The DOI matches its Crossref record, with a small difference in title or year; 65 of the 65 references it cites were found in a registry or an index.
Oral Microbiome Metabolism: From “Who Are They?” to “What Are They Doing?”
Abstract
Recent advances in molecular biology have facilitated analyses of the oral microbiome (“Who are they?”); however, its functions (e.g., metabolic activities) are poorly understood (“What are they doing?”). This review aims to summarize our current understanding of the metabolism of the oral microbiome. Saccharolytic bacteria—including Streptococcus, Actinomyces, and Lactobacillus species—degrade carbohydrates into organic acids via the Embden-Meyerhof-Parnas pathway and several of its branch pathways, resulting in dental caries, while alkalization and acid neutralization via the arginine deiminase system, urease, and so on, counteract acidification. Proteolytic/amino acid–degrading bacteria, including Prevotella and Porphyromonas species, break down proteins and peptides into amino acids and degrade them further via specific pathways to produce short-chain fatty acids, ammonia, sulfur compounds, and indole/skatole, which act as virulent and modifying factors in periodontitis and oral malodor. Furthermore, it is suggested that ethanol-derived acetaldehyde can cause oral cancer, while nitrate-derived nitrite can aid caries prevention and systemic health. Microbial metabolic activity is influenced by the oral environment; however, it can also modify the oral environment, enhance the pathogenicity of bacteria, and induce microbial selection to create more pathogenic microbiome. Taking a metabolomic approach to analyzing the oral microbiome is crucial to improving our understanding of the functions of the oral microbiome.
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In the citing paper
“These bacteria can cause demineralization of dental enamel and development of carious lesions, and on the other hand, promote bacterial acidogenicity and acidification by increasing cell membrane permeability to protons, induction of H+- ATPase activity, and stimulation of metabolic pathways involved in acid neutralization and alkalinization [83].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“They are broken down into peptides and amino acids (aspartate, serine, and cysteine) through the action of host proteases and peptidases [83].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“However, the degradation of protein substrates plays an important role in the pathogenesis of the periodontal disease [83].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“Fermentation of amino acids neutralizes acidic environments, creating a more favorable atmosphere for the growth of other periodontitis’ pathogens [83].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“Amino acids are fermented to generate short-chain fatty acids, such as propionate, butyrate, succinate, acetate, and formate [83].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“The increased depth of the gingival pocket and the increased production of gingival crevicular fluid induces an increase in bacteria involved in protein degradation.”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“Over 250 species from the oral cavity have been isolated in culture and characterized, including several key pathogens, such as Streptococcus mutans, Porphyromonas gingivalis, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans, involved in the etiology of dental caries and periodontal disease.7, 8, 9”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Moreover, processed carbohydrate consumption has been associated with increased incidence of periodontal disease.8, 24, 26, 181, 188, 251”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Digestion of starch is initiated in the oral cavity through the action of salivary alpha‐amylase that catalyzes the hydrolysis of starch by cleaving α‐1,4‐glycosidic linkages to yield smaller saccharide moieties, such as maltose, maltotriose, and alpha‐limit dextrins,279, 280 which can be utilized by early biofilm colonizers as well as by some periodontal pathogens.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Such processes encourage the outgrowth of acidogenic bacteria, such as S mutans, lactobacilli, and bifidobacteria that enhance the carcinogenicity of dental plaque.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Pathways in which sugar is metabolized are also shared among some periodontal pathogens, such as Fusobacterium and Prevotella, which can likewise cause acidification.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“During the development of periodontal disease, protein‐rich and neutral‐alkaline environmental pressures promote the outgrowth of periodontal pathogens.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Inflammatory processes promote the outgrowth of inflammophilic bacteria via the production of proteinaceous substrates resulting from tissue destruction.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Amino acids are fermented to produce short‐chain fatty acids, such as propionate, butyrate, succinate, acetate, and formate.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Amino acid fermentation neutralizes acidic environments, making the environment more favorable for outgrowth of additional periodontitis‐associated pathogens.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Deepening of the gingival crevice and increased production of gingival crevicular fluid increases the relative abundance of protein‐degrading bacteria.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“For instance, saccharolytic (sugar metabolizing) bacteria such as Streptococcus and Lactobacillus have been associated with dental caries, while proteolytic (protein metabolizing) bacteria such as Prevotella and Porphyromonas have been associated with periodontitis and halitosis[183].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [183]
In the citing paper
“Yet, individual bacteria do not act in a vacuum, but rather function in interdependent microbial communities whose conglomerate activity can impact oral and systemic health[183,188,189].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [183]
Citations
Cites
Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · cited 2×
“It was recently reported that nitrite contributes to systemic health by stimulating the circulatory system (Lundberg et al. 2008).”
