White-matter free-water diffusion MRI in schizophrenia: A systematic review and meta-analysis

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Quantification of increased cellularity during inflammatory demyelination

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Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review

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Heterogeneity and Homogeneity of Regional Brain Structure in Schizophrenia

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Inflammation and Schizophrenia

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Neuroinflammation and white matter pathology in schizophrenia: systematic review

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Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset

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Neuroinflammation in psychiatric disorders: PET imaging and promising new targets

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Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

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White matter alterations in early stages of schizophrenia: a systematic review of diffusion tensor imaging studies

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Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models

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Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

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Structural and Functional Brain Abnormalities in Schizophrenia

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A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia

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A Meta-analysis of Immune Parameters, Variability, and Assessment of Modal Distribution in Psychosis and Test of the Immune Subgroup Hypothesis

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Free water determines diffusion alterations and clinical status in cerebral small vessel disease

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Cortical grey matter volume reduction in people with schizophrenia is associated with neuro-inflammation

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In vivo imaging of neuroinflammation in schizophrenia

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The extent of diffusion MRI markers of neuroinflammation and white matter deterioration in chronic schizophrenia

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Equipercentile linking of the BPRS and the PANSS

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Minocycline and Risperidone Prevent Microglia Activation and Rescue Behavioral Deficits Induced by Neonatal Intrahippocampal Injection of Lipopolysaccharide in Rats

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Estimation of Extracellular Volume from Regularized Multi-shell Diffusion MRI

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Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning

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The antipsychotic spiperone attenuates inflammatory response in cultured microglia via the reduction of proinflammatory cytokine expression and nitric oxide production

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Large-Scale Evidence for an Association Between Peripheral Inflammation and White Matter Free Water in Schizophrenia and Healthy Individuals

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Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression

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Characterizing white matter changes in chronic schizophrenia: A free-water imaging multi-site study

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Early detection of schizophrenia by diffusion weighted imaging

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Extracellular free water and glutathione in first-episode psychosis—a multimodal investigation of an inflammatory model for psychosis

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Abnormal white matter microstructure and increased extracellular free-water in the cingulum bundle associated with delusions in chronic schizophrenia

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Comparing free water imaging and magnetization transfer measurements in schizophrenia

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Brain Volumes in Relatives of Patients With Schizophrenia: A Metaanalysis

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Elevated Extracellular Free-Water in a Multicentric First-Episode Psychosis Sample, Decrease During the First 2 Years of Illness

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Microstructural White Matter and Links With Subcortical Structures in Chronic Schizophrenia: A Free-Water Imaging Approach

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White matter abnormalities and cognition in aging and Alzheimer disease

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Immune Dysfunction in Schizophrenia Spectrum Disorders

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Demyelination in psychiatric and neurological disorders: Mechanisms, clinical impact, and novel therapeutic strategies

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The kynurenine pathway in treatment-resistant schizophrenia at the crossroads between pathophysiology and pharmacotherapy

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Neuroinflammation in Schizophrenia: An Overview of Evidence and Implications for Pathophysiology

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Free water alterations in different inflammatory subgroups in schizophrenia

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Spherical means-based free-water volume fraction from diffusion MRI increases non-linearly with age in the white matter of the healthy human brain

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Neuroimaging Biomarkers for Drug Discovery and Development in Schizophrenia

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Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization

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Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging

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Free water imaging in Parkinson’s disease and atypical parkinsonian disorders

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Genetic polymorphism and neuroanatomical changes in schizophrenia

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White matter lipidome alterations in the schizophrenia brain

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The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program

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Association between peripheral inflammation and body mass index on white matter integrity and free water in bipolar II depression

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White matter microstructure alterations in early psychosis and schizophrenia

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Transcallosal white matter and cortical gray matter variations in autistic adults aged 30–73 years

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Free‐Water Imaging in Friedreich Ataxia Using Multi‐Compartment Models

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A fatal alliance: Glial connexins, myelin pathology and mental disorders

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Brain structure in schizophrenia: what do we know and what next?

