Cited by 149Psychedelics and Drug StudiesForensic Toxicology and Drug AnalysisNeurotransmitter Receptor Influence on Behavior

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A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers

Dumont, G. J. H., Verkes, R. J.·2006·Journal of Psychopharmacology

DOI 10.1177/0269881106063271

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Abstract

This review of the literature aims to identify the acute effects of MDMA (ecstasy) in healthy volunteers. The wide range of relevant but methodologically diverse tests was .rst grouped into clusters to allow an evaluation of tests that would otherwise have been excluded due to their low frequency of utilization. The following three types of tests were evaluated: (1) functional tests quantifying executive, attention, visual, motor, visuomotor and auditory functions, (2) phenomenological tests assessing personal, subjective experiences, and (3) physiological measures re.ecting neurophysiological, endocrine and physiological parameters. MDMA showed robust effects on most of the phenomenological and physiological tests. Functional tests were scarce, preventing any meaningful conclusions to be drawn from their evaluation other than that these tests should be incorporated into future acute-effect studies. A striking doseñresponse relationship appeared for cardiovascular effects. At doses below 1.0 mg/kg MDMA no change was observed relative to placebo while above this dose all studies reported signi.cant increases. Furthermore, pupil size, plasma cortisol and plasma prolactin levels proved responsive to MDMA administration. The reported subjective effects of MDMA matched the entactogenic profile. Although interest in the action of MDMA is considerable, the existing knowledge about the cognitive effects of MDMA in humans is still rather limited and further research into the drug's effects is recommended, also in view of potential therapeutic uses of the drug.

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Baggott M, 2005, 3,4-Methylenedioxymethamphetamine (MDMA) A Review of the English-Language Scientific and Medical Literature
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Self-citation

Authors: Dumont, G. J. H., & Verkes, R. J.
Affiliations: Radboud University Medical Center (NL)
ORCID: Dumont, G. J. H.
Verkes, R. J.
Venue: Journal of Psychopharmacology
Publisher: SAGE Publications
Published: 2006-03
Volume: 20
Issue: 2
Pages: 176-187
ISSN: 0269-8811 (ISSN-L)
1461-7285
DOI: 10.1177/0269881106063271
OpenAlex: W2118539399
Cited by: 149
References: 58
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 12 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 6 · 2014: 14 · 2013: 11 · 2012: 7
FWCI: 1.58
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: MDMA, ecstasy, acute drug effects, healthy volunteers, dose-response relationship, cardiovascular effects, pupil size, plasma cortisol, prolactin, subjective effects, cognitive effects, executive function, attention, motor function, visuomotor function, auditory function
MeSH terms: Adolescent, Adult, Affect, Arousal, Brain, Clinical Trials as Topic, Dose-Response Relationship, Drug, Female, Hallucinogens, Humans, Male, Neuropsychological Tests, Reference Values, Serotonin Agents, N-Methyl-3,4-methylenedioxyamphetamine

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A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers

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