BackgroundMicrobial ecology of dental plaque and its significance in health and disease
Marsh, P. D. (1994) · Advances in Dental Research · doi:10.1177/08959374940080022001 · Cited by 1,278
The Role of Bacteria in the Caries Process
Takahashi, N., & Nyvad, B. (2010) · Journal of Dental Research · doi:10.1177/0022034510379602 · Cited by 1,250
Self-citationGottschalk, G. (1986) · Springer series in microbiology · doi:10.1007/978-1-4612-1072-6 · Cited by 695
Caries Ecology Revisited: Microbial Dynamics and the Caries Process
Takahashi, N., & Nyvad, B. (2008) · Caries Research · doi:10.1159/000159604 · Cited by 598
Self-citationThe formation of hydrogen sulfide and methyl mercaptan by oral bacteria
Persson, S., Edlund, M., Claesson, R., & Carlsson, J. (1990) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.1990.tb00645.x · Cited by 514
Alkali production by oral bacteria and protection against dental caries
Burne, R. A., & Marquis, R. E. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09393.x · Cited by 400
Complete Genome Sequence of the Oral Pathogenic Bacterium Porphyromonas gingivalis Strain W83
Nelson, K. E., Fleischmann, R. D., DeBoy, R. T., Paulsen, I. T., Fouts, D. E., Eisen, J. A., Daugherty, S. C., Dodson, R. J., Durkin, A. S., Gwinn, M. L., et al. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.18.5591-5601.2003 · Cited by 389
THE BACTERIAL PHOSPHOENOL-PYRUVATE: GLYCOSE PHOSPHOTRANSFERASE SYSTEM
Meadow, N. D., Fox, D. K., & Roseman, S. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.002433 · Cited by 386
Research works printed but not linked: 3
- Abbe K, 1991, Proc Finn Dent Soc, 87, 477
- Carlsson J, 1986, Textbook of cariology, 74
- de Boever EH, 1994, J Clin Dent, 4, 114
Cited by
Sorted by citations
Items 101–200 of 487
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Karygianni, L., Attin, T., & Thurnheer, T. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9040983 · Cited by 53
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Self-citationFoo, L. H., Balan, P., Pang, L. M., Laine, M. L., & Seneviratne, C. J. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1888867 · Cited by 52
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BackgroundInfluentialMucin glycans drive oral microbial community composition and function
Wu, C. M., Wheeler, K. M., Cárcamo‐Oyarce, G., Aoki, K., McShane, A. E., Datta, S. S., Welch, J. L. M., Tiemeyer, M., Griffen, A. L., & Ribbeck, K. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00378-4 · Cited by 46
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Feng, Y., Licandro, H., Martin, C., Septier, C., Zhao, M., Neyraud, E., & Morzel, M. (2018) · BioMed Research International · doi:10.1155/2018/2838052 · Cited by 49
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Dahlén, G., Fejerskov, O., & Manji, F. (2020) · BMC Oral Health · doi:10.1186/s12903-020-01221-4 · Cited by 45
Fakhruddin, K. S., Egusa, H., Ngo, H. C., Panduwawala, C., Pesee, S., & Samaranayake, L. P. (2020) · BMC Oral Health · doi:10.1186/s12903-020-01133-3 · Cited by 46
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Lyu, J., Chen, S., Nie, Y., Xu, Y., & Tang, K. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128957 · Cited by 46
de Souza, B. M., Neto, C. F., Salomão, P. M. A., de Vasconcelos, L. R. S. M., de Andrade, F. B., & Magalhães, A. C. (2018) · Journal of Applied Oral Science · doi:10.1590/1678-7757-2017-0304 · Cited by 43
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Maki, K. A., Ganesan, S. M., Meeks, B., Farmer, N. M., Kazmi, N., Barb, J. J., Joseph, P. V., & Wallen, G. R. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03785-x · Cited by 42
Yang, Y. L., Mao, M., Lei, L., Li, M., Yin, J., Ma, X., Tao, X., Yang, Y., & Hu, T. (2019) · Molecular Oral Microbiology · doi:10.1111/omi.12253 · Cited by 45
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“These organisms were chosen because they are known to be associated with oral diseases involving either saccharolytic or proteolytic activity, namely dental carries and periodontitis ( Wade, 2013 ; Takahashi, 2015 ).”
