Filifactor alocis : Recent Insights and Advances
Open accessAbstract
Filifactor alocis, a fastidious Gram-positive obligate anaerobic bacterium, is a newly appreciated member of the periodontal community that is now proposed to be a diagnostic indicator of periodontal disease. Its pathogenic characteristics are highlighted by its ability to survive in the oxidative stress–rich environment of the periodontal pocket and to significantly alter the microbial community dynamics by forming biofilms and interacting with several oral bacteria. Here, we describe the current understanding of F. alocis virulence attributes, such as its comparative resistance to oxidative stress, production of unique proteases and collagenases that can cause structural damage to host cells, and dysregulation of the immune system, which enable this bacterium to colonize, survive, and outcompete other traditional pathogens in the inflammatory environment of the periodontal pocket. Furthermore, we explore the recent advancements and future directions for F. alocis research, including the potential mechanisms for oxidative stress resistance and our evolving understanding of the interactions and mechanisms of bacterial survival inside neutrophils. We also discuss the current genetic tools and challenges involved in manipulating the F. alocis genome for the functional characterization of the putative virulence genes. Collectively, this information will expedite F. alocis research and should lead to the identification of prime targets for the development of novel therapeutics to aid in the control and prevention of periodontal disease.
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Fil. alocis is an important species for periodontal disease progression due to its ability to interact and exhibit virulence with various oral bacteria.
“Due to its ability to interact and exhibit virulence with various oral bacteria, Fil. alocis has become an important species for periodontal disease progression [24].”
From Analysis of Chemical Structure and Antibiofilm Properties of Exopolysaccharides from Lactiplantibacillus plantarum EIR/IF-1 Postbiotics (2022) · cites this paper as [24]
Fil. alocis has recently been introduced as a diagnostic indicator of periodontal disease.
“Fil. alocis, a fastidious Gram-positive model, has recently been introduced as a diagnostic indicator of periodontal disease.”
From Analysis of Chemical Structure and Antibiofilm Properties of Exopolysaccharides from Lactiplantibacillus plantarum EIR/IF-1 Postbiotics (2022) · cites this paper as [24]
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“alocis has become an important species for periodontal disease progression [24].”
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Filifactor alocis Pathogenicity Requires TLR2 and the Oral Microbiome
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On‐Site Visualized Periodontitis Screening via Dual‐Signal H 2 S Probe
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Characterization of thioredoxin–thioredoxin reductase system in Filifactor alocis
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Assessing Evidence to Include Filifactor alocis as a Novel Candidate in Socransky's Complexes
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Pleural empyema caused by Filifactor alocis in a man with periodontitis
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Filifactor alocis induces interleukin-1β secretion in THP-1 cells
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Museum specimens reveal evolutionary drivers and functions of oral microbiome in mammalsPreprint
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- Authors
- Aja, E., Mangar, M., Fletcher, H. M., & Mishra, A.
- Affiliations
- Loma Linda University (US)
- Corresponding author
- Mishra, A.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2021-03-14
- Volume
- 100
- Issue
- 8
- Pages
- 790-797
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- PMC
- PMC8261852
- OpenAlex
- W3139502216
- Cited by
- 70
- References
- 61
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 18 · 2023: 9 · 2022: 13 · 2021: 2
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R-56-DE13664, DE019730, DE022508 and DE022724)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Filifactor alocis, periodontal disease, periodontal pathogens, oxidative stress resistance, bacterial virulence factors, proteolytic enzymes, collagenase, immune dysregulation, biofilm formation, bacterial interactions, periodontal pockets, virulence genes
- MeSH terms
- Clostridiales, Eubacteriales, Base Composition, Phylogeny, RNA, Ribosomal, 16S, Sequence Analysis, DNA
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