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Correlation between myelin basic protein levels in cerebrospinal fluid and motor speed in patients with schizophrenia

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NIMH perspectives on future directions in neuroimaging for mental health

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Development of white matter in young adulthood: The speed of brain aging and its relationship with changes in fractional anisotropy

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Lower fractional anisotropy without evidence for neuro-inflammation in patients with early-phase schizophrenia spectrum disorders

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Corpus callosum microstructural organization mediates the effects of physical neglect on social cognition in schizophrenia

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Microstructural imaging of brain changes in schizophrenia via quantitative T1 (qT1): a preliminary comparison of two acquisition protocols

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Exploring the Intersection of Geophysics and Diagnostic Imaging in the Health Sciences

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Applications of MRI in Schizophrenia: Current Progress in Establishing Clinical Utility

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White matter free water and depressive symptoms in medication-free depressed adolescents: moderation by peripheral inflammation

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Microstructural and Microvascular Alterations in Psychotic Spectrum Disorders: A Three-Compartment Intravoxel Incoherent Imaging and Free Water Model

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An MRI evaluation of white matter involvement in paradigmatic forms of spastic ataxia: results from the multi-center PROSPAX study

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Elevated Extracellular Free Water in the Brain Predicts Clinical Improvement in First-Episode Psychosis

Lesh, T. A., Bergé, D., Smucny, J., Guo, J. Y., & Carter, C. S. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.09.014 · Cited by 4 · see citing works

Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial

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A narrative literature review of white matter microstructure in individuals at clinical high risk for psychosis

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Morphological Alterations in Schizophrenia — An Interdisciplinary Review

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Putative glymphatic dysfunction links extracellular fluid dysregulation to white matter degeneration and clinical impairment in amyotrophic lateral sclerosis

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Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum

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Is this the end of precision medicine? Or the beginning?

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High frequency conductivity decomposition by solving physically constraint underdetermined inverse problem in human brain

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Schizophrenia spectrum disorders

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Differential inflammatory profiles in carriers of reciprocal 22q11.2 copy number variants

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Microstructural brain assessment in late-life depression and apathy using diffusion MRI multi-compartments models and tractometry

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Comparative analysis of corpus callosum lipidome and transcriptome in schizophrenia and healthy brain

Osetrova, M., Efimova, O., Zavolskova, M., Stekolshchikova, E., Vladimirov, G., Senko, D., Zhuravleva, T. A., Morozova, A. Y., Zorkina, Y., Andreyuk, D., et al. (2025) · Consortium Psychiatricum · doi:10.17816/cp15491 · Cited by 1 · see citing works

Impact of schizophrenia-associated risk genes on brain functional networks and executive deficits: a study of individuals with schizophrenia and genetic high risk

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Reproducibility and Reliability of Free‐Water‐Corrected Diffusion Tensor Imaging of the Brain: Revisited

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Neurite Density and Kurtosis in the Gray Matter of People With Early Schizophrenia

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40 Years of diffusion MRI in the brain: From history to emerging frontiers

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In the afterglow: Immune dysfunction in schizophrenia spectrum disorders

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Poor Self-Reported Sleep is Associated with Prolonged White Matter T2 Relaxation in Psychotic DisordersPreprint

Yeşilkaya, Ü. H., Chen, X., Watford, L., McCoy, E., Genc, I., Du, F., Öngür, D., & Yüksel, Ç. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.03.601887

Transcallosal white matter and cortical gray matter variations in autistic adults ages 30-73 years: A bi-tensor free water imaging approachPreprint

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Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders

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Differential effect of cannabis use and antipsychotic medication on extracellular free-water in the brain of individuals with early psychosis and controls

Martínez-Sadurní, L., Barrera-Conde, M., Robledo, P., Veza-Estévez, E., García-Quintana, J., Mané, A., Toll, A., Trabsa, A., Lesh, T. A., Carter, C. S., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03287-4

Exploratory MIA study: multimodal magnetic resonance imaging characteristics of rat offspring induced by maternal Poly(I:C) exposure during pregnancy

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Prevalence of covert cerebrovascular changes in schizophrenia: A systematic review and meta-analysis