BackgroundMethodCan oral health and oral‐derived biospecimens predict progression of dementia?
Orr, M. E., Reveles, K. R., Yeh, C., Young, E. H., & Han, X. (2019) · Oral Diseases · doi:10.1111/odi.13201 · Cited by 45
“For example, the oral and gut microbiomes aid in the metabolism of short‐chain fatty acids, organic acids and vitamins, and transforming bile salts, lipids, and amino acids (Canfora, Jocken, & Blaak, 2015; Takahashi, 2015).”
BackgroundLin, S., Xu, Z., Liu, Y., Yang, G., Qi, X., Huang, Y., Zhou, M., & Jiang, X. (2025) · ACS Nano · doi:10.1021/acsnano.4c14305 · Cited by 42
Oral Microbiome Profile of the US Population
Chaturvedi, A. K., Vogtmann, E., Shi, J., Yano, Y., Blaser, M. J., Bokulich, N. A., Caporaso, J. G., Gillison, M. L., Graubard, B. I., Hua, X., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.8283 · Cited by 49
Microbiome and metabolome associated with white spot lesions in patients treated with clear aligners
Song, Z., Fang, S., Guo, T., Wen, Y., Liu, Q., & Jin, Z. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1119616 · Cited by 41
“These metabolites can be used to assess the caries-causing potential of the oral microbiota and to establish the connection between the oral microbiota and diseases (Takahashi, 2015).”
BackgroundPeters, B. A., McCullough, M. L., Purdue, M. P., Freedman, N. D., Um, C. Y., Gapstur, S. M., Hayes, R. B., & Ahn, J. (2018) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-0184 · Cited by 41
Thänert, R., Itzek, A., Hoßmann, J., Hamisch, D., Madsen, M. B., Hyldegaard, O., Skrede, S., Bruun, T., Norrby‐Teglund, A., INFECT study group, et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11722-8 · Cited by 42
Kim, S., Kim, H., Song, Y., Lee, H. A., Kim, S., & Chung, J. (2021) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13516 · Cited by 40
Espinosa-Cristóbal, L. F., Holguín-Meráz, C., Zaragoza‐Contreras, E. A., Martínez-Martínez, R. E., Donohué-Cornejo, A., Loyola-Rodríguez, J. P., Cuevas‐González, J. C., & López, S. Y. R. (2019) · Journal of Nanomaterials · doi:10.1155/2019/3205971 · Cited by 39
“gordonii, Lactobacillus, and Bifidobacteria are commonly found in this demineralization process [15, 19, 20, 60].”
