Cited by 244Psychotherapy Techniques and ApplicationsPsychoanalysis and Psychopathology ResearchTranscranial Magnetic Stimulation Studies

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Toward a Neurobiology of Psychotherapy: Basic Science and Clinical Applications

Etkin, Amit, Pittenger, Christopher, Polan, H. Jonathan, Kandel, Eric R.·2005·The Journal of Neuropsychiatry and Clinical Neurosciences

DOI 10.1176/jnp.17.2.145

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Abstract

Psychotherapy is used commonly to treat a variety of mental illnesses, yet surprisingly little is known about its biological mechanisms especially in comparison with pharmacotherapy. In this review we survey the current knowledge about changes in brain function following psychotherapeutic intervention that are detectable with current neuroimaging techniques. We also consider the possible role for neuroimaging in refining clinical diagnoses and predicting treatment outcome, which would benefit both clinical decision-making and the cognitive neuroscience of psychotherapy.

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Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
Anterior Cingulate Conflict Monitoring and Adjustments in Control
Kerns, J. G., Cohen, J. D., MacDonald, A. W., Cho, R. Y., Stenger, V. A., & Carter, C. S. (2004) · Science · doi:10.1126/science.1089910 · Cited by 2,891
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
National Institute of Mental Health Treatment of Depression Collaborative Research Program: General Effectiveness of Treatments
Elkin, I. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110013002 · Cited by 2,300
Pan-cultural elements in facial displays of emotion
Ekman, P., Sorenson, E. R., & Friesen, W. V. (1969) · Science · doi:10.1126/science.164.3875.86 · Cited by 1,775
Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression: Treatment for Adolescents With Depression Study (TADS) Randomized Controlled Trial
(2004) · JAMA · doi:10.1001/jama.292.7.807 · Cited by 1,735
Anxiety-related attentional biases and their regulation by attentional control.
Derryberry, D., & Reed, M. A. (2002) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.111.2.225 · Cited by 1,729
A cognitive-motivational analysis of anxiety.
Mogg, K., & Bradley, B. P. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(98)00063-1 · Cited by 1,642
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585
The Physiology and Psychology of Behavioral Inhibition in Children
Kagan, J., Reznick, J. S., & Snidman, N. C. (1987) · Child Development · doi:10.2307/1130685 · Cited by 1,368
An information processing model of anxiety: Automatic and strategic processes
Beck, A. T., & Clark, D. A. (1997) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(96)00069-1 · Cited by 1,317
Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder
Baxter, L. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820090009002 · Cited by 1,293
Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders
Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146
Depression: Perspectives from Affective Neuroscience
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138
Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: A functional MRI study
Rauch, S. L., Whalen, P. J., Shin, L. M., McInerney, S. C., Macklin, M. L., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00828-3 · Cited by 1,111
Modulation of Cortical-Limbic Pathways in Major Depression: Treatment-Specific Effects of Cognitive Behavior Therapy
Goldapple, K., Segal, Z., Garson, C., Lau, M., Bieling, P., Kennedy, S., & Mayberg, H. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.34 · Cited by 1,068
Cognitive Enhancers as Adjuncts to Psychotherapy: Use of D-Cycloserine in Phobic Individuals to Facilitate Extinctionof Fear
Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1136 · Cited by 1,063
Behavioral Inhibition: Linking Biology and Behavior within a Developmental Framework
Fox, N. A., Henderson, H. A., Marshall, P. J., Nichols, K. E., & Ghera, M. M. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.141532 · Cited by 1,040