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Signatures of altered free-water and cognition and associations with symptom severity in psychosis spectrum disorders

Stiltner, B., Kelly, S., Karayumak, S. C., Trotti, R. L., Parker, D. A., Zeng, V., Pearlson, G. D., Clementz, B. A., McDowell, J. E., Hill, S. K., et al. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106537

Multimodal neuroimaging alterations in schizophrenia model rats and the modulatory effects of risperidone: a pilot study

Zhu, S., Yunxia, L., Zhang, Y., Feng, Z., & Sun, W. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1757297

Two patterns of abnormal FA with different radial features and their relation to polygenic risks in first-episode schizophrenia and unaffected siblings

Huang, W., Liu, Z., Tan, W., Chen, X., Wu, G., Han, L., Liu, X., & Pan, Y. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.04.004

MK-801-induced cognitive dysfunction in a schizophrenia model: mechanistic links between interstitial fluid drainage impairment and neural metabolic disturbances

Mao, X. Y., Gao, T., Yang, S., Tan, H., Su, S., & Long, R. (2026) · Exploration of neuroscience · doi:10.37349/en.2026.1006140

Longitudinal White Matter Trajectories in Clinical High Risk and First-Episode Psychosis: Findings from the Multi-Centre PSYSCAN StudyPreprint

Bolte, L., Gifford, G., Serpa, M. H., Cottaar, M., Dazzan, P., Fusar‐Poli, P., Tognin, S., Kempton, M. J., Rossum, I. W.-V., Slot, M. I. E., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.20.739516

A Data- and Physical- Features Driven Graph Convolution Network for Explainable Prediction of Schizophrenia With Electroencephalography

Chen, B., Hou, Z., Cheng, Y., Qi, W., & Chan, S. C. (2026) · IEEE Access · doi:10.1109/access.2026.3729893

Psychosocial Interventions, Recovery, and Mediating Mechanisms in Schizophrenia-Spectrum Disorders: A Systematic Review and Meta-Analysis of Longitudinal Studies

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Sex-specific role of systemic inflammation in moderating the association between choroid plexus volume and depressive severity: findings from sBEAD cohort

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Response to Letter to the Editor re: “Lacto-ovo-vegetarian and vegan diets in children and adolescents: a systematic review and meta-analysis of nutritional and health outcomes”

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Characterizing the Role of Neuroinflammation in Depression Using Free Water MRI Biomarkers and Investigating Its Therapeutic Relevance

Braband, B. (2026) · Critical Debates in Humanities Science and Global Justice · doi:10.68709/001c.160313

Characterizing Extracellular White Matter Pathologies Using Free Water Imaging Across the Schizophrenia Illness Course: A Multi-Site Harmonized Diffusion MRI Study

Karayumak, S. C., Pasternak, O., Zhang, F., Seitz, J., Elad, D., Pearlson, G. D., Tamminga, C. A., Sweeney, J. A., Clementz, B. A., Schretlen, D. J., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.02.226

Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization.

Karayumak, S. C., Lyall, A. E., Biase, M. A. D., Seitz‐Holland, J., Zhang, F., Kelly, S., Elad, D., Pearlson, G., Tamminga, C. A., Sweeney, J. A., et al. (2023) · Open Access CRIS of the University of Bern · doi:10.48350/181973

158. Female-Specific Excessive Extracellular Free-Water in Prodromal Schizophrenia

Pasternak, O., Seitz, J., Kubicki, M. R., Seidman, L. J., Zinberg, J. L., Bearden, C. E., Cannon, T. D., & Shenton, M. E. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx021.216

White-matter free-water diffusion MRI in schizophrenia

Figueiredo, I. C. (2023) · Research Portal (King's College London)

Characterizing white matter changes in chronic schizophrenia: A free-water imaging multi-site study

Oestreich, L., Lyall, A. E., Pasternak, O., Kikinis, Z., Newell, D. T., Savadjiev, P., Sylvain Bouix, A., Shenton, M. E., Kubicki, M. R., Whitford, T. J., et al. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.02.006 · Cited by 64 · see citing works