Cited by 343Stress Responses and CortisolChild and Adolescent Psychosocial and Emotional DevelopmentNeural and Behavioral Psychology Studies

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The Teenage Brain: The Stress Response and the Adolescent Brain

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Romeo, Russell D.·2013·Current Directions in Psychological Science

DOI 10.1177/0963721413475445PMC PMC4274618

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Abstract

Adolescence is a time of many psychosocial and physiological changes. One such change is how an individual responds to stressors. Specifically, adolescence is marked by significant shifts in hypothalamic-pituitary-adrenal (HPA) axis reactivity, resulting in heightened stress-induced hormonal responses. It is presently unclear what mediates these changes in stress reactivity and what impacts they may have on an adolescent individual. However, stress-sensitive limbic and cortical brain areas that continue to mature during adolescence may be particularly vulnerable to these shifts in responsiveness. Consequently, perturbations of the maturing adolescent brain may contribute to the increase in stress-related psychological dysfunctions, such as anxiety, depression, and drug abuse, often observed during this stage of development. The purpose of this review is to describe the changes that occur in HPA function during adolescence, as well as to briefly discuss the possible ramifications of these changes on the developing brain and psychological health.

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Authors: Romeo, R. D.
Affiliations: Columbia University (US)
Corresponding author: Romeo, Russell D.
ORCID: Romeo, Russell D.
Venue: Current Directions in Psychological Science
Publisher: SAGE Publications
Published: 2013-04
Volume: 22
Issue: 2
Pages: 140-145
ISSN: 0963-7214 (ISSN-L)
1467-8721
DOI: 10.1177/0963721413475445
PMC: PMC4274618
OpenAlex: W2103027336
Cited by: 343
References: 28
Citations by year: 2026: 43 · 2025: 29 · 2024: 35 · 2023: 39 · 2022: 39 · 2021: 43 · 2020: 23 · 2019: 19 · 2018: 26 · 2017: 11 · 2016: 15 · 2015: 11 · 2014: 7 · 2013: 3
FWCI: 5.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Current Directions in Psychological Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R03MH090224)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: adolescence, hypothalamic-pituitary-adrenal axis, stress reactivity, adolescent brain development, cortical maturation, anxiety, depression, drug abuse

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The Teenage Brain: The Stress Response and the Adolescent Brain

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