The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers
Abstract
This review of the literature aims to identify the acute effects of MDMA (ecstasy) in healthy volunteers. The wide range of relevant but methodologically diverse tests was .rst grouped into clusters to allow an evaluation of tests that would otherwise have been excluded due to their low frequency of utilization. The following three types of tests were evaluated: (1) functional tests quantifying executive, attention, visual, motor, visuomotor and auditory functions, (2) phenomenological tests assessing personal, subjective experiences, and (3) physiological measures re.ecting neurophysiological, endocrine and physiological parameters. MDMA showed robust effects on most of the phenomenological and physiological tests. Functional tests were scarce, preventing any meaningful conclusions to be drawn from their evaluation other than that these tests should be incorporated into future acute-effect studies. A striking doseñresponse relationship appeared for cardiovascular effects. At doses below 1.0 mg/kg MDMA no change was observed relative to placebo while above this dose all studies reported signi.cant increases. Furthermore, pupil size, plasma cortisol and plasma prolactin levels proved responsive to MDMA administration. The reported subjective effects of MDMA matched the entactogenic profile. Although interest in the action of MDMA is considerable, the existing knowledge about the cognitive effects of MDMA in humans is still rather limited and further research into the drug's effects is recommended, also in view of potential therapeutic uses of the drug.
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“Drug doses were selected based on previous research; MDMA doses in this low-to-moderate range have been safely administered to humans previously, and produce modest to robust alterations in mood state [24].”
From Is Ecstasy an “Empathogen”? Effects of +/- 3,4-Methylenedioxymethamphetamine on Prosocial Feelings and Identification of Emotional States in Others (2010) · cites this paper as [24]
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Cites
A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
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The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
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Gender differences in the subjective effects of MDMA
Liechti, M. E., Gamma, A., & Vollenweider, F. X. (2001) · Psychopharmacology · doi:10.1007/s002130000648 · Cited by 360
Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research
Parrott, A. C. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.351 · Cited by 337
(±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Studies in Animals
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Research works printed but not linked: 2
- Baggott M, 2005, 3,4-Methylenedioxymethamphetamine (MDMA) A Review of the English-Language Scientific and Medical Literature
- 10.1038/sj.npp.1395197 · DOI · Paper page
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Bedi, G., Hyman, D., & de Wit, H. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.003 · Cited by 247
Characterizing the cognitive effects of cocaine: a comprehensive review.
Spronk, D. B., van Wel, J. H. P., Ramaekers, J. G., & Verkes, R. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.003 · Cited by 245
Self-citationDumont, G. J. H., Sweep, F. C. G. J., van der Steen, R., Hermsen, R., Donders, A. R. T., Touw, D. J., van Gerven, J. M. A., Buitelaar, J. K., & Verkes, R. J. (2009) · Social Neuroscience · doi:10.1080/17470910802649470 · Cited by 238
Self-citationSutcliffe, P., Hummel, S., Simpson, E., Young, T., Rees, A., Wilkinson, A., Hamdy, F. C., Clarke, N. W., & Staffurth, J. (2009) · Health Technology Assessment · doi:10.3310/hta13050 · Cited by 237
Effects of MDMA on sociability and neural response to social threat and social reward
Bedi, G., Phan, K. L., Angstadt, M., & de Wit, H. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1635-z · Cited by 206
Metadata
- Authors
- Dumont, G. J. H., & Verkes, R. J.
- Affiliations
- Radboud University Medical Center (NL)
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2006-03
- Volume
- 20
- Issue
- 2
- Pages
- 176-187
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2118539399
- Cited by
- 149
- References
- 58
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 12 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 6 · 2014: 14 · 2013: 11 · 2012: 7
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- MDMA, ecstasy, acute drug effects, healthy volunteers, dose-response relationship, cardiovascular effects, pupil size, plasma cortisol, prolactin, subjective effects, cognitive effects, executive function, attention, motor function, visuomotor function, auditory function
- MeSH terms
- Adolescent, Adult, Affect, Arousal, Brain, Clinical Trials as Topic, Dose-Response Relationship, Drug, Female, Hallucinogens, Humans, Male, Neuropsychological Tests, Reference Values, Serotonin Agents, N-Methyl-3,4-methylenedioxyamphetamine
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