Psychological theories of depressive relapse and recurrence: A systematic review and meta-analysis of prospective studies
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Psychological factors hypothesized to account for relapse of major depressive disorder (MDD) roughly originate from five main theories: Cognitive, diathesis-stress, behavioural, psychodynamic, and personality-based. In a meta-analysis we investigated prospective, longitudinal evidence for these leading psychological theories and their factors in relation to depressive relapse. Included studies needed to establish history of MDD and prospective depressive relapse through a clinical interview, have a longitudinal and prospective design, and measure at least one theory-derived factor before relapse. We identified 66 eligible articles out of 43,586 records published up to November 2018. Pooled odds ratios (OR) indicated a significant relationship between the cognitive, behavioural, and personality-based theories and depressive relapse (cognitive: k = 17, OR = 1.24, 95% CI = 1.10-1.40; behavioural, k = 8, OR = 1.15, 95% CI = 1.05-1.25; personality: k = 12, OR = 1.26, 95% CI = 1.02-1.54), but not for the psychodynamic theories (k = 4, OR = 1.29, 95% CI = 0.83-1.99). Pooled hazard ratios of the theories were not significant. There were no articles identified for the diathesis-stress theories. To conclude, there is a restricted number of prospective studies, and some evidence that the cognitive, behavioural, and personality-based theories indeed partially account for depressive relapse.
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The dataset used in this study comes from a systematic review-based meta-analysis focusing on evidence for leading psychological and biological theories on the onset, maintenance, and relapse of depressive disorders.
“The dataset used in this study comes from a systematic review-based meta-analysis focusing on the evidence for leading psychological and biological theories on the onset, maintenance, and relapse of depressive disorders (Brouwer et al., 2019; Kennis et al., 2020; Fu et al., 2021).”
From Active learning-based systematic reviewing using switching classification models: the case of the onset, maintenance, and relapse of depressive disorders (2023) · cites this paper as Brouwer et al., 2019
Within a sub-project, researchers screened over 46 thousand records for a question on psychological theories of depressive relapse and identified only 63 eligible papers (0.13% inclusion rate).
“Within a sub-project of this project, the researchers screened over 46 thousand records for a question on psychological theories of depressive relapse. They identified only 63 eligible papers for the final meta-analysis (0.13% inclusion rate).”
From Active learning-based systematic reviewing using switching classification models: the case of the onset, maintenance, and relapse of depressive disorders (2023) · cites this paper as Brouwer et al., 2019
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- Authors
- Brouwer, M. E., Williams, A. D., Kennis, M., Fu, Z., Klein, N. S., Cuijpers, P., & Bockting, C. L. H.
- Affiliations
- Utrecht University (NL)
- University of Groningen (NL)
- Vrije Universiteit Amsterdam (NL)
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Bockting, Claudi L.H.
- ORCID
- Venue
- Clinical Psychology Review
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 74
- Pages
- 101773
- ISSN
- 0272-7358 (ISSN-L)
- OpenAlex
- W2985119860
- Cited by
- 39
- References
- 72
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 11 · 2022: 7 · 2021: 6 · 2020: 2 · 2019: 1
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Psychology Review (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- VU Research Portal (acceptedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Netherlands Institute for Advanced Study in the Humanities and Social Sciences
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Keywords
- depression relapse, major depressive disorder, recurrence, cognitive theory, behavioral theory, psychodynamic theory, diathesis-stress model, psychological risk factors
- MeSH terms
- Major Depressive Disorder, Depressive Disorder, Major, Humans, Psychological Theory, Disease Progression
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