Decreased C-Reactive Protein Levels in Alzheimer Disease

O'Bryant, Sid E.; Waring, Stephen C.; Hobson, Valerie; Hall, James R.; Moore, Carol B.; Bottiglieri, Teodoro; Massman, Paul; Diaz-Arrastia, Ramon

doi:10.1177/0891988709351832

Cited by 103Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Decreased C-Reactive Protein Levels in Alzheimer Disease

Open access

O'Bryant, Sid E., Waring, Stephen C., Hobson, Valerie, Hall, James R., Moore, Carol B., Bottiglieri, Teodoro, Massman, Paul, Diaz-Arrastia, Ramon·2010·Journal of Geriatric Psychiatry and Neurology

DOI 10.1177/0891988709351832PMC PMC3204581

Open this paper in CoChat — free account

Abstract

C-reactive protein (CRP) is an acute-phase reactant that has been found to be associated with Alzheimer disease (AD) in histopathological and longitudinal studies; however, little data exist regarding serum CRP levels in patients with established AD. The current study evaluated CRP levels in 192 patients diagnosed with probable AD (mean age = 75.8 ± 8.2 years; 50% female) as compared to 174 nondemented controls (mean age = 70.6 ± 8.2 years; 63% female). Mean CRP levels were found to be significantly decreased in AD (2.9 µg/mL) versus controls (4.9 µg/mL; P = .003). In adjusted models, elevated CRP significantly predicted poorer (elevated) Clinical Dementia Rating Scale sum of boxes (CDR SB) scores in patients with AD. In controls, CRP was negatively associated with Mini-Mental State Examination (MMSE) scores and positively associated with CDR SB scores. These findings, together with previously published results, are consistent with the hypothesis that midlife elevations in CRP are associated with increased risk of AD development though elevated CRP levels are not useful for prediction in the immediate prodrome years before AD becomes clinically manifest. However, for a subgroup of patients with AD, elevated CRP continues to predict increased dementia severity suggestive of a possible proinflammatory endophenotype in AD.

Integrity signals

Registry

Crossref · 10.1177/0891988709351832

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mean CRP levels decreased significantly in Alzheimer's disease in a study conducted by O'Bryant et al. (2009).
“Mean CRP levels decreased significantly in AD in study conducted by O'Bryant et al. (2009) [48].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [48]

