Frontotemporal lobar degeneration-modified clinical dementia rating (FTLD-CDR) scale and frontotemporal dementia rating scale (FRS) correlation with regional brain perfusion in a series of FTLD patients
Open accessAbstract
Severity assessment scales for frontotemporal lobar degeneration (FTLD) have been recently introduced. In the present study, the authors examined whether the FTLD-modified Clinical Dementia Rating (FTLD-CDR) scale and the Frontotemporal Dementia Rating Scale (FRS) correlated with regional brain perfusion in Greek FTLD patients. A total of 47 behavioral variant frontotemporal dementia (bvFTD) patients and 33 primary progressive aphasia (PPA) patients were assessed for demographic data, cognitive reserve (CR), and severity of dementia and underwent brain single-photon emission computed tomography. Both scales were valid in the bvFTD group, predicting frontal lobe perfusion. In the PPA group, both scales were found to predict temporal hypoperfusion only after accounting for CR, which could imply a potential role for reserve in PPA patients.
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Cites
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · see citing works
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141 · see citing works
Stern, Y. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.03.004 · Cited by 2,943 · see citing works
Brain reserve and dementia: a systematic review
VALENZUELA, M. J., & SACHDEV, P. (2006) · Psychological Medicine · doi:10.1017/s0033291705006264 · Cited by 932 · see citing works
Cognitive Reserve Index questionnaire (CRIq): a new instrument for measuring cognitive reserve
Nucci, M., Mapelli, D., & Mondini, S. (2012) · Aging Clinical and Experimental Research · doi:10.1007/bf03654795 · Cited by 699 · see citing works
Clinical, genetic and pathological heterogeneity of frontotemporal dementia: A review
Seelaar, H., Rohrer, J. D., Pijnenburg, Y. A. L., Fox, N. C., & van Swieten, J. C. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.212225 · Cited by 609 · see citing works
Development of methodology for conducting clinical trials in frontotemporal lobar degeneration
Knopman, D. S., Kramer, J. H., Boeve, B. F., Caselli, R. J., Graff-Radford, N. R., Mendez, M. F., Miller, B. L., & Mercaldo, N. (2008) · Brain · doi:10.1093/brain/awn234 · Cited by 442 · see citing works
Clinical staging and disease progression in frontotemporal dementia
Mioshi, E., Hsieh, S., Savage, S., Hornberger, M., & Hodges, J. R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e04070 · Cited by 362 · see citing works
Neuroimaging in frontotemporal dementia
Rohrer, J. D., & Rosen, H. J. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.778822 · Cited by 104 · see citing works
Ojala-Oksala, J., Jokinen, H., Köpsi, V., Lehtonen, K., Luukkonen, L., Paukkunen, A., Seeck, L., Melkas, S., Pohjasvaara, T., Karhunen, P. J., et al. (2012) · Stroke · doi:10.1161/strokeaha.112.667618 · Cited by 94 · see citing works
Borroni, B., Agosti, C., Premi, E., Cerini, C., Cosseddu, M., Paghera, B., Bellelli, G., & Padovani, A. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02911.x · Cited by 65 · see citing works
Progression in Behavioral Variant Frontotemporal Dementia: A Longitudinal Study
Devenney, E., Bartley, L., Hoon, C., O’Callaghan, C., Kumfor, F., Hornberger, M., Kwok, J. B., Halliday, G. M., Kiernan, M. C., Piguet, O., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.2061 · Cited by 61 · see citing works
Non-fluent progressive aphasia: Cerebral metabolic patterns and brain reserve
Perneczky, R., Diehl‐Schmid, J., Pohl, C., Drzezga, A. E., & Kurz, A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.054 · Cited by 52 · see citing works
Brain reserve capacity in frontotemporal dementia: a voxel-based 18F-FDG PET study
Perneczky, R., Diehl‐Schmid, J., Drzezga, A. E., & Kurz, A. (2007) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-006-0323-z · Cited by 48 · see citing works
Adaptation of the Cognitive Reserve Index Questionnaire (CRIq) for the Greek population
Maiovis, P., Ioannidis, P., Nucci, M., Gotzamani-Psarrakou, A., & Karacostas, D. (2016) · Neurological Sciences · doi:10.1007/s10072-015-2457-x · Cited by 37 · see citing works
Self-citationRelationship between occupation attributes and brain metabolism in frontotemporal dementia
Spreng, R. N., Drzezga, A. E., Diehl‐Schmid, J., Kurz, A., Levine, B., & Perneczky, R. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.09.025 · Cited by 35 · see citing works
Premi, E., Garibotto, V., Alberici, A., Paghera, B., Giubbini, R., Padovani, A., & Borroni, B. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000339366 · Cited by 27 · see citing works
Occupation attributes relate to location of atrophy in frontotemporal lobar degeneration
