The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Prevalence of Olfactory and Gustatory Dysfunction in COVID‐19 Patients: A Systematic Review and Meta‐analysis
Abstract
Objective: To determine the pooled global prevalence of olfactory and gustatory dysfunction in patients with the 2019 novel coronavirus (COVID‐19). Data Sources: Literature searches of PubMed, Embase, and Scopus were conducted on April 19, 2020, to include articles written in English that reported the prevalence of olfactory or gustatory dysfunction in COVID‐19 patients. Review Methods: Search strategies developed for each database contained keywords such as anosmia, dysgeusia, and COVID‐19. Resulting articles were imported into a systematic review software and underwent screening. Data from articles that met inclusion criteria were extracted and analyzed. Meta‐analysis using pooled prevalence estimates in a random‐effects model were calculated. Results: Ten studies were analyzed for olfactory dysfunction (n = 1627), demonstrating 52.73% (95% CI, 29.64%‐75.23%) prevalence among patients with COVID‐19. Nine studies were analyzed for gustatory dysfunction (n = 1390), demonstrating 43.93% (95% CI, 20.46%‐68.95%) prevalence. Subgroup analyses were conducted for studies evaluating olfactory dysfunction using nonvalidated and validated instruments and demonstrated 36.64% (95% CI, 18.31%‐57.24%) and 86.60% (95% CI, 72.95%‐95.95%) prevalence, respectively. Conclusions: Olfactory and gustatory dysfunction are common symptoms in patients with COVID‐19 and may represent early symptoms in the clinical course of infection. Increased awareness of this fact may encourage earlier diagnosis and treatment, as well as heighten vigilance for viral transmission. To our knowledge, this is the first meta‐analysis to report on the prevalence of these symptoms in COVID‐19 patients.
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
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Cited by
Freeman, E. E., McMahon, D. E., Lipoff, J. B., Rosenbach, M., Kovarik, C., Desai, S. R., Harp, J., Takeshita, J., French, L. E., Lim, H. W., et al. (2020) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2020.06.1016 · Cited by 409
Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection
Butowt, R., & von Bartheld, C. S. (2021) · The Neuroscientist · doi:10.1177/1073858420956905 · Cited by 345
Spectrum of neuropsychiatric manifestations in COVID-19.
Nalleballe, K., Reddy Onteddu, S., Sharma, R., Dandu, V., Brown, A., Jasti, M., Yadala, S., Veerapaneni, K., Siddamreddy, S., Avula, A., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.06.020 · Cited by 235
Dysgeusia in COVID-19: Possible Mechanisms and Implications
Lozada-Nur, F., Chainani-Wu, N., Fortuna, G., & Sroussi, H. (2020) · Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2020.06.016 · Cited by 120
Rabinovitz, B., Jaywant, A., & Fridman, C. B. (2020) · The Clinical Neuropsychologist · doi:10.1080/13854046.2020.1803408 · Cited by 46
Metadata
- Authors
- Tong, J. Y., Wong, A., Zhu, D., Fastenberg, J. H., & Tham, T.
- Venue
- Otolaryngology–Head and Neck Surgery
- Publisher
- Wiley
- Published
- 2020-05-05
- Volume
- 163
- Issue
- 1
- Pages
- 3-11
- ISSN
- 0161-6439 (ISSN-L)
- 0194-5998
- 1097-6817
- OpenAlex
- W3020949620
- Cited by
- 613
- References
- 11
- FWCI
- 16.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tong, J. Y., Wong, A., Zhu, D., Fastenberg, J. H., & Tham, T. (2020). The Prevalence of Olfactory and Gustatory Dysfunction in COVID‐19 Patients: A Systematic Review and Meta‐analysis. Otolaryngology–Head and Neck Surgery. https://doi.org/10.1177/0194599820926473
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