“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
[Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients].
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Special Care Units and Traditional Care in Dementia: Relationship with Behavior, Cognition, Functional Status and Quality of Life - A Review
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,803 · see citing works
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,003 · see citing works
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056 · see citing works
Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: A Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart Association
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401 · see citing works
C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · see citing works
MARKERS OF INFLAMMATION AND CARDIOVASCULAR DISEASE: APPLICATION TO CLINICAL AND PUBLIC HEALTH PRACTICE: A STATEMENT FOR HEALTHCARE PROFESSIONALS FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION AND THE AMERICAN HEART ASSOCIATION
PearsonT, A., MensahG, A., & AlexanderR, W. (2003) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200305000-00016 · Cited by 2,937 · see citing works
Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Among Apparently Healthy Women
Ridker, P. M., Buring, J. E., Shih, J., Matias, M., & Hennekens, C. H. (1998) · Circulation · doi:10.1161/01.cir.98.8.731 · Cited by 1,642 · see citing works
Midlife cardiovascular risk factors and risk of dementia in late life
Whitmer, R. A., Sidney, S., Selby, J., Johnston, S. C., & Yaffe, K. (2005) · Neurology · doi:10.1212/01.wnl.0000149519.47454.f2 · Cited by 1,238 · see citing works
Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease
in 't Veld, B. A., Ruitenberg, A., Hofman, A., Launer, L. J., van Duijn, C. M., Stijnen, T., Breteler, M. M. B., & Stricker, B. H. C. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010178 · Cited by 1,196 · see citing works
Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study
Kuller, L. H., Tracy, R. P., Shaten, J., & Meilahn, E. N. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008963 · Cited by 1,098 · see citing works
The metabolic syndrome, inflammation, and risk of cognitive decline
Yaffe, K. (2004) · JAMA · doi:10.1001/jama.292.18.2237 · Cited by 1,025 · see citing works
Relationship of C-Reactive Protein to Risk of Cardiovascular Disease in the Elderly: Results From the Cardiovascular Health Study and the Rural Health Promotion Project
Tracy, R. P., Lemaitre, R. N., Psaty, B. M., Ives, D. G., Evans, R. W., Cushman, M., Meilahn, E. N., & Kuller, L. H. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.6.1121 · Cited by 836 · see citing works
Early inflammation and dementia: A 25‐year follow‐up of the Honolulu‐Asia aging study
Schmidt, R., Schmidt, H., Curb, J. D., Masaki, K., White, L. R., & Launer, L. J. (2002) · Annals of Neurology · doi:10.1002/ana.10265 · Cited by 710 · see citing works
Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies
Etminan, M., Gill, S., & Samii, A. (2003) · BMJ · doi:10.1136/bmj.327.7407.128 · Cited by 511 · see citing works
A Randomized, Double-Blind, Study of Rofecoxib in Patients with Mild Cognitive Impairment
on behalf of the Rofecoxib Protocol 078 study group, Thal, L. J., Ferris, S. H., Kirby, L., Block, G. A., Lines, C. R., Yuen, E., Assaid, C., Nessly, M. L., Norman, B. A., et al. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300690 · Cited by 402 · see citing works
Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial
ADAPT Research Group (2007) · Neurology · doi:10.1212/01.wnl.0000260269.93245.d2 · Cited by 354 · see citing works
Serum inflammatory proteins and cognitive decline in older persons
Dik, M. G., Jonker, C., Hack, C. E., Smit, J. H., Comijs, H. C., & Eikelenboom, P. (2005) · Neurology · doi:10.1212/01.wnl.0000158281.08946.68 · Cited by 338 · see citing works
Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists
Anthony, J. C., Breitner, J., Zandi, P., Meyer, M., Jurasová, I., Norton, M., & Stone, S. (2000) · Neurology · doi:10.1212/wnl.54.11.2066 · Cited by 222 · see citing works
Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementia
van Oijen, M., Witteman, J. C., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2005) · Stroke · doi:10.1161/01.str.0000189721.31432.26 · Cited by 222 · see citing works
Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer’s disease
Galimberti, D., Fenoglio, C., Lovati, C., Venturelli, E., Guidi, I., Corrà, B., Scalabrini, D., Clerici, F., Mariani, C., Bresolin, N., et al. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.007 · Cited by 209 · see citing works
Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging
Ravaglia, G., Forti, P., Maioli, F., Chiappelli, M., Montesi, F., Tumini, E., Mariani, E., Licastro, F., & Patterson, C. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.08.012 · Cited by 198 · see citing works
Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort
Breitner, J. C. S., Haneuse, S., Walker, R. L., Dublin, S., Crane, P. K., Gray, S. L., & Larson, E. B. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a18691 · Cited by 175 · see citing works
Serum C-Reactive Protein and Self-Reported Stroke
Ford, E. S., & Giles, W. H. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.4.1052 · Cited by 138 · see citing works
Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: immunohistochemical study using formic acid pretreatment of tissue sections
Iwamoto, N., Nishiyama, E., Ohwada, J., & Arai, H. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90035-3 · Cited by 129 · see citing works
Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma
Duan, H., Fleming, J. N., Pritchard, D. K., Amon, L. M., Xue, J., Arnett, H. A., Chen, G., Breen, P., Buckner, J. H., Molitor, J. A., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23451 · Cited by 128 · see citing works
C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease
Duong, T., Nikolaeva, M. A., & Acton, P. J. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01359-5 · Cited by 127 · see citing works
Prospective Studies of C-Reactive Protein as a Risk Factor for Cardiovascular Disease
Ridker, P. M., & Haughie, P. (1998) · Journal of Investigative Medicine · doi:10.1177/170882679804600814 · Cited by 114 · see citing works
Brain-Derived Neurotrophic Factor Levels in Alzheimer's Disease
O’Bryant, S. E., Hobson, V. L., Hall, J. R., Waring, S. C., Chan, W., Massman, P. J., Lacritz, L. H., Cullum, C. M., & Diaz-Arrastia, R. R. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1051 · Cited by 101 · see citing works
Self-citation
Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations
Delaleu, N., Immervoll, H., Cornelius, J., & Jonsson, R. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2375 · Cited by 96 · see citing works
Plasma Amyloid β-Protein and C-reactive Protein in Relation to the Rate of Progression of Alzheimer Disease
Locascio, J. J., Fukumoto, H., Yap, L., Bottiglieri, T., Growdon, J. H., Hyman, B. T., & Irizarry, M. C. (2008) · Archives of Neurology · doi:10.1001/archneur.65.6.776 · Cited by 92 · see citing works
Self-citation
Coagulation and inflammatory markers in Alzheimer's and vascular dementia
Gupta, A., Watkins, A., Thomas, P., Majer, R., Habubi, N., Morris, G., & Pansari, K. (2004) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2004.00143.x · Cited by 87 · see citing works
Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: A potential approach to identify atherosclerotic disease progression
Gurbel, P. A., Kreutz, R. P., Bliden, K. P., DiChiara, J., & Tantry, U. S. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.08.021 · Cited by 41 · see citing works
Hemostatic and Inflammatory Markers as Risk Factors for Coronary Disease in the Elderly
Tracy, R. P. (2002) · The American Journal of Geriatric Cardiology · doi:10.1111/j.1076-7460.2002.00997.x · Cited by 28 · see citing works
Inflammatory Proteins in Plasma and the Risk of Dementia: The Rotterdam Study
Engelhart, M. J., Geerlings, M. I., Meijer, J., Kiliaan, A., Ruitenberg, A., van Swieten, J. C., Stijnen, T., Hofman, A., Witteman, J. C. M., & Breteler, M. M. B. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.668 · Cited by 10 · see citing works
Effects of the incubation in vitro with sorbents on serum proteomic pattern and cytokine concentration in cancer patients during chemotherapy—preliminary results
Piccolomini, F., LouWratten, M., Sereni, L., Balestreri, E., Donadio, E., Felicioli, A., Felicioli, R. A., & Donadio, C. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.07.011 · Cited by 9 · see citing works
Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression: A Randomized Controlled Trial
Aisen, P. S., Schafer, K. A., Grundman, M., Pfeiffer, E., Sano, M., Davis, K. L., Farlow, M. R., Jin, S., Thomas, R. G., Thal, L. J., et al. (2003) · JAMA · doi:10.1001/jama.289.21.2819 · Cited by 5 · see citing works

Flagged first, then by citations

1 of the 42 references couldn’t be matched to a known paper.

