The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Apathy Is Not Depression
Abstract
If depression is associated with apathy, then they should be expressed together in different dementia syndromes and should co-occur at varying levels of disease severity. The authors performed a cross-sectional comparison of neuropsychiatric symptoms in 30 Alzheimer's disease, 28 frontotemporal dementia, 40 Parkinson's disease, 34 Huntington's disease, and 22 progressive supranuclear palsy patients, using a standardized rating scale (the Neuropsychiatric Inventory). Apathy did not correlate with depression in the combined sample; apathy (r = -0.40, P < 0.0001), but not depression, correlated with lower cognitive function as measured by the Mini-Mental State Examination. The relationship of apathy to depression also varied across diagnostic groups. Apathy is a specific neuropsychiatric syndrome that is distinct from depression. Distinguishing these two syndromes has therapeutic implications.
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Cites
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Self-citationFrontal-subcortical circuits and human behavior
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Self-citationReliability and validity of the apathy evaluation scale
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Cited by
Apathy and the Functional Anatomy of the Prefrontal Cortex–Basal Ganglia Circuits
Levy, R., & Dubois, B. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj043 · Cited by 1,285
Neuropsychiatric aspects of Huntington’s disease.
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Self-citationThe nosological position of apathy in clinical practice
Starkstein, S. E., & Leentjens, A. F. G. (2008) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.136895 · Cited by 371
van Reekum, R., Stuss, D. T., & Ostrander, L. (2005) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.17.1.7 · Cited by 360
Apathy and anhedonia rating scales in Parkinson's disease: Critique and recommendations
Leentjens, A. F. G., Dujardin, K., Marsh, L., Martinez‐Martin, P., Richard, I. H., Starkstein, S. E., Weintraub, D., Sampaio, C., Poewe, W., Rascol, O., et al. (2008) · Movement Disorders · doi:10.1002/mds.22229 · Cited by 346
Metadata
- Authors
- Levy, M. L., Cummings, J. L., Fairbanks, L. A., Masterman, D., Miller, B. L., Craig, A. H., Paulsen, J. S., & Litvan, I.
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 1998-08
- Volume
- 10
- Issue
- 3
- Pages
- 314-319
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W2010202486
- Cited by
- 678
- References
- 35
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Levy, M. L., Cummings, J. L., Fairbanks, L. A., Masterman, D., Miller, B. L., Craig, A. H., Paulsen, J. S., & Litvan, I. (1998). Apathy Is Not Depression. The Journal of Neuropsychiatry and Clinical Neurosciences. https://doi.org/10.1176/jnp.10.3.314
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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