BackgroundIntraoral Microbial Metabolism and Association with Host Taste Perception
Gardner, A., So, P., & Carpenter, G. H. (2020) · Journal of Dental Research · doi:10.1177/0022034520917142 · Cited by 39
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Liu, H., Tan, L., Fu, G., Chen, L., & Tan, H. (2022) · Medicina · doi:10.3390/medicina58060771 · Cited by 39
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Pietrobon, G., Tagliabue, M., Stringa, L. M., Berardinis, R. D., Chu, F., Zocchi, J., Carlotto, E., Chiocca, S., & Ansarin, M. (2021) · Cancers · doi:10.3390/cancers13174439 · Cited by 36
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Rossoni, R. D., Ribeiro, F. D. C., dos Santos, H. F. S., dos Santos, J. D., Oliveira, N. D. S., Dutra, M. T. D. S., de Lapena, S. A. B., & Junqueira, J. C. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.03.002 · Cited by 36
Antimicrobial effects of a stannous fluoride toothpaste in distinct oral microenvironments
Haraszthy, V. I., Raylae, C. C., & Sreenivasan, P. K. (2019) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2019.01.007 · Cited by 34
Ahrens, A. P., Sanchez-Padilla, D. E., Drew, J. C., Oli, M. W., Roesch, L. F. W., & Triplett, E. W. (2022) · Scientific Reports · doi:10.1038/s41598-022-18020-2 · Cited by 35
Ding, J., Tan, L., Wu, L., Li, J., Zhang, Y., Shen, Z., Zhang, C., Zhao, C., & Gao, L. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00669-y · Cited by 36
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Henne, K., Gunesch, A.-P., Walther, C., Meyer‐Lueckel, H., Conrads, G., & Esteves‐Oliveira, M. (2016) · Caries Research · doi:10.1159/000448485 · Cited by 33
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Chattopadhyay, I., Lu, W., Manikam, R., Malarvili, M. B., Ambati, R. R., & Gundamaraju, R. (2022) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2022.2102877 · Cited by 37
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Basilicata, M., Pieri, M., Marrone, G., Nicolai, E., Lauro, M. D., Paolino, V., Tomassetti, F., Vivarini, I., Bollero, P., Bernardini, S., et al. (2023) · Metabolites · doi:10.3390/metabo13080889 · Cited by 40
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BackgroundXi, S., Dong, X., Lin, Q., Li, X., Ma, J., Zan, F., Biswal, B. K., Awasthi, M. K., Wang, Z., Chen, G., et al. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.128364 · Cited by 32
Neyraud, E., & Morzel, M. (2018) · Journal of Texture Studies · doi:10.1111/jtxs.12363 · Cited by 32
Yama, K., Nishimoto, Y., Kumagai, K., Jo, R., Harada, M., Maruyama, Y., Aita, Y., Fujii, N., Inokuchi, T., Kawamata, R., et al. (2023) · mSystems · doi:10.1128/msystems.00683-23 · Cited by 29
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Chattopadhyay, S., Malayil, L., Chopyk, J., Smyth, E. M., Kulkarni, P., Raspanti, G., Thomas, S. B., Sapkota, A., Mongodin, E. F., & Sapkota, A. R. (2024) · Scientific Reports · doi:10.1038/s41598-024-60730-2 · Cited by 40
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Duarte, D., Castro, B., Pereira, J. L., Marques, J. R. O. F., Costa, A. L., & Gil, A. M. (2020) · Metabolites · doi:10.3390/metabo10120515 · Cited by 34
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Doğramacı, E. J., & Brennan, D. S. (2019) · Community Dentistry And Oral Epidemiology · doi:10.1111/cdoe.12446 · Cited by 31
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Li, B., Zhou, X., Zhou, X., Wu, P., Li, M., Feng, M., Peng, X., Ren, B., & Cheng, L. (2017) · FEMS Microbiology Letters · doi:10.1093/femsle/fnx123 · Cited by 30
“The widely accepted ecological hypothesis of cariogenicity considers dental caries as a result of microecological dysbiosis in dental biofilm (Marsh 2003; Takahashi 2015; Teng et al. 2015; Johansson et al. 2016).”
BackgroundChen, X., Hu, X., Fang, J., Sun, X.-Y., Zhu, F.-F., Sun, Y., & Wang, Y.-Y. (2021) · International Journal of Food Science and Nutrition · doi:10.1080/09637486.2021.1913102 · Cited by 16
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LaMonte, M. J., Genco, R. J., Buck, M. J., McSkimming, D. I., Li, L., Hovey, K. M., Andrews, C., Zheng, W., Sun, Y., Millen, A. E., et al. (2019) · BMC Oral Health · doi:10.1186/s12903-019-0906-2 · Cited by 30
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Benjamin, W. J., Wang, K., Zarins, K. R., Bellile, E. L., Blostein, F., Argirion, I., Taylor, J. M. G., D’Silva, N. J., Chinn, S. B., Rifkin, S. B., et al. (2023) · Cancers · doi:10.3390/cancers15092549 · Cited by 29
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“philic and even anaerobic conditions (5).”
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Jo, J.-K., Seo, S.-H., Park, S.-E., Kim, H.-W., Kim, E.-J., Na, C.-S., Cho, K., Kwon, S.-J., Moon, Y.-H., & Son, H.-S. (2021) · Metabolites · doi:10.3390/metabo11060362 · Cited by 28
The microbiota and radiotherapy for head and neck cancer: What should clinical oncologists know?