Sorted by citations

Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820 · see citing works
IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s Disease: Systematic Review and Meta-Analysis
Ng, A., Tam, W. W., Zhang, M. W., Ho, C. S., Husain, S. F., McIntyre, R. S., & Ho, R. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-30487-6 · Cited by 572 · see citing works
The future of blood‐based biomarkers for Alzheimer's disease
Henriksen, K., O’Bryant, S. E., Hampel, H. J., Trojanowski, J. Q., Montine, T. J., Jeromin, A., Blennow, K., Lönneborg, A., Wyss‐Coray, T., Soares, H. D., et al. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.01.013 · Cited by 312 · see citing works
Self-citation
Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in <i>ApoE4</i> Carriers
Tao, Q., Ang, T. F. A., DeCarli, C., Auerbach, S. H., Devine, S., Stein, T. D., Zhang, X., Massaro, J., Au, R., & Qiu, W. Q. (2018) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.3597 · Cited by 239 · see citing works
A Blood-Based Screening Tool for Alzheimer's Disease That Spans Serum and Plasma: Findings from TARC and ADNI
O’Bryant, S. E., Xiao, G., Barber, R. C., Huebinger, R. M., Wilhelmsen, K. C., Edwards, M., Graff‐Radford, N. R., Doody, R. S., Diaz-Arrastia, R. R., & Initiative, A. D. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028092 · Cited by 156 · see citing works
Self-citation
C‐reactive protein and ageing
Tang, Y., Fung, E., Xu, A., & Lan, H. Y. (2017) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12758 · Cited by 145 · see citing works
Increased plasma levels of lipocalin 2 in mild cognitive impairment
Choi, J., Lee, H., & Suk, K. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.03.023 · Cited by 119 · see citing works
Biomarkers of Vascular Risk, Systemic Inflammation, and Microvascular Pathology and Neuropsychiatric Symptoms in Alzheimer's Disease
Hall, J. R., Wiechmann, A. R., Johnson, L. A., Edwards, M., Barber, R. C., Winter, A. S., Singh, M., & O’Bryant, S. E. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122359 · Cited by 101 · see citing works
Self-citation
Alzheimer’s Disease and Inflammaging
Kosyreva, A., Sentyabreva, A., Tsvetkov, I., & Makarova, O. (2022) · Brain Sciences · doi:10.3390/brainsci12091237 · Cited by 98 · see citing works
A Blood-Based Algorithm for the Detection of Alzheimer’s Disease
O’Bryant, S. E., Xiao, G., Barber, R. C., Reisch, J., Hall, J. R., Cullum, C. M., Doody, R. S., Fairchild, T., Adams, P. M., Wilhelmsen, K. C., et al. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000330750 · Cited by 96 · see citing works
Self-citation
Shared biological pathways for frailty and cognitive impairment: A systematic review
Sargent, L. J., Nalls, M. A., Starkweather, A. R., Hobgood, S. E., Thompson, H., Amella, E. J., & Singleton, A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.08.001 · Cited by 92 · see citing works
Differences between early and late onset Alzheimer's disease.
Panegyres, P. K., & Chen, H.-Y. (2013) · Europe PMC (PubMed Central) · Cited by 88 · see citing works
Exploring Biomarkers for Alzheimer’s Disease
Sharma, N. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/18828.8166 · Cited by 86 · see citing works
Biomarkers of Alzheimer's Disease Among Mexican Americans
O’Bryant, S. E., Xiao, G., Edwards, M., Devous, M. D., Gupta, V. B., Martins, R. N., Zhang, F., & Barber, R. C. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122074 · Cited by 80 · see citing works
Self-citation
Neuroinflammation in Alzheimer’s disease: Pleiotropic roles for cytokines and neuronal pentraxins
Swanson, A., Wolf, T., Sitzmann, A., & Willette, A. A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.015 · Cited by 72 · see citing works
The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease
Azizi, G., Navabi, S. S., Al-Shukaili, A. K., Seyedzadeh, M. H., Yazdani, R., & Mirshafiey, A. (2015) · Sultan Qaboos University medical journal · doi:10.18295/squmj.2015.15.03.002 · Cited by 72 · see citing works
Serum Brain-Derived Neurotrophic Factor Levels Are Specifically Associated with Memory Performance among Alzheimer’s Disease Cases
O’Bryant, S. E., Hobson, V. L., Hall, J. R., Barber, R. C., Zhang, S., Johnson, L. A., & Diaz-Arrastia, R. R. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000321980 · Cited by 70 · see citing works
Self-citation
Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load
Goozee, K. G., Chatterjee, P., James, I., Shen, K., Sohrabi, H. R., Asih, P. R., Dave, P., ManYan, C., Taddei, K., Ayton, S., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.146 · Cited by 69 · see citing works
Systemic Inflammation Is Associated With Longitudinal Changes in Cognitive Performance Among Urban Adults
Beydoun, M. A., Dore, G. A., Canas, J. A., Liang, H., Beydoun, H. A., Evans, M. K., & Zonderman, A. B. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00313 · Cited by 67 · see citing works
Peripheral Versus Central Nervous System APOE in Alzheimer’s Disease: Interplay across the Blood-Brain Barrier
Chernick, D., Ortiz-Valle, S., Jeong, A., Qu, W., & Li, L. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134306 · Cited by 54 · see citing works
Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer’s and Parkinson’s Diseases
Mayo, S., Benito‐León, J., Peña‐Bautista, C., Baquero, M., & Cháfer‐Pericás, C. (2020) · Current Neuropharmacology · doi:10.2174/1570159x19666201223154009 · Cited by 60 · see citing works
Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease
Yarchoan, M. M., Louneva, N., Xie, S. X., Swenson, F. J., Hu, W. T., Soares, H. D., Trojanowski, J. Q., Lee, V. M. ‐., Kling, M. A., Shaw, L. M. J., et al. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.05.028 · Cited by 58 · see citing works
A Meta-Analysis of C-Reactive Protein in Patients With Alzheimer’s Disease
Gong, C., Wei, D., Wang, Y., Ma, J., Yuan, C., Zhang, W., Yu, G., & Zhao, Y. (2015) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317515602087 · Cited by 53 · see citing works
Disease Risk Factors Identified Through Shared Genetic Architecture and Electronic Medical Records
Li, L., Ruau, D., Patel, C. J., Weber, S., Chen, R., Tatonetti, N. P., Dudley, J. T., & Butte, A. J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007191 · Cited by 53 · see citing works
Contra-Directional Expression of Serum Homocysteine and Uric Acid as Important Biomarkers of Multiple System Atrophy Severity: A Cross-Sectional Study
Chen, D., Wei, X., Zou, J., Wang, R., Liu, X., Xu, X., Lu, J., Wang, Z., Tang, B., Wang, B. Z., et al. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00247 · Cited by 49 · see citing works
Plasma Inflammatory Factors Are Associated with Anxiety, Depression, and Cognitive Problems in Adults with and without Methamphetamine Dependence: An Exploratory Protein Array Study
Huckans, M. S., Fuller, B. E., Chalker, A. L. N., Adams, M. K. M., & Loftis, J. M. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00178 · Cited by 49 · see citing works
A Precision Medicine Model for Targeted NSAID Therapy in Alzheimer’s Disease
O’Bryant, S. E., Zhang, F., Johnson, L. A., Hall, J. R., Edwards, M., Grammas, P., Oh, E. S., Lyketsos, C. G., & Rissman, R. A. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180619 · Cited by 49 · see citing works
Self-citation
The Link Between C-Reactive Protein and Alzheimer's Disease Among Mexican Americans
O'Bryant, S. E., for the Texas Alzheimer's Research & Care Consortium, Johnson, L., Edwards, M., Soares, H., Devous, M. D., Ross, S., Rohlfing, G., & Hall, J. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-122071 · Cited by 47 · see citing works
Self-citation
A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community‐dwelling Mexican Americans and non‐Hispanic Whites: A method for increasing representation of diverse populations in clinical research
O’Bryant, S. E., Zhang, F., Petersen, M. E., Hall, J. R., Johnson, L. A., Yaffe, K. S., Mason, D., Braskie, M. N., Barber, R. C., Rissman, R. A., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12382 · Cited by 43 · see citing works
Self-citation
C-reactive protein level is decreased in patients with Alzheimer's disease and related to cognitive function and survival time
Nilsson, K. H., Gustafson, L., & Hultberg, B. L. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.07.011 · Cited by 40 · see citing works
Association of C-Reactive Protein and Motoric Cognitive Risk Syndrome in Community-Dwelling Older Adults: The China Health and Retirement Longitudinal Study
Bai, A., Shi, H., Huang, X., Xu, W., & Deng, Y. (2021) · The journal of nutrition health & aging · doi:10.1007/s12603-021-1678-3 · Cited by 39 · see citing works
Multi‐analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection
Huckans, M. S., Fuller, B. E., Olavarria, H., Sasaki, A. W., Chang, M., Flora, K. D., Kolessar, M., Kříž, D., Anderson, J. R., Vandenbark, A. A., et al. (2013) · Brain and Behavior · doi:10.1002/brb3.200 · Cited by 38 · see citing works
Molecular Links and Biomarkers of Stroke, Vascular Dementia, and Alzheimer's Disease
Vijayan, M., Kumar, S., Bhatti, J. S., & Reddy, P. H. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.014 · Cited by 38 · see citing works
The association of high sensitivity C-reactive protein and incident Alzheimer disease in patients 60 years and older: The HUNT study, Norway
Gabin, J. M., Saltvedt, I. T., Tambs, K., & Holmen, J. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0106-3 · Cited by 39 · see citing works
Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease
Lathe, R., Schultek, N. M., Balin, B. J., Ehrlich, G. D., Alberi, L. A., Perry, G. L., Breitschwerdt, E. B., Corry, D. B., Doty, R. L., Rissman, R. A., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13076 · Cited by 37 · see citing works
Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer’s Disease: Testosterone as a Modifier
Asih, P. R., Tegg, M., Sohrabi, H. R., Carruthers, M. E., Gandy, S., Saad, F., Verdile, G., Ittner, L. M., & Martins, R. N. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161259 · Cited by 34 · see citing works
Morphometric Changes to Corneal Dendritic Cells in Individuals With Mild Cognitive Impairment
Dehghani, C., Frost, S. M., Jayasena, R., Fowler, C. J., Masters, C. L., Kanagasingam, Y., Jiao, H., Lim, J. K. H., Chinnery, H. R., & Downie, L. E. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.556137 · Cited by 34 · see citing works
Programmed ageing: decline of stem cell renewal, immunosenescence, and Alzheimer's disease
Lathe, R., & Clair, D. S. (2023) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12959 · Cited by 36 · see citing works
Relationship between Serum Levels of Tau Fragments and Clinical Progression of Alzheimer's Disease
