The DOI matches its Crossref record; 60 of the 61 references it cites were found in a registry or an index.
Anhedonia in substance use disorders: A systematic review of its nature, course and clinical correlates
Abstract
OBJECTIVE: There is growing evidence that anhedonia is a commonly experienced symptom among substance-using populations. This systematic review synthesises findings across a range of substances to address questions regarding the time course of anhedonia, how anhedonia relates to other symptoms of substance dependence and whether it is similarly prevalent across all addictive drugs. METHOD: A literature search was conducted on PubMed, PsycINFO and MEDLINE, yielding 32 studies that used self-report measures of anhedonia among participants with a history of a substance abuse, dependence or long-term daily use of addictive substances. RESULTS: Findings from these studies indicate that anhedonia (1) is elevated in samples dependent on a range of substances; (2) typically appears as a consequence of substance abuse or dependence, and diminishes with abstinence; and (3) predicts increased drug cravings and the likelihood of relapse in those attempting abstinence. CONCLUSIONS: The common experience of anhedonia in substance-dependent populations, and its relationship to relapse, emphasises the importance of developing therapeutic interventions that specifically target anhedonia in the treatment of all substance use disorders.
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“Those correlations have been reproduced through several studies; research on the subject identifies, in a somewhat paradoxical way, that the experience of anhedonia may be a consequence of substance use (48).”
From Mobile intervention for individuals with psychosis, dual disorders, and their common comorbidities: A literature review (2019) · cites this paper as [48]
In the citing paper
“The emotional processes observed in substance use disorders suggest that the search for stimulation through the consumption of substances would aim to lessen the experience of anhedonia, an often-reported state in this population (47, 48).”
From Mobile intervention for individuals with psychosis, dual disorders, and their common comorbidities: A literature review (2019) · cites this paper as [48]
In the citing paper
“Deficits in reward processing are found in MDD (Admon and Pizzagalli, 2015), substance use disorders (Garfield et al., 2014; Tobler et al., 2016), posttraumatic stress disorder (PTSD) (Kalebasi et al., 2015), schizophrenia (McCarthy et al., 2016), and ADHD (van Hulst et al., 2016).”
From The effects of early life stress on reward processing (2018) · cites this paper as Garfield et al., 2014
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,168
Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Dufour, M. C., Compton, W., Pickering, R. P., & Kaplan, K. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.807 · Cited by 2,889
Negative Symptoms in Schizophrenia: Definition and Reliability
Andreasen, N. C. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290070020005 · Cited by 2,247
A scale for the assessment of hedonic tone the Snaith-Hamilton pleasure scale
Snaith, R. P., Hamilton, M., Morley, S., Humayan, A., Hargreaves, D., & Trigwell, P. (1995) · British Journal of Psychiatry · doi:10.1192/bjp.167.1.99 · Cited by 1,778
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579
Bunney, W. E., Hippius, H., Laakmann, G., & Schmauß, M. (1990) · Springer eBooks · doi:10.1007/978-3-642-74034-3 · Cited by 1,523
Scales for physical and social anhedonia.
Chapman, L. J., Chapman, J. P., & Raulin, M. L. (1976) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.85.4.374 · Cited by 1,234
Dramatic decreases in brain reward function during nicotine withdrawal
Epping-Jordan, M. P., Watkins, S. S., Koob, G. F., & Markou, A. (1998) · Nature · doi:10.1038/30001 · Cited by 674
Postcocaine anhedonia. An animal model of cocaine withdrawal.
Markou, A., & Koob, G. F. (1991) · PubMed · Cited by 505
The nature, time course and severity of methamphetamine withdrawal
McGregor, C., Srisurapanont, M., Jittiwutikarn, J., Laobhripatr, S., Wongtan, T., & White, J. M. (2005) · Addiction · doi:10.1111/j.1360-0443.2005.01160.x · Cited by 458 · cited 5×
“, 2008), methamphetamine (McGregor et al., 2005) and opioid (Stevens et al.”
