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The D 2 Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome

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Blum, K, Sheridan, P J, Wood, R C, Braverman, E R, Chen, T J H, phd, J G Cull, Comings, D E·1996·Journal of the Royal Society of Medicine

DOI 10.1177/014107689608900711PMC PMC1295855

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Abstract

The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.

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Authors: Blum, K., Sheridan, P. J., Wood, R. C., Braverman, E. R., Chen, T. J. H., phd, J. G. C., & Comings, D. E.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
Department of Clinical Science, The PATH Foundation, Princeton, New Jersey, USA
Chang Jung University, College of Public Health, Tainan, Taiwan, Republic of China
Neurodevelopmental Institutes of North America, Ltd, San Antonio, Texas
City Of Hope National Medical Center (US)
ORCID: Braverman, E R
Venue: Journal of the Royal Society of Medicine
Publisher: SAGE Publications
Published: 1996-07
Volume: 89
Issue: 7
Pages: 396-400
ISSN: 0141-0768 (ISSN-L)
1758-1095
DOI: 10.1177/014107689608900711
PMC: PMC1295855
OpenAlex: W1920680810
Cited by: 443
References: 58
Citations by year: 2026: 6 · 2025: 14 · 2024: 17 · 2023: 11 · 2022: 22 · 2021: 16 · 2020: 19 · 2019: 23 · 2018: 27 · 2017: 21 · 2016: 29 · 2015: 35 · 2014: 28 · 2013: 27 · 2012: 31
FWCI: 0.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of the Royal Society of Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: dopamine D2 receptor, reward deficiency syndrome, dopaminergic system, reward processing, genetic variants, alcoholism, drug addiction, tobacco use, gambling addiction, Tourette syndrome, attention deficit hyperactivity disorder
MeSH terms: Compulsive Behavior, Humans, Genetic Linkage, Risk Factors, Syndrome, Receptors, Dopamine D2, Substance-Related Disorders

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The D 2 Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome

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