Ferreira, M. R., Pastò, A., Ng, T., Patel, V., Urbano, T. G., Sears, C. L., & Wade, W. G. (2022) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2022.102442 · Cited by 28
López-Dávalos, P. C., Requena, T., Pozo‐Bayón, M. Á., & Muñoz‐González, C. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112660 · Cited by 28
“It has also been proposed that the metabolism of tastants, such as sucrose, would participate in the formation of building material for biofilms (Takahashi, 2015).”
Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria
Solinski, A. E., Ochoa, C., Lee, Y. E., Paniak, T. J., Kozlowski, M. C., & Wuest, W. M. (2017) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.7b00178 · Cited by 28
Stankevič, E., Kern, T., Borisevich, D., Poulsen, C. S., Madsen, A. L., Hansen, T. H., Jonsson, A. E., Schubert, M., Nygaard, N., Nielsen, T., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-65538-8 · Cited by 28
Śmiga, M., & Olczak, T. (2025) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf019 · Cited by 30
Duan, X., Chen, X., Gupta, M., Seriwatanachai, D., Xue, H., Xiong, Q., Xu, T., Li, D., Mo, A., Tang, X., et al. (2020) · BMC Nephrology · doi:10.1186/s12882-020-02009-y · Cited by 28
Compositional profile of mucosal bacteriome of smokers and smokeless tobacco users
Gopinath, D., Wie, C. C., Banerjee, M., Thangavelu, L. P., Rathinavelu, P. K., Nallaswamy, D., V, Botelho, M. G., & Johnson, N. W. (2021) · Clinical Oral Investigations · doi:10.1007/s00784-021-04137-7 · Cited by 33
Belstrøm, D., Constancias, F., Markvart, M., Sikora, M., Sørensen, C. E., & Givskov, M. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.752664 · Cited by 27
“Finally, Streptococcus species are proficient in carbohydrate metabolism, which is most often the prime nutrient offered by the oral cavity (Takahashi, 2015).”
BackgroundLozano, C., Díaz‐Garrido, N., Kreth, J., & Giacaman, R. A. (2018) · Caries Research · doi:10.1159/000490950 · Cited by 27
Biofilms and oral health: nanotechnology for biofilm control
Govindarajan, D. K., Mohanarangam, M., Kadirvelu, L., Sivaramalingam, S. S., Jothivel, D., Ravichandran, A., Periasamy, S., & Kandaswamy, K. (2025) · Discover Nano · doi:10.1186/s11671-025-04299-3 · Cited by 27
A cytometric approach to follow variation and dynamics of the salivary microbiota
van Gelder, S., Röhrig, N., Schattenberg, F., Cichocki, N., Schumann, J., Schmalz, G., Haak, R., Ziebolz, D., & Müller, S. (2017) · Methods · doi:10.1016/j.ymeth.2017.08.009 · Cited by 25
Varoni, E. M., Bavarian, R., Robledo‐Sierra, J., Amy, D. P. B., Wade, W. G., Paster, B. J., Kerr, A. R., Peterson, D. E., & Lau, E. F. (2019) · Oral Diseases · doi:10.1111/odi.13063 · Cited by 27
Oral Microbiota-Host Interaction Mediated by Taste Receptors
Dong, H., Liu, J., Zhu, J., Zhou, Z., Tizzano, M., Peng, X., Zhou, X., Xu, X., & Zheng, X. M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.802504 · Cited by 25
“Some specific intraoral bacteria like Porphyromonas gingivalis (P. gingivalis) are capable of utilizing salivary glutamates so as to modulate their concentration, ultimately affecting the taste perception (Takahashi, 2015).”
