Human neutrophils and oral microbiota: a constant tug‐of‐war between a harmonious and a discordant coexistence

Uriarte, Silvia M.; Edmisson, Jacob S.; Jimenez‐Flores, Emeri

doi:10.1111/imr.12451

Cited by 112Oral microbiology and periodontitis researchDental Research and COVID-19Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Human neutrophils and oral microbiota: a constant tug‐of‐war between a harmonious and a discordant coexistence

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Uriarte, Silvia M., Edmisson, Jacob S., Jimenez‐Flores, Emeri·2016·Immunological Reviews

DOI 10.1111/imr.12451PMC PMC5353849

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Abstract

Summary: Neutrophils are a major component of the innate host response, and the outcome of the interaction between the oral microbiota and neutrophils is a key determinant of oral health status. The composition of the oral microbiome is very complex and different in health and disease. Neutrophils are constantly recruited to the oral cavity, and their protective role is highlighted in cases where their number or functional responses are impeded, resulting in different forms of periodontal disease. Periodontitis, one of the more severe and irreversible forms of periodontal disease, is a microbial‐induced chronic inflammatory disease that affects the gingival tissues supporting the tooth. This chronic inflammatory disease is the result of a shift of the oral bacterial symbiotic community to a dysbiotic more complex community. Chronic inflammatory infectious diseases such as periodontitis can occur because the pathogens are able to evade or disable the innate immune system. In this review, we discuss how human neutrophils interact with both the symbiotic and the dysbiotic oral community; an understanding of which is essential to increase our knowledge of the periodontal disease process.

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Under the stimulus of a biofilm, neutrophils and macrophages are recruited to the pocket site and activated.
“Under the stimulus of a biofilm, neutrophils40, and macrophages41 are recruited to the pocket site and activated.”
From Recent advances in the pathogenesis and prevention strategies of dental calculus (2024) · cites this paper as [40]

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Authors: Uriarte, S. M., Edmisson, J. S., & Jimenez‐Flores, E.
Affiliations: University of Louisville (US)
Corresponding author: Uriarte, Silvia M.
ORCID: Uriarte, Silvia M.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2016-08-25
Volume: 273
Issue: 1
Pages: 282-298
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/imr.12451
PMC: PMC5353849
OpenAlex: W2516511483
Cited by: 112
References: 183
Citations by year: 2026: 8 · 2025: 8 · 2024: 15 · 2023: 6 · 2022: 12 · 2021: 19 · 2020: 15 · 2019: 9 · 2018: 8 · 2017: 10 · 2016: 2
FWCI: 1.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Dental and Craniofacial Research (DE024509)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: neutrophils, oral microbiota, periodontitis, periodontal disease, innate immunity, dysbiosis, host-microbe interactions, oral inflammation
MeSH terms: Animals, Bacterial Infections, Humans, Immunity, Innate, Mouth, Neutrophils, Periodontal Diseases, Host-Pathogen Interactions, Microbiota, Dysbiosis

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Human neutrophils and oral microbiota: a constant tug‐of‐war between a harmonious and a discordant coexistence

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