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Cited by 311Attention Deficit Hyperactivity DisorderNeural and Behavioral Psychology StudiesAutism Spectrum Disorder Research

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Evaluation of Cerebellar Size in Attention-Deficit Hyperactivity Disorder

Mostofsky, Stewart H., Reiss, Allan L., Lockhart, Paula, Denckla, Martha Bridge·1998·Journal of Child Neurology
DOI 10.1177/088307389801300904
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Abstract

Evidence from animal and human research suggests that the cerebellum may play a role in cognition. This includes domains of executive function that are normally attributed to the prefrontal cortex and are typically deficient in individuals with attention-deficit hyperactivity disorder (ADHD). To investigate cerebellar structure in ADHD, magnetic resonance imaging morphometry was used to measure the area of the cerebellar vermis in 12 males with ADHD and 23 male controls matched for age and Wechsler Full-Scale IQ. Analyses were conducted to evaluate group differences, as well as differences between matched pairs of subjects with ADHD and those without ADHD. All measurements were corrected for overall brain size. Both analyses revealed that the size of the posterior vermis was significantly decreased in males with ADHD (P < .05 in both analyses), and that within the posterior vermis, the inferior posterior lobe (lobules VIII-X) was involved in this reduction (P < .05 for group analysis, P < .005 for matched pair analysis), while the superior posterior lobe (lobules VI/VII) was not involved in the reduction. The finding of abnormal inferior posterior vermal size suggests that dysfunction within this region of the cerebellum may underlie clinical deficits seen in individuals with ADHD.

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Research works printed but not linked: 8

  1. 10.1037/0033-2909.121.1.65 · DOI · Paper page
  2. Reiss AL, 1991, Am JHum Genet, 49, 279
  3. Mostofsky SH, Neurology
  4. Reiss AL, 1997, Brainimage (Version 2.x)
  5. Reader MJ, 1994, Neuropsychol, 10, 493
  6. Lou HC, 1989, Arch Neurol, 41, 825
  7. Barkley RA, J Int Neuropsychol Soc
  8. Ivry RB, 1989, J Cogn Neurosci, 1, 134

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Related

Metadata

Authors
Mostofsky, S. H., Reiss, A. L., Lockhart, P., & Denckla, M. B.
Affiliations
  • Kennedy Krieger Institute (US)
  • Johns Hopkins University (US)
ORCID
Venue
Journal of Child Neurology
Publisher
SAGE Publications
Published
1998-09
Volume
13
Issue
9
Pages
434-439
ISSN
  • 0883-0738 (ISSN-L)
  • 1708-8283
DOI
10.1177/088307389801300904
OpenAlex
W2080273559
Cited by
311
References
50
Citations by year
2026: 2 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 9 · 2015: 5 · 2014: 8 · 2013: 14 · 2012: 13
FWCI
5.74
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Child Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (P50 NS 35359, P50NS035359)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD24061, P30HD024061, R01HD031715, HD31715)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
attention deficit hyperactivity disorder, cerebellum, cerebellar vermis, posterior vermis, cerebellar morphology, executive function, brain structure, boys
MeSH terms
Adolescent, Attention Deficit Disorder with Hyperactivity, Cerebellum, Child, Cognition, Female, Humans, Magnetic Resonance Imaging, Male, Sex Factors

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