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Structural and Functional Brain Abnormalities in Schizophrenia

Open access
Karlsgodt, Katherine H., Sun, Daqiang, Cannon, Tyrone D.·2010·Current Directions in Psychological Science

Abstract

Schizophrenia is associated with changes in the structure and functioning of a number of key brain systems, including prefrontal and medial temporal lobe regions involved in working memory and declarative memory, respectively. Imaging techniques provide an unparalleled window into these changes, allowing repeated assessments across pre- and post-onset stages of the disorder and in relation to critical periods of brain development. Here we review recent directions in structural and functional neuroimaging research on schizophrenia. The view emerging from this work is that schizophrenia is fundamentally a disorder of disrupted neural connectivity, the sources of which appear to be genetic and environmental risk factors influencing brain development both prenatally and during adolescence.

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Metadata

Authors
Karlsgodt, K. H., Sun, D., & Cannon, T. D.
Venue
Current Directions in Psychological Science
Published
2010-08
Volume
19
Issue
4
Pages
226-231
ISSN
  • 0963-7214 (ISSN-L)
  • 1467-8721
OpenAlex
W2168445735
Cited by
192
References
4
FWCI
1.20
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Structural and Functional Brain Abnormalities in Schizophrenia. https://app.cochat.ai/papers/10.1177/0963721410377601
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Karlsgodt, K. H., Sun, D., & Cannon, T. D. (2010). Structural and Functional Brain Abnormalities in Schizophrenia. Current Directions in Psychological Science. https://doi.org/10.1177/0963721410377601

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.