Henriksen, K., Byrjalsen, I., Christiansen, C., & Karsdal, M. A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140984 · Cited by 33 · see citing works
C-reactive protein as a predictor of mild cognitive impairment conversion into Alzheimer's disease dementia
Fernandes, A. S., Tábuas‐Pereira, M., Duro, D., Lima, M., Gens, H., Santiago, B., Durães, J., Almeida, M. R., Leitão, M. J., Baldeiras, I., et al. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111004 · Cited by 36 · see citing works
Pentraxins and Alzheimer's disease: At the interface between biomarkers and pharmacological targets
Osera, C., Pascale, A., Amadio, M., Venturini, L., Govoni, S. M., & Ricevuti, G. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.004 · Cited by 30 · see citing works
Nanomolar aluminum induces expression of the inflammatory systemic biomarker C-reactive protein (CRP) in human brain microvessel endothelial cells (hBMECs)
Alexandrov, P. N., Kruck, T. P. A., & Lukiw, W. J. (2015) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2015.07.013 · Cited by 29 · see citing works
Association between an inflammatory biomarker score and future dementia diagnosis in the population-based UK Biobank cohort of 500,000 people
Mekli, K., Lophatananon, A., Maharani, A., Nazroo, J. Y., & Muir, K. R. (2023) · PLoS ONE · doi:10.1371/journal.pone.0288045 · Cited by 28 · see citing works
Plasma Proteomic Profiles of Cerebrospinal Fluid-Defined Alzheimer’s Disease Pathology in Older Adults
Dayon, L., Wojcik, J., Galindo, A. N., Corthésy, J., Cominetti, O., Oikonomidi, A., Henry, H., Migliavacca, E., Bowman, G. L., & Popp, J. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170426 · Cited by 26 · see citing works
The Hachinski Ischemic Scale and cognition: the influence of ethnicity
Johnson, L. A., Cushing, B., Rohlfing, G., Edwards, M., Davenloo, H., D'Agostino, D., Hall, J. R., & O’Bryant, S. E. (2013) · Age and Ageing · doi:10.1093/ageing/aft189 · Cited by 24 · see citing works
Self-citation
A Depressive Endophenotype of Mild Cognitive Impairment and Alzheimer’s Disease
Johnson, L. A., Hall, J. R., & O’Bryant, S. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068848 · Cited by 25 · see citing works
Self-citation
Decreased plasma C‐reactive protein levels in APOE ε4 allele carriers
Martiskainen, H., Takalo, M., Solomon, A., Stančáková, A., Marttinen, M., Natunen, T., Haapasalo, A., Herukka, S., Kuusisto, J., Soininen, H. S., et al. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.639 · Cited by 25 · see citing works
Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS) study
Petersen, M. E., Zhang, F., Schupf, N., Krinsky‐McHale, S. J., Hall, J. R., Mapstone, M. E., Cheema, A. K., Silverman, W. P., Lott, I. T., Rafii, M. S., et al. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12039 · Cited by 23 · see citing works
Self-citation
Elevated C-Reactive Protein in Alzheimer’s Disease Without Depression in Older Adults: Findings From the Health and Retirement Study
Natale, G., Clouston, S., & Smith, D. M. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab282 · Cited by 22 · see citing works
The Role of Inflammation and Infection in Age-Related Neurodegenerative Diseases: Lessons From Bacterial Meningitis Applied to Alzheimer Disease and Age-Related Macular Degeneration
Too, L. K., Hunt, N. H., & Simunovic, M. P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.635486 · Cited by 21 · see citing works
The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer’s disease
Huang, J., Tao, Q., Ang, T. F. A., Farrell, J. J., Zhu, C., Wang, Y., Stein, T. D., Lunetta, K. L., Massaro, J. M., Mez, J. B., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02281-6 · Cited by 21 · see citing works
Vaccines and Dementia: Part II. Efficacy of BCG and Other Vaccines Against Dementia
Greenblatt, C. L., & Lathe, R. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231323 · Cited by 21 · see citing works
A Novel Panel of Plasma Proteins Predicts Progression in Prodromal Alzheimer’s Disease
Araújo, D. C., Initiative, A. D. N., Veloso, A., Gomes, K. B., de Souza, L. C., Ziviani, N., & Caramelli, P. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220256 · Cited by 19 · see citing works
Molecular Markers of Amnestic Mild Cognitive Impairment among Mexican Americans
Edwards, M., Hall, J. R., Williams, B. J., Johnson, L. A., & O’Bryant, S. E. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150553 · Cited by 17 · see citing works
Self-citation
APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid1
Berger, M., Cooter, M., Roesler, A. S., Chung, S., Park, J., Modliszeski, J. L., VanDusen, K. W., Thompson, J. W., Moseley, M. A., Devinney, M. J., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200747 · Cited by 15 · see citing works
Chronic immune stimulation as a contributing cause of chronic disease in opiate addiction including multi-system ageing
Reece, A. S. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.07.047 · Cited by 16 · see citing works
Chronically raised C-reactive protein is inversely associated with cortical β-amyloid in older adults with subjective memory complaints
Hooper, C., Barreto, P. D. S., Cantet, C., Cesari, M., Payoux, P., Salabert, A., & Vellas, B. J. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.04.014 · Cited by 16 · see citing works
Molecular Neuropsychology: Creation of Test-Specific Blood Biomarker Algorithms
