Asperger's Syndrome and Cortical Neuropathology
Abstract
Asperger's disorder or syndrome is characterized by impaired social interaction, normal intelligence, and adequate language skills in the areas of grammar and vocabulary. The symptoms are pervasive in nature and usually manifested in childhood. Despite the gravity and chronicity of the condition, the medical literature remains sparse and offers no information about possible neuropathologic underpinnings. The present study is a case report on two patients with Asperger's syndrome. Neuropathologic examination revealed no degenerative changes or gliosis. A more detailed assessment with computerized image analysis indicated abnormalities in the minicolumnar organization of the three areas examined (9, 21, 22) (P = .032). Specifically, minicolumns were smaller, and their component cells were more dispersed than normal. A similar neuropathology has recently been reported for autism and disputes the uniqueness of these findings. The minicolumnar changes provide a possible link to receptive field abnormalities and a useful clinicopathologic correlate to Asperger's syndrome. (J Child Neurol 2002;17:142-145).
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ASD patients have smaller and more numerous minicolumns with more dispersed neurons in Brodmann areas 9, 21, and 22, while Asperger's syndrome patients have smaller, less compact minicolumns in the temporal neocortex.
“Patients with ASD have smaller and more numerous minicolumns with more dispersed neurons in Brodmann’s areas 9, 21, and 22 [57, 58], and patients with Asperger’s syndrome have smaller, less compact minicolumns in the temporal neocortex [56].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [56]
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- Authors
- Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E.
- Affiliations
- Augusta University (US)
- Charlie Norwood VA Medical Center (US)
- Venue
- Journal of Child Neurology
- Publisher
- SAGE Publications
- Published
- 2002-02
- Volume
- 17
- Issue
- 2
- Pages
- 142-145
- ISSN
- 0883-0738 (ISSN-L)
- 1708-8283
- OpenAlex
- W1973054160
- Cited by
- 91
- References
- 21
- Citations by year
- 2023: 1 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 4
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- Asperger syndrome, autism spectrum disorder, clinicopathological correlation, social interaction deficits, cerebral cortex
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Cerebral Cortex, Child, Female, Gliosis, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Nerve Degeneration, Neurons, Asperger Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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