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Salivary α-Amylase: Role in Dental Plaque and Caries Formation
Open accessAbstract
Salivary α-amylase, one of the most plentiful components in human saliva, has at least three distinct biological functions. The enzymatic activity of a-amylase undoubtedly plays a role in carbohydrate digestion. Amylase in solution binds with high affinity to a selected group of oral streptococci, a function that may contribute to bacterial clearance and nutrition. The fact that a-amylase is also found in acquired enamel pellicle suggests a role in the adhesion of a-amylase-binding bacteria. All of these biological activities seem to depend on an intact enzyme conformation. Binding of a-amylase to bacteria and teeth may have important implications for dental plaque and caries formation. a-Amylase bound to bacteria in plaque may facilitate dietary starch hydrolysis to provide additional glucose for metabolism by plaque microorganisms in close proximity to the tooth surface. The resulting lactic acid produced may be added to the pool of acid in plaque to contribute to tooth demineralization.
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Citations
Cited by
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Nater, U. M., Rohleder, N., Gaab, J., Berger, S., Jud, A., Kirschbaum, C., & Ehlert, U. (2005) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2004.09.009 · Cited by 618
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Saliva-Bacterium Interactions in Oral Microbial Ecology
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Self-citationClinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: a systematic review
Soares Nunes, L. A., Mussavira, S., & Sukumaran Bindhu, O. (2015) · Biochemia Medica · doi:10.11613/bm.2015.018 · Cited by 333
Rohleder, N., Wolf, J. M., Maldonado, E. F., & Kirschbaum, C. (2006) · Psychophysiology · doi:10.1111/j.1469-8986.2006.00457.x · Cited by 321
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Mass Transport of Macromolecules within an In Vitro Model of Supragingival Plaque
Thurnheer, T., Gmür, R., Shapiro, S., & Guggenheim, B. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.3.1702-1709.2003 · Cited by 145
Nobbs, A. H., Zhang, Y., Khammanivong, A., & Herzberg, M. C. (2007) · Journal of Bacteriology · doi:10.1128/jb.01535-06 · Cited by 53
A disposable biosensor for the determination of alpha-amylase in human saliva
Mahosenaho, M., Caprio, F., Micheli, L., Sesay, A. M., Palleschi, G., & Virtanen, V. (2010) · Microchimica Acta · doi:10.1007/s00604-010-0360-y · Cited by 45
da Silva Modesto, K. B., de Godói Simões, J. B., de Souza, A. F., Damaceno, N., Duarte, D. A., Leite, M. F., & de Almeida, E. R. (2015) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2015.08.007 · Cited by 28
Metadata
- Authors
- Scannapieco, F. A., Torres, G., & Levine, M. J.
- Venue
- Critical Reviews in Oral Biology & Medicine
- Publisher
- SAGE Publications
- Published
- 1993-04
- Volume
- 4
- Issue
- 3
- Pages
- 301-307
- ISSN
- 1045-4411 (ISSN-L)
- 1544-1113
- OpenAlex
- W1934037969
- Cited by
- 270
- References
- 0
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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