The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Pharmacokinetics of Anthocyanins and Ellagic Acid in Healthy Volunteers Fed Freeze‐Dried Black Raspberries Daily for 7 Days
Abstract
Eleven subjects completed a clinical trial to determine the safety/tolerability of freeze‐dried black raspberries (BRB) and to measure, in plasma and urine, specific anthocyanins‐cyanidin‐3‐glucoside, cyanidin‐3‐sambubioside, cyanidin‐3‐rutinoside, and cyanidin‐3‐xylosylrutinoside, as well as ellagic acid. Subjects were fed 45 g of freeze‐dried BRB daily for 7 days. Blood samples were collected predose on days 1 and 7 and at 10 time points postdose. Urine was collected for 12 hours predose on days 1 and 7 and at three 4‐hour intervals postdose. Maximum concentrations of anthocyanins and ellagic acid in plasma occurred at 1 to 2 hours, and maximum quantities in urine appeared from 0 to 4 hours. Overall, less than 1% of these compounds were absorbed and excreted in urine. None of the pharmacokinetic parameters changed significantly between days 1 and 7. In conclusion, 45 g of freeze‐dried BRB daily are well tolerated and result in quantifiable anthocyanins and ellagic acid in plasma and urine.
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Cites
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Bravo, L. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01670.x · Cited by 4,030
Vegetables, Fruit, and Cancer Prevention
STEINMETZ, K. A., & POTTER, J. D. (1996) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(96)00273-8 · Cited by 2,118
Vegetables, fruit, and cancer. II. Mechanisms
Steinmetz, K. A., & Potter, J. D. (1991) · Cancer Causes and Control · doi:10.1007/bf00054304 · Cited by 804
Youdim, K. A., Martin, A., & Joseph, J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00329-4 · Cited by 312
Cited by
Effects of anthocyanins on the prevention and treatment of cancer
Lin, B., Gong, C., Song, H., & Cui, Y. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13627 · Cited by 435
Espín, J. C., González-Barrio, R., Cerdá, B., López-Bote, C., Rey, A. I., & Tomás-Barberán, F. A. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0723864 · Cited by 352
Metadata
- Authors
- Stoner, G. D., Sardo, C., Apseloff, G., Mullet, D., Wargo, W., Pound, V., Singh, A., Sanders, J., Aziz, R., Casto, B., & Sun, X.
- Venue
- The Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2005-10
- Volume
- 45
- Issue
- 10
- Pages
- 1153-1164
- ISSN
- 0021-9754 (ISSN-L)
- 0091-2700
- 1552-4604
- OpenAlex
- W2101072227
- Cited by
- 163
- References
- 4
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pharmacokinetics of Anthocyanins and Ellagic Acid in Healthy Volunteers Fed Freeze‐Dried Black Raspberries Daily for 7 Days. https://app.cochat.ai/papers/10.1177/0091270005279636
- The paper
- Stoner, G. D., Sardo, C., Apseloff, G., Mullet, D., Wargo, W., Pound, V., Singh, A., Sanders, J., Aziz, R., Casto, B., & Sun, X. (2005). Pharmacokinetics of Anthocyanins and Ellagic Acid in Healthy Volunteers Fed Freeze‐Dried Black Raspberries Daily for 7 Days. The Journal of Clinical Pharmacology. https://doi.org/10.1177/0091270005279636
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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