Cingulate function in depression: a potential predictor of treatment response
Mayberg, H. S., Brannan, S. K., Mahurin, R. K., Jerabek, P. A., Brickman, J. S., Tekell, J. L., Silva, J. A., McGinnis, S., Glass, T. G., Martin, C. C., et al. (1997) · NeuroReport · doi:10.1097/00001756-199703030-00048 · Cited by 1,029
The Amygdala: a functional analysis
Aggleton, J. P. (2000) · Cited by 966
A Functional Magnetic Resonance Imaging Study of Amygdala and Medial Prefrontal Cortex Responses to Overtly Presented Fearful Faces in Posttraumatic Stress Disorder
Shin, L. M., Wright, C. I., Cannistraro, P. A., Wedig, M. M., McMullin, K., Martis, B., Macklin, M. L., Lasko, N. B., Cavanagh, S. R., Krangel, T. S., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.3.273 · Cited by 960
Attentional bias for threat: evidence for delayed disengagement from emotional faces
Fox, E., Russo, R., & Dutton, K. (2002) · Cognition & Emotion · doi:10.1080/02699930143000527 · Cited by 954
Regional Cerebral Blood Flow Measured During Symptom Provocation in Obsessive-Compulsive Disorder Using Oxygen 15—Labeled Carbon Dioxide and Positron Emission Tomography
Rauch, S. L. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010062008 · Cited by 880
Behavioral Inhibition and Stress Reactivity: The Moderating Role of Attachment Security
Nachmias, M., Gunnar, M., Mangelsdorf, S., Parritz, R. H., & Buss, K. (1996) · Child Development · doi:10.2307/1131829 · Cited by 730
Behavioral Inhibition and Stress Reactivity: The Moderating Role of Attachment Security
Nachmias, M., Gunnar, M. R., Mangelsdorf, S. C., Parritz, R. H., & Buss, K. A. (1996) · Child Development · doi:10.1111/j.1467-8624.1996.tb01748.x · Cited by 724
Systematic Changes in Cerebral Glucose Metabolic Rate After Successful Behavior Modification Treatment of Obsessive-Compulsive Disorder
Schwartz, J. M. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830020023004 · Cited by 694
Individual Differences in Trait Anxiety Predict the Response of the Basolateral Amygdala to Unconsciously Processed Fearful Faces
Etkin, A., Klemenhagen, K. C., Dudman, J. T., Rogan, M. T., Hen, R., Kandel, E. R., & Joy Hirsch, C. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.006 · Cited by 679
Further evidence of association between behavioral inhibition and social anxiety in children
Biederman, J., Hirshfeld-Becker, D. R., Rosenbaum, J. F., Hérot, C., Friedman, D., Snidman, N., Kagan, J., & Faraone, S. V. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.10.1673 · Cited by 655
The emotional counting stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division
Whalen, P. J., Bush, G., McNally, R. J., Wilhelm, S., McInerney, S. C., Jenike, M. A., & Rauch, S. L. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00251-0 · Cited by 650
Anterior Cingulate Activity as a Predictor of Degree of Treatment Response in Major Depression: Evidence From Brain Electrical Tomography Analysis
Pizzagalli, D., Pascual-Marqui, R. D., Nitschke, J. B., Oakes, T. R., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Koger, J. V., Benca, R. M., & Davidson, R. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.3.405 · Cited by 630
Stability and social-behavioral consequences of toddlers’ inhibited temperament and parenting behaviors
Rubin, K. H., Burgess, K. B., & Hastings, P. D. (2002) · Child Development · doi:10.1111/1467-8624.00419 · Cited by 617
Response inhibition and impulsivity: An fMRI study
Horn, N. R., Dolan, M., Elliott, R., Deakin, J. F. W., & Woodruff, P. W. R. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(03)00077-0 · Cited by 604
Increased Amygdala Activation to Angry and Contemptuous Faces in Generalized Social Phobia
Stein, M. B., Goldin, P. R., Sareen, J., Zorrilla, L. T. E., & Brown, G. G. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.11.1027 · Cited by 598
Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy
Furmark, T., Tillfors, M., Marteinsdottir, I., Fischer, H., Pissiota, A., Långström, B., & Fredrikson, M. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.5.425 · Cited by 530
