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The D 2 Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome
Open accessAbstract
The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.
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“Some studies have reported evidence of decreased striatal recruitment in adolescents relative to children and/or adults during reward tasks (Bjork et al., 2004, Blum et al., 1996, Geier et al., 2010).”
From Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience (2014) · cites this paper as Blum et al., 1996
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Metadata
- Authors
- Blum, K., Sheridan, P. J., Wood, R. C., Braverman, E. R., Chen, T. J. H., phd, J. G. C., & Comings, D. E.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Department of Clinical Science, The PATH Foundation, Princeton, New Jersey, USA
- Chang Jung University, College of Public Health, Tainan, Taiwan, Republic of China
- Neurodevelopmental Institutes of North America, Ltd, San Antonio, Texas
- City Of Hope National Medical Center (US)
- ORCID
- Braverman, E R
- Venue
- Journal of the Royal Society of Medicine
- Publisher
- SAGE Publications
- Published
- 1996-07
- Volume
- 89
- Issue
- 7
- Pages
- 396-400
- ISSN
- 0141-0768 (ISSN-L)
- 1758-1095
- PMC
- PMC1295855
- OpenAlex
- W1920680810
- Cited by
- 443
- References
- 58
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 17 · 2023: 11 · 2022: 22 · 2021: 16 · 2020: 19 · 2019: 23 · 2018: 27 · 2017: 21 · 2016: 29 · 2015: 35 · 2014: 28 · 2013: 27 · 2012: 31
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the Royal Society of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- dopamine D2 receptor, reward deficiency syndrome, dopaminergic system, reward processing, genetic variants, alcoholism, drug addiction, tobacco use, gambling addiction, Tourette syndrome, attention deficit hyperactivity disorder
- MeSH terms
- Compulsive Behavior, Humans, Genetic Linkage, Risk Factors, Syndrome, Receptors, Dopamine D2, Substance-Related Disorders
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