Brain metabolic alterations in mice subjected to postnatal traumatic stress and in their offspring
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Adverse environmental and social conditions early in life have a strong impact on health. They are major risk factors for mental diseases in adulthood and, in some cases, their effects can be transmitted across generations. The consequences of detrimental stress conditions on brain metabolism across generations are not well known. Using high-field (14.1 T) magnetic resonance spectroscopy, we investigated the neurochemical profile of adult male mice exposed to traumatic stress in early postnatal life and of their offspring, and of undisturbed control mice. We found that, relative to controls, early life stress-exposed mice have metabolic alterations consistent with neuronal dysfunction, including reduced concentration of N-acetylaspartate, glutamate and γ-aminobutyrate, in the prefrontal cortex in basal conditions. Their offspring have normal neurochemical profiles in basal conditions. Remarkably, when challenged by an acute cold swim stress, the offspring has attenuated metabolic responses in the prefrontal cortex, hippocampus and striatum. In particular, the expected stress-induced reduction in the concentration of N-acetylaspartate, a putative marker of neuronal health, was prevented in the cortex and hippocampus. These findings suggest that paternal trauma can confer beneficial brain metabolism adaptations to acute stress in the offspring.
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Early-life stress-exposed mice show reductions in N-acetylaspartate in the frontal cortex and hypothalamus.
“These include reductions in N-acetylaspartate (a marker of neuronal integrity) in the frontal cortex and hypothalamus in early-life stress-exposed mice [97–99]”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [97]
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Cincotta, S. A., Richardson, N., Foecke, M. H., & Laird, D. J. (2023) · eLife · doi:10.7554/elife.90164.2
Role of GIRK2 channels in morphine-induced metabolite changes in the rostral ventromedial medulla
Dehkordi, O., Lin, S., Mohamud, S., Dávila‐García, M. I., Millis, R. M., & Wang, P. C. (2026) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2026.110668
da Silva, B. R. D., Nunes, P. I. G., de Matos, R. S., Silva, L. M. A., FILHO, E. D. G. A., de Brito, E. S., de Bruin, P. F. C., & de Bruin, V. M. S. (2026) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2025e14816
- Authors
- Gapp, K., Corcoba, A., van Steenwyk, G., Mansuy, I. M., & Duarte, J. M.
- Affiliations
- University of Zurich (CH)
- École Polytechnique Fédérale de Lausanne (CH)
- Laboratory of Neuroepigenetics, University of Zurich and Swiss Federal Institute of Technology, Zürich, Switzerland
- Corresponding author
- Duarte, João MN
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2016-10-01
- Volume
- 37
- Issue
- 7
- Pages
- 2423-2432
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- PMC
- PMC5531341
- OpenAlex
- W2516097749
- Cited by
- 48
- References
- 53
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 2
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Lund University Publications (Lund University) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- École Polytechnique Fédérale de Lausanne
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (148250)
- Centre d'Imagerie BioMédicale
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- early life stress, traumatic stress, transgenerational transmission, brain metabolism, neurochemical profile, N-acetylaspartate, glutamate, GABA, prefrontal cortex, hippocampus, striatum, acute stress response, neuronal dysfunction
- MeSH terms
- Animals, Animals, Newborn, Brain, Brain Chemistry, Cerebral Cortex, Corpus Striatum, Female, Hippocampus, Male, Maternal Deprivation, Mice, Inbred C57BL, Magnetic Resonance Spectroscopy, Pregnancy, Prenatal Exposure Delayed Effects, Restraint, Physical, Stress, Psychological, Swimming
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