BackgroundSangha, J. S., Barrett, P., Curtis, T. P., Métris, A., Jakubovics, N. S., & Ofiţeru, I. D. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.03713-23 · Cited by 24
Pagnussatti, M. E. L., Santos, H. S. D. B., Parolo, C. C. F., Hilgert, J. B., & Arthur, R. A. (2024) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2024.106070 · Cited by 26
Jiménez-Ramírez, A. J., Martínez-Martínez, R. E., Ayala-Herrera, J. L., Zaragoza‐Contreras, E. A., Domínguez-Pérez, R. A., López, S. Y. R., Donohué-Cornejo, A., Cuevas‐González, J. C., Silva-Benítez, E. D. L., & Espinosa-Cristóbal, L. F. (2021) · Journal of Nanomaterials · doi:10.1155/2021/5587455 · Cited by 24
Salivary metabolites associated with a 5-year tooth loss identified in a population-based setting
Andörfer, L., Holtfreter, B., Weiß, S., Matthes, R., Pitchika, V., Schmidt, C. O., Samietz, S., Kastenmüller, G., Nauck, M. A., Völker, U., et al. (2021) · BMC Medicine · doi:10.1186/s12916-021-02035-z · Cited by 24
Liu, F., Sheng, J., Hu, L., Zhang, B., Guo, W., Wang, Y., Gu, Y., Jiang, P., Lin, H., Brako, L., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03602-5 · Cited by 26
Amino acid composition and amino acid-metabolic network in supragingival plaque
Washio, J., Ogawa, T., Suzuki, K., Tsukiboshi, Y., WATANABE, M., & Takahashi, N. (2016) · Biomedical Research · doi:10.2220/biomedres.37.251 · Cited by 24
Self-citationGene expression of bacterial collagenolytic proteases in root caries
Damé‐Teixeira, N., Parolo, C. C. F., Maltz, M., Rup, A. G., DeVine, D., & Do, T. (2018) · Journal of Oral Microbiology · doi:10.1080/20002297.2018.1424475 · Cited by 24
Dynamic Alterations of Oral Microbiota Related to Halitosis in Preschool Children
Zhang, Y., Zhu, C., Cao, G.-Z., Zhan, J., Feng, X., & Chen, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.599467 · Cited by 24
“At the molecular level, Prevotella metabolizes various proteins and peptides into amino acids, which further biodegrades into sulfur compounds, short-chain fatty acids, ammonia and indole/skatole, contributing to the progression of periodontitis and halitosis (Kazor et al., 1999; Takahashi, 2015).”
BackgroundUnlocking the potential of probiotic administration in caries management: a systematic review
Lopes, P. C., Gomes, A. T. P. C., Mendes, K., Blanco, L., & Correia, M. J. (2024) · BMC Oral Health · doi:10.1186/s12903-024-03893-8 · Cited by 25
Oral Microbiota Changes Contribute to Autism Spectrum Disorder in Mice
Qiao, Y., Gong, W., Li, B., Xu, R., Wang, M., Shen, L., Shi, H. Y., & Li, Y. (2022) · Journal of Dental Research · doi:10.1177/00220345211070470 · Cited by 23
“Moreover, they were previously demonstrated to degrade polysaccharides and produce short chain fatty acids such as propionic acid (Takahashi 2015), which was reported to induce ASD symptoms by enhancing calcium-dependent serotonin and glutamate release (MacFabe 2015; Olsen et al. 2019).”
BackgroundFiore, M., Minni, A., Cavalcanti, L., Raponi, G., Puggioni, G., Mattia, A., Gariglio, S., Colizza, A., Meliante, P. G., Zoccali, F., et al. (2023) · Antioxidants · doi:10.3390/antiox12061233 · Cited by 23
Arias‐Moliz, M. T., Pérez‐Carrasco, V., Uroz-Torres, D., Ramos, J. D. S., Garcia-Salcedo, J. A., & Soriano, M. (2024) · International Endodontic Journal · doi:10.1111/iej.14046 · Cited by 24
Phenotype and Tissue Residency of Lymphocytes in the Murine Oral Mucosa
Park, J., Chung, H., Choi, Y., & Park, J.-H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00250 · Cited by 23
Oral hygiene might prevent cancer
Cordero, O. J., & Varela‐Calviño, R. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00879 · Cited by 25
“Proteolytic/amino acid-degrading bacteria, including Prevotella and Porphyromonas species, by deamination finally produce shortchain fatty acids, ammonia, sulfur compounds, and indole/skatole, all of them virulent factors in periodontitis and oral malodor and that can cause oral cancer [120].”