O’Bryant, S. E., Xiao, G., Barber, R. C., Cullum, C. M., Weiner, M., Hall, J. R., Edwards, M., Grammas, P., Wilhelmsen, K. C., Doody, R. S., et al. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000345605 · Cited by 16 · see citing works
Self-citation
Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease
Zhang, Y., Tatewaki, Y., Nakase, T., Liu, Y., Tomita, N., Thyreau, B., Zheng, H., Muranaka, M., Takano, Y., Nagasaka, T., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1227325 · Cited by 14 · see citing works
Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD)
Tachibana, A., Iga, J., Ozaki, T., Yoshida, T., Yoshino, Y., Shimizu, H., Mori, T., Furuta, Y., Shibata, M., Ohara, T., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-57922-1 · Cited by 16 · see citing works
Biomarkers of Basic Activities of Daily Living in Alzheimer's Disease
Hall, J. R., Johnson, L. A., Barber, R. C., Vo, H. T., Winter, A. S., & O’Bryant, S. E. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111481 · Cited by 14 · see citing works
Self-citation
A depressive endophenotype of poorer cognition among cognitively healthy community‐dwelling adults: results from the Western Australia memory study
Johnson, L. A., Sohrabi, H. R., Hall, J. R., Taddei, K., Edwards, M., O’Bryant, S. E., & Martins, R. N. (2014) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4231 · Cited by 12 · see citing works
Self-citation
Investigating Changes in the Serum Inflammatory Factors in Alzheimer’s Disease and Their Correlation with Cognitive Function
Hao, J., Qiao, Y., Li, T., Yang, J., Song, Y., Jia, L., & Jia, J. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210552 · Cited by 12 · see citing works
Air pollution is linked to cognitive decline independent of hypersensitive C-reactive protein: insights from middle-aged and older Chinese
Huang, L., Hu, X., Liu, J., Wang, J., Zhou, Y., Li, G., Dong, G., & Dong, H. (2024) · Environmental Health · doi:10.1186/s12940-024-01148-1 · Cited by 11 · see citing works
C-Reactive Protein Levels in the First Three Hours After Acute Cerebral Infarction
Camerlingo, M., Valente, L., Tognozzi, M., Beretta, G. L., Moschini, L., & Cesana, B. M. (2010) · International Journal of Neuroscience · doi:10.3109/00207454.2010.530005 · Cited by 11 · see citing works
Molecular markers of neuropsychological functioning and Alzheimer's disease
Edwards, M., Balldin, V. H., Hall, J. R., & O’Bryant, S. E. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2014.11.001 · Cited by 10 · see citing works
Self-citation
“Let's talk about sex, inflammaging, and cognition, baby”: A meta-analysis and meta-regression of 106 case-control studies on mild cognitive impairment and Alzheimer's disease
Childs, R., Karamacoska, D., Lim, C. K., & Steiner, G. Z. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100819 · Cited by 9 · see citing works
Differences in C-reactive Protein Level in Patients with Alzheimers Disease and Mild Cognitive Impairment
Shin, H. K. A. (2015) · African Journal of Psychiatry · doi:10.4172/psychiatry.1000194 · Cited by 9 · see citing works
Integrative blood-based characterization of oxidative mitochondrial DNA damage variants implicates Mexican American’s metabolic risk for developing Alzheimer’s disease
Reid, D. M., Barber, R. C., Jones, H. P., Thorpe, R. J., Sun, J., Zhou, Z., & Phillips, N. (2023) · Scientific Reports · doi:10.1038/s41598-023-41190-6 · Cited by 9 · see citing works
Assessing Genetic Overlap and Causality Between Blood Plasma Proteins and Alzheimer’s Disease
Handy, Á., Initiative, O. B. O. T. A. D. N., Lord, J., Green, R., Xu, J., Aarsland, D., Velayudhan, L., Hye, A., Dobson, R., & Proitsi, P. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210462 · Cited by 8 · see citing works
Translational research into frailty from bench to bedside: Salivary biomarkers for inflammaging
Cárdenas, A. N., Bareke, H., Juanes‐Velasco, P., Landeira‐Viñuela, A., Hernández, Á., Montalvillo, E., Góngora, R., Arroyo-Anlló, E. M., Puente-González, A. S., Sánchez, R. M., et al. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.112040 · Cited by 8 · see citing works
Advances in biomarkers and diagnostic significance of organ aging
Chen, Y., Li, J., Liu, X., Geng, Z., Xu, K., & Su, J. (2023) · Fundamental Research · doi:10.1016/j.fmre.2023.03.009 · Cited by 8 · see citing works
Optimization of prebiotics in soybean milk using mixture experiments
Sugkhaphan, P., & Kijroongrojana, K. (2009) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 6 · see citing works
Comparison of commonly measured plasma and cerebrospinal fluid proteins and their significance for the characterization of cognitive impairment status
Rehman, H., Initiative, F. T. A. D. N., Ang, T. F. A., Tao, Q., Espenilla, A. L., Au, R., Farrer, L. A., Zhang, X., & Qiu, W. Q. (2024) · Journal of Alzheimer's Disease · doi:10.3233/jad-230837 · Cited by 7 · see citing works
Linking atherosclerosis to Alzheimer's disease: focus on biomarkers
Emanuele, E. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/411 · Cited by 7 · see citing works
Systemic inflammatory markers and their association with Alzheimer’s disease: A cross-sectional analysis
Khatri, A., Prakash, O., Agarwal, R., & Kushwaha, S. S. (2024) · Indian Journal of Psychiatry · doi:10.4103/indianjpsychiatry.indianjpsychiatry_975_23 · Cited by 6 · see citing works
Inflammation Friend or Foe?
Lewis, T. J., & Trempe, C. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812112-2.00007-0 · Cited by 6 · see citing works
Independent role of Alzheimer's disease genetics and C-reactive protein on cognitive ability in aging
Supiyev, A., Karlsson, R., Wang, Y., Koch, E. M., Hägg, S., & Kauppi, K. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.02.006 · Cited by 5 · see citing works
C-Reactive Protein: An Overview
Vashist, S. K. (2013) · Journal of Basic & Applied Sciences · doi:10.6000/1927-5129.2013.09.64 · Cited by 5 · see citing works
Amaryllidaceae, Lycopodiaceae Alkaloids and Coumarins—A Comparative Assessment of Safety and Pharmacological Activity
Herbet, M., Widelski, J., Piątkowska‐Chmiel, I., Pawłowski, K., Dymek, A., & Mroczek, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154291 · Cited by 5 · see citing works
Recent Advancements in the Early Diagnosis and Treatment of Alzheimer's Disease
Wu, Y., Fu, L., Li, Q., Gao, X., Zhang, Y., Jin, C., Ding, F., Hong, S. C., Cai, H., & Li, Y. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300181 · Cited by 4 · see citing works
Peripheral Inflammatory Biomarkers of Alzheimer’s Disease
Hao, J., Guo, Y., Guo, K., & Yang, Q. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215422 · Cited by 5 · see citing works
Associations of circulating c-reactive protein levels with central Alzheimer’s disease biomarkers
Choi, H., Byun, M. S., Yi, D., Ahn, H., Jung, G., Park, S., Jung, J. H., Keum, M., Sohn, B. K., Kim, Y., et al. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100368 · Cited by 4 · see citing works
Soluble Interleukin‐6 Receptor Levels and Risk of Dementia: One More Signpost on a Long Road Ahead
Thambisetty, M., & Ferrucci, L. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12737 · Cited by 4 · see citing works
C-Reactive Protein and Neurodegenerative Diseases
Cardoso, I. L., & Leal, M. F. C. (2020) · Springer eBooks · doi:10.1007/978-981-15-6787-2_2 · Cited by 4 · see citing works
Novel Plasma Biomarkers for Alzheimer’s Disease: Insights from Organotypic Brain Slice and Microcontact Printing Techniques
Yılmaz, N., Steiner, K., Marksteiner, J., Faserl, K., Sarg, B., & Humpel, C. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl36257 · Cited by 3 · see citing works
KIF6 719Arg Carrier Status Association with Homocysteine and C-Reactive Protein in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Patients
Malek‐Ahmadi, M. H., Patel, A., & Sabbagh, M. N. (2013) · International Journal of Alzheimer s Disease · doi:10.1155/2013/242303 · Cited by 3 · see citing works
Regional Differences in Microbial Infiltration of Brain Tissue from Alzheimer’s Disease Patients and Control Individuals
Jones, T. B., Chu, P., Wilkey, B., Lynch, L. M., & Jentarra, G. M. (2024) · Brain Sciences · doi:10.3390/brainsci14070677 · Cited by 2 · see citing works
A Clinical Significance of High-Sensitivity C-reactive Protein Level in Alzheimer's Disease and Vascular Dementia
Wang, M.-J., Lim, E. Y., Kim, Y., Song, I., Chung, S., & Yang, Y. (2012) · Dementia and Neurocognitive Disorders · doi:10.12779/dnd.2012.11.4.131 · Cited by 2 · see citing works
Fluid biomarkers for Alzheimer's disease in Down syndrome: Current status and novel trends
Iulita, M. F., Granholm, A., Carmona‐Iragui, M., Hamlett, E. D., Fortea, J., & Ledreux, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818845-3.00010-4 · Cited by 2 · see citing works
Acute Phase Protein’s Levels as Potential Biomarkers for Early Diagnosis of Neurodegenerative Diseases
Pablos, D., Barcia, C., Je, Y., Ros-Bernal, F., Ma, C. D., Fernández-Villalba, E., & Herrero, M. (2011) · InTech eBooks · doi:10.5772/22626 · Cited by 2 · see citing works
The Role of Inflammatory Biomarkers as a Diagnostic Tool for Possible Late-Life Cognitive Decline and Dementias
Katsoulaki, M., Kastrinis, A., Konstantoudaki, X., & Τσεκούρα, Μ. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-78787-5_6 · Cited by 1 · see citing works
The Role of Diet, Erythrocyte Membrane Fatty Acid Composition, and Alzheimer's-related Genes in Systemic Inflammation in the Cache County Memory Study
Jalloun, R. A. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/4558-0376
2010 Faculty Bibliography of Publications
Lindsey, M., & Mason, T. (2011) · Digital Commons @ UNT Health Science Center
Original Article Differences between early and late onset Alzheimer's disease
Panegyres, P. K., & Chen, H.-Y. (2013)
Evaluating the Role of C-reactive Protein on Cognition and Depressive Symptoms Among Women by Mexican American Ethnicity
Huerta, S. (2014) · doi:10.12794/metadc700036
Compilação sobre possíveis biomarcadores para doença de Alzheimer
Ribeiro, M., & Urbano, P. R. P. (2020) · Revista Brasileira de Ciências Biomédicas · doi:10.46675/rbcbm.v1i2.13
Current awareness in geriatric psychiatry
John Wiley & Sons, L. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2396
The Role of Periodontitis as Modifiable Risk Factor for Alzheimer’s Disease- A Recent Update
Rai, P., Chande, Y., Mukadam, M., & Shetty, A. (2023) · Journal Of Advanced Zoology · doi:10.17762/jaz.v44i5.2806
Circulating C-reactive protein influences polygenic risk of inflammatory genes expressed in brain endothelia for Alzheimer’s disease
Huang, J., Rehman, H., Doan, C., Stein, T. D., Mez, J. B., Ang, T. F. A., Tao, Q., Au, R., Farrer, L. A., Zhang, X., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107257

