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Cited by 70Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPersonality Disorders and Psychopathology

Personality and Clinical Predictors of Recurrence of Depression

Berlanga, Carlos, Heinze, Gerardo, Torres, Marina, Apiquián, Rogelio, Caballero, Alejandro·1999·Psychiatric Services
DOI 10.1176/ps.50.3.376
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Abstract

OBJECTIVE: To help clinicians more accurately predict outcomes of treatment for depression, variables associated with recurrence of depression in the year after treatment were examined in a group of patients who completed treatment for an index episode of depression. METHODS: Forty-two depressed patients who participated in a double-blind pharmacological treatment study were followed for one year after treatment was discontinued. Length of treatment for the index episode was determined by clinicians and ranged from eight to 76 consecutive weeks. Eighteen patients who had a recurrent episode (43 percent) and 24 patients who did not (57 percent) were compared on sociodemographic and clinical variables, including scores on the Eysenck Personality Questionnaire (EPQ). RESULTS: A combination of three variables predicted recurrence of depression in 90 percent of cases. They were an elevated EPQ score on the neuroticism subscale, a short duration of treatment of the index episode, and a slow onset of response to treatment of the index episode. CONCLUSIONS: The findings suggest that personality traits, treatment duration, and variations in response to treatment might have an impact on long-term treatment outcome. Clinicians should consider these factors when making treatment decisions for depressed patients.

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  • Number of previous episodes, residual symptoms, and other factors robustly increase the risk of relapse independent of medication discontinuation.

    “Many of the factors reported on here appear to have robust properties as predictors of relapse or recurrence risk independent of medication discontinuation: number of previous episodes (Berlanga et al. 1999; Kendler et al. 2000; Burcusa & Iacono, 2007; Hardeveld et al. 2010), residual symptoms (Hardeveld et al. 2010; Nierenberg et al. 2010) and other factors all robustly increase the risk of rela”

    From Predicting relapse after antidepressant withdrawal – a systematic review (2017) · cites this paper as Berlanga et al. 1999

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Authors
Berlanga, C., Heinze, G., Torres, M., Apiquián, R., & Caballero, A.
ORCID
Venue
Psychiatric Services
Publisher
American Psychiatric Association Publishing
Published
1999-03
Volume
50
Issue
3
Pages
376-380
ISSN
  • 0022-1597 (ISSN-L)
  • 1075-2730
  • 1557-9700
DOI
10.1176/ps.50.3.376
OpenAlex
W2171344924
Cited by
70
References
26
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 2 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 4
FWCI
1.30
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatric Services (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords
depression recurrence, personality traits, neuroticism, treatment duration, treatment response, antidepressant treatment outcome, Eysenck Personality Questionnaire, long-term follow-up
MeSH terms
Adult, Analysis of Variance, Antidepressive Agents, Depressive Disorder, Female, Humans, Male, Middle Aged, Personality, Prognosis, Prospective Studies, Recurrence, Risk Factors, Socioeconomic Factors, Logistic Models, Case-Control Studies

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