Prediction and Prevention of Psychosis in Youth at Clinical High Risk

Addington, Jean; Heinssen, Robert

doi:10.1146/annurev-clinpsy-032511-143146

Cited by 189Schizophrenia research and treatmentPsychopathy, Forensic Psychiatry, Sexual OffendingMaternal Mental Health During Pregnancy and Postpartum

Prediction and Prevention of Psychosis in Youth at Clinical High Risk

Addington, Jean, Heinssen, Robert·2012·Annual Review of Clinical Psychology

DOI 10.1146/annurev-clinpsy-032511-143146

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Abstract

Most individuals with schizophrenia retrospectively report a prodromal period characterized by increasing problems in thinking, feeling, and behaving. However, it is less clear how many individuals who display prodromal symptoms will subsequently develop a psychotic illness. Thus, a precondition for early intervention in psychosis is the accurate detection of those who may be at true risk of developing a psychotic illness. The aim of this article is to review current work addressing prediction and prevention in the prodrome to psychosis. First, we describe research efforts to develop and test operational criteria for prospectively assessing psychosis liability over time. Second, the clinical, functional, and biological features of the prodrome are presented, along with a discussion of the variables most frequently associated with psychosis onset. Next, treatment studies are reviewed. The review concludes with a framework for future early identification and treatment studies.

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Circadian disruptions in adolescents at high risk of psychosis and in individuals with mood disorders predict worse prognosis and symptoms in longitudinal studies.
“circadian disruptions in adolescents who are at high risk of psychosis (that is, subthreshold symptoms of psychosis, social impairment and higher suspicion–paranoia)197 and individuals with mood disorders predict worse prognosis and symptoms in longitudinal studies198,199”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [197]

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Authors: Addington, J., & Heinssen, R.
Affiliations: University of Calgary (CA)
National Institute of Mental Health (US)
ORCID: Addington, Jean
Venue: Annual Review of Clinical Psychology
Publisher: Annual Reviews
Published: 2012-04-27
Volume: 8
Issue: 1
Pages: 269-289
ISSN: 1548-5943 (ISSN-L)
1548-5951
DOI: 10.1146/annurev-clinpsy-032511-143146
OpenAlex: W2124237100
Cited by: 189
References: 109
Citations by year: 2026: 6 · 2025: 11 · 2024: 7 · 2023: 11 · 2022: 10 · 2021: 17 · 2020: 11 · 2019: 13 · 2018: 11 · 2017: 17 · 2016: 20 · 2015: 14 · 2014: 20 · 2013: 16 · 2012: 5
FWCI: 2.37
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Clinical Psychology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords: prodromal psychosis, clinical high risk for psychosis, psychosis prediction, psychosis prevention, early intervention, schizophrenia, prodromal symptoms, early detection
MeSH terms: Adolescent, Humans, Predictive Value of Tests, Psychiatric Status Rating Scales, Psychotic Disorders, Risk Factors, Schizophrenia, Schizophrenic Psychology

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Prediction and Prevention of Psychosis in Youth at Clinical High Risk

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