Inhibited and uninhibited infants “grown up”: adult amygdalar response to novelty
Schwartz, C. E., Wright, C. I., Shin, L. M., Kagan, J., & Rauch, S. L. (2003) · Science · doi:10.1126/science.1083703 · Cited by 528
Evidence for Abnormal Cortical Functional Connectivity During Working Memory in Schizophrenia
Meyer‐Lindenberg, A., Poline, J., Kohn, P. D., Holt, J. L., Egan, M. F., Weinberger, D. R., & Berman, K. F. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1809 · Cited by 511
Functional neuroimaging studies of depression: The anatomy of melancholia
Drevets, W. C. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.341 · Cited by 500
The neural substrates of affective processing in depressed patients treated with venlafaxine
Davidson, R. J., Irwin, W., Anderle, M. J., & Kalin, N. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.64 · Cited by 487
Functional Anatomy of Obsessive–Compulsive Phenomena
McGuire, P. K., Bench, C. J., Frith, C., Marks, I. M., Frackowiak, R. S. J., & Dolan, R. J. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.164.4.459 · Cited by 453
“Change the mind and you change the brain”: effects of cognitive-behavioral therapy on the neural correlates of spider phobia
Paquette, V., Lévesque, J., Mensour, B., Leroux, J.-M., Beaudoin, G., Bourgouin, P., & Beauregard, M. (2003) · NeuroImage · doi:10.1016/s1053-8119(02)00030-7 · Cited by 452
Localized Orbitofrontal and Subcortical Metabolic Changes and Predictors of Response to Paroxetine Treatment in Obsessive-Compulsive Disorder
Saxena, S. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00082-2 · Cited by 379
Cerebral Blood Flow in Subjects With Social Phobia During Stressful Speaking Tasks: A PET Study
Tillfors, M., Furmark, T., Marteinsdóttir, Í., Fischer, H., Pissiota, A., Långström, B., & Fredrikson, M. G. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.8.1220 · Cited by 357
Addiction, a condition of compulsive behaviour? Neuroimaging and neuropsychological evidence of inhibitory dysregulation
Lubman, D. I., Yücel, M., & Pantelis, C. (2004) · Addiction · doi:10.1111/j.1360-0443.2004.00808.x · Cited by 348
Prediction of Antidepressant Effects of Sleep Deprivation by Metabolic Rates in the Ventral Anterior Cingulate and Medial Prefrontal Cortex
Wu, J. C., Buchsbaum, M. S., Gillin, J. C., Tang, C. Y., Cadwell, S., Wiegand, M. H., Najafi, A., Klein, E., Hazen, K., & Bunney, W. E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1149 · Cited by 330
Brain Blood Flow Changes in Depressed Patients Treated With Interpersonal Psychotherapy or Venlafaxine Hydrochloride
Martin, S. D., Martin, E., Rai, S. S., Richardson, M. A., & Royall, R. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.7.641 · Cited by 324
Neuroimaging findings in post-traumatic stress disorder. Systematic review.
Hull, A. M. (2002) · PubMed · Cited by 307
FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder
Brody, A. L., Saxena, S., Schwartz, J. M., Stoessel, P. W., Maidment, K., Phelps, M. E., & Baxter, L. R. (1998) · Psychiatry Research: Neuroimaging · doi:10.1016/s0925-4927(98)00041-9 · Cited by 285
Psychotherapy and the Single Synapse
Kandel, E. R. (1979) · New England Journal of Medicine · doi:10.1056/nejm197911083011904 · Cited by 219
Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression
Saxena, S., Brody, A. L., Ho, M. L., Zohrabi, N., Maidment, K. M., & Baxter, L. R. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.522 · Cited by 210
Temperament, Emotion, and Cognition at Fourteen Months: The MacArthur Longitudinal Twin Study
Emde, R. N., Plomin, R. J., Robinson, J., Corley, R. P., DeFries, J. C., Fulker, D. W., Reznick, J. S., Campos, J., Kagan, J., & Zahn‐Waxler, C. (1992) · Child Development · doi:10.1111/j.1467-8624.1992.tb01706.x · Cited by 207
Influence of the Serotonin Transporter Promoter Gene and Shyness on Children’s Cerebral Responses to Facial Expressions
Battaglia, M., Ogliari, A. L., Zanoni, A., Citterio, A., Pozzoli, U., Giorda, R., Maffei, C., & Marino, C. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.1.85 · Cited by 188
