulsive therapy

McGrory, C. L., Ryan, K., Kolshus, E., Finnegan, M., & McLoughlin, D. M. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.11.1047

Tet2-mediated responses to environmental stress

Song, W. S., & Xia, M. (2023) · Stress and Brain · doi:10.26599/sab.2023.9060003

Childhood insulin resistance and neural stem cell dysfunction in psychiatric disorders: Role of de novo lipogenesis and treatment perspectives

Khan, M. M., Khan, Z. A., Khan, M. A., & Pandey, G. (2025) · World Journal of Stem Cells · doi:10.4252/wjsc.v17.i7.106194

Treadmill Exercise in Rats Attenuates Chronic Unpredictable Stress-Induced Depressive-like Behavior Associated with Melatonin–SIRT1/Nrf2 Signaling in the Prefrontal Cortex

He, J.-P., Su, X.-Y., Men, J., Cui, J.-M., & Zhang, L.-N. (2026) · Physiological Research · doi:10.33549/physiolres.935743

New Hippocampal Neurons Mature Rapidly in Response to Ketamine But Are Not Required for Its Acute Antidepressant Effects on Neophagia in Rats

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Potential link between antidepressant-like effects of ketamine and promotion of adult neurogenesis in the ventral hippocampus of mice

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P.1.009 Persistent changes in hippocampal glutamate receptor expression and depressive symptoms in mice after single treatment with ketamine

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Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: effect of ketamine

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Downregulation of Egr-1 Expression Level via GluN2B Underlies the Antidepressant Effects of Ketamine in a Chronic Unpredictable Stress Animal Model of Depression

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