The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Cytochemical Methods for the Detection of Apoptosis
Open accessAbstract
Detection of apoptotic cell death in cells and tissues has become of paramount importance in many fields of modern biology, including studies of embryonic development, degenerative disease, and cancer biology. In addition to methods that employ biochemical analysis of large populations of cells, cytochemical methods have recently been extensively used both in individual cells and in tissues. Most of these methods exploit properties of dying cells that are more or less specific for the apoptotic process. However, considerable confusion exists over the interpretation of some of these methods and their usefulness in all settings. This review attempts to summarize the more recent advances in cytochemical detection of apoptosis and emphasizes some of the pitfalls that confuse the interpretation of results of these methods.
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Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,725
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824
Koopman, G., Reutelingsperger, C., Kuijten, G., Keehnen, R., Pals, S., & van Oers, M. (1994) · Blood · doi:10.1182/blood.v84.5.1415.1415 · Cited by 2,681
Lemasters, J. J., Nieminen, A.-L., Qian, T., Trost, L. C., Elmore, S. P., Nishimura, Y., Crowe, R. A., Cascio, W. E., Bradham, C. A., Brenner, D. A., et al. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00112-1 · Cited by 1,387
Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis
Hall*, P. A., Coates, P. J., Ansari, B., & Hopwood, D. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.12.3569 · Cited by 816
Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview
Wyllie, A. H. (1992) · Cancer and Metastasis Review · doi:10.1007/bf00048057 · Cited by 587
Ansari, B., Coates, P. J., Greenstein, B. D., & Hall, P. A. (1993) · The Journal of Pathology · doi:10.1002/path.1711700102 · Cited by 577
Morphological and biochemical characterization and analysis of apoptosis
Allen, R. T., Hunter, W. J., & Agrawal, D. K. (1997) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(97)00033-6 · Cited by 477
Major DNA Fragmentation Is a Late Event in Apoptosis
Collins, J. A., Schandl, C. A., Young, K. K., Vesely, J., & Willingham, M. C. (1997) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549704500702 · Cited by 471
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Filonova, L. H., Bozhkov, P. V., Brukhin, V. B., Daniel, G., Zhivotovsky, B., & Arnold, S. V. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.24.4399 · Cited by 257
Metadata
- Authors
- Willingham, M. C.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 1999-09
- Volume
- 47
- Issue
- 9
- Pages
- 1101-1109
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2162607898
- Cited by
- 309
- References
- 39
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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