The DOI matches its Crossref record, with a small difference in title or year; 65 of the 65 references it cites were found in a registry or an index.
Oral Microbiome Metabolism: From “Who Are They?” to “What Are They Doing?”
Abstract
Recent advances in molecular biology have facilitated analyses of the oral microbiome (“Who are they?”); however, its functions (e.g., metabolic activities) are poorly understood (“What are they doing?”). This review aims to summarize our current understanding of the metabolism of the oral microbiome. Saccharolytic bacteria—including Streptococcus, Actinomyces, and Lactobacillus species—degrade carbohydrates into organic acids via the Embden-Meyerhof-Parnas pathway and several of its branch pathways, resulting in dental caries, while alkalization and acid neutralization via the arginine deiminase system, urease, and so on, counteract acidification. Proteolytic/amino acid–degrading bacteria, including Prevotella and Porphyromonas species, break down proteins and peptides into amino acids and degrade them further via specific pathways to produce short-chain fatty acids, ammonia, sulfur compounds, and indole/skatole, which act as virulent and modifying factors in periodontitis and oral malodor. Furthermore, it is suggested that ethanol-derived acetaldehyde can cause oral cancer, while nitrate-derived nitrite can aid caries prevention and systemic health. Microbial metabolic activity is influenced by the oral environment; however, it can also modify the oral environment, enhance the pathogenicity of bacteria, and induce microbial selection to create more pathogenic microbiome. Taking a metabolomic approach to analyzing the oral microbiome is crucial to improving our understanding of the functions of the oral microbiome.
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In the citing paper
“These bacteria can cause demineralization of dental enamel and development of carious lesions, and on the other hand, promote bacterial acidogenicity and acidification by increasing cell membrane permeability to protons, induction of H+- ATPase activity, and stimulation of metabolic pathways involved in acid neutralization and alkalinization [83].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“They are broken down into peptides and amino acids (aspartate, serine, and cysteine) through the action of host proteases and peptidases [83].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“However, the degradation of protein substrates plays an important role in the pathogenesis of the periodontal disease [83].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“Fermentation of amino acids neutralizes acidic environments, creating a more favorable atmosphere for the growth of other periodontitis’ pathogens [83].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“Amino acids are fermented to generate short-chain fatty acids, such as propionate, butyrate, succinate, acetate, and formate [83].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“The increased depth of the gingival pocket and the increased production of gingival crevicular fluid induces an increase in bacteria involved in protein degradation.”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [83]
In the citing paper
“Over 250 species from the oral cavity have been isolated in culture and characterized, including several key pathogens, such as Streptococcus mutans, Porphyromonas gingivalis, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans, involved in the etiology of dental caries and periodontal disease.7, 8, 9”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Moreover, processed carbohydrate consumption has been associated with increased incidence of periodontal disease.8, 24, 26, 181, 188, 251”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Digestion of starch is initiated in the oral cavity through the action of salivary alpha‐amylase that catalyzes the hydrolysis of starch by cleaving α‐1,4‐glycosidic linkages to yield smaller saccharide moieties, such as maltose, maltotriose, and alpha‐limit dextrins,279, 280 which can be utilized by early biofilm colonizers as well as by some periodontal pathogens.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Such processes encourage the outgrowth of acidogenic bacteria, such as S mutans, lactobacilli, and bifidobacteria that enhance the carcinogenicity of dental plaque.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Pathways in which sugar is metabolized are also shared among some periodontal pathogens, such as Fusobacterium and Prevotella, which can likewise cause acidification.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“During the development of periodontal disease, protein‐rich and neutral‐alkaline environmental pressures promote the outgrowth of periodontal pathogens.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Inflammatory processes promote the outgrowth of inflammophilic bacteria via the production of proteinaceous substrates resulting from tissue destruction.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Amino acids are fermented to produce short‐chain fatty acids, such as propionate, butyrate, succinate, acetate, and formate.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Amino acid fermentation neutralizes acidic environments, making the environment more favorable for outgrowth of additional periodontitis‐associated pathogens.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“Deepening of the gingival crevice and increased production of gingival crevicular fluid increases the relative abundance of protein‐degrading bacteria.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [8]
In the citing paper
“For instance, saccharolytic (sugar metabolizing) bacteria such as Streptococcus and Lactobacillus have been associated with dental caries, while proteolytic (protein metabolizing) bacteria such as Prevotella and Porphyromonas have been associated with periodontitis and halitosis[183].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [183]
In the citing paper
“Yet, individual bacteria do not act in a vacuum, but rather function in interdependent microbial communities whose conglomerate activity can impact oral and systemic health[183,188,189].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [183]
Citations
Cites
Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · cited 2×
“It was recently reported that nitrite contributes to systemic health by stimulating the circulatory system (Lundberg et al. 2008).”
