Specific Lactobacillus/Mutans Streptococcus Co-aggregation
Abstract
Selective interaction of mutans streptococci with benign bacteria could present an opportunity for their removal from the mouth without disruption of other oral flora. This study was conducted to find probiotic lactobacilli that could specifically co-aggregate in vitro with mutans streptococci, but not with other plaque commensals. A search of 624 lactobacilli among a large culture library revealed 6 strains, all classifiable as L. paracasei or L. rhamnosus, which met this criterion. Such novel, specific co-aggregation, however, was not a general characteristic of these species or the genus Lactobacillus. The co-aggregation by these specific lactobacilli was characterized as heat treatment (autoclaving)- and protease-resistant, lectin-independent, not inactivated by sugar substitutes, operational over a wide pH range, unaffected by whole saliva, but calcium-dependent. It is thus seen to present a potential strategy for in vivo alteration of plaque biofilm and caries.
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Selected bacterial strains belonging to the genera Lactobacillus or Bifidobacterium have demonstrated a capacity to aggregate with oral pathogens such as Fusobacterium nucleatum or Streptococcus mutans in vitro and in vivo.
“Selected bacterial strains belonging to the genera Lactobacillus or Bifidobacterium have been applied as probiotics and have demonstrated a capacity to aggregate with oral pathogens, such as Fusobacterium nucleatum or Streptococcus mutans, in vitro [8–10] and in vivo [11].”
From Coaggregation of oral pathogens by postbiotic lactobacilli (2025) · cites this paper as [11]
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“Selected bacterial strains belonging to the genera Lactobacillus or Bifidobacterium have been applied as probiotics and have demonstrated a capacity to aggregate with oral pathogens, such as Fusobacterium nucleatum or Streptococcus mutans , in vitro [8–10] and in vivo [11].”
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- Authors
- Lang, C., Böttner, M., Holz, C., Veen, M., Ryser, M., Reindl, A., Pompejus, M., & Tanzer, J. M.
- Affiliations
- BASF (Germany) (DE)
- ORGANOBALANCE GmbH, Gustav-Meyer-Allee 25, D–13355 Berlin, Germany;
- ORCID
- Veen, M.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2009-12-30
- Volume
- 89
- Issue
- 2
- Pages
- 175-179
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2148070607
- Cited by
- 83
- References
- 17
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 13 · 2021: 1 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 8 · 2013: 8 · 2012: 3
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
- Keywords
- Lactobacillus, mutans streptococci, probiotics, Lactobacillus paracasei, Lactobacillus rhamnosus, dental plaque, dental caries, calcium-dependent adhesion, oral commensals
- MeSH terms
- Adult, Bacterial Adhesion, Dental Plaque, Hot Temperature, Humans, Hydrogen-Ion Concentration, Lactobacillus, Peptide Hydrolases, Saliva, Streptococcus mutans, Sucrose, Biofilms, Probiotics, Microbial Interactions
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