Venlafaxine Extended Release vs Placebo and Paroxetine in Social Anxiety Disorder
Liebowitz, M. R., Gelenberg, A. J., & Munjack, D. J. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.190 · Cited by 163
A Review of Functional Neuroimaging in Mood Disorders: Positron Emission Tomography and Depression
Kennedy, S. H., Javanmard, M., & Vaccarino, F. J. (1997) · The Canadian Journal of Psychiatry · doi:10.1177/070674379704200502 · Cited by 161
Behavioral inhibition and disinhibition as hypothesized precursors to psychopathology
Hirshfeld‐Becker, D. R., Biederman, J., Calltharp, S., Rosenbaum, E. D., Faraone, S. V., & Rosenbaum, J. F. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00316-0 · Cited by 114
Skills for Social and Academic Success: A School-Based Intervention for Social Anxiety Disorder in Adolescents
Fisher, P. H., Masia‐Warner, C., & Klein, R. G. (2004) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-004-6088-7 · Cited by 107
Children's Discrimination of Expressions of Emotions: Relationship With Indices of Social Anxiety and Shyness
Battaglia, M., Ogliari, A. L., Zanoni, A., Villa, F., Citterio, A., Binaghi, F., Fossati, A., & Maffei, C. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200403000-00019 · Cited by 76
Anxiety, Signal Anxiety, and Unconscious Anticipation: Neuroscientific Evidence for an Unconscious Signal Function in Humans
Wong, P. S. (1999) · Journal of the American Psychoanalytic Association · doi:10.1177/00030651990470031901 · Cited by 51
Can response to partial sleep deprivation in depressed patients be predicted by regional changes of cerebral blood flow?
Volk, S., Kaendler, S., Hertel, A., Maul, F. D., Manoocheri, R., Weber, R., Georgi, K., Pflug, B., & Hör, G. (1997) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(97)00021-8 · Cited by 49
Overview of panic and social anxiety disorders.
Westenberg, H. G. M., & Liebowitz, M. R. (2004) · PubMed · Cited by 36
Comorbidity, neurobiology, and pharmacotherapy of social anxiety disorder.
Pollack, M. H. (2001) · PubMed · Cited by 33
Neuroimaging findings in post-traumatic stress disorder
Hull, A. M. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.181.2.102 · Cited by 33
Cognitive behavioural therapy reduces short term rehospitalisation compared with psychoeducation in inpatients with schizophrenia
Rector, N. A. (2005) · Evidence-Based Mental Health · doi:10.1136/ebmh.8.1.8 · Cited by 5
Regional Brain Metabolic Changes in Patients With Major Depression Treated With Either Paroxetine or Interpersonal Therapy: Preliminary Findings
Brody, A. L., Saxena, S., Stoessel, P., Gillies, L. A., Fairbanks, L. A., Alborzian, S., Phelps, M. E., Huang, S.-C., Wu, H.-M., Ho, M. L., et al. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.7.631 · Cited by 5

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See all 244

Authors: Etkin, A., Pittenger, C., Polan, H. J., & Kandel, E. R.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Etkin, Amit
Pittenger, Christopher
Kandel, Eric R.
Venue: The Journal of Neuropsychiatry and Clinical Neurosciences
Publisher: American Psychiatric Association Publishing
Published: 2005-05
Volume: 17
Issue: 2
Pages: 145-158
ISSN: 0895-0172 (ISSN-L)
1545-7222
DOI: 10.1176/jnp.17.2.145
OpenAlex: W1988088970
Cited by: 244
References: 63
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 10 · 2015: 27 · 2014: 12 · 2013: 13 · 2012: 15
FWCI: 13.59
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropsychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords: psychotherapy, neurobiology of psychotherapy, brain function changes, neuroimaging, treatment outcome prediction, diagnosis, drug therapy comparison
MeSH terms: Mental Disorders, Consciousness, Diagnostic Imaging, Humans, Neurobiology, Psychotherapy, Treatment Outcome

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Toward a Neurobiology of Psychotherapy: Basic Science and Clinical Applications

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