The Link Between C-Reactive Protein and Alzheimer's Disease Among Mexican Americans
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BACKGROUND: The aim of this study is to evaluate the link between C-reactive protein (CRP) and Alzheimer's disease (AD) and mild cognitive impairment (MCI) among Mexican Americans. METHODS: Non-fasting serum CRP levels, Mini-Mental State Examination scores, and Clinical Dementia Rating scale (CDR) scores were analyzed from 1,066 participants (Mexican American n = 471; non-Hispanic n = 595) of the Texas Alzheimer's Research & Care Consortium. RESULTS: Among the total cohort, CRP levels among AD cases were significantly decreased as compared to normal controls (p < 0.001) and MCI cases (p = 0.002). CRP levels among MCI cases were decreased relative to controls (p = 0.03). Among Mexican American and non-Hispanic AD cases, CRP levels were significantly decreased among AD cases as compared to controls. CRP levels were only associated with disease severity (CDR scores) among non-Hispanics (p = 0.03) AD cases. CONCLUSIONS: These results show that while CRP levels are decreased among Mexican American AD cases, CRP does not appear to be related to clinical variables as it is among non-Hispanic whites.
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In the mentioned study, decreased levels of CRP were observed among Mexican American Alzheimer's disease patients.
“In the mentioned study they observed decreased levels of CRP among Mexican American AD patients [49].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [49]
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- Authors
- O'Bryant, S. E., for the Texas Alzheimer's Research & Care Consortium, Johnson, L., Edwards, M., Soares, H., Devous, M. D., Ross, S., Rohlfing, G., & Hall, J.
- Affiliations
- University of North Texas Health Sciences Center, Department of Internal Medicine, Fort Worth, TX, USA
- University of North Texas (US)
- Bristol-Myers Squibb (United States) (US)
- The University of Texas Southwestern Medical Center (US)
- University of North Texas Health Science Center (US)
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2013-03-04
- Volume
- 34
- Issue
- 3
- Pages
- 701-706
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC3608400
- OpenAlex
- W2124593272
- Cited by
- 47
- References
- 25
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 7 · 2013: 1
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30AG012300, R01AG039389)
- National Institute on Minority Health and Health Disparities (L60 MD001849)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- C-reactive protein, Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, C-Reactive Protein, Female, Humans, Male, Middle Aged, Risk Factors, Cohort Studies, Biomarkers, Down-Regulation, Mexican Americans, White People, Cognitive Dysfunction
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