Cited by 125Adrenal Hormones and DisordersPharmacogenetics and Drug MetabolismPharmaceutical studies and practices

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Prednisolone Pharmacokinetics and Pharmacodynamics in Relation to Sex and Race

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Magee, Mindy He, Blum, Robert A., Lates, Christian D., Jusko, William J.·2001·The Journal of Clinical Pharmacology

DOI 10.1177/00912700122012733PMC PMC4207281

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Abstract

Prednisolone pharmacokinetics (PK) and pharmacyodynamics (PD) were investigated in relation to sex and race in white males, black males, white females, and black females (n = 8/group) after a single oral dose (0.27 mg/kg) of prednisone. The study consisted of baseline and prednisone phases with 32‐hour sampling in each phase. Women were studied during the luteal phase of their menstrual cycle. Total and free plasma prednisolone concentrations were assayed by HPLC and ultrafiltration, and pharmacokinetic data were analyzed by compartmental fitting using WinNonlin. Plasma cortisol concentrations were assayed by HPLC; T‐helper, T‐suppressor lymphocyte, and neutrophil cell counts were determined by FACS and hemocytometry, and these pharmacodynamic data were evaluated by basic and extended indirect response models using ADAPT II. Total body weight‐normalized free prednisolone oral clearance and apparent volume of distribution were higher in men compared with women, regardless of race (by 22% in whites and 40% in blacks for oral clearance, p < 0.01; by 32% in whites and 38% in blacks for apparent volume of distribution, p < 0.01). The 50% inhibitory concentration (IC50) values for T‐suppressor cell‐trafficking inhibition were higher in whites than in blacks, regardless of sex (by 125% in men and 208% in women, p < 0.01). The IC50 or SC50 values for effects of prednisolone on cortisol secretion and T‐helper lymphocyte or neutrophil trafficking were not statistically different between men and women, blacks and whites. The findings of this study suggest that there are some prednisolone PK/PD differences related to sex and race. However, these differences do not suggest the need for dosage adjustments, and additional experiments with repeat dosing are needed to fully evaluate the clinical implication of these findings.

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FAUCI, A. S., DALE, D. C., & BALOW, J. E. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-3-304 · Cited by 1,044
Female Gender as a Risk Factor for Torsades de Pointes Associated With Cardiovascular Drugs
Makkar, R. (1993) · JAMA · doi:10.1001/jama.270.21.2590 · Cited by 972
Comparison of four basic models of indirect pharmacodynamic responses
Dayneka, N., Garg, V., & Jusko, W. J. (1993) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf01061691 · Cited by 821
Self-citation
Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action.
Ahmed, S. A., Penhale, W. J., & Talal, N. (1985) · PubMed · Cited by 815
Gender Effects in Pharmacokinetics and Pharmacodynamics
Harris, R. Z., Benet, L. Z., & Schwartz, J. B. (1995) · Drugs · doi:10.2165/00003495-199550020-00003 · Cited by 504
Regulation of L-selectin and CD18 on bovine neutrophils by glucocorticoids: effects of cortisol and dexamethasone
Burton, J. L., Kehrli, M. E., Kapil, S. J., & Horst, R. L. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.57.2.317 · Cited by 277
Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.
Schuetz, E. G., Furuya, K. N., & Schuetz, J. D. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12089-2 · Cited by 266
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IMMUNOSUPPRESSIVE THERAPY IN HIGH-RISK TRANSPLANT PATIENTS
Neylan, J. F. (1997) · Transplantation · doi:10.1097/00007890-199711150-00008 · Cited by 185
Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics
Lew, K. H., Ludwig, E. A., Milad, M. A., Donovan, K., Middleton, E., Ferry, J. J., & Jusko, W. J. (1993) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1993.167 · Cited by 169
Self-citation

Show all 44 references

Research works printed but not linked: 4

10.1001/jama.1993.03510210076031 · DOI
Spahn JBE, 1999, Do African Americans display a diminished response to glucocorticoids?, J Allergy Clin Immunology, 104, S62
Jusko WJ, 1995, Applied Pharmacokinetics: Principle of Therapeutic Drug Monitoring.
D'Argenio DZ, 1997, ADAPT II Users' Guide: Pharmacokinetic/Pharmacodynamic Systems Analysis Software.

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Authors: Magee, M. H., Blum, R. A., Lates, C. D., & Jusko, W. J.
Affiliations: Kaleida Health (US)
Corresponding author: Jusko, William J.
ORCID: Magee, Mindy He
Jusko, William J.
Venue: The Journal of Clinical Pharmacology
Publisher: Wiley
Published: 2001-11
Volume: 41
Issue: 11
Pages: 1180-1194
ISSN: 0021-9754 (ISSN-L)
0091-2700
1552-4604
DOI: 10.1177/00912700122012733
PMC: PMC4207281
OpenAlex: W2065913585
Cited by: 125
References: 44
Citations by year: 2026: 2 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 13 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 5
FWCI: 4.14
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4145 d)
Locations: The Journal of Clinical Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R37GM024211, GM 24211, R01GM024211)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords: prednisolone, pharmacokinetics, pharmacodynamics, sex differences, racial differences, prednisone, oral clearance, volume of distribution, cortisol secretion, T helper cells, T suppressor lymphocytes, neutrophil trafficking, indirect response model, dose adjustment
MeSH terms: Adolescent, Adult, Anti-Inflammatory Agents, Female, T-Lymphocytes, Helper-Inducer, Humans, Hydrocortisone, Male, Middle Aged, Neutrophils, Prednisolone, Sex Factors, Black People, White People, T-Lymphocytes, Regulatory

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Prednisolone Pharmacokinetics and Pharmacodynamics in Relation to Sex and Race

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