BackgroundMicrobial ecology of dental plaque and its significance in health and disease
Marsh, P. D. (1994) · Advances in Dental Research · doi:10.1177/08959374940080022001 · Cited by 1,278
The Role of Bacteria in the Caries Process
Takahashi, N., & Nyvad, B. (2010) · Journal of Dental Research · doi:10.1177/0022034510379602 · Cited by 1,250
Self-citationGottschalk, G. (1986) · Springer series in microbiology · doi:10.1007/978-1-4612-1072-6 · Cited by 695
Caries Ecology Revisited: Microbial Dynamics and the Caries Process
Takahashi, N., & Nyvad, B. (2008) · Caries Research · doi:10.1159/000159604 · Cited by 598
Self-citationThe formation of hydrogen sulfide and methyl mercaptan by oral bacteria
Persson, S., Edlund, M., Claesson, R., & Carlsson, J. (1990) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.1990.tb00645.x · Cited by 514
Alkali production by oral bacteria and protection against dental caries
Burne, R. A., & Marquis, R. E. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09393.x · Cited by 400
Complete Genome Sequence of the Oral Pathogenic Bacterium Porphyromonas gingivalis Strain W83
Nelson, K. E., Fleischmann, R. D., DeBoy, R. T., Paulsen, I. T., Fouts, D. E., Eisen, J. A., Daugherty, S. C., Dodson, R. J., Durkin, A. S., Gwinn, M. L., et al. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.18.5591-5601.2003 · Cited by 389
THE BACTERIAL PHOSPHOENOL-PYRUVATE: GLYCOSE PHOSPHOTRANSFERASE SYSTEM
Meadow, N. D., Fox, D. K., & Roseman, S. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.002433 · Cited by 386
Kleinberg, I. (2002) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130201300202 · Cited by 362
Evaluation of bacterial nitrate reduction in the human oral cavity
Doel, J. J., Benjamin, N., Hector, M. P., Rogers, M., & Allaker, R. P. (2005) · European Journal of Oral Sciences · doi:10.1111/j.1600-0722.2004.00184.x · Cited by 362
Dental Caries from a Molecular Microbiological Perspective
Nyvad, B., Crielaard, W., Mira, Á., Takahashi, N., & Beighton, D. (2012) · Caries Research · doi:10.1159/000345367 · Cited by 262
Self-citationRussell, R. R. B., Aduse‐Opoku, J., Sutcliffe, I. C., Tao, L., & Ferretti, J. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42880-3 · Cited by 234
The relationship between oral malodor, gingivitis, and periodontitis. A review
Ratcliff, P. A., & Johnson, P. W. (1999) · Journal of Periodontology · doi:10.1902/jop.1999.70.5.485 · Cited by 228
Takahashi, N. (2005) · International Congress Series · doi:10.1016/j.ics.2005.06.071 · Cited by 202
Self-citationCarlsson, J., Iwami, Y., & YAMADA, T. (1983) · Infection and Immunity · doi:10.1128/iai.40.1.70-80.1983 · Cited by 196
Liu, Y., Nascimento, M. M., & Burne, R. A. (2012) · International Journal of Oral Science · doi:10.1038/ijos.2012.54 · Cited by 190
Homann, N., Tillonen, J., Rintamäki, H., Salaspuro, M. P., Lindqvist, C. M., & Meurman, J. H. (2001) · Oral Oncology · doi:10.1016/s1368-8375(00)00076-2 · Cited by 189
Hydrogen sulfide-producing bacteria in tongue biofilm and their relationship with oral malodour
Washio, J., Sato, T., Koseki, T., & Takahashi, N. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46118-0 · Cited by 179
Self-citationOxygen metabolism, oxidative stress and acid-base physiology of dental plaque biofilms
Marquis, R. (1995) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/bf01569826 · Cited by 176
Short-Chain Carboxylic-Acid-Stimulated, PMN-Mediated Gingival Inflammation
Niederman, R., Zhang, J., & Kashket, S. (1997) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411970080030301 · Cited by 142
Formation of Methyl Mercaptan from l -Methionine by Porphyromonas gingivalis
Yoshimura, M., Nakano, Y., Yamashita, Y., Oho, T., Saito, T., & Koga, T. (2000) · Infection and Immunity · doi:10.1128/iai.68.12.6912-6916.2000 · Cited by 136
Abbe, K., Takahashi, S., & YAMADA, T. (1982) · Journal of Bacteriology · doi:10.1128/jb.152.1.175-182.1982 · Cited by 135
Takahashl, N., Saito, K., Schachtele, C. F., & YAMADA, T. (1997) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.1997.tb00733.x · Cited by 133
Protective effect of salivary nitrate and microbial nitrate reductase activity against caries
Doel, J. J., Hector, M. P., Amirtham, C. V., Al‐Anzan, L. A., Benjamin, N., & Allaker, R. P. (2004) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2004.00153.x · Cited by 131
Lactate Metabolism by Veillonella parvula
Ng, S. K. C., & Hamilton, I. R. (1971) · Journal of Bacteriology · doi:10.1128/jb.105.3.999-1005.1971 · Cited by 130
Takahashi, N., Sato, T., & Yamada, T. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.17.4704-4710.2000 · Cited by 126
Self-citationMetabolomics of supragingival plaque and oral bacteria
Takahashi, N., Washio, J., & Mayanagi, G. (2010) · Journal of Dental Research · doi:10.1177/0022034510377792 · Cited by 107
Self-citationButyric Acid Induces Apoptosis in Inflamed Fibroblasts
Kurita‐Ochiai, T., Seto, S., Suzuki, N., Yamamoto, M., Otsuka, K., Abe, K., & Ochiai, K. (2008) · Journal of Dental Research · doi:10.1177/154405910808700108 · Cited by 104
Metabolomic Effects of Xylitol and Fluoride on Plaque Biofilm in Vivo
Takahashi, N., & Washio, J. (2011) · Journal of Dental Research · doi:10.1177/0022034511423395 · Cited by 98
Self-citationAcid‐induced acid tolerance and acidogenicity of non‐mutans streptococci
Takahashi, N., & YAMADA, T. (1999) · Oral Microbiology and Immunology · doi:10.1034/j.1399-302x.1999.140105.x · Cited by 93
Self-citationTakahashi, N. (2003) · Oral Microbiology and Immunology · doi:10.1034/j.1399-302x.2003.00054.x · Cited by 86
Self-citationCurtis, M. A., Percival, R. S., DeVine, D., Darveau, R. P., Coats, S. R., Rangarajan, M., Tarelli, E., & Marsh, P. D. (2011) · Infection and Immunity · doi:10.1128/iai.00900-10 · Cited by 79
Crow, V. L., Davey, G. P., Pearce, L. E., & Thomas, T. D. (1983) · Journal of Bacteriology · doi:10.1128/jb.153.1.76-83.1983 · Cited by 76
Eh, D. B., De Uzeda, M., & Wj, L. (1994) · PubMed · Cited by 76
Glucose and Lactate Metabolism By Actinomyces Naeslundii
Takahashi, N., & YAMADA, T. (1999) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411990100040501 · Cited by 68
Self-citationTakahashi, N., Abbe, K., Takahashi‐Abbe, S., & YAMADA, T. (1987) · Infection and Immunity · doi:10.1128/iai.55.3.652-656.1987 · Cited by 68
Self-citationUematsu, H., Sato, N., Hossain, M. Z., Ikeda, T., & Hoshino, E. (2003) · Archives of Oral Biology · doi:10.1016/s0003-9969(03)00031-1 · Cited by 65
Fukamachi, H., Nakano, Y., Okano, S., Shibata, Y., Abiko, Y., & Yamashita, Y. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.139 · Cited by 61