A Meta-Analysis of C-Reactive Protein in Patients With Alzheimer’s Disease
Gong, C., Wei, D., Wang, Y., Ma, J., Yuan, C., Zhang, W., Yu, G., & Zhao, Y. (2015) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317515602087 · Cited by 53 · see citing works
Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease
Yarchoan, M. M., Louneva, N., Xie, S. X., Swenson, F. J., Hu, W. T., Soares, H. D., Trojanowski, J. Q., Lee, V. M. ‐., Kling, M. A., Shaw, L. M. J., et al. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.05.028 · Cited by 58 · see citing works
C‐reactive protein as an inflammatory biomarker for early Alzheimer’s Disease pathogenesis
Dey, A., Kern, S., & Skoog, I. G. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.086271 · Cited by 2 · see citing works
Differences in C-reactive Protein Level in Patients with Alzheimers Disease and Mild Cognitive Impairment
Shin, H. K. A. (2015) · African Journal of Psychiatry · doi:10.4172/psychiatry.1000194 · Cited by 9 · see citing works
C-reactive protein level is decreased in patients with Alzheimer's disease and related to cognitive function and survival time
Nilsson, K. H., Gustafson, L., & Hultberg, B. L. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.07.011 · Cited by 40 · see citing works

Authors: O'Bryant, S. E., Waring, S. C., Hobson, V., Hall, J. R., Moore, C. B., Bottiglieri, T., Massman, P., & Diaz-Arrastia, R.
Affiliations: Department of Neurology, F. Marie Hall Institute for Rural & Community Health, Texas Tech University Health Sciences Center, Lubbock, Texas,
Marshfield Clinic Research Foundation (US)
Texas Tech University (US)
University of North Texas Health Science Center (US)
The University of Texas Southwestern Medical Center (US)
Baylor University Medical Center (US)
Baylor College of Medicine (US)
ORCID: Waring, Stephen C.
Hall, James R.
Bottiglieri, Teodoro
Diaz-Arrastia, Ramon
Venue: Journal of Geriatric Psychiatry and Neurology
Publisher: SAGE Publications
Published: 2009-11-20
Volume: 23
Issue: 1
Pages: 49-53
ISSN: 0891-9887 (ISSN-L)
1552-5708
DOI: 10.1177/0891988709351832
PMC: PMC3204581
OpenAlex: W2056433678
Cited by: 103
References: 42
Citations by year: 2026: 4 · 2025: 2 · 2024: 6 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 1 · 2018: 9 · 2017: 6 · 2016: 1 · 2015: 8 · 2014: 5 · 2013: 13 · 2012: 2
FWCI: 3.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Geriatric Psychiatry and Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01 AG17869, P30AG012300, P30AG-12300)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: C-reactive protein, Alzheimer's disease, acute phase proteins, dementia severity, Clinical Dementia Rating, Mini-Mental State Examination, inflammation, prodromal Alzheimer's disease, endophenotypes, serum biomarkers
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, C-Reactive Protein, Dementia, Female, Humans, Immunoassay, Male, Mental Status Schedule, Middle Aged, Predictive Value of Tests, Psychiatric Status Rating Scales, Severity of Illness Index, Time Factors, Biomarkers, Linear Models

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Decreased C-Reactive Protein Levels in Alzheimer Disease

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks