Cited by 648Animal testing and alternativesMicrobial infections and disease researchAnimal Behavior and Welfare Studies

The DOI matches its Crossref record; 381 of the 382 references it cites were found in a registry or an index.

FELASA recommendations for the health monitoring of mouse, rat, hamster, guinea pig and rabbit colonies in breeding and experimental units

Open access

FELASA working group on revision of guidelines for health monitoring of rodents and rabbits, Mähler (Convenor), M, Berard, M, Feinstein, R, Gallagher, A, Illgen-Wilcke, B, Pritchett-Corning, K, Raspa, M·2014·Laboratory Animals

DOI 10.1177/0023677213516312

Open this paper in CoChat — free account Open PDF

Abstract

The microbiological quality of experimental animals can critically influence animal welfare and the validity and reproducibility of research data. It is therefore important for breeding and experimental facilities to establish a laboratory animal health monitoring (HM) programme as an integrated part of any quality assurance system. FELASA has published recommendations for the HM of rodent and rabbit colonies in breeding and experimental units (Nicklas et al. Laboratory Animals, 2002), with the intention of harmonizing HM programmes. As stated in the preamble, these recommendations need to be adapted periodically to meet current developments in laboratory animal medicine. Accordingly, previous recommendations have been revised and shall be replaced by the present recommendations. These recommendations are aimed at all breeders and users of laboratory mice, rats, Syrian hamsters, guinea pigs and rabbits as well as diagnostic laboratories. They describe essential aspects of HM, such as the choice of agents, selection of animals and tissues for testing, frequency of sampling, commonly used test methods, interpretation of results and HM reporting. Compared with previous recommendations, more emphasis is put on the role of a person with sufficient understanding of the principles of HM, opportunistic agents, the use of sentinel animals (particularly under conditions of cage-level containment) and the interpretation and reporting of HM results. Relevant agents, testing frequencies and literature references are updated. Supplementary information on specific agents and the number of animals to be monitored and an example of a HM programme description is provided in the appendices.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1177/0023677213516312

Cites

381 of 381 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Histopathological Features of Capillaria hepatica Infection in Laboratory Rabbits
Mowat, V., Turton, J. A., Stewart, J., et al. (2009) · Toxicologic Pathology · doi:10.1177/0192623309339501 · Cited by 13
Retracted
How long do nosocomial pathogens persist on inanimate surfaces? A systematic review
Krämer, A., Schwebke, I., & Kampf, G. (2006) · BMC Infectious Diseases · doi:10.1186/1471-2334-6-130 · Cited by 2,508
A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease
Jonsson, C. B., Figueiredo, L. T. M., & Vapalahti, O. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00062-09 · Cited by 1,181
The Mouse in Biomedical Research
(1983) · Elsevier eBooks · doi:10.1016/c2013-0-10677-0 · Cited by 1,021
Coronavirus Pathogenesis
Weiss, S. R., & Leibowitz, J. L. (2011) · Advances in virus research · doi:10.1016/b978-0-12-385885-6.00009-2 · Cited by 926
Effects of Air Temperature and Relative Humidity on Coronavirus Survival on Surfaces
Casanova, L. M., Jeon, S., Rutala, W. A., Weber, D. J., & Sobsey, M. D. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.02291-09 · Cited by 736
Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units
Nicklas, W., Baneux, P. J. R., Boot, R., Decelle, T., Deeny, A., Fumanelli, M., & Illgen-Wilcke, B. (2002) · Laboratory Animals · doi:10.1258/0023677021911740 · Cited by 547
Self-citation
Citrobacter rodentium of mice and man
Mundy, R., Macdonald, T., Dougan, G., Frankel, G., & Wiles, S. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00625.x · Cited by 545
Pathology of Laboratory Rodents and Rabbits
Percy, D. H., & Barthold, S. W. (2007) · Wiley eBooks · doi:10.1002/9780470344613 · Cited by 537
The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents
Suckow, M. A. (2012) · Elsevier eBooks · doi:10.1016/c2009-0-30495-x · Cited by 375

Show all 382 references

Research works printed but not linked: 19

Nicklas W, 1993, Lab Anim Sci, 43, 296
Koszdin KL, 2002, Contemp Top Lab Anim Sci, 41, 18
Ike F, 2007, Comp Med, 57, 272
Berard M, 2009, Comp Med, 59, 187
Liang CT, 2009, J Am Assoc Lab Anim Sci, 48, 381
Nicklas W, 1988, Lab Anim Sci, 38, 152
Agca Y, 2007, Comp Med, 57, 51
Lipman NS, 2000, Comp Med, 50, 426
Labelle P, 2009, Comp Med, 59, 180
ILAR. Committee on Long-Term Holding of Laboratory Rodents, 1976, ILAR News, 19, L1
Dubin S, 1991, Lab Anim (NY), 20, 29
Besselsen DG, 2000, Comp Med, 50, 498
Janus LM, 2008, Comp Med, 58, 360
Thomas ML, 2007, Comp Med, 57, 74
Compton SR, 2004, Comp Med, 54, 382
Smith PC, 2007, Comp Med, 57, 90
Feinstein RE, 2011, Handbook of laboratory animal science, Vol. 1, Essential principles and practices, 613
Boot R, 2001, Scand J Lab Anim Sci, 28, 2
Besselsen DG, 2007, Comp Med, 57, 66

Sorted by citations

Items 501–600 of 648

Building for the future: essential infrastructure for rodent ageing studies
Wells, S. E., & Bellantuono, I. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9646-7 · Cited by 1
Certificação de métodos microbiológicos de diagnóstico do Laboratório de Controle Qualidade Sanitária do CEMIB/UNICAMP junto ao ICLAS
Moreira, J. C. D. O., Demolin, D. M. R., Issei, C. Y. M., et al. (2016) · Revista Saberes Universitários · doi:10.20396/saberes.v1i1.6950 · Cited by 1
OVARIECTOMISED AND LONG TERM INDUCED (OLI) RAT MODEL FOR PRECLINICAL ASSESSMENT OF OSTEOPOROTIC THERAPEUTICS.
Chandran, S., Sreelatha, H. V., & John, A. T. (2017) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v7i2.1400 · Cited by 1
Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide
Tsuru, M., Sata, M., Tanaka, M., et al. (2017) · Translational Oncology · doi:10.1016/j.tranon.2017.10.001 · Cited by 1
“[11] Mahler M, Berard M, Feinstein R, Gallagher A, Illgen B, Pritchett K, and Raspa M”
Background
Decontamination of genetically modified mice strains by embryo transfer for obtaining SPF colonies in a Brazilian animal facility
Antiorio, A. T. F. B., Massironi, S. M. G., de Luca, R. R., et al. (2019) · Brazilian Journal of Veterinary Research and Animal Science · doi:10.11606/issn.1678-4456.bjvras.2019.143588 · Cited by 1
Impact of environmental conditions on the levels of stress and breeding performance in Wistar rats: conventional environment versus environmentally controlled housing.
Harikrishnan, V. (2021) · The Applied Biology & Chemistry Journal · doi:10.52679/tabcj.2021.0009 · Cited by 3
Identification of vacuolar autophagic aggregates in the skeletal muscles of inbred C57BL/6NCrl mice
Biase, D. D., Pagano, T. B., Malanga, D., Russo, V., Piegari, G., d’Aquino, I., Iovane, V., Scarfò, M., Papparella, S., Wojcik, S. P., et al. (2023) · Laboratory Animals · doi:10.1177/00236772221138942 · Cited by 1
Microbial exposure during early life regulates development of bile duct inflammation
Oldereid, T. S., Jiang, X., Øgaard, J., Schrumpf, E., Bjørnholt, J. V., Rasmussen, H., & Melum, E. (2023) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2023.2278423 · Cited by 1
“GF status was verified monthly by aerobic and anaerobic microbial cultivation of collected fecal pellets and mold trap samples from the GF isolator, and yearly serology and PCR testing according to FELASA 2014 recommendations [26].”
Method
SNX27: A trans-species cognitive modulator with implications for anxiety and stress susceptibility
Armada, G., Roque, S., Serre-Miranda, C., Ferreira, L., Vale, A., Rodrigues, A. J., Hong, W., Correia‐Neves, M., & Vieira, N. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100619 · Cited by 1
Impact of the day/night cycle on functional connectome in ageing male and female mice
Lokossou, A., Rabuffo, G., Bernard, M., Bernard, C., Viola, A., & Perles‐Barbacaru, T. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120576 · Cited by 1
Assessment of the Inflammatory Effects of Gut Microbiota from Human Twins Discordant for Ulcerative Colitis on Germ-free Mice
Knudsen, L. A., Zachariassen, L. F., Strube, M. L., Havelund, J. F., Pilecki, B., Nexøe, A. B., Møller, F. T., Sørensen, S. B., Marcussen, N., Færgeman, N. J., et al. (2024) · Comparative Medicine · doi:10.30802/aalas-cm-23-000065 · Cited by 2
Experimental colonization with H. hepaticus, S. aureus and R. pneumotropicus does not influence the metabolic response to high-fat diet or incretin-analogues in wildtype SOPF mice
Wunderlich, M., Miller, M., Ritter, B., Gleut, R. L., Marchi, H., Majzoub‐Altweck, M., Knerr, P. J., Douros, J. D., Müller, T. D., & Brielmeier, M. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101992 · Cited by 1
“The bacteria were selected based on their prevalence in animal husbandry and their relevance to diabetic patients [11,13].”
Background
Statistical design for health monitoring in laboratory animal facilities using sentinel animals
Sorzano, C. Ó. S., Sánchez, I., & Naranjo, A. (2024) · Laboratory Animals · doi:10.1177/00236772231219292 · Cited by 1
Low‐gainer diet‐induced obese microbiota transplanted mice exhibit increased fighting
Mentzel, C. M. J., Yan, H., Hammerich, T. M. S., Klug‐Dambmann, M., Liu, Y., Zachariassen, L. F., Hansen, L. H., Aslampaloglou, A., Kiersgaard, M. K., Nielsen, D. S., et al. (2024) · Clinical and Translational Science · doi:10.1111/cts.13906 · Cited by 1
Health Management and Monitoring
Kolstrup, S. H., Hansen, A. K., & Pedersen, T. B. (2024) · Laboratory animal science and medicine · doi:10.1007/978-3-031-65414-5_8 · Cited by 1
Investigation of natural infection of BALB C mice by Bartonella henselae
dos Santos, L. S., Martins, S. A. S., Scheffer, F. R., et al. (2024) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2024.104483 · Cited by 1
Murine astrovirus infection course and antibody response in different mouse strains
Seib, J., Höfler, D., Hornetz, L., Ohl, N., Götz, K., Vogel, K. A., Butt, J., & Schmidt, K. (2025) · Lab Animal · doi:10.1038/s41684-025-01573-w · Cited by 1
Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles
Joncour, V. L., Evans, A. D., Bergström, C., et al. (2025) · Advanced Science · doi:10.1002/advs.202509590 · Cited by 1
Preclinical In-Vivo Assessment of Tissue Engineered Vascular Grafts and Selection of Appropriate Animal Models
Bergmeister, H., & Podesser, B. K. (2019) · Springer eBooks · doi:10.1007/978-3-319-71530-8_5-1 · Cited by 1
Morphogenesis of Penile Cavernous Fibrosis in Hypotestosteronemia: an Experimental Study
Коган, М. И., Todorov, S. S., Popov, I. V., Popov, I. V., Kulishova, M. A., Ermakov, A. M., & Sizyakin, D. V. (2020) · Urology Herald · doi:10.21886/2308-6424-2020-8-1-14-24 · Cited by 1
Distribution of Corynebacterium Species and Comparative Results of Diagnostic Methods for Identifying Corynebacterium in Experimental Mice in Korea
Park, S., Shin, H., Kim, S., et al. (2022) · Veterinary Sciences · doi:10.3390/vetsci9070328 · Cited by 1
“Such microbiological monitoring programs are essential to the operation of experimental animal facilities, not only to guarantee quality experimental results, but also for general animal welfare and to protect researchers against zoonotic disease [4].”
Background
The freeze-dried extracts of Salvia coccinea Juss. Ex Murray attenuate myocardial ischemia reperfusion injury in a global ischemia Rat modelPreprint
Nyaga, N. M., Mwangi, P. W., & Bukachi, F. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/396119 · Cited by 1
Tissue-wide Effects Overrule Cell-intrinsic Gene Function in Cortical Projection Neuron MigrationPreprint
Hansen, A. H., Pauler, F. M., Riedl, M., Streicher, C., Heger, A., Laukoter, S., Sommer, C., Nicolas, A., Hof, B., Tsai, L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.16.480659 · Cited by 1
Enhanced Cultured Diversity of the Mouse Gut Microbiota Enables Custom-Made Synthetic CommunitiesPreprint
Afrizal, A., Jennings, S. A. V., Hitch, T. C. A., Riedel, T., Basic, M., Panyot, A., Treichel, N. S., Hager, F. T., Wong, E. O. Y., Viehof, A., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4102621 · Cited by 1
The laboratory rat
de Boer, S. F., & Koolhaas, J. M. (2024) · Wiley eBooks · doi:10.1002/9781119555278.ch22 · Cited by 1
The laboratory mouse
Pritchett‐Corning, K. R., & Garner, J. P. (2024) · Wiley eBooks · doi:10.1002/9781119555278.ch21 · Cited by 2
Self-citation
The Syrian hamster
Winnicker, C., & Pritchett‐Corning, K. R. (2024) · doi:10.1002/9781119555278.ch24 · Cited by 1
Self-citation
Mechanical problem solving in micePreprint
Boon, M. N., Andresen, N., Traverso, S., Meier, S., Schuessler, F., Hellwich, O., Lewejohann, L., Thöne‐Reineke, C., Sprekeler, H., & Hohlbaum, K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.29.605658 · Cited by 3
“They were free of pathogens listed in the FELASA recommendation [21].”
Automatic pain face analysis in mice: Applied to a varied dataset with non-standardized conditionsPreprint
Andresen, N., Wöllhaf, M., Wilzopolski, J., Lang, A., Wolter, A., Howe-Wittek, L., Bekemeier, C., Pawlak, L.-I., Beyer, S., Cynis, H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.16.706098 · Cited by 1
Influence of predator and food chemical cues in the behaviour of the house mouse (Mus musculus)
Paricio, C. G. (2019) · theses.fr (ABES) · doi:10.70675/caadfcf8z4a4cz4fdez9b9ezaa55a308131f · Cited by 1
On the importance of health monitoring
Riederer, B. M. (2014) · Laboratory Animals · doi:10.1177/0023677214537785
Experimental study of ionized tap water on the status of female rats
Audickaitė, A., Stankevič, J., Šimčikas, V., et al. (2014)
A harmonized health reporting format for international transfer of rodents. AALAS–FELASA Working Group on Health Monitoring of Rodents for Animal Transfer
Prins, J. (2015) · Laboratory Animals · doi:10.1177/0023677215602998
“The consensus formats for mice and rats presented by this working group are more detailed than those suggested by the FELASA working group on health monitoring.(2) The working group has provided a list of agents in order to create a standardized health report.”
Method
Caracterização anatomopatológica, microbiológica e parasitológica de ratos Wistar (Rattus norvegicus) em diferentes idades
Paiva, V. L. G. D. S. (2016) · doi:10.11606/d.10.2016.tde-23032016-164918
Animal nutrition and breeding conditions modify the physiology of isolated primary cells
Milisav, I., Banič, B., & Šuput, D. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.02.012
Effect of Cross-Fostering on a Variety of Viral Agents in Conventionally Bred Rats
Karaman, M., Baltacao glu, G., Kolatan, H. E., et al. (2017) · Journal of Animal Research and Nutrition · doi:10.21767/2572-5459.100032
“For this purpose, the Federation of European Laboratory Animal Science Associations (FELASA) is regularly revising its recommendations on monitoring the health of the production colonies or experimental units [7].”
Background
Estudio de la prevalencia de infecciones producidas por el Virus Diminuto del Ratón (MVM) en bioterios de Argentina y su influencia en la contaminación de tumores trasplantables
Laborde, J. M. (2017) · doi:10.35537/10915/61115
PCR-based detection of Helicobacter spp. in mice from different animal houses in Rio de Janeiro, BrazilPreprint
Matos-Rodrigues, G. E., MASSERON, C. C., da Silva, F. J. M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/727420
Microbiological monitoring of laboratory mice environment in a barrier experimental facility
Svoboda, T., Špelina, V., Petřáš, P., et al. (2019) · Hygiena · doi:10.21101/hygiena.a1720
“Jedná se o mikrobiologické vyšetření namátkově vybraných zvířat, která jsou pro tento účel usmrcována (2).”
Cinco anos de avaliação diagnóstica de desempenho junto ao programa animal Quality Network do ICLAS
Moreira, J. C. D. O., Lacerda, J. L. A., Minagawa, C. Y., et al. (2019) · Resumos... · doi:10.20396/sinteses.v0i7.10248
Development of an animal-free methodology for mechanical performance assessment of engineered skin substitutes
Aldieri, A., Terzini, M., Massai, D., Bignardi, C., & Audenino, A. L. (2020) · Biomedical Science and Engineering · doi:10.4081/bse.2019.103
Health monitoring program for the control of laboratory animal diseases
Romano, C., Cacciamali, A., Dotti, S., et al. (2020) · Biomedical Science and Engineering · doi:10.4081/bse.2019.117
Prevalencia del virus diminuto del ratón, determinada mediante una técnica de PCR semianidada, en ratones de experimentación de bioterios de Argentina
Laborde, J. M., Sguazza, G. H., Fuentealba, N. A., et al. (2020) · Analecta Veterinaria · doi:10.24215/15142590e046
Simultaneous serodetection of major rat infectious pathogens by a multiplex immunochromatographic assay
Tosa, N., Ishida, T., Yoshimatsu, K., et al. (2020) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.20-0099
“according to recommendations from the Federation of European Laboratory animal science associations (FELasa), health monitoring programs in laboratory animal facilities should include at least 11 pathogens [24].”
Method
Risk-Based Approach to the Assessment of Sanitary Safety of Vivariums and Breeding Facilities, and Health Status of Personnel and Laboratory Animals
Bondareva, E. D., Евгеньевна, Б. К., & Макарова, М. Н. (2020) · The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products Regulatory Research and Medicine Evaluation · doi:10.30895/1991-2919-2020-10-4-257-266
“Федерация европейских научных ассоциаций по лабораторным животным (Federation for Laboratory Animal Science Associations, FELASA) рекомендует проводить контроль микробиологического статуса животных по определенному перечню патогенов [3].”
Simulation of Air Travel-Related Irradiation Exposure of Cryopreserved Mouse Germplasm Samples
Voggenreiter, T., Laport, E., Kahn-Schapowal, B., et al. (2021) · Biopreservation and Biobanking · doi:10.1089/bio.2020.0046
Modern Approach to Assessing Quality of Laboratory Animals Used for Experimental Purposes
Семакова, А. П., Германчук, В. Г., & Shavina, N. Y. (2021) · ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT · doi:10.35627/2219-5238/2021-335-2-84-90
Should doses exceeding 0.2 mg/kg of oral meloxicam be given to reduce surgical recovery time in rabbits and should twice daily administration be considered?
Best, E. (2021) · Veterinary Evidence · doi:10.18849/ve.v6i3.372
Detection of pathogens from environmental samples for the evaluation of the health status of laboratory animals
Cacciamali, A., Romano, C., Checco, M. A., et al. (2021) · Biomedical Science and Engineering · doi:10.4081/bse.2021.159
Closing an Eye for the Reliability of Orbital Tightening in Pain Detection: A Model-Specific Simplification of the Mouse Grimace ScalePreprint
Ernst, L., Bruch, S., Kopaczka, M., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-1152582/v1
Rodentibacter
Christensen, H. K., Nicklas, W., Bisgaard, M., et al. (2020) · Bergey's Manual of Systematics of Archaea and Bacteria · doi:10.1002/9781118960608.gbm01855
Generación de una colonia de ratones transgénicos homocigotas K18-hACE2 para la evaluación de candidatos vacunales y terapéuticos contra el SARS-CoV-2
Berengeno, A. L., Matiller, V., Díaz, P. U., REBELINDO, E., RODRIGUEZ, F. M., ANWEG, A., SILVESTRINI, P., CATTANEO, M. L., Peralta, M. B., Durante, L. I., et al. (2022) · FAVE Sección Ciencias Veterinarias · doi:10.14409/favecv.v20isuppl..11212
Identificação de norovírus murino (MNV) nos biotérios brasileiros
Demolin, D. M. R. (2017) · doi:10.47749/t/unicamp.2017.980847
Institutional Preconditions for Small Animal Imaging
Tolba, R. H. (2017) · Springer eBooks · doi:10.1007/978-3-319-42202-2_5
Faculty Opinions recommendation of Heterochronic faecal transplantation boosts gut germinal centres in aged mice.
Valenzano, D. R. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735897629.793564141
KIỂM TRA VÀ GIÁM SÁT MỘT SỐ VI SINH VẬT GÂY BỆNH TRÊN ĐỘNG VẬT THÍ NGHIỆM BẰNG PHƯƠNG PHÁP NUÔI CẤY
Hưng, H. T., Hiếu, N. C., Hồng, T. T., et al. (2022) · JOURNAL OF CONTROL VACCINES AND BIOLOGICALS · doi:10.56086/jcvb.v2i1.21
Effects of flumethrin and eprinomectin in naturally infected mice with Myocoptes musculinus
Aktas, S., Bakırcı, S., Bilgiç, H. B., et al. (2022) · Experimental Parasitology · doi:10.1016/j.exppara.2022.108307
A New CUT&RUN Low Volume-Urea (LoV-U) protocol uncovers Wnt/β-catenin tissue-specific genomic targetsPreprint
Zambanini, G., Nordin, A., Jonasson, M. E., Pagella, P., & Cantù, C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.06.498999
Scopulariopsis brevicaulis fungal outbreak in laboratory rats
Mazzarotto, G. A. C. A., Cruz, R. C. B., Demolin, D. M. R., et al. (2022) · Biological Models Research and Technology · doi:10.4322/2675-9225.00042022
Detection of Waterborne and Airborne Microorganisms in a Rodent Facility
SILVA, L. M. D., Santiago, M. B., de Aguiar, P. A. D. F., et al. (2022) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202220220150
Pre-immunization with inactivated pathogens recapitulates adult human immune memory in laboratory micePreprint
Falkenberg, C., Toft, M., Skov, S., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2165344/v1
Health Monitoring for Laboratory Salamanders
Crim, M. J., & Hart, M. L. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2659-7_3
Avaliação comportamental de camundongos após administração de meloxicam e tramadol como forma de manejo da dor aguda pós-operatória
Antiorio, A. T. F. B. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2021.tde-18112022-102737
Triple Aim - Metodologia de gestão para instalações animais: definição de indicadores de bem-estar e saúde em camundongos de laboratório
Cintra, L. (2022) · doi:10.11606/t.10.2022.tde-30112022-085150
Eficácia do método de graham para o diagnóstico de Syphacia obvelata (Rudolphi, 1802) no monitoramento sanitário de camundongos Swiss Webster de um biotério de criação
dos Santos, I. S., da Silva, C. S., Hooper, C., et al. (2022) · Biological Models Research and Technology · doi:10.4322/2675-9225.00092022
Assessment of the Spread of Certain Pathogens Among Laboratory Rodents at Universities and Academic Institutes of Almaty, Kazakhstan
Islamov, R., Турегелдиева, Д. А., Rysbekova, A. K., et al. (2022) · Journal of Animal Health and Production · doi:10.17582/journal.jahp/2023/11.1.1.6
Cultivo de células troncales de médula ósea de ratas para uso en regeneración de tejidos
Pirela, A. E., Tobón, L. F. T., Molina, N. S. R., et al. (2022) · Universitas Odontologica · doi:10.11144/javeriana.uo41.rbms
Opening a window to the acutely injured brain: Simultaneous retinal and cerebral vascular monitoring in rats
Warner, L., Bach-Hagemann, A., Schmidt, T. P., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1116841
“Health monitoring was performed according to the Federation of European Laboratory Animal Science Associations (FELASA) recommendations (Mähler et al., 2014).”
Method
Brazilian laboratory rats and mice: decades pass, but parasite infections remain
Pedro, D. A., Barreto, M. L., & Castro, H. C. (2023) · Ciência Rural · doi:10.1590/0103-8478cr20220452
Effect of Systemic Administration of CD4+ T cells and Local Administration of T-cell Stimulants on T-cell Activity in Psoriatic Skin Xenografts on NOG Mice
Christensen, P. K. F., Hansen, A. K., Skov, S., et al. (2023) · Comparative Medicine · doi:10.30802/aalas-cm-23-000006
Preclinical Studies Design and Place of Rabbits
Sandgren, R. (2023) · Springer eBooks · doi:10.1007/978-3-031-37234-6_3
Detection of pathogens from environmental samples for the evaluation of the health status of laboratory animals
Cacciamali, A., Romano, C., Checco, M. A., et al. (2021) · Biomedical Science and Engineering · doi:10.4081/bse.159
Swollen Ampulla as an Indicator of Successful Pregnancy in B6C3F1 Recipient Mice used for Assisted Reproduction
Gougoula, C., Benten, W. P. M., Kaplanian, A., et al. (2023) · Journal of the American Association for Laboratory Animal Science · doi:10.30802/aalas-jaalas-23-000051
“HOOF WOODPECKER” AT CORONARY BAND AND HOOF WALL LEVEL IN FORESTRY ENVIRONEMENT WORKING HORSES
Iasi, U., Lazăr, C., Mihăilă, I., et al. (2023) · Lucrări Ştiinţifice - Medicină Veterinară, Universitatea de Ştiinţe Agricole şi Medicină Veterinară "Ion Ionescu de la Brad" Iaşi · doi:10.61900/spjvs.2023.02.02
Risk-based approach to the health monitoring of rabbits
Bondareva, E. D., Макарова, М. Н., Akimov, D. Y., et al. (2023) · Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science) · doi:10.57034/2618723x-2023-03-01
FACTORIAL ANALYSIS OF SOME INDICATORS IN CHRONIC OSTEOATICULAR MODEL OF RABBITS
Lungu, B. C., Bratu, D. G., Spătaru, I.-I., et al. (2023) · Lucrări Ştiinţifice - Medicină Veterinară, Universitatea de Ştiinţe Agricole şi Medicină Veterinară "Ion Ionescu de la Brad" Iaşi · doi:10.61900/spjvs.2023.03.02
JoVE Video Dataset
Hohlbaum, K., Kahnau, P., Wilzopolski, J., & Fischer-Tenhagen, C. (2024) · doi:10.3791/66008-v
Transportation of laboratory animals
Chou, S. T., Clemons, D. J., Dudoignon, N., et al. (2024) · doi:10.1002/9781119555278.ch12
The laboratory rabbit
Lidfors, L., & Edström, T. (2024) · doi:10.1002/9781119555278.ch28
Additional file 2 of A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver
Kopasz, A. G., Pusztai, D. Z., Karkas, R., Hudoba, L., Abdullah, K. S. A., Imre, G., Pankotai-Bodó, G., Migh, E., Nagy, A., Kriston, A., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19498032
Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development
Grammer, C., Komorowska, J. A., & Swann, J. B. (2024) · iScience · doi:10.1016/j.isci.2024.110258
“Regular health monitoring was performed according to FELASA guidelines, 78 and all mice were healthy at the time of use.”
Retrospective analysis on the occurrence of kidney cysts in mice in a central animal facility in the years 2009–2019
Becker, K. (2024) · Laboratory Animals · doi:10.1177/00236772241242538
Viruses and Viral Diagnostics
Hansen, A. K., Rasmussen, T. S., & Andresen, L. O. (2024) · Laboratory animal science and medicine · doi:10.1007/978-3-031-59103-7_9
Bacteria and Bacterial Diagnostics
Christensen, H. K., & Nicklas, W. (2024) · Laboratory animal science and medicine · doi:10.1007/978-3-031-59103-7_10
Health Monitoring Programmes and International Standards
Nicklas, W., Buchheister, S., & Bleich, A. (2024) · Laboratory animal science and medicine · doi:10.1007/978-3-031-59103-7_7
Comparison of Biological Augmentation in Rotator Cuff Repair Using Inflamed Versus Noninflamed Bursal Tissue in Rats
Zhang, A., Ficklscherer, A., Niethammer, T. R., Woiczinski, M., Davies-Knorr, P., Holzapfel, B. M., & Müller, P. E. (2024) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2024.07.036
Efficacy of filter top cages to reduce cross-contamination in mice housed in experimental facilitiesPreprint
Montagna, D. R., Stefani, K. M., Almirón, J. P., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4797394/v1
The Transcription Factor Binding Landscape of Mouse DevelopmentPreprint
Nordin, A., Zambanini, G., Jonasson, M. E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.23.609315
“The mice were free of all viral, bacterial and parasitic pathogens listed in FELASA recommendations (Mähler et al., 2014).”
Background
Murine astrovirus (MuAstV) infection in mouse facilities in Brazil: First South American report
de Oliveira, M. S. C., de Castro, T. X., Baez, C. F., et al. (2024) · Laboratory Animals · doi:10.1177/00236772241257132
Production, analysis, and safety assessment of a soil and plant-based natural material with microbiome- and immune-modulatory effects
Parajuli, A., Mäkelä, I., Roslund, M. I., Ringqvist, E. E., Manninen, J., Sun, Y., Nurminen, N., Oikarinen, S., Laitinen, O. H., Hyöty, H., et al. (2024) · Methods · doi:10.1016/j.ymeth.2024.09.011
Biosecurity and Gnotobiology
Berard, M. (2024) · Laboratory animal science and medicine · doi:10.1007/978-3-031-65414-5_9
Self-citation
Case report: C57BL/6NTac and C57BL/6NCrl mice displaying neurological signs after deworming with ivermectin
Eriksson, M., & Nylén, S. (2024) · Laboratory Animals · doi:10.1177/00236772241286214
Cardiac inotropy and cardiac calcium sensitization of PanLN800(-Forte), a cationic heptamethine indocyanine fluorescent contrast agent for intraoperative pan lymph node imaging
Faber, R. A., Baart, V. M., Bordo, M. W., et al. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.117222
Gut Microbiota-Based Strategies for Targeting Hepatic Encephalopathy
Romaní‐Pérez, M., Cénit, M. C., & Agustí, A. (2025) · Neuromethods · doi:10.1007/978-1-0716-4354-9_10
A communication pipeline for in vivo imaging core facilities
Ntafis, V. (2025) · Laboratory Animals · doi:10.1177/00236772241309759
Loss of ING3 in the Prostate Leads to Activation of DNA Damage Repair Markers
Lang, V., Barones, L., Hu, S. M., Hashemi, F., Blote, K. R., Riabowol, K. T., & Fink, D. (2025) · Cancers · doi:10.3390/cancers17061037
“Mice were housed in a specific pathogen-free environment in compliance with FE-LASA recommendations [28] in individually ventilated cages (Eurostandard Type IIL; Tecniplast, Buguggiate, Italy) with adequate enrichment and nesting material.”
Guidance on Establishing Health Monitoring Panels for Laboratory Mice to Reflect Contemporary Pathogen Prevalence
Hanson, W. H., Hibl, B. M., Manuel, C. A., et al. (2025) · Journal of the American Association for Laboratory Animal Science · doi:10.30802/aalas-jaalas-24-134
Case Report and Treatment of Streptobacillus moniliformis in Laboratory and Wild Thirteen-Lined Ground Squirrels (Ictidomys tridecemlineatus)
Brundage, C., Gehrke, G., & Cooper, S. (2025) · Journal of the American Association for Laboratory Animal Science · doi:10.30802/aalas-jaalas-25-015
A Cohort Effect on AOM/DSS Colorectal Cancer Model Performance in C57BL/6 Mice
Achasova, K. M., & Kozhevnikova, E. N. (2025) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093025020061
The Impact of Human Milk Oligosaccharides on Antibiotic-Induced Microbial Dysbiosis and Gut Inflammation in Mice
Christensen, K. R., Rasmussen, T. S., Mentzel, C. M. J., Lanng, S. K., Meloni, E. T. G., Bertram, H. C., Hansen, C. H. F., & Hansen, A. K. (2025) · Antibiotics · doi:10.3390/antibiotics14050488
“Health monitoring, following FELASA guidelines [86], revealed no indications of listed infections.”

Authors: FELASA working group on revision of guidelines for health monitoring of rodents and rabbits, Mähler (Convenor), M., Berard, M., Feinstein, R., Gallagher, A., Illgen-Wilcke, B., Pritchett-Corning, K., & Raspa, M.
Affiliations: GV-SOLAS, Gesellschaft für Versuchstierkunde
Swedish Veterinary Agency (SE)
Medical Research Council (GB)
University of Washington (US)
AALAS, American Association for Laboratory Animal Science
National Research Council (IT)
ORCID: Berard, M
Raspa, M
Venue: Laboratory Animals
Publisher: SAGE Publications
Published: 2014-02-04
Volume: 48
Issue: 3
Pages: 178-192
ISSN: 0023-6772 (ISSN-L)
1758-1117
DOI: 10.1177/0023677213516312
OpenAlex: W2153218957
Semantic Scholar: 3f0f57dfc81bdbf0b4adc599d3696d57bd2535a2
Cited by: 646
References: 382
Citations by year: 2026: 36 · 2025: 63 · 2024: 69 · 2023: 60 · 2022: 67 · 2021: 73 · 2020: 62 · 2019: 62 · 2018: 47 · 2017: 42 · 2016: 28 · 2015: 24 · 2014: 12
FWCI: 51.91
Type: journal article
Language: en
Update notices: correction (2014-09-02)
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Laboratory Animals (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Behavior and Welfare Studies
Keywords: laboratory animal health monitoring, sentinel animals, opportunistic pathogens, laboratory mice, laboratory rats, golden hamster, guinea pig, rabbits, laboratory animal medicine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

FELASA recommendations for the health monitoring of mouse, rat, hamster, guinea pig and rabbit colonies in breeding and experimental units

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks