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Clock Genes, Oscillators, and Cellular Networks in the Suprachiasmatic Nuclei
Abstract
The mammalian SCN contains a biological clock that drives remarkably precise circadian rhythms in vivo and in vitro. Recent advances have revealed molecular and cellular mechanisms required for the generation of these daily rhythms and their synchronization between SCN neurons and to the environmental light cycle. This review of the evidence for a cell-autonomous circadian pacemaker within specialized neurons of the SCN focuses on 6 genes implicated within the pace making mechanism, an additional 4 genes implicated in pathways from the pacemaker, and the intercellular and intracellular mechanisms that synchronize SCN neurons to each other and to solar time.
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Metadata
- Authors
- Hastings, M. H., & Herzog, E. D.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Washington University in St. Louis (US)
- Corresponding author
- Hastings, Michael H.
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 2004-10
- Volume
- 19
- Issue
- 5
- Pages
- 400-413
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- OpenAlex
- W2060140960
- Cited by
- 246
- References
- 84
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 13 · 2015: 5 · 2014: 8 · 2013: 15 · 2012: 12
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biological Rhythms (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH063104, MH 63104)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
- Physical Sciences › Computer Science › Computer Networks and Communications › Network Time Synchronization Technologies
- Keywords
- suprachiasmatic nucleus, circadian clock, clock genes, circadian pacemaker, neuronal synchronization, light entrainment, cellular networks
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Gene Expression Regulation, Humans, Kinetics, Light, Models, Biological, Oscillometry, Periodicity, Suprachiasmatic Nucleus, Time Factors, Photoperiod
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