Cited by 125Stress Responses and CortisolNeuroendocrine regulation and behaviorChild Abuse and Trauma

Early life stress disrupts social behavior and prefrontal cortex parvalbumin interneurons at an earlier time-point in females than in males

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Holland, Freedom H., Ganguly, Prabarna, Potter, David N., Chartoff, Elena H., Brenhouse, Heather C.·2014·Neuroscience Letters

Abstract

Early life stress exposure (ELS) yields risk for psychiatric disorders that might occur though a population-specific mechanism that impacts prefrontal cortical development. Sex differences in ELS effects are largely unknown and are also essential to understand social and cognitive development. ELS can cause dysfunction within parvalbumin (PVB)-containing inhibitory interneurons in the prefrontal cortex and in several prefrontal cortex-mediated behaviors including social interaction. Social behavior deficits are often the earliest observed changes in psychiatric disorders, therefore the time-course and causation of social interaction deficits after ELS are important to determine. PVB interneuron dysfunction can disrupt social behavior, and has been correlated in males with elevated markers of oxidative stress and inflammation, such as cyclooxygenase-2 after ELS. Here, we measured the effects of maternal separation ELS on social interaction behaviors in males and females. Prefrontal cortex PVB and cyclooxygenase-2 were also measured in juveniles and adolescents using Western blots. ELS led to social interaction alterations earlier in females than males. Sexually dimorphic behavioral changes were consistent with prefrontal cortex PVB loss after ELS. PVB levels were decreased in ELS-exposed juvenile females, while males exposed to ELS do not display parvalbumin decreases until adolescence. Early behavioral and PVB changes in females did not appear to be mediated through cyclooxygenase-2, since levels were not affected in ELS females. Therefore, these data suggest that ELS affects males and females differently and with distinct developmental profiles.

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  1. [28]Miczek KA Boer SF Agressive, Defensive, and Submissive Behavior 2005 New York Oxford University Press, New York

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Authors
Holland, F. H., Ganguly, P., Potter, D. N., Chartoff, E. H., & Brenhouse, H. C.
Affiliations
  • Northeastern University (US)
  • McLean Hospital (US)
Corresponding author
Brenhouse, Heather C.
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2014-04
Volume
566
Pages
131-136
ISSN
0304-3940 (ISSN-L)
OpenAlex
W2023467429
Cited by
125
References
39
Citations by year
2026: 13 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 8 · 2021: 21 · 2020: 14 · 2019: 11 · 2018: 15 · 2017: 2 · 2016: 6 · 2015: 6 · 2014: 1
FWCI
2.45
Type
journal article
Language
en
Open access
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R21MH097182)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
early life stress, maternal separation, sex differences, social behavior, social interaction deficits, parvalbumin interneurons, prefrontal cortex, cyclooxygenase-2, oxidative stress, inflammation, juvenile development, adolescent development, mental illness
MeSH terms
Animals, Female, Interneurons, Male, Maternal Deprivation, Motor Activity, Parvalbumins, Sex Factors, Social Behavior, Stress, Psychological, Rats, Sprague-Dawley, Prefrontal Cortex, Cyclooxygenase 2

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