Cited by 614Treatment of Major DepressionBipolar Disorder and TreatmentClinical practice guidelines implementation

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The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders

Malhi, Gin S, Bell, Erica, Bassett, Darryl, Boyce, Philip, Bryant, Richard, Hazell, Philip, Hopwood, Malcolm, Lyndon, Bill, Mulder, Roger, Porter, Richard, Singh, Ajeet B, Murray, Greg·2021·Australian & New Zealand Journal of Psychiatry

DOI 10.1177/0004867420979353

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Abstract

Objectives: To provide advice and guidance regarding the management of mood disorders, derived from scientific evidence and supplemented by expert clinical consensus to formulate s that maximise clinical utility. Methods: Articles and information sourced from search engines including PubMed, EMBASE, MEDLINE, PsycINFO and Google Scholar were supplemented by literature known to the mood disorders committee (e.g. books, book chapters and government reports) and from published depression and bipolar disorder guidelines. Relevant information was appraised and discussed in detail by members of the mood disorders committee, with a view to formulating and developing consensus-based recommendations and clinical guidance. The guidelines were subjected to rigorous consultation and external review involving: expert and clinical advisors, key stakeholders, professional bodies and specialist groups with interest in mood disorders. Results: The Royal Australian and New Zealand College of Psychiatrists mood disorders clinical practice guidelines 2020 (MDcpg 2020 ) provide up-to-date guidance regarding the management of mood disorders that is informed by evidence and clinical experience. The guideline is intended for clinical use by psychiatrists, psychologists, primary care physicians and others with an interest in mental health care. Conclusion: The MDcpg 2020 builds on the previous 2015 guidelines and maintains its joint focus on both depressive and bipolar disorders. It provides up-to-date recommendations and guidance within an evidence-based framework, supplemented by expert clinical consensus. Mood disorders committee: Gin S Malhi (Chair), Erica Bell, Darryl Bassett, Philip Boyce, Richard Bryant, Philip Hazell, Malcolm Hopwood, Bill Lyndon, Roger Mulder, Richard Porter, Ajeet B Singh and Greg Murray.

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Background
Randomised control trial indicates micronutrient supplementation may support a more robust maternal microbiome for women with antenatal depression during pregnancy
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“2005), and the general recommendation to stabilize daily rhythms in mood disorder treatment guidelines (Malhi et al. 2021).”
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Acute effects of mind-body practices and exercise in depressed inpatients: A randomized clinical trial
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Alterations in gut microbiota caused by major depressive disorder or a low FODMAP diet and where they overlap
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Profiling rTMS: A critical response
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Psychodynamic therapy of depression
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“Some references given by Malhi et al. (2021) need correction (see Online Supplement #9).”
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PAX-D: study protocol for a randomised placebo-controlled trial evaluating the efficacy and mechanism of pramipexole as add-on treatment for people with treatment resistant depression
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“Additionally, many pharmacologic treatments are available for both BD and PTSD (Phoenix Australia - Centre for Posttraumatic Mental Health, n.d.; Malhi et al., 2015, 2021; National Institute for Health and Care Excellence, 2020).”
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The association between neuroendocrine/glucose metabolism and clinical outcomes and disease course in different clinical states of bipolar disorders
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“The 2020 RANZCP guidelines (Malhi et al., 2021) provided one (ACE) model, partitioning mood disorders into ‘activity’, ‘cognition’ and ‘emotion’ (ACE-based) states, and provided one model for identifying phenotypes.”
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Integrating Physical Activity Into Routine Psychiatric Care
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“…as the American Psychological Association (APA), the Royal Australian and New Zealand College of Psychiatrists Clinical Practice (PANZCP), the United Kingdom National Institute for Health and Care Excellence (NICE), and the United States Preventive Services Task Force (USPSTF) [1, 2, 5, 6, 37, 38].”
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“This is despite improvements in mental health treatment, new models of recovery-focused care and a shift towards earlier intervention (e.g., Malhi et al., 2021).”
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“Further, (4) it is likely that some of the children diagnosed as having PBD do not eventually develop ABCD and they may instead progress to other conditions.”
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“Australian & New Zealand Journal of Psychiatry, 56(6) released clinical practice guidelines (CPG) for the treatment of depression, ignore psychoanalysis and the psychodynamic therapies based on it (Malhi et al., 2021).”
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NICE guideline for depression ranks short‐term psychodynamic psychotherapy ( STTP )
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“44,72 Notably, we included a recent study that analyzed 43 RCTs on tDCS for substance abuse, showing good effectiveness for various substances but poorer results for alcohol addiction.”
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Efficacy, User Engagement, and Acceptability of Cognitive Behavioral Therapy–Oriented Psychological Chatbots for Adults With Depressive and/or Anxiety Symptoms: Systematic Review and Meta-Analysis of Randomized Controlled Trials
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Practices, knowledge, and attitudes about lithium treatment: Results of online surveys completed by clinicians and lithium-treated patients
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Mostly harmless? Clinical practice guidelines need further consideration of psychotherapy adverse effects
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Thing one and thing two 1 : What ‘Doctors use’ to doctor you?
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“Professor Gordon Parker concludes his critique of the recently published clinical practice guidelines for mood disorders (MDcpg2020) (Malhi et al., 2021) with an amusing quip – ‘The dis-”
BackgroundInfluentialSelf-citation
A neural network approach to optimising treatments for depression using data from specialist and community psychiatric services in Australia, New Zealand and Japan
Cousins, A., Nakano, L., Schofield, E. C., & Kabaila, R. (2022) · Neural Computing and Applications · doi:10.1007/s00521-021-06710-3 · Cited by 7
“SSRIs are likely to be the most prescribed medication class due to the existing treatment guidelines in Japan [119], New Zealand and Australia [120] recommending them as ﬁrst-line medications.”
Background
Differential Response to Three Antidepressants in Patients with Major Depressive Episode Who Suffered Covid-19-Related Trauma
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“In Australia, guidelines recommend medication for 6 – 12 months for a single episode of major depression (Malhi et al .”
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“Incorporating these interventions into cancer care routines could enhance long-term health and reduce mortality risk, making them critical components of survivorship care [62].”
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Wallis, K. A., King, A., & Moncrieff, J. (2025) · The Medical Journal of Australia · doi:10.5694/mja2.52645 · Cited by 6
“32 The lack of diversity in the RANZCP guidelines panel, which was overwhelmingly male, is relevant, noting that women are prescribed antidepressants at a higher rate than men and that guideline authors should represent consumer demographics.”

Authors: Malhi, G. S., Bell, E., Bassett, D., Boyce, P., Bryant, R., Hazell, P., Hopwood, M., Lyndon, B., Mulder, R., Porter, R., Singh, A. B., & Murray, G.
Affiliations: The University of Sydney (AU)
Consultant Psychiatrist, Perth, WA, Australia
UNSW Sydney (AU)
The University of Melbourne (AU)
University of Otago (NZ)
Deakin University (AU)
Swinburne University of Technology (AU)
Corresponding author: Malhi, Gin S
ORCID: Malhi, Gin S
Bell, Erica
Boyce, Philip
Bryant, Richard
Hazell, Philip
Hopwood, Malcolm
Mulder, Roger
Porter, Richard
Singh, Ajeet B
Murray, Greg
Venue: Australian & New Zealand Journal of Psychiatry
Publisher: SAGE Publications
Published: 2020-12-22
Volume: 55
Issue: 1
Pages: 7-117
ISSN: 0004-8674 (ISSN-L)
1440-1614
DOI: 10.1177/0004867420979353
OpenAlex: W3145708260
Semantic Scholar: aebe450498c0d007898716e02f680b40b9ae3f78
Cited by: 614
References: 648
Citations by year: 2026: 115 · 2025: 131 · 2024: 101 · 2023: 117 · 2022: 82 · 2021: 65 · 2020: 3
FWCI: 40.01
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Australian & New Zealand Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Funders: RANZCP
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
Keywords: mood disorders, depression, bipolar disorder, depression treatment, bipolar disorder management
MeSH terms: Australia, Humans, New Zealand, Psychiatry, Societies, Medical, Practice Guidelines as Topic, Mood Disorders

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The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders

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