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Cited by 725

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Frontal-subcortical circuits and neuropsychiatric disorders

·1994·The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Five parallel anatomic circuits link regions of the frontal cortex to the striatum, globus pallidus/substantia nigra, and thalamus. The circuits originate in the supplementary motor area, frontal eye fields, dorsolateral prefrontal region, lateral orbito-frontal area, and anterior cingulate cortex. Open loop structures that provide input to or receive output from specific circuits share functions, cytoarchitectural features, and phylogenetic histories with the relevant circuits. The circuits mediate motor and oculomotor function as well as executive functions, socially responsive behavior, and motivation. Neuropsychiatric disorders of frontal-subcortical circuits include impaired executive function, disinhibition, and apathy; indicative mood disorders include depression, mania, and lability. Transmitters, modulators, receptor subtypes, and second messengers within the circuits provide a chemoarchitecture that can inform pharmacotherapy.

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Crossref · 10.1176/jnp.6.4.358

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Metadata

Venue
The Journal of Neuropsychiatry and Clinical Neurosciences
Published
1994-11-01
Volume
6
Issue
4
Pages
358-370
ISSN
  • 0895-0172 (ISSN-L)
  • 1545-7222
OpenAlex
W1548466807
Cited by
725
References
8
FWCI
8.86
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Frontal-subcortical circuits and neuropsychiatric disorders. https://app.cochat.ai/papers/10.1176/jnp.6.4.358
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Frontal-subcortical circuits and neuropsychiatric disorders. (1994). The Journal of Neuropsychiatry and Clinical Neurosciences. https://doi.org/10.1176/jnp.6.4.358

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.