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Anhedonia in substance use disorders: A systematic review of its nature, course and clinical correlates
Abstract
OBJECTIVE: There is growing evidence that anhedonia is a commonly experienced symptom among substance-using populations. This systematic review synthesises findings across a range of substances to address questions regarding the time course of anhedonia, how anhedonia relates to other symptoms of substance dependence and whether it is similarly prevalent across all addictive drugs. METHOD: A literature search was conducted on PubMed, PsycINFO and MEDLINE, yielding 32 studies that used self-report measures of anhedonia among participants with a history of a substance abuse, dependence or long-term daily use of addictive substances. RESULTS: Findings from these studies indicate that anhedonia (1) is elevated in samples dependent on a range of substances; (2) typically appears as a consequence of substance abuse or dependence, and diminishes with abstinence; and (3) predicts increased drug cravings and the likelihood of relapse in those attempting abstinence. CONCLUSIONS: The common experience of anhedonia in substance-dependent populations, and its relationship to relapse, emphasises the importance of developing therapeutic interventions that specifically target anhedonia in the treatment of all substance use disorders.
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“Those correlations have been reproduced through several studies; research on the subject identifies, in a somewhat paradoxical way, that the experience of anhedonia may be a consequence of substance use (48).”
From Mobile intervention for individuals with psychosis, dual disorders, and their common comorbidities: A literature review (2019) · cites this paper as [48]
In the citing paper
“The emotional processes observed in substance use disorders suggest that the search for stimulation through the consumption of substances would aim to lessen the experience of anhedonia, an often-reported state in this population (47, 48).”
From Mobile intervention for individuals with psychosis, dual disorders, and their common comorbidities: A literature review (2019) · cites this paper as [48]
In the citing paper
“Deficits in reward processing are found in MDD (Admon and Pizzagalli, 2015), substance use disorders (Garfield et al., 2014; Tobler et al., 2016), posttraumatic stress disorder (PTSD) (Kalebasi et al., 2015), schizophrenia (McCarthy et al., 2016), and ADHD (van Hulst et al., 2016).”
From The effects of early life stress on reward processing (2018) · cites this paper as Garfield et al., 2014
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Валерьевна, Р. К., Vyazova, A. I., Goncharov, O. V., Петровна, С. Е., Андреевна, Б. А., Георгиевна, К. С., & Krupitsky, E. M. (2025) · V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY · doi:10.31363/2313-7053-2025-4-2-1195 · Cited by 2
Metadata
- Authors
- Garfield, J. B. B., Lubman, D. I., & Yücel, M.
- Affiliations
- Eastern Health (AU)
- Monash University (AU)
- Venue
- Australian & New Zealand Journal of Psychiatry
- Publisher
- SAGE Publications
- Published
- 2013-11-22
- Volume
- 48
- Issue
- 1
- Pages
- 36-51
- ISSN
- 0004-8674 (ISSN-L)
- 1440-1614
- OpenAlex
- W2148297013
- Cited by
- 213
- References
- 61
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 11 · 2023: 22 · 2022: 11 · 2021: 18 · 2020: 58 · 2019: 13 · 2018: 14 · 2017: 3 · 2016: 12 · 2015: 6 · 2013: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian & New Zealand Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anhedonia, substance use disorders, substance dependence, abstinence, relapse, drug craving, drugs of abuse, therapeutic interventions
- MeSH terms
- Humans, Substance-Related Disorders, Anhedonia
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