BackgroundGhesquière, J., Simoens, K., Koos, E., Boon, N., Teughels, W., & Bernaerts, K. (2023) · Applied and Environmental Microbiology · doi:10.1128/aem.01081-23 · Cited by 22
Schueller, K., Riva, A., Pfeiffer, S., Berry, D., & Somoza, V. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00416 · Cited by 22
Philip, N. I., Leishman, S. J., Bandara, N., & Walsh, L. J. (2019) · Caries Research · doi:10.1159/000499869 · Cited by 21
Effect of mechanically stimulated saliva on initial human dental biofilm formation
Inui, T., Palmer, R. J., Jr., Shah, N., Li, W., Cisar, J. O., & Wu, C. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-48211-3 · Cited by 21
de Sousa, E. T., Lima‐Holanda, A. T., & Nobre‐dos‐Santos, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-61128-6 · Cited by 21
Verspecht, T., Holm, W. V., Boon, N., Bernaerts, K., Daep, C. A., Masters, J. G., Zayed, N., Quirynen, M., & Teughels, W. (2021) · Journal of Oral Microbiology · doi:10.1080/20002297.2021.1910462 · Cited by 19
Nrf2 in the Field of Dentistry with Special Attention to NLRP3
Schieffer, L., Manzl, C., Schatz, C., Haybaeck, J., & Crismani, A. G. (2022) · Antioxidants · doi:10.3390/antiox11010149 · Cited by 20
Sánchez, M. C., Velapatiño, Á., Llama‐Palacios, A., Valdés, A., Cifuentes, A., Ciudad, M. J., & Yurrita, L. C. (2022) · Molecular Oral Microbiology · doi:10.1111/omi.12363 · Cited by 30
Bajaj, J. S., Rodríguez, M. P., Reau, A. L., Phillips, W., Fuchs, M. A., Davis, B., Sterling, R. K., Sikaroodi, M., Fagan, A., Shamsaddini, A., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-328403 · Cited by 23
Hou, J., Xu, J., Liu, Y. F., Zhang, H., Wang, S., Yao, J., Guo, L., & Li, S. (2022) · BMC Oral Health · doi:10.1186/s12903-022-02255-6 · Cited by 19
Inflammatory Response in Oral Biofilm during Pregnancy: A Systematic Review
Lieske, B., Makarova, N., Jagemann, B., Walther, C., Ebinghaus, M., Zyriax, B., & Aarabi, G. (2022) · Nutrients · doi:10.3390/nu14224894 · Cited by 19
Malheiros, S. S., NAGAY, B. E., Bertolini, M., de Ávila, É. D., Shibli, J. A., Souza, J. G. S., & Barão, V. A. R. (2023) · Expert Review of Medical Devices · doi:10.1080/17434440.2023.2218547 · Cited by 19
Murai, H., Kuboniwa, M., Kakiuchi, M., Matsumura, R., Hirata, Y., & Amano, A. (2024) · Journal of Oral Microbiology · doi:10.1080/20002297.2024.2373040 · Cited by 19
Bacterial protease uses distinct thermodynamic signatures for substrate recognition
Bezerra, G. A., Ohara‐Nemoto, Y., Cornaciu, I., Fedosyuk, S., Hoffmann, G., Round, A. R., Márquez, J. A., Nemoto, T., & Djinović‐Carugo, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-03220-y · Cited by 19
Metadata
- Authors
- Takahashi, N.
- Affiliations
- Tohoku University (JP)
- Corresponding author
- Takahashi, N.
- ORCID
- Takahashi, N.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2015-09-16
- Volume
- 94
- Issue
- 12
- Pages
- 1628-1637
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2177799539
- Semantic Scholar
- 07829a891f6241d91d38c3b9b26b4c8d9c2bf4a9
- Cited by
- 488
- References
- 65
- Citations by year
- 2026: 45 · 2025: 65 · 2024: 49 · 2023: 49 · 2022: 55 · 2021: 50 · 2020: 43 · 2019: 48 · 2018: 27 · 2017: 38 · 2016: 16 · 2015: 2
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (26293439)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
- Keywords
- oral microbiota, microbial metabolism, dental caries, periodontitis, halitosis, arginine deiminase system, urease, short-chain fatty acids, acetaldehyde, nitrite, Streptococcus, Lactobacillus, Porphyromonas, Prevotella, glycolysis, microbial metabolomics
- MeSH terms
- Bacteria, Dental Caries, Dental Plaque, Humans, Mouth, Oral Health, Periodontal Diseases, Microbiota
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