Disease progression in frontotemporal dementia and Alzheimer disease: the contribution of staging scales
Open accessAbstract
Introduction: There is a shortage of validated instruments to estimate disease progression in frontotemporal dementia (FTD). Objectives: To evaluate the ability of the FTD Rating Scale (FTD-FRS) to detect functional and behavioral changes in patients diagnosed with the behavioral variant of FTD (bvFTD), primary progressive aphasia (PPA), and Alzheimer disease (AD) after 12 months of the initial evaluation, compared to the Clinical Dementia Rating scale−frontotemporal lobar degeneration (CDR-FTLD) and the original Clinical Dementia Rating scale (CDR). Methods: The sample consisted of 70 individuals, aged 40+ years, with at least 2 years of schooling, 31 with the diagnosis of bvFTD, 12 with PPA (8 with semantic variant and 4 with non-fluent variant), and 27 with AD. The FTD-FRS, the CDR, and the 2 additional CDR-FTLD items were completed by a clinician, based on the information provided by the caregiver with frequent contact with the patient. The Addenbrooke Cognitive Examination-Revised was completed by patients. After 12 months, the same protocol was applied. Results: The FTD-FRS, CDR-FTLD, and CDR detected significant decline after 12 months in the 3 clinical groups (exception: FTD-FRS for PPA). The CDR was less sensitive to severe disease stages. Conclusions: The FTD-FRS and the CDR-FTLD are especially useful tools for dementia staging in AD and in the FTD spectrum.
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Longitudinal studies on FTD-FRS captured a multi-domain deterioration over time in sporadic and genetic bvFTD (1-5 years).
“Longitudinal studies on FTD-FRS captured a multi-domain deterioration over time in sporadic and genetic bvFTD (1–5 years) (Devenney et al., 2015; Schubert et al., 2016; Lima-Silva et al., 2021).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Lima-Silva et al., 2021
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · see citing works
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141 · see citing works
Sugestões para o uso do mini-exame do estado mental no Brasil
Brucki, S. M. D., Nitríni, R., Caramelli, P., Bertolucci, P. H. F., & Okamoto, I. H. (2003) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2003000500014 · Cited by 2,236 · see citing works
Self-citationMioshi, E., Dawson, K., Mitchell, J., Arnold, R., & Hodges, J. R. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1610 · Cited by 2,016 · see citing works
Self-citationCautionary Statement for Forensic Use of DSM-5
(2014) · Diagnostic and Statistical Manual of Mental Disorders, 5th Edition · doi:10.1176/appi.books.9780890425596.744053 · Cited by 624 · see citing works
Clinical, genetic and pathological heterogeneity of frontotemporal dementia: A review
Seelaar, H., Rohrer, J. D., Pijnenburg, Y. A. L., Fox, N. C., & van Swieten, J. C. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.212225 · Cited by 609 · see citing works
The epidemiology of frontotemporal dementia
Onyike, C. U., & Diehl-Schmid, J. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.776523 · Cited by 543 · see citing works
Development of methodology for conducting clinical trials in frontotemporal lobar degeneration
Knopman, D. S., Kramer, J. H., Boeve, B. F., Caselli, R. J., Graff-Radford, N. R., Mendez, M. F., Miller, B. L., & Mercaldo, N. (2008) · Brain · doi:10.1093/brain/awn234 · Cited by 442 · see citing works
Survival in frontotemporal dementia
Hodges, J. R., Davies, R., Xuereb, J. H., Kril, J. J., & Halliday, G. M. (2003) · Neurology · doi:10.1212/01.wnl.0000078928.20107.52 · Cited by 406 · see citing works
Clinical staging and disease progression in frontotemporal dementia
Mioshi, E., Hsieh, S., Savage, S., Hornberger, M., & Hodges, J. R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e04070 · Cited by 362 · see citing works
Self-citationSemantic dementia: demography, familial factors and survival in a consecutive series of 100 cases
Hodges, J. R., Mitchell, J., Dawson, K., Spillantini, M. G., Xuereb, J. H., McMonagle, P., Nestor, P. J., & Patterson, K. E. (2009) · Brain · doi:10.1093/brain/awp248 · Cited by 282 · see citing works
The Cambridge Behavioural Inventory revised
Wear, H. J., Wedderburn, C. J., Mioshi, E., Williams-Gray, C. H., Mason, S. L., Barker, R. A., & Hodges, J. R. (2008) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642009dn20200005 · Cited by 225 · see citing works
Self-citationChaves, M. L. F., Camozzato, A. L., Godinho, C., Kochhann, R., Schuh, A. F. S., de Almeida, V. L., & Kaye, J. A. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31811ff2b4 · Cited by 186 · see citing works
The utility of the Cambridge Behavioural Inventory in neurodegenerative disease
Wedderburn, C. J., Wear, H. J., Brown, J. M., Mason, S. J., Barker, R., Hodges, J. R., & Williams‐Gray, C. H. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.122028 · Cited by 167 · see citing works
Natural history of primary progressive aphasia
Rhun, É. L., Richard, F., & Pasquier, F. (2005) · Neurology · doi:10.1212/01.wnl.0000175982.57472.84 · Cited by 122 · see citing works
Frota, N. A. F., Nitríni, R., Damasceno, B. P., Forlenza, O. V., Dias‐Tosta, E., da Silva, A. B., Herrera, E., & Magaldi, R. M. (2011) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642011dn05030002 · Cited by 118 · see citing works
Self-citationLanguage and behavior domains enhance the value of the clinical dementia rating scale
Knopman, D. S., Weintraub, S., & Pankratz, V. S. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.12.006 · Cited by 105 · see citing works
Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials
Staffaroni, A. M., Ljubenkov, P. A., Kornak, J., Cobigo, Y., Datta, S., Marx, G., Walters, S. M., Chiang, K., Olney, N., Elahi, F. M., et al. (2019) · Brain · doi:10.1093/brain/awy319 · Cited by 105 · see citing works
Global measures: utility in defining and measuring treatment response in dementia
Reisberg, . (2007) · International Psychogeriatrics · doi:10.1017/s1041610207005261 · Cited by 100 · see citing works
Natural History of Frontotemporal Dementia: Comparison with Alzheimer’s Disease
Pasquier, F., Richard, F., & Lebert, F. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000077148 · Cited by 95 · see citing works
Profiles of Decline in Activities of Daily Living in Non-Alzheimer Dementia
Wicklund, A. H., Johnson, N., RADEMAKER, A. W., Weitner, B. B., & Weıntraub, S. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3180324549 · Cited by 82 · see citing works
Rate of Change of Functional Abilities in Frontotemporal Dementia
Mioshi, E., & Hodges, J. R. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000255652 · Cited by 79 · see citing works
Self-citationCarvalho, V. A., Barbosa, M. T., & Caramelli, P. (2010) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0b013e3181c5e2e5 · Cited by 79 · see citing works
Self-citationCésar‐Freitas, K. G., Yassuda, M. S., Porto, F. H. G., Brucki, S. M. D., & Nitríni, R. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217000734 · Cited by 78 · see citing works
Self-citationLongitudinal change in everyday function and behavioral symptoms in frontotemporal dementia
O'Connor, C. M., Clemson, L., Hornberger, M., Leyton, C. E., Hodges, J. R., Piguet, O., & Mioshi, E. (2016) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000000264 · Cited by 73 · see citing works
Self-citationMMSE Scores Decline at a Greater Rate in Frontotemporal Degeneration than in AD
Chow, T. W., Hynan, L. S., & Lipton, A. M. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000094870 · Cited by 60 · see citing works
Assessment of Functional Changes in Alzheimer's Disease
Gauthier, L., & Gauthier, S. G. (1990) · Neuroepidemiology · doi:10.1159/000110771 · Cited by 48 · see citing works
Longitudinal memory profiles in behavioral-variant frontotemporal dementia and Alzheimer’s disease
Schubert, S., Leyton, C. E., Hodges, J. R., & Piguet, O. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150802 · Cited by 37 · see citing works
Hallikainen, I. T., Hänninen, T., zu Fraunberg, M. V. U., Hongisto, K., Välimäki, T. H., Hiltunen, A., Karppi, P., Sivenius, J., Soininen, H. S., & Koivisto, A. M. (2013) · International Psychogeriatrics · doi:10.1017/s1041610213000653 · Cited by 35 · see citing works
Detecting clinical change with the CDR-FTLD: differences between FTLD and AD dementia
Mioshi, E., Flanagan, E., & Knopman, D. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4556 · Cited by 29 · see citing works
Self-citationA 2‐year follow‐up of 233 very mild (CDR 0.5) Alzheimer's disease patients (REAL.FR cohort)
Nourhashémi, F., Ousset, P., Guyonnet, S., Cantet, C., Andrieu, S., & Vellas, B. J. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1904 · Cited by 23 · see citing works
Are we comparing frontotemporal dementia and Alzheimer disease patients with the right measures?
Deutsch, M. B., Liang, L.-J. F., Jimenez, E. E., Mather, M. J., & Mendez, M. F. (2016) · International Psychogeriatrics · doi:10.1017/s1041610216000582 · Cited by 20 · see citing works
Lima-Silva, T. B., Bahia, V. S., Carvalho, V. A., Guimarães, H. C., Caramelli, P., Balthazar, M., Damasceno, B., Bottino, C. M. D. C., Brucki, S. M. D., Mioshi, E., et al. (2013) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642013dn74000006 · Cited by 19 · see citing works
Self-citationAdaptación y validación de la Frontotemporal Dementia Rating Scale (FTD-FRS) al castellano
Garriga, O. T., Contreras, C. H., Cladera, J. O., Mioshi, E., Valero, C. P., Pueyo, J. O., Garre‐Olmo, J., & Sánchez‐Valle, R. (2016) · Neurología · doi:10.1016/j.nrl.2015.12.004 · Cited by 7 · see citing works
Self-citationGarriga, O. T., Contreras, C. H., Cladera, J. O., Mioshi, E., Valero, C. P., Pueyo, J. O., Garre‐Olmo, J., & Sánchez‐Valle, R. (2017) · Neurología (English Edition) · doi:10.1016/j.nrleng.2015.12.002 · Cited by 6 · see citing works
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Research works printed but not linked: 1
- Brucki SMD, Nitrini R, Caramelli P, et al. Suggestions for utilization of the mini-mental state examination in Brazil. Arq Neuro-Psiquiatr 2003;61: 777-781.
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Fieldhouse, J. L. P., van Paassen, D. N., van Engelen, M.-P. E., De Boer, S. C. M., Hartog, W. L., Braak, S., Schoonmade, L. J., Schouws, S. N. T. M., Krudop, W. A., Oudega, M. L., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1382593 · Cited by 8 · see citing works
- Authors
- Lima-Silva, T. B., Mioshi, E., Bahia, V. S., Cecchini, M. A., Cassimiro, L., Guimarães, H. C., Gambogi, L. B., Caramelli, P., Balthazar, M., Damasceno, B., Brucki, S. M. D., de Souza, L. C., Nitrini, R., & Yassuda, M. S.
- Affiliations
- Neurology Department, University of São Paulo, São Paulo, Brazil
- University of East Anglia (GB)
- Universidade de São Paulo (BR)
- Universidade Federal de Minas Gerais (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Cognitive and Behavioral Neurology Research Group, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
- Corresponding author
- Yassuda, Mônica Sanches
- ORCID
- Venue
- Journal of Geriatric Psychiatry and Neurology
- Publisher
- SAGE Publications
- Published
- 2020-08-07
- Volume
- 34
- Issue
- 5
- Pages
- 397-404
- ISSN
- 0891-9887 (ISSN-L)
- 1552-5708
- OpenAlex
- W3047981838
- Cited by
- 18
- References
- 39
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- green
- ueaeprints.uea.ac.uk
- Locations
- Journal of Geriatric Psychiatry and Neurology (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88881.131619/2016-01)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (151684/2014-6)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- frontotemporal dementia, Alzheimer's disease, disease progression, dementia staging, Clinical Dementia Rating, behavioral variant frontotemporal dementia, primary progressive aphasia, functional decline, behavioral decline
- MeSH terms
- Mental Status and Dementia Tests, Alzheimer Disease, Humans, Disease Progression, Aphasia, Primary Progressive, Frontotemporal Dementia
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