The Function of Wnt Ligands on Osteocyte and Bone Remodeling
Abstract
Bone homeostasis is continually maintained by the process of bone remodeling throughout life. Recent studies have demonstrated that Wnt signaling pathways play a fundamental role in the process of bone homeostasis and remodeling. Intracellular Wnt signaling cascades are initially triggered by a Wnt ligand–receptor complex formation. In previous studies, the blocking of Wnt ligands from different osteoblastic differentiation stages could cause defective bone development at an early stage. Osteocytes, the most abundant and long-lived type of bone cell, are a crucial orchestrator of bone remodeling. However, the role of Wnt ligands on osteocyte and bone remodeling remains unclear. In our present study, we found that, besides osteoblasts, osteocytes also express multiple Wnt ligands in the bone environment. Then, we used a Dmp1-Cre mouse line, in which there is expression in a subset of osteoblasts but mainly osteocytes, to study the function of Wnt ligands on osteocyte and bone remodeling in vivo. Furthermore, we explored the role of Wnt ligands on osteocytic mineralization ability, as well as the regulatory function of osteocytes on the process of osteoblastic differentiation and osteoclastic migration and maturity in vitro. We concluded that Wnt proteins play an important regulatory role in 1) the process of perilacunar/canalicular remodeling, as mediated by osteocytes, and 2) the balance of osteogenesis and bone resorption at the bone surface, as mediated by osteoblasts and osteoclasts, at least partly through the canonical Wnt/β-catenin signaling pathway and the OPG/RANKL signaling pathway.
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Osteocytes can be considered the social coordinators of bone cells because they are responsible for maintaining bone physiological responsiveness to mechanical and metabolic demands; when osteocytic coordination fails, severe osteoporosis develops.
“These findings indicate that osteocytes can be considered the “social” coordinators of bone cells because they are responsible for maintaining bone physiological responsiveness to mechanical and metabolic demands. When osteocytic coordination fails, severe osteoporosis develops.110”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [110]
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- Authors
- Du, J. H., Lin, S. X., Wu, X. L., Yang, S. M., Cao, L. Y., Zheng, A., Wu, J. N., & Jiang, X. Q.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Tongji University (CN)
- Corresponding author
- Jiang, X.Q.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2019-07
- Volume
- 98
- Issue
- 8
- Pages
- 930-938
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2958619211
- Cited by
- 35
- References
- 40
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 3
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2016YFC1102900)
- National Natural Science Foundation of China (81430012)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- Wnt ligands, osteocytes, bone remodeling, bone homeostasis, Wnt/β-catenin signaling, osteogenic differentiation, bone resorption, bone formation
- MeSH terms
- Animals, Bone Resorption, Ligands, Osteocytes, Bone Remodeling, Mice, Wnt Signaling Pathway
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