Spreng, R. N., Rosen, H. J., Strother, S. C., Chow, T. W., Diehl‐Schmid, J., Freedman, M., Graff‐Radford, N. R., Hodges, J. R., Lipton, A. M., Mendez, M. F., et al. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.08.020 · Cited by 24 · see citing works
Konstantinopoulou, E., Aretouli, E., Ioannidis, P., Karacostas, D., & Kosmidis, M. H. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3907 · Cited by 21 · see citing works
Self-citationRusso, G., Russo, M. J., Buyatti, D., Chrem, P., Bagnati, P., Suarez, M. F., Campos, J., Cohen, G., Amengual, A., Allegri, R., et al. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.06.024 · Cited by 19 · see citing works
Phenotypic variety in the presentation of frontotemporal lobar degeneration
Shinagawa, S. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2012.743877 · Cited by 15 · see citing works
Clinical Staging of Semantic Dementia in an FDG-PET Study Using FTLD-CDR
Kim, E., Kim, B. C., Kim, S.-J., Jung, D. S., Sin, J.-S., Yoon, Y.-J., Chin, J., Lee, K.-H., & Na, D. L. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000345506 · Cited by 11 · see citing works
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Tzeng, R.-C., Yang, Y., Hsu, K.-C., Chang, H.-T., & Chiu, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1021792 · Cited by 62 · see citing works
Maiovis, P., Ioannidis, P., Gerasimou, G., Gotzamani-Psarrakou, A., & Karacostas, D. (2018) · Neurodegenerative Diseases · doi:10.1159/000486621 · Cited by 30 · see citing works
Self-citationArdellier, F.-D., Baloglu, S., Sokolska, M., Noblet, V., Lersy, F., Collange, O., Ferré, J., Maamar, A., Carsin-Nicol, B., Helms, J., et al. (2023) · Journal of Neuroradiology · doi:10.1016/j.neurad.2023.01.005 · Cited by 20 · see citing works
Avicenna (980–1037 CE) and his Early Description and Classification of Dementia
Taheri-Targhi, S., GJEDDE, A. H., Araj‐Khodaei, M., Rikhtegar, R., Parsian, Z., Zarrintan, S., Torbati, M., & Vafaee, M. S. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190345 · Cited by 15 · see citing works
da Silva, T. B. L., Bahia, V. S., Cecchini, M. A., Cassimiro, L., Guimarães, H. C., Gambogi, L. B., Caramelli, P., Balthazar, M. L. F., Damasceno, B. P., Brucki, S. M. D., et al. (2018) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000246 · Cited by 12 · see citing works
Fieldhouse, J. L. P., van Paassen, D. N., van Engelen, M.-P. E., De Boer, S. C. M., Hartog, W. L., Braak, S., Schoonmade, L. J., Schouws, S. N. T. M., Krudop, W. A., Oudega, M. L., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1382593 · Cited by 8 · see citing works
Chatzidimitriou, E., Ioannidis, P., Aretouli, E., Papaliagkas, V. T., & Μoraitou, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813810 · Cited by 10 · see citing works
Self-citationChatzidimitriou, E., Ntritsos, G., Lagoudaki, R., Poptsi, E., Tsardoulias, E., Symeonidis, A. L., Tsolaki, M., Konstantinopoulou, E., Papadopoulou, K., Charalambous, P., et al. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15100466 · Cited by 7 · see citing works
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Sintila, S.-A., Boziki, M. K., Bakirtzis, C., Stardeli, T., Smyrni, N., Nikolaidis, I., Parissis, D., Afrantou, T., Karapanayiotides, T., Koutroulou, I., et al. (2023) · Medicina · doi:10.3390/medicina59020266 · Cited by 3 · see citing works
Self-citationChatzidimitriou, E., Sioka, C., Aretouli, E., Iakovou, I. P., Ioannidis, P., & Moraitou, D. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1737054 · Cited by 2 · see citing works
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Self-citation
- Authors
- Maiovis, P., Ioannidis, P., Gerasimou, G., Gotzamani-Psarrakou, A., & Karacostas, D.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- From the B Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (PM, PI, DK); and the B Laboratory of Nuclear Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (GG, A G-P).
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2017-01
- Volume
- 29
- Issue
- 1
- Pages
- 26-30
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W2463720395
- Cited by
- 15
- References
- 22
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2019: 2 · 2018: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Aristotle University of Thessaloniki
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal lobar degeneration, severity assessment scale, behavioral variant frontotemporal dementia, primary progressive aphasia, cognitive reserve, frontal lobe hypoperfusion, temporal lobe hypoperfusion, single photon emission computed tomography
- MeSH terms
- Aged, Brain, Cerebrovascular Circulation, Female, Greece, Humans, Male, Severity of Illness Index, Cohort Studies, Tomography, Emission-Computed, Single-Photon, Linear Models, Aphasia, Primary Progressive, Frontotemporal Dementia
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