Effects of pH and Lactate on Hydrogen Sulfide Production by Oral Veillonella spp
Washio, J., Shimada, Y., Yamada, M., Sakamaki, R., & Takahashi, N. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00606-14 · Cited by 61
Self-citationDesulfuration of Cysteine and Methionine by Fusobacterium nucleatum
Pianotti, R. S., Lachette, S., & Dills, S. S. (1986) · Journal of Dental Research · doi:10.1177/00220345860650061101 · Cited by 59
β-Galactosidase Activity in Saliva is Associated with Oral Malodor
Sterer, N., Greenstein, R. B., & Rosenberg, M. (2002) · Journal of Dental Research · doi:10.1177/0810182 · Cited by 57
Preferential Utilization of Dipeptides by Porphyromonas gingivalis
Takahashi, N., & Sato, T. (2001) · Journal of Dental Research · doi:10.1177/00220345010800050801 · Cited by 54
Self-citationSterer, N., & Rosenberg, M. (2006) · Journal of Dental Research · doi:10.1177/154405910608501007 · Cited by 54
Intracellular xylitol‐phosphate hydrolysis and efflux of xylitol in Streptococcus sobrinus
Trahan, L., Néron, S., & Bareil, M. (1991) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.1991.tb00450.x · Cited by 52
Pathways of glutamate catabolism among Fusobacterium species
Gharbia, S. E., & Shah, H. N. (1991) · Journal of General Microbiology · doi:10.1099/00221287-137-5-1201 · Cited by 52
Pathways for amino acid metabolism by Prevotella intermedia and Prevotella nigrescens
Takahashi, N., & YAMADA, T. (2000) · Oral Microbiology and Immunology · doi:10.1034/j.1399-302x.2000.150205.x · Cited by 48
Self-citationOxygen and the sugar metabolism in oral streptococci.
Abbe, K., Carlsson, J., Takahashi‐Abbe, S., & YAMADA, T. (1991) · PubMed · Cited by 48
The decarboxylation of amino acids by bacteria derived from human dental plaque
Hayes, M. L., & Hyatt, A. T. (1974) · Archives of Oral Biology · doi:10.1016/0003-9969(74)90177-0 · Cited by 47
Sheng, J., Baldeck, J. D., Nguyen, P. T. M., Quivey, R. G., & Marquis, R. E. (2010) · Canadian Journal of Microbiology · doi:10.1139/w10-039 · Cited by 47
The relationship between oral malodor, gingivitis, and periodontitis
Ratcliff, P. A. (1999) · Medical Entomology and Zoology · Cited by 47
Codipilly, D. M., & Kleinberg, I. (2008) · Journal of Breath Research · doi:10.1088/1752-7155/2/1/017017 · Cited by 45
Futile xylitol cycle in Lactobacillus casei
Hausman, S. Z., Thompson, J. F., & London, J. (1984) · Journal of Bacteriology · doi:10.1128/jb.160.1.211-215.1984 · Cited by 38
Hendrickson, E. L., Xia, Q., Wang, T., Lamont, R. J., & Hackett, M. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-185 · Cited by 38
Abbe, K., Takahashi, S., & YAMADA, T. (1983) · Infection and Immunity · doi:10.1128/iai.39.3.1007-1014.1983 · Cited by 30
Yoshida, Y., Sasaki, T., Ito, S., Tamura, H., Kunimatsu, K., & Kato, H. (2009) · Microbiology · doi:10.1099/mic.0.024174-0 · Cited by 29
Saito, K., Takahashi, N., Horiuchi, H., & Yamada, T. (2001) · Journal of Periodontal Research · doi:10.1034/j.1600-0765.2001.360602.x · Cited by 28 · cited 2×
“…acidic supragingival site, but it increases its protease activity and cytotoxic end product production when sugar is omitted from the culture medium (Saito et al. 2001), suggesting that its pathogenicity might increase after it colonizes subgingival sites (where the carbohydrate supply is limited).”
BackgroundSelf-citationHamid, M. A., Iwaku, M., & Hoshino, E. (1994) · Archives of Oral Biology · doi:10.1016/0003-9969(94)90080-9 · Cited by 23
Wade, W. D. (2005) · Elsevier eBooks · Cited by 18
Aspartate and asparagine as electron acceptors for Wolinella recta
Ohta, H., Gottschal, J. C., Fukui, K., & Kato, K. (1991) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.1991.tb00455.x · Cited by 16
Stickland reactions of dental plaque
Curtis, M. A., Kemp, C. W., Robrish, S. A., & Bowen, W. H. (1983) · Infection and Immunity · doi:10.1128/iai.42.1.431-433.1983 · Cited by 12
Complete Genome Sequence of the Oral Pathogenic Bacterium Porphyromonas gingivalis StrainW83
Nelson, K. E., Fleischmann, R. D., DeBoy, R. T., Paulsen, I. T., Fouts, D. E., Eisen, J. A., Daugherty, S. C., Dodson, R. J., Durkin, A. S., Gwinn, M. L., et al. (2003) · Journal of Bacteriology · doi:10.1128/jb.186.2.593.2004 · Cited by 12
Smalley, J. W., Birss, A. J., Percival, R. S., & Marsh, P. D. (2000) · Current Microbiology · doi:10.1007/s002840010144 · Cited by 6
Degradation of serine‐containing oligopeptides by Peptostreptococcus micros ATCC 33270
Uematsu, H., Hossain, M. Z., Alam, T., Ikeda, T., Kuvatanasuchati, J., & Hoshino, E. (2007) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2007.00374.x · Cited by 3
Research works printed but not linked: 3
- Abbe K, 1991, Proc Finn Dent Soc, 87, 477
- Carlsson J, 1986, Textbook of cariology, 74
- de Boever EH, 1994, J Clin Dent, 4, 114
Cited by
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Lamont, R. J., Koo, H., & Hajishengallis, G. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0089-x · Cited by 2,217
Occlusal Caries: Biological Approach for Its Diagnosis and Management
Carvalho, J. C., Dige, I., Mačhiulskienė, V., Qvist, V., Bakhshandeh, A., Parolo, C. C. F., & Maltz, M. (2016) · Caries Research · doi:10.1159/000448662 · Cited by 2,159
The oral microbiome – an update for oral healthcare professionals
Kilian, M., Chapple, I. L. C., Hannig, M., Marsh, P. D., Meuric, V., Pedersen, A. M. L., Tonetti, M. S., Wade, W. G., & Zaura, E. (2016) · British Dental Journal · doi:10.1038/sj.bdj.2016.865 · Cited by 1,269
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
Ecological Hypothesis of Dentin and Root Caries
Takahashi, N., & Nyvad, B. (2016) · Caries Research · doi:10.1159/000447309 · Cited by 737
Self-citation
Metadata
- Authors
- Takahashi, N.
- Affiliations
- Tohoku University (JP)
- Corresponding author
- Takahashi, N.
- ORCID
- Takahashi, N.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2015-09-16
- Volume
- 94
- Issue
- 12
- Pages
- 1628-1637
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2177799539
- Semantic Scholar
- 07829a891f6241d91d38c3b9b26b4c8d9c2bf4a9
- Cited by
- 488
- References
- 65
- Citations by year
- 2026: 45 · 2025: 65 · 2024: 49 · 2023: 49 · 2022: 55 · 2021: 50 · 2020: 43 · 2019: 48 · 2018: 27 · 2017: 38 · 2016: 16 · 2015: 2
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (26293439)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
- Keywords
- oral microbiota, microbial metabolism, dental caries, periodontitis, halitosis, arginine deiminase system, urease, short-chain fatty acids, acetaldehyde, nitrite, Streptococcus, Lactobacillus, Porphyromonas, Prevotella, glycolysis, microbial metabolomics
- MeSH terms
- Bacteria, Dental Caries, Dental Plaque, Humans, Mouth, Oral Health, Periodontal Diseases, Microbiota
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