BackgroundMethodInfluentialCannabis Abuse as a Risk Factor for Depressive Symptoms
BOVASSO, G. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2033 · Cited by 455
Assessing Anhedonia in Psychiatric Patients
FAWCETT, J. A. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790010081010 · Cited by 419
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
Ahmed, S. H., Kenny, P. J., Koob, G. F., & Markou, A. (2002) · Nature Neuroscience · doi:10.1038/nn872 · Cited by 389
Franken, I. H. A., Rassin, E., & Muris, P. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.08.020 · Cited by 373
Decreased brain reward produced by ethanol withdrawal
Schulteis, G., Markou, A., Cole, M., & Koob, G. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5880 · Cited by 345
Anhedonia and Substance Dependence: Clinical Correlates and Treatment Options
Hatzigiakoumis, D. S., Martinotti, G., Giannantonio, M. D., & Janiri, L. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00010 · Cited by 245
Methamphetamine Abstinence Syndrome: Preliminary Findings
Newton, T. F., Kalechstein, A. D., Duran, S., Vansluis, N., & Ling, W. W. (2004) · American Journal on Addictions · doi:10.1080/10550490490459915 · Cited by 220
Measuring hedonic capacity in depression: A psychometric analysis of three anhedonia scales
Leventhal, A. M., Chasson, G. S., Tapia, E., Miller, E. K., & Pettit, J. W. (2006) · Journal of Clinical Psychology · doi:10.1002/jclp.20327 · Cited by 211
Withdrawal from chronic amphetamine induces Depressive-Like behavioral effects in rodents
Cryan, J. F., Hoyer, D., & Markou, A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01730-4 · Cited by 199
Affect dysregulation in cannabis abusers
Dorard, G., Berthoz, S., Phan, O., Corcos, M., & Bungener, C. (2008) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-007-0663-7 · Cited by 181
Anhedonia: a neglected symptom of psychopathology
Snaith, P. R. (1993) · Psychological Medicine · doi:10.1017/s0033291700026428 · Cited by 179
Janiri, L., Martinotti, G., Dario, T., Reina, D., Paparello, F., Pozzi, G., Addolorato, G., Giannantonio, M. D., & Risio, S. D. (2005) · Neuropsychobiology · doi:10.1159/000086176 · Cited by 150
Alcohol Protracted Withdrawal Syndrome: The Role of Anhedonia
Martinotti, G., Nicola, M. D., Reina, D., Andreoli, S., Focà, F., Cunniff, A. L., Tonioni, F., Bria, P., & Janiri, L. (2008) · Substance Use & Misuse · doi:10.1080/10826080701202429 · Cited by 142
Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model
Powell, J. E., Dawkins, L., & Davis, R. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01208-2 · Cited by 137
Martinotti, G., Cloninger, C. R., & Janiri, L. (2008) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990701877078 · Cited by 116 · cited 11×
“…tobacco smokers attempting to quit (Cook et al., 2010; Leventhal et al., 2009), and positively correlates with drug cravings in detoxified alcohol(Martinotti et al., 2008a, 2008b) and opioid-dependent (Janiri et al., 2005; Martinotti et al., 2008a) users, as well as recently abstinent tobacco…”
BackgroundMethodResultInfluentialWithdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds
Wise, R. A., & Munn, E. M. (1995) · Psychopharmacology · doi:10.1007/bf02245178 · Cited by 115
Zijlstra, F., Booij, J., van den Brink, W., & Franken, I. H. A. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.11.002 · Cited by 109
Leventhal, A. M., Brightman, M., Ameringer, K. J., Greenberg, J. B., Mickens, L., Ray, L. A., Sun, P., & Sussman, S. Y. (2010) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0021964 · Cited by 109
Paterson, N. E., Myers, C., & Markou, A. (2000) · Psychopharmacology · doi:10.1007/s002130000559 · Cited by 103
Martinotti, G., Andreoli, S., Reina, D., Nicola, M. D., Ortolani, I., Tedeschi, D., Fanella, F., Pozzi, G., Iannoni, E., D'Iddio, S., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.01.013 · Cited by 101
Schmidt, K., Nolte-Zenker, B., Patzer, J., Bauer, M., Schmidt, L. G., & Heinz, A. (2001) · Pharmacopsychiatry · doi:10.1055/s-2001-15184 · Cited by 97
A double-blind placebo controlled experimental study of nicotine: I—effects on incentive motivation
Dawkins, L., Powell, J. H., West, R., Powell, J., & Pickering, A. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0588-8 · Cited by 97
Skjei, K. L., & Markou, A. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1414-1 · Cited by 93
Lin, D. C.-H., Koob, G. F., & Markou, A. (1999) · Psychopharmacology · doi:10.1007/s002130051060 · Cited by 92
Relations between anhedonia and smoking motivation
Leventhal, A. M., Waters, A. J., Kahler, C. W., Ray, L. A., & Sussman, S. Y. (2009) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntp098 · Cited by 92
Hedonic capacity, cigarette craving, and diminished positive mood
Cook, J. W., Spring, B. J., McChargue, D. E., & Hedeker, D. (2004) · Nicotine & Tobacco Research · doi:10.1080/14622200310001656849 · Cited by 89
Effects of anhedonia on days to relapse among smokers with a history of depression: A brief report
Cook, J. W., Spring, B. J., McChargue, D. E., & Doran, N. (2010) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq118 · Cited by 89
Animal models and treatments for addiction and depression co-morbidity
Paterson, N. E., & Markou, A. (2007) · Neurotoxicity Research · doi:10.1007/bf03033479 · Cited by 85
Stevens, A., Peschk, I., & Schwarz, J. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.01823.x · Cited by 82
Kenny, P. J., Polis, I. Y., Koob, G. F., & Markou, A. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02443.x · Cited by 80
Influence of nicotine on positive affect in anhedonic smokers
Cook, J. W., Spring, B. J., & McChargue, D. E. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0688-5 · Cited by 80
Kwapil, T. R. (1996) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.105.1.114 · Cited by 79
Cognitive and psychological correlates of smoking abstinence, and predictors of successful cessation
Powell, J. H., Pickering, A. D., Dawkins, L., West, R., & Powell, J. F. (2004) · Addictive Behaviors · doi:10.1016/j.addbeh.2004.06.006 · Cited by 74
Dawkins, L., Powell, J. H., Pickering, A. D., Powell, J. F., & West, R. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02522.x · Cited by 74
Anhedonia and relapse in alcoholism
Marra, D., Warot, D., Payan, C., Hispard, É., Dally, S., & Puech, A. J. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00054-7 · Cited by 73
Spielewoy, C., & Markou, A. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300124 · Cited by 73
Predictors of psychosis severity in individuals with primary stimulant addictions
Lichlyter, B., Purdon, S. E., & Tibbo, P. G. (2010) · Addictive Behaviors · doi:10.1016/j.addbeh.2010.08.019 · Cited by 70
The Assessment of Post-Detoxification Anhedonia: Influence of Clinical and Psychosocial Variables
Pozzi, G., Martinotti, G., Reina, D., Dario, T., Frustaci, A., Janiri, L., & Bria, P. (2008) · Substance Use & Misuse · doi:10.1080/00952990701202954 · Cited by 65
Zhornitsky, S., Rizkallah, É., Pampoulova, T., Chiasson, J., Lipp, O., Stip, É., & Potvin, S. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.07.046 · Cited by 51
The relationship between reward-based learning and nicotine dependence in smokers with schizophrenia
AhnAllen, C. G., Liverant, G. I., Gregor, K. L., Kamholz, B. W., Levitt, J. J., Gulliver, S. B., Pizzagalli, D. A., Koneru, V. K., & Kaplan, G. B. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.09.011 · Cited by 42
Anhedonia: A Construct Validation Approach
Peterson, C. A., & Knudson, R. M. (1983) · Journal of Personality Assessment · doi:10.1207/s15327752jpa4705_16 · Cited by 40
Carton, S., Houezec, J. L., Lagrue, G., & Jouvent, R. (2000) · Addictive Behaviors · doi:10.1016/s0306-4603(00)00067-8 · Cited by 29
Martinotti, G., Reina, D., Nicola, M. D., Andreoli, S., Tedeschi, D., Ortolani, I., Pozzi, G., Iannoni, E., D'Iddio, S., & Janiri, L. (2010) · Alcohol and Alcoholism · doi:10.1093/alcalc/agq039 · Cited by 26
Anhedonia predicts altered processing of happy faces in abstinent cigarette smokers
Leventhal, A. M., Munafo, M. R., Tidey, J. W., Sussman, S. Y., Monterosso, J. R., Sun, P., & Kahler, C. W. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2649-5 · Cited by 25
D’Haenen, H. (1996) · European Psychiatry · doi:10.1016/s0924-9338(97)81056-5 · Cited by 24
Responsiveness to reward following cessation of smoking
Snuggs, S. J., & Hájek, P. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2874-y · Cited by 23
MMPI correlates of social and physical anhedonia.
Penk, W. E., Carpenter, J., & Rylee, K. (1979) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.47.6.1046 · Cited by 20
Dawes, G. M., Sitharthan, T., Conigrave, K. M., Phung, N., & Weltman, M. (2011) · Journal of Substance Use · doi:10.3109/14659891.2010.499491 · Cited by 14
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Alcohol use disorder relapse factors: A systematic review.
Sliedrecht, W., de Waart, R., Witkiewitz, K., & Roozen, H. G. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.05.038 · Cited by 358
Secondary negative symptoms — A review of mechanisms, assessment and treatment
Kirschner, M., Aleman, A., & Kaiser, S. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.05.003 · Cited by 215
The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192
“, 2016), substance use disorder (CastellanosRyan et al., 2011; Garfield et al., 2014), and conduct disorder (Rubia et al.”
BackgroundLawn, W., Freeman, T. P., Pope, R. A., Joye, A., Harvey, L. A., Hindocha, C., Mokrysz, C., Moss, A., Wall, M. B., Bloomfield, M., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4383-x · Cited by 182
Metadata
- Authors
- Garfield, J. B. B., Lubman, D. I., & Yücel, M.
- Affiliations
- Eastern Health (AU)
- Monash University (AU)
- Venue
- Australian & New Zealand Journal of Psychiatry
- Publisher
- SAGE Publications
- Published
- 2013-11-22
- Volume
- 48
- Issue
- 1
- Pages
- 36-51
- ISSN
- 0004-8674 (ISSN-L)
- 1440-1614
- OpenAlex
- W2148297013
- Cited by
- 213
- References
- 61
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 11 · 2023: 22 · 2022: 11 · 2021: 18 · 2020: 58 · 2019: 13 · 2018: 14 · 2017: 3 · 2016: 12 · 2015: 6 · 2013: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian & New Zealand Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anhedonia, substance use disorders, substance dependence, abstinence, relapse, drug craving, drugs of abuse, therapeutic interventions
- MeSH terms
- Humans, Substance-Related Disorders, Anhedonia
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