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Toward a Neurobiology of Psychotherapy: Basic Science and Clinical Applications
Abstract
Psychotherapy is used commonly to treat a variety of mental illnesses, yet surprisingly little is known about its biological mechanisms especially in comparison with pharmacotherapy. In this review we survey the current knowledge about changes in brain function following psychotherapeutic intervention that are detectable with current neuroimaging techniques. We also consider the possible role for neuroimaging in refining clinical diagnoses and predicting treatment outcome, which would benefit both clinical decision-making and the cognitive neuroscience of psychotherapy.
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“This is a fundamentally new perspective because psychotherapy research to date has only considered the patient’s brain as the locus of therapeutic effects (Etkin et al., 2005; Beauregard, 2014; Weingarten and Strauman, 2015).”
From Synchrony in Psychotherapy: A Review and an Integrative Framework for the Therapeutic Alliance (2016) · cites this paper as Etkin et al., 2005
In the citing paper
“An equivalent model in anxiety disorders has been proposed (Etkin et al., 2005).”
From Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety (2018) · cites this paper as Etkin et al., 2005
In the citing paper
“Patients with affective disorders who remit have been found to show recovery in the imbalance between these two systems (DeRubeis et al., 2008; Etkin et al., 2005; Siegle et al., 2007).”
From Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety (2018) · cites this paper as Etkin et al., 2005
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Metadata
- Authors
- Etkin, A., Pittenger, C., Polan, H. J., & Kandel, E. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2005-05
- Volume
- 17
- Issue
- 2
- Pages
- 145-158
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W1988088970
- Cited by
- 244
- References
- 63
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 10 · 2015: 27 · 2014: 12 · 2013: 13 · 2012: 15
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- psychotherapy, neurobiology of psychotherapy, brain function changes, neuroimaging, treatment outcome prediction, diagnosis, drug therapy comparison
- MeSH terms
- Mental Disorders, Consciousness, Diagnostic Imaging, Humans, Neurobiology, Psychotherapy, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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